Show
01-03-2010Shows of the week In January 2010
Depression Saps Endurance of the Brain's Reward Circuitry--Supplements or Herbs or Food to consider
Relatives of Boys With Sexual Birth Defects Not at Risk for Testicular Germ Cell Cancer
Recipe
ScienceDaily (Dec. 25, 2009)
— Researchers at Emory University in Atlanta, GA, recommend that progesterone (PROG), a naturally occurring hormone found in both males and females that can protect damaged cells in the central and peripheral nervous systems, be considered a viable treatment option for traumatic brain injuries, according to a clinical perspective.----"Traumatic brain injury (TBI) is an important clinical problem in the United States and around the world," said Donald G. Stein, PhD, lead author of the paper. "TBI has received more attention recently because of its high incidence among combat casualties in Iraq and Afghanistan. Current Department of Defense statistics indicated that as many as 30 percent of wounded soldiers seen at Walter Reed Army Hospital have suffered a TBI, a finding that has stimulated government interest in developing a safe and effective treatment for this complex disorder," said Stein.--"Growing evidence indicates that post-injury administration of PROG in a variety of brain damage models can have beneficial effects, leading to substantial and sustained improvements in brain functionality. PROG given to both males and females can cross the blood-brain barrier and reduce edema (swelling) levels after TBI; in different models of cerebral ischemia (restriction of blood supply), significantly reduce the area of necrotic cell death and improve behavioral outcomes; and protect neurons distal to the injury that would normally die," said Stein.---PROG was recently tested in two phase 2 clinical trials for traumatic brain injury and will begin a phase 3 NIH sponsored trial soon.---"Given its relatively high safety profile, its ease of administration, its low cost and ready availability, PROG should be considered a viable treatment option -- especially because, in brain injury, so little else is currently available," said Stein.---This study appears in the January issue of the American Journal of Roentgenology. --Story Source:--Adapted from materials provided by American College of Radiology / American Roentgen Ray Society, via EurekAlert!, a service of AAAS.
Depression Saps Endurance of the Brain's Reward Circuitry
ScienceDaily (Dec. 22, 2009) — A new study at the University of Wisconsin-Madison
suggests that depressed patients are unable to sustain activity in brain areas related to positive emotion.---The study challenges previous notions that individuals with depression show less brain activity in areas associated with positive emotion. Instead, the new data suggest similar initial levels of activity, but an inability to sustain them over time. The new work was reported online the week of Dec. 21 in the Proceedings of the National Academy of Sciences.---"Anhedonia, the inability to experience pleasure in things normally rewarding, is a cardinal symptom of depression," explains UW-Madison graduate student Aaron Heller, who led the project. "Scientists have generally thought that anhedonia is associated with a general reduction of activity in brain areas thought to be important for positive emotion and reward. In fact, we found that depressed patients showed normal levels of activity early on in the experiment. However, towards the end of the experiment, those levels of activity dropped off precipitously.---"Those depressed subjects who were better able to sustain activity in brain regions related to positive emotion and reward also reported higher levels of positive emotion in their everyday experience," Heller continues.---"Being able to sustain and even enhance one's own positive emotional experience is a critical component of health and well-being," notes the study's senior author, Richard Davidson, professor of psychology and psychiatry and director of both the UW-Madison Center for Investigating Healthy Minds, and the Waisman Laboratory for Brain Imaging and Behavior. "These findings may lead to therapeutic interventions that enable depressed individuals to better sustain positive emotion in their daily lives."---During the study, 27 depressed patients and 19 control participants were presented with visual images intended to evoke either a positive or a negative emotional response. While viewing these images, participants were instructed to use cognitive strategies to increase, decrease or maintain their emotional responses to the images by imagining themselves in similar scenarios. Heller and colleagues used functional magnetic resonance imaging (fMRI) to measure brain activity in the target areas. The scientists examined the extent to which activation in the brain's reward centers to positive pictures was sustained over time.---The work was funded by grants from the National Institute of Mental Health, Wyeth-Ayerst Pharmaceuticals, Fetzer Institute and Impact Foundation, and by gifts from the John W. Kluge Foundation, Bryant Wangard, Ralph Robinson and Keith and Arlene Bronstein.--Story Source:--Adapted from materials provided by University of Wisconsin-Madison, via EurekAlert!, a service of AAASSupplements or Herbs or Food to consider
Pregnenolone--increases Progesterone Naturally and is part of the anti depression chemicals that is produced in the brain but can diminish in production through age---suggested dose should be 15 mgs first thing in the morning---the studies done on this was that in the early stages of the industrial age when manufacturing was starting people would be depressed and un-attentive --when given pregnenolone there was a marked improvement in mood and production
Tyrosine-- Taken again first thing in the morning can enhance anti depressant effective and when combo'd with iodine this to will regulate the T4-T3 conversions---dose would be 500 mgs-1000mgs in the morning and midday
Iodine--taken before bed at night 1-2 drops in 2 ounces of water used daily has been researched to alleviate depression and reverse some cases of bipolar
Niacinamide--taken at night 500 mgs before bed has also been found to assist in the reversal of being depressed
Cocoa-- taken straight or even in a food or beverage can also increase endorphins which are anti depressing can be combo's with other supplements like inositol or niacinamide--can be used with nutmeg and vanilla as well
Nutmeg-- impacts the brain and it's connectiveness and the utilization of signals --this to can have an antidepressing effect
Vitex or Chaste tree berry-- this is a natural way to increase progesterone---use in teas or capsule formats take the suggested dose on the bottle 1-3 times a day or make a tea---this can as well have a deterring effect on the libido for women--reversing this would be to lay off the vitex for a period of time after using this herb for a period of time
Relatives of Boys With Sexual Birth Defects Not at Risk for Testicular Germ Cell Cancer
ScienceDaily (Dec. 29, 2009) — Boys with the sexual birth defects known as hypospadias and cryptorchidism are at risk for developing testicular germ cell cancer, but their relatives are not, according to a new study published online December 21 in the Journal of the National Cancer Institute.--
Although hypospadias, the birth defect that involves an abnormally-placed urinary opening, and cryptorchidism, the lack of descension of one or both testes in the scrotal sac, are associated with a risk of developing testicular germ cell cancer, it was unclear whether all three were part of an inheritable dysgenesis syndrome. ( My foot note here ---in Europe they have correlated this to the introduction of SOY contamination in there foods)---To study this relationship, Tine H. Schnack, M.D., of the Department of Epidemiology Research, Statens Serum Institute, in Copenhagen, and colleagues identified over 2 million men born since 1953. They were followed from April 1968 through May 2008. First-, second-, and third-degree relatives were identified in the Danish Family Relations Database; cryptorchidism and hypospadias patients were identified in the Danish Hospital Discharge Register; and testicular germ cell cancer patients were identified in the Danish Cancer Register.---Men with a personal history of cryptorchidism or hypospadias had an increased relative risk of developing testicular germ cell cancer, but their relatives did not. A total of 5,441 patients developed testicular germ cell cancer. ( Again another Note this would be a form of Birth control by affecting the male genitalia)--The authors write that "…a family history of hypospadias or cryptorchidism was not associated with a general increase in the risk of developing [testicular germ cell cancer]. Thus, our data do not support the hypothesis of shared inheritability of the disorders described under testicular dysgenesis syndrome."---Study limitations: Misclassification of legal and biological fathers because of privacy could lead to bias in coding of relatives. Diagnoses of cryptorchidism and hypospadias were not recorded for births until 1977, and only later diagnoses made during adolescence could be used.--Story Source:--Adapted from materials provided by Journal of the National Cancer Institute,---ØØThere has been a direct link to Mums feeding on Soy during pregnancies is a large contributor to this condition, in Europe
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Thai black pepper, protects against neurodegeneration and cognitive impairment--Piperine, the main alkaloid of Thai black pepper, protects against neurodegeneration and cognitive impairment in animal model of cognitive deficit like condition of Alzheimer's disease.Food Chem Toxicol. 2009 Dec 21;--Authors: Chonpathompikunlert P, Wattanathorn J, Muchimapura S
Recently, numerous medicinal plants possessing profound central nervous system effects and antioxidant activity have received much attention as food supplement to improve cognitive function against cognitive deficit condition including in Alzheimer's disease condition. Based on this information, the effect of piperine, a main active alkaloid in fruit of Piper nigrum, on memory performance and neurodegeneration in animal model of Alzheimer's disease have been investigated. Adult male Wistar rats (180-220 g) were orally given piperine at various doses ranging from 5, 10 and 20 mg/kg BW at a period of 2 weeks before and 1 week after the intracerebroventricular administration of ethylcholine aziridinium ion (AF64A) bilaterally.
The results showed that piperine at all dosage range used in this study significantly improved memory impairment and neurodegeneration in hippocampus. The possible underlying mechanisms might be partly associated with the decrease lipid peroxidation and acetylcholinesterase enzyme. Moreover, piperine also demonstrated the neurotrophic effect in hippocampus. However, further researches about the precise underlying mechanism are still required.PMID: 20034530 [PubMed - as supplied by publisher]
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Piperine, the potential functional food for mood and cognitive disorders.Wattanathorn J, Chonpathompikunlert P, Muchimapura S, Priprem A, Tankamnerdthai O.Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand. jintanapornw@yahoo.com
The effect of piperine, the main alkaloid from piper nigrum, on the central nervous system is not clearly known until now. In the present study, male Wistar rats were administered piperine at various doses ranging from 5, 10 and 20mg/kg BW once daily for 4 weeks and the animals were determined the neuropharmacological activity after single, 1, 2, 3 and 4 weeks of treatment. The results showed that piperine at all dosage range used in this study
possessed anti-depression like activity and cognitive enhancing effect at all treatment duration. Therefore, piperine may be served as the potential functional food to improve brain function. However, further investigations about precise underlying mechanism are still required
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Black pepper and its pungent principle-piperine: a review of diverse physiological effects.Srinivasan K.-Department of Biochemistry and Nutrition, Central Food Technological Research Institute, Mysore, India. ksri.cftri@gmail.com
Black pepper (Piper nigrum) is one of the most widely used among spices. It is valued for its distinct biting quality attributed to the alkaloid, piperine. Black pepper is used not only in human dietaries but also for a variety of other purposes such as medicinal, as a preservative, and in perfumery. Many physiological effects of black pepper, its extracts, or its major active principle, piperine, have been reported in recent decades. Dietary piperine, by favorably stimulating the digestive enzymes of pancreas,
enhances the digestive capacity and significantly reduces the gastrointestinal food transit time. Piperine has been demonstrated in in vitro studies to protect against oxidative damage by inhibiting or quenching free radicals and reactive oxygen species. Black pepper or piperine treatment has also been evidenced to lower lipid peroxidation in vivo and beneficially influence cellular thiol status, antioxidant molecules and antioxidant enzymes in a number of experimental situations of oxidative stress. The most far-reaching attribute of piperine has been its inhibitory influence on enzymatic drug biotransforming reactions in the liver. It strongly inhibits hepatic and intestinal aryl hydrocarbon hydroxylase and UDP-glucuronyl transferase. Piperine has been documented to enhance the bioavailability of a number of therapeutic drugs as well as phytochemicals by this very property. Piperine's bioavailability enhancing property is also partly attributed to increased absorption as a result of its effect on the ultrastructure of intestinal brush border. Although initially there were a few controversial reports regarding its safety as a food additive, such evidence has been questionable, and later studies have established the safety of black pepper or its active principle, piperine, in several animal studies. Piperine, while it is non-genotoxic, has in fact been found to possess anti-mutagenic and anti-tumor influences.ØØRecipe-- Add black pepper with papaya seed---Take 1 tsp of black pepper and 1 tsp of papaya seed put in blender and blend til fine and then sift the pulverized mix till all the cource or rough particles are left behind----add this to your meats before cooking and this will tenderize your meats as well as have an antiparasitical effect---add 1/2 tsp of this to a 2 ounce glass of water and 1 tablespoon of vinegar ( you may want to put this in a blender as well to fuse or mix) when done sip slowly this will improve circulation and digestion and assist in the removing of congestion in the colon---DO NOT MIX THIS WITH ANY PHARMACEUTICALS!!!!!!--This can be taken 2 hours before or after the use of prescribed drugs---IF YOU FIND THIS OVER POWERING , THEN ONLY USE TEASPOON AMOUNTS AGAIN THIS IS POTENT!!!
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Antidepressant-like effects of piperine and its neuroprotective mechanismDepertment of Clinical Pharmacology and Pharmacy, Chinese PLA General Hospital, Beijing 100853, China.
OBJECTIVE: To observe the antidepressant effect of piperine and its neuroprotective mechanism. METHOD: The behavioral studies were performed in forced swimming test (FST) and tail suspension test (TST). To further explore the mechanisms underlying their antidepressant-like activities, CORT-induced neuroblastoma SH-SY5Y cells and isolated and cultured neural progenitor cells. By using MTT assay, the effect of piperine on neural cells proliferation was observed. RESULT:
The research results indicated that after a week of administration, piperine (10, 20 mg x kg(-1)) could significantly reduce the duration of immobility in both FST and TST. Piperine has the protective effect on neuroblastoma cells and increased proliferation of hippocampus neural progenitor cells. CONCLUSION: In the present study, we demonstrated that the antidepressant-like effects of piperine and its mechanisms might be involved by up-regulation of the progenitor cell proliferation of hippocampus and cytoprotective activity.PMID: 19777847 [PubMed - indexed for MEDLINE]
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Recipe—Take 1 tsp of Pepper---1/2 tsp of nutmeg—2 tablespoons of cocoa and 3 tablespoon of honey ---mix till smooth ( hand stir or use a blender ) when done use ½ tsp ---Utilize this anytime when you feel a need for a pick me up or even if you just want to use this---All 3 of these materials will enhance brain and mood and the bonus here is the increased level of circulation and digestion as well as antioxidant activity—and analgesic effect as wellØ
Anti-inflammatory and antiarthritic effects of piperine in human interleukin 1beta-stimulated fibroblast-like synoviocytes and in rat arthritis models.Bang JS, Oh da H, Choi HM, Sur BJ, Lim SJ, Kim JY, Yang HI, Yoo MC, Hahm DH, Kim KS.
East-West Bone & Joint Research Institute, East-West Neo Medical Center, Kyung Hee University, Gangdong-gu, Seoul, Republic of Korea.
INTRODUCTION: The objective of this study was to determine the anti-inflammatory, nociceptive, and antiarthritic effects of piperine, the active phenolic component in black pepper extract. METHODS: The in vitro anti-inflammatory activity of piperine was tested on interleukin 1beta (IL1beta)-stimulated fibroblast-like synoviocytes derived form patients with rheumatoid arthritis. The levels of IL6, matrix metalloproteinase (MMPs), cyclo-oxygenase 2 (COX-2), and prostaglandin E2 (PGE2) were investigated by ELISA and RT-PCR analysis. The analgesic and antiarthritic activities of piperine were investigated on rat models of carrageenan-induced acute paw pain and arthritis. The former were evaluated with a paw pressure test, and the latter by measuring the squeaking score, paw volume, and weight distribution ratio. Piperine was administrated orally to rats at 20 and 100 mg/kg/day for 8 days. RESULTS: Piperine inhibited the expression of IL6 and MMP13 and reduced the production of PGE2 in a dose dependant manner at concentrations of 10 to 100 microg/ml. In particular, the production of PGE2 was significantly inhibited even at 10 microg/ml of piperine. Piperine inhibited the migration of activator protein 1 (AP-1), but not nuclear factor (NF)kappaB, into the nucleus in IL1beta-treated synoviocytes. In rats, piperine significantly reduced nociceptive and arthritic symptoms at days 8 and 4, respectively. Histological staining showed that piperine significantly reduced the inflammatory area in the ankle joints. CONCLUSIONS: These results suggest that piperine has anti-inflammatory, antinociceptive, and antiarthritic effects in an arthritis animal model. Thus, piperine should be further studied with regard to use either as a pharmaceutical or as a dietary supplement for the treatment of arthritis.
PMID: 19327174 [PubMed - indexed for MEDLINE]
---You want to feed your kids but are tired of the chemicals and preservatives and most of all lack of meat products---all vegetarian or little meat and then there is SOY---and potentially canola---Here is a suggestion--- take some ground beef—3- 5 oz---put in blender---add wine1/4 cup---add water ( distilled or RO water)1/4 cup---season it the way you like it remember though to reduce the amount a baby cannot handle the volume at that point in time---Salt 1 tablespoon---pepper—1/4 tsp—Vitamin C 1 tsp---rosemary 1 sprig or 1 tsp thyme 1 sprig or 1 tsp blend till liquefied then cook til well down---then pour everything back in the blender and again re blend at a high speed till everything is smooth then pour contents into a jar ( glass ) as storage---the rosemary and thyme will preserve this---refrigerate what you will not use or wrap everything in wax papper in small portions so you can reheat later in a bain marie---(A glass container inside a boiling water) when heated to the right temp ( do a touch test on your wrist to determine if it still hot or cold ) and from there feed the child or those who are having teeth issues you can use these as well
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Citrus Peels Healing Properties--- Antioxidant, anti-inflammatory and analgesic potential of the Citrus decumana L. peel extract-- Update on uses and properties of citrus flavonoids
TB=Tuberculosis--- What can be done naturally??-- Remedy --XDR TB
First Case of Highly Drug-Resistant TB Found in US
Citrus Peels Healing Properties
Targeting excessive free radicals with peels and juices of citrus fruits: Grapefruit, lemon, lime and orange.
Guimarães R, Barros L, Barreira JC, Sousa MJ, Carvalho AM, Ferreira IC.
CIMO/Escola Superior Agrária, Instituto Politécnico de Bragança, Campus de Santa Apolónia, Apartado 1172, 5301-855 Bragança, Portugal.
A comparative study between the antioxidant properties of peel (flavedo and albedo) and juice of some commercially grown citrus fruit (Rutaceae), grapefruit (Citrus paradisi), lemon (Citrus limon), lime (Citrusxaurantiifolia) and sweet orange (Citrus sinensis) was performed. Different in vitro assays were applied to the volatile and polar fractions of peels and to crude and polar fraction of juices: 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging capacity,
reducing power and inhibition of lipid peroxidation using beta-carotene-linoleate model system in liposomes and thiobarbituric acid reactive substances (TBARS) assay in brain homogenates. Reducing sugars and phenolics were the main antioxidant compounds found in all the extracts. Peels polar fractions revealed the highest contents in phenolics, flavonoids, ascorbic acid, carotenoids and reducing sugars, which certainly contribute to the highest antioxidant potential found in these fractions. Peels volatile fractions were clearly separated using discriminant analysis, which is in agreement with their lowest antioxidant potential.PMID: 19770018 [PubMed - as supplied by publisher]
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Kilogram=2.2 lbs---to get your KG weight divide this by 2.2---example 150 lb man would be 150/2.2 =68 kg then figure the mg strength based on the measurements they have here –so at 300mg/kg would be 20,040 mgs 0r a little over 20 grams******Antioxidant, anti-inflammatory and analgesic potential of the Citrus decumana L. peel extract.
Sood S, Arora B, Bansal S, Muthuraman A, Gill NS, Arora R, Bali M, Sharma PD.
Rayat Institute of Pharmacy, Nawanshahr District, Near Railmajra, Ropar, 144533, Punjab, India, soodshalu@gmail.com.
The present study was designed to investigate the
antioxidant, anti-inflammatory and analgesic potential of Citrus decumana peel extract. Antioxidant activity of Citrus decumana peel extract in four solvent systems was evaluated by 1,1-diphenyl-2-picrylhydrazyl (DPPH(.)) and hydrogen peroxide (H(2)O(2)) radical scavenging methods. Ethyl acetate peel extract of Citrus decumana (EtCD) was studied for its anti-inflammatory and analgesic activities at a dose level of 100, 200 and 300 mg/kg. Anti-inflammatory activity was performed using carrageenan-induced paw edema in rats. Analgesic activity was evaluated for its central and peripheral pharmacological actions in mice. EtCD showed significant antioxidant activity in a dose-dependent manner when compared with ascorbic acid. EtCD at the dose of 300 mg/kg produced significant decrease in paw volume and pain when compared with reference drug diclofenac and morphine, respectively. The Citrus decumana peel extract may be useful as a natural antioxidant in the treatment of inflammation and pain.PMID: 19763789 [PubMed - as supplied by publisher]
Benavente-García O, Castillo J.
Research and Development Department of Nutrafur-Furfural Español S.A., Camino Viejo de Pliego s/n, 80320 Alcantarilla, Murcia, Spain. laboratorio@nutrafur.com
Significantly, much of the activity of Citrus flavonoids appears to impact blood and microvascular endothelial cells, and it is not surprising that
the two main areas of research on the biological actions of Citrus flavonoids have been inflammation and cancer. Epidemiological and animal studies point to a possible protective effect of flavonoids against cardiovascular diseases and some types of cancer. Although flavonoids have been studied for about 50 years, the cellular mechanisms involved in their biological action are still not completely known. Many of the pharmacological properties of Citrus flavonoids can be linked to the abilities of these compounds to inhibit enzymes involved in cell activation. Attempts to control cancer involve a variety of means, including the use of suppressing, blocking, and transforming agents. Suppressing agents prevent the formation of new cancers from procarcinogens, and blocking agents prevent carcinogenic compounds from reaching critical initiation sites, while transformation agents act to facilitate the metabolism of carcinogenic components into less toxic materials or prevent their biological actions. Flavonoids can act as all three types of agent. Many epidemiological studies have shown that regular flavonoid intake is associated with a reduced risk of cardiovascular diseases. In coronary heart disease, the protective effects of flavonoids include mainly antithrombotic, anti-ischemic, anti-oxidant, and vasorelaxant. It is suggested that flavonoids decrease the risk of coronary heart disease by three major actions: improving coronary vasodilatation, decreasing the ability of platelets in the blood to clot, and preventing low-density lipoproteins (LDLs) from oxidizing. The anti-inflammatory properties of the Citrus flavonoids have also been studied. Several key studies have shown that the anti-inflammatory properties of Citrus flavonoids are due to its inhibition of the synthesis and biological activities of different pro-inflammatory mediators, mainly the arachidonic acid derivatives, prostaglandins E 2, F 2, and thromboxane A 2. The anti-oxidant and anti-inflammatory properties of Citrus flavonoids can play a key role in their activity against several degenerative diseases and particularly brain diseases. The most abundant Citrus flavonoids are flavanones, such as hesperidin, naringin, or neohesperidin. However, generally, the flavones, such as diosmin, apigenin, or luteolin, exhibit higher biological activity, even though they occur in much lower concentrations. Diosmin and rutin have a demonstrated activity as a venotonic agent and are present in several pharmaceutical products. Apigenin and their glucosides have been shown a good anti-inflammatory activity without the side effects of other anti-inflammatory products. In this paper, we discuss the relation between each structural factor of Citrus flavonoids and the anticancer, anti-inflammatory, and cardiovascular protection activity of Citrus flavonoids and their role in degenerative diseases
Citrus Surprise Vitamin C Boosts the Reprogramming of Adult Cells Into Stem Cells
ScienceDaily (Dec. 29, 2009) — Famous for its antioxidant properties and role in tissue repair, vitamin C is touted as beneficial for illnesses ranging from the common cold to cancer and perhaps even for slowing the aging process. Now, a study published online on December 24th by Cell Press in the journal Cell Stem Cell uncovers an unexpected new role for this natural compound: facilitating the generation of embryonic-like stem cells from adult cells.---Over the past few years, we have learned that adult cells can be reprogrammed into cells with characteristics similar to embryonic stem cells by turning on a select set of genes. Although the reprogrammed cells, called induced pluripotent stem cells (iPSCs), have tremendous potential for regenerative medicine, the conversion is extremely inefficient.---"The low efficiency of the reprogramming process has hampered progress with this technology and is indicative of how little we understand it. Further, this process is most challenging in human cells, raising a significant barrier for producing iPSCs and serious concerns about the quality of the cells that are generated," explains senior study author Dr. Duanqing Pei from the South China Institute for Stem Cell Biology and Regenerative Medicine at the Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences.--Dr. Pei and colleagues measured the production of reactive oxygen species or ROS during reprogramming and discovered a potential link between high ROS and low reprogramming efficiency. They became particularly interested in antioxidants, hypothesizing that they might suppress ROS and cell senescence, which seems to be a major roadblock for the generation of iPSCs.---The researchers found that adding vitamin C, an essential nutrient that is abundant in citrus fruits, enhanced iPSC generation from both mouse and human cells. Vitamin C accelerated gene expression changes and promoted a more efficient transition to the fully reprogrammed state. Somewhat to their surprise, they found that other antioxidants do not have the same effect, but vitamin C does seem to act at least in part through slowing cell senescence.---"Our results highlight a simple way to improve iPSC generation and provide additional insight into the mechanistic basis of reprogramming," concludes Dr. Pei. "It is also of interest that a vitamin with long-suspected anti-aging effects has such a potent influence on reprogramming, which can be considered a reversal of the aging process at the cellular level. It is likely that our work may stimulate further research in this area as well."----Story Source:----Adapted from materials provided by Cell Press, via EurekAlert!, a service of AAAS
Global XDR TB - An --'Untreatable, Unstoppable
Calamity'
By Adriana Stuijt--6-13-7
SEATTLE, WASHINGTON -- The Seattle Times in the USA has published an editorial -- co-authored by United States Democratic congressman Adam Smith (of Tacoma), a co-sponsor of the Stop TB Now Act of 2007; as well as by Dr. David R. Park and Dr. James K. O'Brien, co- chairmen of the Washington State TB Advisory Council -- warning that: "unless steps are taken now to strengthen (TB) control efforts at home (in the USA); in Africa and throughout the world, these deadly Extremely-Drug-Resistant Tuberculosis strains will continue to spread and multiply. The resulting global XDR-TB epidemic will be an untreatable and unstoppable calamity." -- 'XDR-TB ... the public health crisis of 2007' ---Congressman Smith, Drs. Park and O'Brien warn in their editorial that in South Africa, 100 patients had recently fled a hospital after paramedics wearing head-to-toe protection brought in eight people with the same contagious infection. ---"This very real and very lethal disease is the same disease that has made headline news recently - it is a new form of tuberculosis called "extensively drug-resistant TB," or XDR-TB," they write. "No one is safe from XDR-TB. As if to highlight the point, the widely publicized travels of (Atlanta attorney) Andrew Speaker remind us all that exposure to tuberculosis, and XDR-TB, can occur anywhere and at any time. Just recently, King County (i.e. Seattle) reported that TB cases have doubled in the county compared with the same period last year. And while extremely drug-resistant TB hasn't arrived here yet, it is shaping up to be the public health crisis of 2007...." they warned. XDR-TB is shaping up to be the public health crisis of 2007... --"The deadly strain has been identified in 28 countries on five continents. It kills almost everyone it touches (up to 85 percent) with remarkable speed. In the first large outbreak in South Africa, 52 of 53 patients died within 14 days of diagnosis (in October 2006). ---"The (grossly-understated) official SA death rate thus far this year is 600 people - in all of the country's provinces. And while Extremely drug-resistant TB hasn't arrived here in Seattle yet, it is shaping up to be the public health crisis of 2007," they warned. ---"Most people with the latent form will never experience symptoms, but TB thrives in those with weakened immune systems. The combination of TB and HIV/AIDS in sub-Saharan Africa is particularly explosive. TB is the biggest killer of people with AIDS. But while international attention has focused on preventing and treating HIV/AIDS, inadequate funding for TB control has allowed the disease to grow unchecked and mutate into frightening forms," they also warned. ---* (Note by Adriana Stuijt -- In South Africa, 61 percent of the more than 250,000 people diagnosed each year (and rapidly dying of ) Tuberculosis each year are also co-infected with the human- immune deficiency virus and thus become untreatable with any known medicines, i.e. such patients rapidly die of XDR-TB. Since the year 2000, World Health Organisation records also show, at least 2,6-million South Africans have already died of this uncurable TB+Aids coinfection, according to Dr De Cock, head of the HIV-Aids department of the World Health Organisation in Geneve, Switserland.) Seattle... struggles to treat the growing number of TB-infected people here... The Seattle editorial continues that funding for elimination of (TB) in the U.S. has plummeted so low that the Centers for Disease Control can no longer fulfill its mandated task to eliminate the disease. Meanwhile, King County (Seattle, Washington State) is struggling to screen and treat the growing number of infected people here". --"... our inability to protect our population against this deadly strain..." ---They quote Dr Paul Nunn, the World Health Organisation's coordinator of HIV- and drug-resistant tuberculosis programs, as saying: "It is here, it is really scary, and it is an emergency." They also noted that the U.S. Centers for Disease Control's Advisory Council for the Elimination of Tuberculosis has warned that "unless we take immediate measures, we as a nation will be forced to confront the inability to protect our population against this deadly strain." "Unless steps are taken now to strengthen control efforts at home, in Africa and throughout the world, these deadly strains will continue to spread and multiply. The resulting global XDR-TB epidemic will be an untreatable and unstoppable calamity. ---Start funding solutions... "It's time for the world - including the U.S. - to stop manufacturing dangerous forms of TB and to start funding solutions. The "Stop TB Now Act of 2007" aims to do just that by supporting the Global Plan to Stop TB 2006 - 2015. If funded and implemented, the plan will cut TB deaths in half by 2015 and ultimately eliminate TB as a global health problem by 2050. Through the Stop TB Now Act, the U.S. would help to create the first new TB fighting drugs in nearly 50 years, the first new diagnostic test in over 100 years, and the very first effective vaccine," the writers concluded. ---
http://seattletimes.nwsource.com:80/html/opinion/2003743613_tb12.html
No XDR-TB cases in Botswana thus far
... health ministry ---June 13 2007 -- Botswana's Health Minister Professor Sheila Tlou said the World Health Organisation would 'strengthen its support to countries mostly affected by multi-drug resistant and Extensively Drug-Resistant (XDR) TB while also supporting, in terms of personnel and research, for those affected by a combination of HIV and TB." She was giving feedback to the news media on her return from Geneva for the World Health Organsiation's assembly meeting last Friday. ---Botswana's deputy permanent secretary (health services) Dr Loeto Mazhani also noted that there is still no laboratory evidence of patients with Extremely-drug-resistant tuberculosis (XDR TB) in Botswana. He however said that they were still awaiting results of a survey for tests they had sent to South Africa. "We have never had to isolate anyone," he said.http://www.mmegi.bw:80/2007/June/Tuesday12/7.php
South Africa's health minister quotes 2006 statistics in parliament: From South Africa, journalist Wyndham Hartley also reports from Cape Town that South Africa's health minister Manto Tshabalala- Msimang has finally broken her public silence about XDR-TB -- but quoted old health department data from the year 2006 when replying to a parliamentary question. Up to the end of 2006, at least 403 XDR-TB cases had been officially identified and of these about 265 had died, she claimed. And there even were 135 patients still undergoing treatment, she added. --The South African government is being widely accused by top TB-Aids experts of being far too slow to respond to the threat of extremely drug-resistant tuberculosis (XDR-TB) since its fourth outbreak since 2003 occurred in the country in October 2006. While the first three outbreaks were contained inside the confines of TB-hospitals in the country -- the latest outbreak has now gone out of control from KwaZulu-Natal province, and is now found in all nine provinces of the country. ---The South African health minister continued to quote old statistics in her reply to a written parliamentary question from Inkatha Freedom Party MP Ruth Rabinowitz., admitting for the first time however that XDR-TB has now been identified in all nine provinces of South Africa -- and claiming that these patients now were 'under treatment". --She also mentioned with considerable acrimony that "about 13 patients in Gauteng were being 'held against their will' in (Sizwe hospital for tropical diseases in Rietfontein) hospital."---Her official health policy regarding such 'forced incarceration of XDR-TB patients" is explained on the following video:---http://youtube.com/watch?v=Zz5lI3Hc5Xc --http://www.allafrica.com:80/stories/200706120119.html
First Case of Highly Drug-Resistant TB Found in US
Filed Under Emerging Diseases
It started with a cough, an autumn hack that refused to go away. Then came the fevers. They bathed and chilled the skinny frame of Oswaldo Juarez, a 19-year-old Peruvian visiting to study English. His lungs clattered, his chest tightened and he ached with every gasp. During a wheezing fit at 4 a.m., Juarez felt a warm knot rise from his throat. He ran to the bathroom sink and spewed a mouthful of blood.--I’m dying, he told himself, "because when you cough blood, it’s something really bad." It was really bad, and not just for him.--Doctors say Juarez’s incessant hack was a sign of what they have both dreaded and expected for years — this country’s first case of a contagious, aggressive, especially drug-resistant form of tuberculosis. The Associated Press learned of his case, which until now has not been made public, as part of a six-month look at the soaring global challenge of drug resistance.--Juarez’s strain — so-called extremely drug-resistant (
XXDR) TB — has never before been seen in the U.S., according to Dr. David Ashkin, one of the nation’s leading experts on tuberculosis. XXDR tuberculosis is so rare that only a handful of other people in the world are thought to have had it.--"He is really the future," Ashkin said. "This is the new class that people are not really talking too much about. These are the ones we really fear because I’m not sure how we treat them."Forty years ago, the world thought it had conquered TB and any number of other diseases through the new wonder drugs: Antibiotics. U.S. Surgeon General William H. Stewart announced it was "time to close the book on infectious diseases and declare the war against pestilence won."--Today, all the leading killer infectious diseases on the planet — TB, malaria and HIV among them — are mutating at an alarming rate, hitchhiking their way in and out of countries. The reason: Overuse and misuse of the very drugs that were supposed to save us.---Just as the drugs were a manmade solution to dangerous illness, the problem with them is also manmade. It is fueled worldwide by everything from counterfeit drugmakers to the unintended consequences of giving drugs to the poor without properly monitoring their treatment. Here’s what the AP found:·
In Cambodia, scientists have confirmed the emergence of a new drug-resistant form of malaria, threatening the only treatment left to fight a disease that already kills 1 million people a year.·
In Africa, new and harder to treat strains of HIV are being detected in about 5 percent of new patients. HIV drug resistance rates have shot up to as high as 30 percent worldwide.·
In the U.S., drug-resistant infections killed more than 65,000 people last year — more than prostate and breast cancer combined. More than 19,000 people died from a staph infection alone that has been eliminated in Norway, where antibiotics are stringently limited."Drug resistance is starting to be a very big problem. In the past, people stopped worrying about TB and it came roaring back. We need to make sure that doesn’t happen again," said Dr. Thomas Frieden, director of the U.S. Centers for Disease Control and Prevention, who was himself infected with tuberculosis while caring for drug-resistant patients at a New York clinic in the early ’90s. "We are all connected by the air we breathe, and that is why this must be everyone’s problem."--This April, the World Health Organization sounded alarms by holding its first drug-resistant TB conference in Beijing. The message was clear —
the disease has already spread to all continents and is increasing rapidly. Even worse, WHO estimates only 1 percent of resistant patients received appropriate treatment last year.--We have seen a huge upburst in resistance," said CDC epidemiologist Dr. Laurie Hicks.-Juarez’ strain of TB puzzled doctors. He had never had TB before. Where did he pick it up? Had he passed it on? And could they stop it before it killed him?---At first, mainstream doctors tried to treat him. But the disease had already gnawed a golf-ball-sized hole into his right lung.--TB germs can float in the air for hours, especially in tight places with little sunlight or fresh air. So every time Juarez coughed, sneezed, laughed or talked, he could spread the deadly germs to others.--"You feel like you’re killing somebody, like you could kill a lot of people. That was the worst part," he said.--Tuberculosis is the top single infectious killer of adults worldwide, and it lies dormant in one in three people, according to WHO. Of those, 10 percent will develop active TB, and about 2 million people a year will die from it.---Simple TB is simple to treat — as cheap as a $10 course of medication for six to nine months. But if treatment is stopped short, the bacteria fight back and mutate into a tougher strain. It can cost $100,000 a year or more to cure drug-resistant TB, which is described as multi-drug-resistant (MDR), extensively drug-resistant (XDR) and XXDR.--There are now about 500,000 cases of MDR tuberculosis a year worldwide. XDR tuberculosis killed 52 of the first 53 people diagnosed with it in South Africa three years ago.---Drug-resistant TB is a "time bomb," said Dr. Masae Kawamura, who heads the Francis J. Curry National Tuberculosis Center in San Francisco, "a manmade problem that is costly, deadly, debilitating, and the biggest threat to our current TB control strategies."--Juarez underwent three months of futile treatment in a Fort Lauderdale hospital. Then in December 2007 he was sent to A.G. Holley State Hospital, a 60-year-old massive building of brown concrete surrounded by a chain-link fence, just south of West Palm Beach.---"They told me my treatment was going to be two years, and I have only one chance at life," Juarez said. "They told me if I went to Peru, I’m probably going to live one month and then I’m going to die."--Holley is the nation’s last-standing TB sanitarium, a quarantine hospital that is now managing new and virulent forms of the disease.--Tuberculosis has been detected in the spine of a 4,400-year-old Egyptian mummy. In the 1600s, it was known as the great white plague because it turned patients pale. In later centuries, as it ate through bodies, they called it "consumption." By 1850, an estimated 25 percent of Europeans and Americans were dying of tuberculosis, often in isolated sanatoriums like Holley where they were sent for rest and nutrition.--Then in 1944 a critically ill TB patient was given a new miracle antibiotic and immediately recovered. New drugs quickly followed. They worked so well that by the 1970s in the U.S., it was assumed the disease was a problem of the past.--Once public health officials decided TB was gone, the disease was increasingly missed or misdiagnosed. And without public funding, it made a comeback among the poor. Then immigration and travel flourished, breaking down invisible walls that had contained TB.--Drug resistance emerged worldwide. Doctors treated TB with the wrong drug combinations. Clinics ran out of drug stocks. And patients cut their treatment short when they felt better, or even shared pills with other family members.--There are two ways to get drug resistant TB. Most cases develop from taking medication inappropriately. But it can also be transmitted like simple TB, a cough or a sneeze.---In the 1980s, HIV and AIDS brought an even bigger resurgence of TB cases. TB remains the biggest killer of HIV patients today.--For decades, drug makers failed to develop new medicines for TB because the profits weren’t there. With the emergence of resistant TB, several private drug companies have started developing new treatments, but getting an entire regimen on the market could take 24 years. In the meantime, WHO estimates each victim will infect an average of 10 to 15 others annually before they die.---A.G. Holley was back in business.--Holley’s corridors are long and dark, with fluorescent tubes throwing harsh white light on drab walls. One room is filled with hulking machines once used to collapse lungs, sometimes by inserting ping pong balls. Antique cabinets hold metal tools for spreading and removing ribs — all from a time when TB was rampant and the hospital’s 500 beds were filled.--Only 50 beds are funded today, but those are mostly full. More than half the patients are court-ordered into treatment after refusing to take their meds on the outside.--Juarez came voluntarily. In the beginning, he was isolated and forced to wear a mask when he left his room. He could touch his Peruvian family only in pictures taped to the wall. He missed his dad, his siblings, his dog, his parrot, and especially his mother.--"I was very depressed," he said. "I had all this stuff in my mind."--He spent countless hours alone inside the sterile corner room reserved for patients on extended stays — dubbed "the penthouse" because it is bigger and lined by a wall of windows.--His moods ran hot and cold. He punched holes in the walls out of frustration, played loud reggaeton music with a thumping beat and got into fights with other patients. He covered his door’s small window with a drawing of an evil clown to keep nurses from peering inside. He made friends with new patients, but was forced to stay long after many of them came, got cured, and left.--Early on, Juarez’s treatment was similar to chemotherapy. Drugs were pumped into his bloodstream intravenously three times a day, and he choked down another 30 pills, including some that turned his skin a dark shade of brown. He swallowed them with spoonfuls of applesauce, yogurt, sherbet and chocolate pudding, but once they hit his stomach, waves of nausea sometimes sent him heaving. He would then have to force them all down again.---"When he first came in we really had to throw everything and the kitchen sink at him," said Ashkin, the hospital’s medical director, who experimented on Juarez with high doses of drugs, some not typically used for TB. "It was definitely cutting edge and definitely somewhat risky because it’s not like I can go to the textbooks or … journal articles to find out how to do this."--After 17 years of handling complex cases — including TB in the brain and spine — Ashkin had never seen a case so resistant. He believed he would have to remove part of Juarez’s lung.--Ashkin dialed Peru to talk to the young man’s father.--It’s a rare disease, said Ashkin, hard to define. Your son is one of two people in the world known to have had this strain, he said.--"What happened to the other person?" his father asked.--"He died."--About 60 million people visit the U.S. every year, and most are not screened for TB before arrival. Only refugees and those coming as immigrants are checked. The top category of multidrug-resistant patients in the U.S. — 82 percent of the cases identified in 2007 — was foreign-born patients, according to the CDC.--The results are startling among those tested, said Dr. Angel Contreras, who screens Dominicans seeking to enter the U.S. on immigrant visas. The high rate of MDR-TB in the Dominican Republic coupled with high HIV rates in neighboring Haiti are a health crisis in the making, he said.--"They’re perfect ingredients for a disaster," he said.--Juarez’s homeland, Peru, is also a hotspot for multidrug-resistant TB. DNA fingerprinting linked his disease to similar strains found there and in China, but none with the same level of resistance.--"So the question is: Is this a strain that’s evolving? That’s mutating? That’s becoming more and more resistant?" asked Ashkin. "I think the answer is yes."--Doctors grappling with these new strains inadvertently give the wrong medicines, and so the TB mutates to become more aggressive and resistant.--Poor countries also do not have the resources to determine whether a patient’s TB is drug-resistant. That requires sputum culturing and drug-susceptibility testing — timely, expensive processes that must be performed in capable labs. WHO is working to make these methods more available in high-risk countries as well as negotiating cheaper prices for second-line drugs.--"There’s a lot of MDR and XDR-TB that hasn’t been diagnosed in places like South Africa and Peru, Russia, Estonia, Latvia," said Dr. Megan Murray, a tuberculosis expert at Harvard. "We think it’s a big public health threat."---Experts argue if wealthy countries do not help the worst-hit places develop comprehensive TB programs, it puts everyone at risk.--"You’re really looking at a global issue,’" said Dr. Lee Reichman, a TB expert at the New Jersey Medical School Global Tuberculosis Institute. "It’s not a foreign problem, you can’t keep these TB patients out. It’s time people realize that."--Juarez spent a year and a half living alone in a room plastered with bikini-clad blondes, baseball caps and a poster of Mt. Everest for inspiration. There were days when he simply shut down and refused his meds until his family convinced him to keep fighting.---"I was thinking that maybe if I need to die, then that’s what I need to do," he said, perched on his bed in baggy jeans. "I felt like: ‘I’m never going to get better. I’m never going to get out of here.’"--When put side by side, his CAT scans from before and after treatment are hard to believe. The dark hole is gone, and only a small white scar tattoos his lung.--"They told me the TB is gone, but I know that TB, it doesn’t have a cure. It only has a treatment like HIV," he said, his English now fluent and his body weight up 32 pounds from when he first arrived. "The TB can come back. I saw people who came back to the hospital twice and some of them died. So, it’s very scary."--His treatment cost Florida taxpayers an estimated $500,000, a price tag medical director Ashkin says seems like an astronomical amount to spend on someone who’s not an American citizen. But he questions how the world can afford not to treat Juarez and others sick with similar lethal strains.--"This is an airborne spread disease … so when we treat that individual, we’re actually treating and protecting all of us," he said. "This is true homeland security."--In July, at age 21 — 19 months after checking in — Juarez swallowed his last pills, packed a few small suitcases and wheeled them down the hospital’s long corridor.--The last time doctors saw him, he was walking out of the sanitarium into south Florida’s soupy heat.http://abcnews.go.com/Health/wirestory?id=9427607&page=1
Here are some things you can take as either a preventative or a remedy---remember the things you consume such as canola oil can scar the lungs—opening you to infection of the respiratory system---things that are as well genetically altered with the mosaic virus ( and that is the main means of the genetic manipulation in the crops we are marketing as foods) can also have a weakening effect on the immune system as well as the respiratory trac
Watercress
Watercress has been use in South america as a remedy for tuberculosis, by making a syrup out of the vegetable. Some of the other qualities of watercress are, Copper, Potassium, Magnesium, SODIUM, and iodine. it can also be used for arthritc issues, thyroid issues, Pancreas, liver, blood restorer, AND calcium deficiency. The asians will include this in their diet, usully following a day after eating soy to cleanse the body of soy contamination. the chinese are the ones who do THIS; there perspective is to take an antidote, for the poison to avoid an issue. it is a good concept to adapt to
.Cabbage
another food that can be utilized in the defence against tuberculosis, this vegetable has many other hidden benefits s well, one of these benefits are the fact that those who eat cabbage has the lowest rates of stomach cancers, and it seems to hep with the restoring of the stomach from ulcers as well, whether by juicing or consumption. the koreans ferment there cabbage and as a result there is very little concern with avian flu or any other type of flu viruses. it apparently has been studies as well and found that those who consumed the most cabbage had the lowest death rates from cancer.
Herbs for Tuberculosis
mountain ebony is used in india for tuberculosis, it is taken in several different ways. here is a list of some of those ways to use this herb., for a tb they would mix rice water and ginger as a tea, for a tumour the would make a paste with the herb and the bark and apply to the area., they would also use this bark in combination with ginger, black pepper, long pepper, cardamon, cinnamon and cinnamon leaves, blended as a tea with triphali. the TRIPHALI IS a cleanser combo, mixed with the bark and other herbs/spices/ will have a very powerful effect in ridding the body of this. each one of these herbs has a specific and a multiplex effect on the immune system and the way they carry the compnents through the body and the way they target specific things, the eliminate or kill the causes and the triphali actually cleans the system of the toxins and strenghtens the body.-
--Sarsaparilla
kills some forms of Detrimental Bacteria: -Sarsaparilla kills Mycobacterium tuberculosis (a common cause of Tuberculosis)Black Walnut-- alleviates Tuberculosis
Pau D’Arco (tincture) reputedly alleviates Tuberculosis
Vitamin A --can also protect against being infected---if there is a deficiency then there is a higher susceptibility to this---best sources are animal fats from butter
Essential oils used for tuberculosis
essential oils are EXTREMELY powerful healing AGENTS THAT are the very essence and life energies from plants and minerals. they are extracted in such high strength that very little is required to see some spectacular results. I incorporate them all the time in all I do with myself as a means to ward off unwanted diseases or pathogens that might be airborne or in my food, or in my drinking water. I will give you a list of these oils that you can apply to yourself that are easy to use and can be very healthful. cajeput
, clove, eucalyptus, garlic, hyssop, lavender, lemon, nialoui, origanum, PEPPERMINT, pine, sage, terebinth, and thyme. now I will mention a few that if you wore on yourself, by applying this to your feet ( 1 drop blended in a carrier oil) the impact is impressive to say the least. here are some oils that will prevent contagion: clove, eucalyptus, hyssop ( which can neutralize the tuberculosis bascilli) lavender, has anitvenomous properties, in the alps if a dog gets bitten by a adder, hunters will get the flower of lavender, crush it and put into where the dogs were bitten and it immediately NEUTRALIZES THE VENOM. it will kill the bacteria of tuberculosis as well as the pneumonia bacteria as well as typhoid and diptheria…..peppermint, kills the the tuberculosis bacteria , thyme, the inhalation was effective as an antibacericidal against tuberculosi
Teas that can be used to treat tuberculosis
hyssop, iceland moss, irish moss
, this is a trio that can keep you and your families strong all year long, no matter where you live, or what climate you are in. I will give you a brief insight on this, hyssop has been used in the past for respiratory issues, and asthma and congestion, it has been found to be an effective anti viral against herpes and hiv in vitro (In Vitro biological study is one which is carried out in isolation from a living organism) ICELAND MOSS, this is used for dry cough, and a tendency towards infection. it has been histrically used for lung disease. irish MOSS SOOTHES membranes of the LUNGS THAT are irritated by coughs, bronchitis, and tuberculosis. this you would make a tea with of equal parts and consume regularly, this can be made into a refreshing ice tea, drank warm and at anytime--I will mention some other herbs that have ben used as well...Tormentil, used in russia for emphysema and tuberculosis, st john’s wort, prescribed in russia for tuberculosis, nettle, which can be applied to exterior wounds by crushing the leaves and seeds and adding salt to apply to wounds, this too is used for the reatment of tuberculosis when added to other herbs. Marjoram, lady’s mantle (A remedy made with wine as a fusion, boiled together for 5 MINUTES) let cool and drink 1/3 cup before meals. COMFREY IT heals damage mucous membranes and is USED FOR tuberculosis.Antibacterial
assays of Helichrysum pedunculatum (a plant used during circumcision rites) showed that dichloromethane extracts are active against all the gram positive bacteria tested, as well as two gram negative bacteria, Enterobacter cloacae and Serratia marcescens. A water extract was effective against Staphylococcus aureus and Micrococcus kristinae. (Department of Botany, University of Pretoria, South Africa).--Twenty South African medicinal plants used to treat pulmonary diseases were screened for activity against drug-resistant and drug-sensitive strains of Mycobacterium tuberculosis. A preliminary screening of acetone and water plant extracts against a drug-sensitive strain of Mycobacterium tuberculosis, H37Rv, was done by the agar plate method. Acetone as well as water extracts of Cryptocarya latifolia, Euclea natalensis, Helichrysum melanacme, Nidorella anomala and Thymus vulgaris inhibited the growth of M. tuberculosis. Given the activity, a further study was done to confirm the inhibitory activity. These active acetone extracts were screened against the H37Rv strain as well as a strain resistant to the drugs isoniazid and rifampin. Extracts of Chenopodium ambrosioides, Ekebergia capensis, Euclea natalensis, Helichrysum melanacme, Nidorella anomala and Polygala myrtifolia were active against the resistant strain at 0.1 mg/ml. (Department of Botany, University of Pretoria, South Africa).---There are over 600 species of Helichrysum occurring worldwide, with 245 found in southern Africa. The word Helichrysum is derived from the Greek "helios" meaning sun and "chrysos" meaning gold, referring to the colour of many of the flowers of species in this genus.---Seldom is so much offered by such an easy-to-grow plant. African, European, Eastern and North American cultures use Helichrysums for their medicinal value. Its uses include food, medicinal, ornamental and spiritual.Supplements that can reinforce the lungs
nac with vitamin c (ASCORBIC ACID) 2:1 ratio with the vitamin c being the higher. (EXAMPLE of this would be 1000MGS OF vitamin c to 5oomgs to nac) alpha lipoic acid, vitamin b6, dmg, wheat germ oil, quercitin, piperine, an aces formula (VITAMIN a, vitmin c, vitamin e {NON soy} zinc and selenium) and iodine
Foods that will definitely strenghten lungs
apple, cherry, garlic, white wine, onion, thyme, rosemary, sage, parsley, watercress, seaweed, cabbage, fermented broccoli, safflower, pepper {red and black and white}
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Tincture a remedy of iceland moss—Irish moss and hyssop and utilize this throughout the day---the impact here is to build the lungs up and make them resistant to this type of bacterial infection---it appears to hit people with weakened immune or respiratory---so maintain your immune system
Recipe for Congestion and Mucous build up
EFSA, FDA, Health Canada to discuss health claims
U.S. wants farmers to use coal waste on fields
Comparison of treatment protocols for removing metallic foreign objects from the ventriculus of budgerigars (Melopsittacus undulatus).------------- Recipe—Waste Removal
---What you will need is Nutmeg ( 3 nutmeg balls or 1 ½ tsp of the powder ) 2 sprigs of rosemary—1/2 tsp of black pepper and ¼ cup of coffee ( instant will work as well ) take the components and put all in a blender and then allow the pulverize everything into a fine powder---afterwards sift this to get anything that will not pulverize any further----put into coffee maker---add to a pot ---into a filter glass pour hot water and then consume—Impacts the brain for alertness—focus---Steady Functioning—Increased Circulation—May see increased endurance—Increased Oxygen—Antioxidant effect and body protection of brain intestines and liver..Recipe for Congestion and Mucous build up
---take 1 cup of black coffee and ad 1 drop of peppermint oil ( 1 drop is adequate here ) stir and sip slow---when first approaching the cup keep the eyes close the peppermint will be strong—this will open all the sinus cavity –lung and even warmth in the stomach area---will feel more able to breathe—Impacting Digestive—Lung—Liver—Intestines—Mental Clarity ( due to the increase oxygen flow ) This remedy is potent and should be approached with some caution for it is extremely fast acting –Now if this method is to strong then use a Peppermint tea bag and simmer with your coffee it will not be as potent and more may be required to consume but it still will work-- ---What’s the difference—is there something that makes these different? The whole idea of a soup or a tea is to get something good inside---the teas can range from any herb or bark or even animal—soups as well can be the same the difference would be the herbs or vegetables that would be used or even the type of animal protein---Lets say you make a herbal tea and you add some herbs like burdock—nettle and milk thistle and dandelion with parsley---this fusion of herbs will give a list of health benefits from liver –kidney—spleen ---blood—anti cancer—antioxidant---balancing hormones---regulating water and a list of other health benefits---Now if we add meats to this tea can actually utilize it as a soup and getting the benefits of this as well as the meats ( fish—chicken---turkey—beef—lamb-) or you can add other vegetables to this or even gelatin or other things as well. This will incorporate a relatively easy way to get your system Hydrated and Nourished---and can have a cleansing effect at the same time based on what you add to the mix…let’s say you have some chicken---and you add sea salt—pepper—tumeric—garlic powder—onion—celery seed—and savoury---and you add as well your fowl when cooked or boiled or simmered these properties are absorbed in the meat utilizing there antioxidant and immune protective effects as well--- now if you add the above mentioned herbs you may find in this way that the nutrition and protective value is higher and more effective and can be felt with anyone who maybe ill or in good health—SOUP or TEA either way you have a benefit
EFSA, FDA, Health Canada to discuss health claims
07-Jan-2010
The European Food Safety Authority, US Food and Drug Administration, and Health Canada will share a platform at an upcoming Cantox-hosted health claims conference. The "Progress of Health Claims in Europe: A New Perspective" conference will see the regulatory authorities from the EU, US, and Canada provide insights into the regulation and approval of health claims in Europe and North America. ---To be held on 23rd February 2010 at the Crowne Plaza Hotel in Brussels, the conference will also have experts discuss how to ensure biomarkers and outcome measures are valid.
( My Personel Take on this is that they are going to cooperate and create more regulations so that the drug Companies take it over completely as well as the corporate food manufactures---108 Billion dollars is what the Health food industry is getting to)---keep an eye on your access it may become prohibitive due to cost or regulationU.S. wants farmers to use coal waste on fields
By Associated Press--Wednesday, December 23, 2009; A17
The federal government is encouraging farmers to spread a chalky waste from coal-fired power plants on their fields to loosen and fertilize soil even as it considers regulating coal wastes for the first time. ---The material is produced by power plant "scrubbers" that remove acid-rain-causing sulfur dioxide from plant emissions. A synthetic form of the mineral gypsum, it also contains mercury, arsenic, lead and other heavy metals. --The Environmental Protection Agency says those toxic metals occur in only tiny amounts that pose no threat to crops, surface water or people
( funny How in the 80’s the issue of acid rain was the biggest news of the decade and how much devastation this was causing to the farms—peoples homes---the cars on the road –and the environment-NOWWW it is OK!!!) But some environmentalists say too little is known about how the material affects crops, and ultimately human health, for the government to suggest that farmers use it. --"This is a leap into the unknown," said Jeff Ruch, executive director of Public Employees for Environmental Responsibility. "This stuff has materials in it that we're trying to prevent entering the environment from coal-fired power plants, and then to turn around and smear it across agra lands raises some real questions." --With wastes piling up around the coal-fired plants that produce half the nation's power, the EPA and U.S. Department of Agriculture began promoting what they call the wastes' "beneficial uses" during the Bush administration. --Part of that push is to expand the use of synthetic gypsum -- a whitish, calcium-rich material known as flue gas desulfurization gypsum, or FGD gypsum. The Obama administration has continued promoting FGD gypsum's use in farming. ---The administration is also drafting a regulatory rule for coal waste, in response to a spill from a coal ash pond near Knoxville, Tenn., one year ago Tuesday. Ash and water flooded 300 acres, damaging homes and killing fish. The cleanup is expected to cost about $1 billion. ( Now you have to ask the question what happens if the are floods where they are smearing this??? What happens then ?)--The EPA is expected to announce its proposals for regulation early next year, setting the first federal standards for storage and disposal of coal wastes. EPA officials declined to talk about the agency's promotion of FGD gypsum before then and would not say whether the draft rule would cover it. --Field studies have shown that mercury, the main heavy metal of concern because it can harm nervous-system development, does not accumulate in crops or run off fields in surface water at "significant" levels, the EPA said. --"EPA believes ( what no proof??)that the use of FGD gypsum in agriculture is safe in appropriate soil and hydrogeologic conditions," the statement said. --Eric Schaeffer, executive director of the Environmental Integrity Project, which advocates for more effective enforcement of environmental laws, said he is not overly worried about FGD gypsum's use on fields because research shows it contains only tiny amounts of heavy metals. But he said federal limits on the amounts of heavy metals in FGD gypsum sold to farmers would help allay concerns. ---"That would give them assurance that they've got clean FGD gypsum," he said. Since the EPA-USDA partnership began in 2001, farmers' use of the material has more than tripled, from about 78,000 tons spread on fields in 2002 to nearly 279,000 tons last year, according to the American Coal Ash Association, a utility industry group. About half of the 17.7 million tons of FGD gypsum produced in the United States last year was used to make drywall, said Thomas Adams, the association's executive director. But he said it is important to find new uses for it and other coal wastes because the United States will probably rely on coal-fired power plants for decades to come. -"If we can find safe ways to recycle those materials, we're a lot better off doing that than we are creating a whole bunch of new landfills," Adams said
J Avian Med Surg. 2009 Sep;23(3):186-93--Authors: Lupu C, Robins S
To compare the efficacy of treatment protocols recommended to aid passage of metallic foreign objects from the ventriculus of birds
, ( stomach area) a 1-mm metal sphere, made from solder wire, was placed into the crop of each of 44 budgerigars (Melopsittacus undulatus). After survey radiographs confirmed the spheres were lodged in the ventriculus, birds were divided into 6 groups. Each group received 1 of 6 different treatment protocols: psyllium with grit, acidic drinking water, fine grit, coarse grit, cathartic emollients (peanut butter and mineral oil), and a control group. All birds were treated simultaneously with a chelating agent, dimercaptosuccinic acid (DMSA), to prevent heavy-metal toxicosis. Successive survey radiographs were used to monitor elimination of the spheres from the digestive tract. Of all protocols tested, birds treated with either fine or large grit had the shortest mean elimination time of the metal spheres. These results indicate that administration of grit particles, either fine or coarse, appears to be effective in hastening the passage of metallic foreign objects from the ventriculus of budgerigars. using oatmeal with the bran will have a similar impact on the human stomach as well allowing for proper soaking the fine will effect as well as any coarse in tis case relieving the blockages with a MILDER way---a lot of the products today do not have this in mind and can in fact increase blockages so if there is a need to remove blockages utilize the finer and use a mild lubricant like an olive oil or almond oils or even sesame seed oils---castor oil as well if the toxins are deeper---there maybe a nausea as a result of the releasing of these leftover toxinsù ù ù ==My Comments
Experts slam calls for vitamins to be OTC
Czechs--EC must clarify food supplement enforcement policies
How To Destroy Confidence In Vitamins When You Do Not Have The Facts
The Food and Drug Administration’s commitment to greater transparency is bearing fruit in the dietary supplements area, with the availability of GMP 483 reports providing valuable insights into potential GMP pitfalls. --Commenting on the ever-evolving Good Manufacturing Practice process, Israelsen said:
"FDA inspectors are exchanging notes, increasing their collective knowledge base and, in my view, as the inspection process rolls on, you should expect more sophisticated and in-depth questions, investigations and an awareness of where common weak spots are likely to be found." ù ù ù (Underhanded tricks and fines to eliminate the small business man who manufactures or produces supplements)---483 reports detail FDA inspections. A scan of a selection of 483s performed by Israelsen reveals key areas where companies have fallen down. These include:·
Failure to prepare a written master manufacturing record for each unique formulation of a dietary supplement.- ù ù ù this would be on the bottle itself so again this would be private information so as to not allow others to steal there ideas·
Failure to establish component specifications for strength and composition.- ù ù ù this is found unfortunately in proprietary blends and need to be addressed years ago so people would not be taken advantaged of·
Failure to fill out material rejection/rework sheets.- ù ù ù again there is already standards and criteria having to be met in the purity of materials and standards of production and what is being allowed·
Failure to collect information regarding customer hospitalizations in in-bound complaints in order to determine if a MedWatch report needs to be submitted.—Another excuse-ù ù ù there has never been one incident of death by supplements nor can you connect anything to a supplement directly---they are food nutrient additives nothing more---·
Failure to establish a sampling plan for obtaining representative samples of components.—again this is a cost that only drug companies can incurù ù ù again these are not drugs, they are concentrated forms of either food---foodnutrient additives—what is being required here is not required in either the food industry or the drug industry·
No documentation to explain the rationale behind the testing performed and the specifications for various raw materials using USP methods intended for use in testing drug products but no evidence that these testing methods are suitable for use in testing DS ingredients and finished products.---- ù ù ù AGAIN—these are not drugs·
Indicating "PASS" instead of identifying specific ID test results.·
Non-use of metal detection equipment for liquid DS products. ù ù ù I would like to see them do a metal testing on the drugs being prescribed today---they would all be toxic levels of some metal·
GMP training is not conducted on a continuing basis to assure that employees remain familiar with CGMP requirements.- ù ù ù this has just been implemented and there is a 2 year developing period so this would not really be an issue not for another 2 years for some companies·
Failure to conduct appropriate tests or examinations or rely on a C of A to determine whether components met established specs.·
The firm's training records do not reflect training of personnel in DS GMPs. ù ù ù again this is really irrelevant and will produce an unnecessary cost to the consumer as well as the retailer and the manufacturer·
Batch records are general and printed out blank.--"There are many other observations, but the above are helpful insights as to what FDA inspectors are looking for and looking at," Israelsen said.Experts slam calls for vitamins to be OTC
Vitamins A, E, D, niacin and folic acid should be regulated as over-the-counter (OTC) medicines,
according to a review of adverse events from Canada. ---In an article in The Annals of Pharmacotherapy three Canadian pediatricians reviewed adverse effects and events of vitamins in light of their current prevalence of use and concluded that vitamins should be viewed as OTCs. --"Our recommendation is that vitamins A, E, D, folic acid, and niacin should be categorized as OTC medications. Labeling of vitamins, especially those intended for children and/or vulnerable groups, should include information on possible toxicities, dosing, recommended upper intake limits, and concurrent use with other products," --ù ù ù -the interesting thing here is again there has never been a single death from supplements, never anyone getting hurt, yet here we are being lead to believe that vitamins have been problematic for people, And yet aspirin—tobacco—tylenol—ibuprofren—statins—percacets are sold indiscriminately without any warning or regulating--wrote Alexander Rogovik, Sunita Vohra, and Ran Goldman.--"Vitamin A should be excluded from multivitamin supplementations and food fortificants," they added. ù ù ù the reason being this would then see a rise in cancers that otherwise would not be---smokers who smoke would potentially have an issue and again potentially—there is still debate whether or not vitamin A mixed with smoking is causative to cancer—common sense would indicate that with over 4000 carcinogens in smoking then it would appear more so to quit the habit of smokingSelective science
The findings were dismissed by both the Natural Products Association (NPA) and the Council for Responsible Nutrition (CRN). ---"This article, though published in a peer-reviewed journal
, is a pre-determined conclusion in search of evidence to support it," said Andrew Shao, senior vice president, scientific and regulatory affairs, CRN. "The authors have clearly cherry-picked literature to support their position and did not assess the totality of evidence in order to develop their unbalanced recommendation." --Daniel Fabricant, PhD, vice president for scientific and regulatory affairs at NPA told NutraIngredients-USA: "The authors need to understand that what they're asking isn’t data driven, there is an adverse events reporting (AER) system, and if any of these such theoretical issues they bring up were in-fact real, there would be a signal in the post-market surveillance system which the authors should recognize is the same for medical prescriptions, devices, and OTCs. --"Most importantly, they need to understand that the risk needs to be attributed to the riskier product, which all medical scientists, toxicologists, and so on worth their salt would agree is the pharmaceutical," added Fabricant.Review data
The reviewers focused on collecting data from predominantly randomized controlled clinical trials. Data was also used from surveys on vitamin-drug interactions from a pediatric emergency department. --Vitamin use is extensive, said the reviewers, with data from the National Institutes of Health indicating
that over one-third of Americans regularly use multivitamin supplements.---Regarding adverse events, the reviewers quote results from randomized clinical trials of vitamins A, E, D, niacin and folic acid, many of which were performed in diseased populations, and with relatively high doses of vitamins. --"This article focused on vitamin-related adverse effects and interactions, many of which have been shown to be significant in randomized controlled trials and at a population level, in light of very high prevalence of vitamin use and food fortification, rather than on evaluating the impact of recommended policy changes on vitamin manufacturers or the food industry, which is not our expertise," explained Rogovik, Vohra, and Goldman. --Dr Rogovik is the assistant director of the Pediatric Research in Emergency Therapeutics (PRETx) Program at St. Michael’s Hospital, Toronto. Dr Vohra is the director of the Complementary and Alternative Research and Education (CARE) Program in the Department of Pediatrics at Stollery Children’s Hospital in Edmonton. Dr Goldman is an associate professor in the Department of Pediatrics at the University of British Columbia.Strong reaction
Dr Shao told this website that the authors use outdated and incomplete evidence to support their preconceived conclusions on the safety profile of individual vitamins, while omitting important evidence countering their assertions
. ---"The authors pay lip service to the Institute of Medicine’s (IOM) safe upper intake level (UL), but ignore the principles on which it is based, namely nutrient risk assessment," explained Dr Shao. "Risk assessment is a globally accepted scientific methodology for assessing risk of exposure to nutrients and is endorsed or practiced by the IOM, UK EVM and Codex, to name a few. It is based on the well known concept that the dose makes the poison and the process involves examining the totality of the evidence. All nutrients, and in fact anything ingestible can be toxic, even water, at the right dose. ---"By mentioning the UL, but merely citing those studies that support their preconceived conclusions rather than assessing all the evidence, the authors present a poorly contrived, unconvincing argument and reflect their ignorance of the subject matter, extreme bias, or both," added Shao. --Dr Fabricant added that it is well known that very active pharmaceuticals like warfarin will interact with many things, including foods. "But does that mean that because spinach interacts with warfarin, that we should go out and make spinach an OTC? Of course not." ---"These folks fail to understand that supplements with good reason are appropriately and adequately regulated as foods, and provide all the appropriate measures to protect the consumer and just as ridiculous is the notion that spinach would be an OTC is the notion that vitamin D should be one as well," added Fabricant. Source: The Annals of Pharmacotherapy --February 2010, Volume 44, doi: 10.1345/aph.1M238--"Safety Considerations and Potential Interactions of Vitamins: Should Vitamins Be Considered Drugs?"Czechs--EC must clarify food supplement enforcement policies
The European Commission needs to let the European supplements industry know how the Food Supplements Directive (FSD) will be enforced across the 27-member bloc,
as companies deal with existing stocks that contain now prohibited nutrients, a Czech trade association has said. ---The Czech Association of Special Foods (CASP) said many players were unsure how to proceed, and called on the EC "to communicate with industry" about enforcement procedures for the Directive, which became enforceable from January 1, 2010. ---"While it could be said that it is better not to know than be told that all products have to be removed tomorrow, we would prefer some kind of statement so that the position is clear," said CASP president, Martina Simova. --Non-approved chromium forms that tended to originate in the US, where they are legal and present in many supplements, were the most common problem area in the € 170m Czech food supplements industry , Simova said.Transition periods
The Czech situation is complicated, she said, by the fact that the Czech Ministry of Health gave assurances to the industry that a 12-month transition period would be granted, meaning any products bearing unapproved nutrients could remain on-market through 2010. ---
That assurance, relevant as recently as December last year, has been subsequently withdrawn as the Ministry revealed it did not in fact have the authority to grant such an extension. --Simova said the Ministry had been in contact with the EC to try and work out some kind of compromise position, and was due to report back to industry the results of those discussions imminently. ---In the meantime, the CASP had been in touch with other trade associations to determine the situation in other member states, and is considering directly contacting the enforcement agency in the Czech republic - Czech Agriculture and Food Inspection Authority (CAFIA). --"If there is no possibility elsewhere we will consider negotiating directly with the control body (CAFIA)," she said. "The ministers have promised to find a solution so we wait to hear from them what the situation is."Going soft?
The 2002 Food Supplements Directive became enforceable on January 1 this year
but the manner of its enforcement is unclear. The EC told NutraIngredients.com last week that enforcement was the remit of member state agencies like CAFIA, unless it received specific consumer complaints in which case it may act independently. ---But trade associations in some member states believe the EC needs to do more because the member state enforcement agencies are waiting to be led on the issue, creating a potentially very damaging ambiguity. ----Although it has only been a matter of days, an EC spokesperson said she had no knowledge of any enforcement action taken in any EU member state. ---The argument for "soft enforcement" is bolstered by the fact some substances have failed to make the FSD positive lists of vitamins and minerals and their sub-forms, not because they have been deemed unsafe necessarily, but because European Food Safety Authority scientists have found a lack of evidence demonstrating safety. ---The Czech market is dominated by eastern European supplements giant, Walmark, but supports about 500 small-to-medium enterprises and features about 4000 individual products
How To Destroy Confidence In Vitamins When You Do Not Have The Facts
(OMNS, January 11, 2010) "Ladies and Gentlemen, welcome to this year's annual meeting of the World Headquarters Of Pharmaceutical Politicians, Educators, and Reporters (WHOPPER).---"Let us get right to the point. Many of our members and affiliates have complained about what is, for us, an alarming and dangerous segment of health care: so-called 'orthomolecular medicine.'
We wish to assure you, although this therapeutic approach is, unfortunately, very effective in preventing and treating disease, that we will make sure the public will never learn of it. We can say this with considerable confidence, since for over 50 years we have managed to keep virtually all psychiatrists from using niacin to treat schizophrenia; we have kept cardiologists from prescribing vitamin E and co enzyme Q10 for heart disease; and we have kept general practitioners from prescribing vitamin C for viral illnesses.---"Yes, it has really been a triumphant half-century. How did we do it? It is really quite easy. Here is a summary for those of you that may have missed the last WHOPPER meeting.---"Our guiding principle is, keep the public afraid. Any fear will do, but we have been especially pleased with, and therefore recommend instilling, the fear of new strains of flu viruses, fear of vaccine shortages, and most especially, the fear of vitamin toxicity. Our success with this last one has been nothing short of spectacular.--"Of course, you know that decades of poison control center statistics show that there have been no deaths from vitamins. (1) You also know that drugs, properly prescribed and taken as directed, kill at least 100,000 Americans annually. Clearly, the last thing we want is for the public to actually figure out that vitamin therapy is tens of thousands of times safer than drug therapy.---"Therefore, we endorse the following tactics:"1)
Always demand 100% safety and 100% efficacy from nutritional therapy. This is particularly effective when you, at the very same time, continually remind the public that they have to expect and accept a reasonable amount of dangerous, even fatal, side effects with drug therapy. And, if one drug does not work, there is always another, still more expensive drug that might."2)
Always give priority to publishing research that portrays vitamins as ineffective, or as outright harmful. Select the low-dose vitamin study; ignore the high-dose study. Our master stroke is when we criticize low-dose nutrient studies for ineffectiveness, while discrediting effective high-dose studies because they might be dangerous. Remember: pick the one negative vitamin study; ignore the hundreds of positive vitamin studies."3)
If a positive megavitamin study is actually submitted to your department, medical society or journal, reject it on a technicality, and take a year or two to do so. Better still, make the authors publish in the Journal of Orthomolecular Medicine. After all, whatever is published there will not be indexed by the U.S. National Library of Medicine.(3) Therefore, the public's annual 700 million MEDLINE searches will utterly fail to find it. People cannot read what cannot be located."4) Obfuscation works.
Cloud and confuse the issue. Never let the truth stand in the way of a good press release. This we learned from the tobacco industry: If you cannot wow 'em with wisdom, baffle them with baloney. Remember, with vitamins, always highlight the negative; ignore the positive. Never let the facts get in the way of as good argument. A good argument is one that you win. This is about power, not health."5) While half the population takes vitamins,
fewer than 1% of physicians practice orthomolecular medicine. That is a very small minority. How hard can it be to shut them up? After all, look what we did to Linus Pauling. When he spoke out for vitamin C, we got the entire medical world to openly snicker at the only person in history to win two unshared Nobel prizes. Talk about a WHOPPER!"6) Take heed of what behaviorist B.F. Skinner said:
Education is a very large number of very small steps. The secret is to keep plugging away, every chance we get. Every time we tell a WHOPPER in the news media or in the medical press, it is one additional, cumulative step towards washing the public's mind clean as a whistle, and stamping out nutritional medicine for good.--"Now go back to your word-processors and get to work. Wade through those nutrition studies and latch onto the negative ones. The news media are waiting to hear from you."References:
(1) The most recent annual report of the American Association of Poison Control Centers published in the journal Clinical
Toxicology shows zero deaths from multiple vitamins; zero deaths from any of the B vitamins; zero deaths from vitamins A, C, D, or E; and zero deaths from any other vitamin. Furthermore, there were zero deaths from any dietary mineral supplement.---Bronstein AC, Spyker DA, Cantilena LR Jr, Green JL, Rumack BH, Heard SE; American Association of Poison Control Centers. 2007 Annual Report of the American Association of Poison Control Centers' National Poison Data System (NPDS): 25th Annual Report. Clin Toxicol (Phila). 2008 Dec;46(10):927-1057. Full text article available for free download at http://www.aapcc.org/DNN/Portals/0/NPDS%20reports/2008%20AAPCC%20Annual%20Report.pdf Vitamins statistics are found in Table 22B, journal pages 1027-1028. Minerals are in the same table, page 1024.(2) Lazarou J, Pomeranz B, Corey P. Incidence of adverse drug reactions in hospitalized patients. JAMA. 1998;279:1200-1205. See also: Leape LL. Error in medicine. JAMA. 1994 Dec 21;272(23):1851-7.
(3) Saul AW. Medline bias: update. [Editorial] J Orthomolecular Med, 2006. Vol 21, No 2, p 67. http://www.doctoryourself.com/medlineup.html
For Further Reading:
Pharmaceutical Advertising Biases Journals Against Vitamin Supplements. Orthomolecular Medicine News Service, February 5, 2009. http://orthomolecular.org/resources/omns/v05n02.shtml
FDA Claims "Food Supplement" Deaths; Hides Details from the Public. Orthomolecular Medicine News Service, October 9, 2008. http://orthomolecular.org/resources/omns/v04n13.shtml
What is a Lipsome?---- Liposomes can fuse with Cells and thereby deliver their internal load.--- The inner space of Liposomes can be loaded with any other drugs/nutrients (i.e. active ingredients) and used as delivery systems to deliver these active ingredients to their target sites. This aspect of Liposomes also applies to topically-delivered compounds.
Ok lets make our own---it will be potent enough for your needs and can make a huge difference in the delivery of some of the antioxidant or supplement---by using fats like coconut---cream---ghee---butter or even oil—or lecithin----you can utilize for a start an antioxidant –
Ø
Take Rosemary--- either the herb or tincture---add it to a ghee-- either in a baine marie ( double broiler ) put in a glass container and heat in either in pot of simmering water or frying pan heat til you see the rosemary fuse in the oil once this happens then either cool down the heat or just shut off til the ghee cools down---strain and you have made an lipsomal rosemary antioxidant mix ---you can do this with cayenne---tumeric—garlic—or even with supplements such as Cq10—alpha lipoic acid—green tea—Ø
Another way is to put cream into a blender and the utilize Vitamin C and Elderberry—and then blend til the cream whips up thick-- again you have made another lipsome antioxidant mix---now if you continue you can make it into a butter and have the components fused in and will have the antioxidants in the fats---you can add tumeric---red pepper---rosemary—sage—thyme –oregano—you can add Vitamin E---Cq10—Alpha Lipoic---Cinnamon—Clove—Paprika—Carrot Powder---Beta Carotene—Vitamin A---these are some suggestionØ
Another way is to fuse oil with herbs or spices or even supplement in a glass container and let sit in a window sill and let the sun hit this for 2 weeks---blend and strain through a handkerchief it will take time ---if you can filter it out in another way to reduce the sediment the oil then do soØ
Another way is to preheat the oil before you cook and then add any herb you like and when it turns the colour of the herb you know it is fused in ( bay leaf—thyme-) and then add your food you are going to prepare this will increase the levels ofTake these anyway you like ---tsp amounts---add to foods ---use in salad oils---mix in nut butters---or seed milks
—
2009 review-- FDA warning letters clampdown
Japan to ban 125 nutrients including glucosamine form
2009 review-- FDA warning letters clampdown
In 2008, the Food and Drug Administration (FDA) issued 44 warning letters with internet cancer claims being the primary target. In 2009, the agency upped the ante, issuing 73 letters, half of which targeted swine flu (H1N1) products. Washington DC-based advertising and labeling attorney, Ivan Wasserman, looks back on a busy year for the FDA.
Our review identified 73 warning letters involving dietary supplements issued by FDA in 2009.
| TARGET OF LETTER | NUMBER OF LETTERS | |
| 'Drug/Disease' claims | 72 | |
| H1N1claims | 37 | |
| Heart Disease/cardiovascular claims | 11 | |
| Diabetes claims | 8 | |
| Cold/Flu (other than H1N1) Claims | 8 | |
| Cancer claims | 8 | |
| Other "drug/disease" claims | 20 | |
| Claims made on websites | 72 | |
| Claims made in metatags | 6 | |
| Claims made on labels and labeling | 12 | |
| Claims concerning "FDA approval" | 1 | |
| Claims made in broadcast or print advertising | 1 | |
| Tainted products | 1 | |
| GMP violations | 0 | |
The 73 Warning letters issued in 2009 compare to 44 issued in 2008 – a 66 percent increase.
When new leadership came to FDA in 2009, they came with a promise to step-up enforcement compared to the previous administration. While some of the increase in warning letters in 2009 can be attributed to the prevalence of products claiming to treat the 2009 H1N1 flu virus, it certainly appears at least that the ‘new’ FDA will be more vigilant in policing the dietary supplement industry. --Web focus --Out of 73 Warning letters, 72 involved claims made on web sites. That’s consistent with 2008. As a general rule, FDA can consider any statement or claim that appears on dietary supplement web pages to be a labeling claim for the product. This can include claims made in consumer testimonials, metatags, and in third party literature excerpts and citations.2009 – all bout H1N1
In terms of product categories, in 2009, the FDA’s main target was dietary supplements that made any type of H1N1 claim. That should be no surprise, as H1N1 generally, and targeting illegal H1N1 products specifically, was certainly a high-profile priority for FDA in 2009. --In addition to warning letters,
FDA created dedicated sections of its web site and issued press releases in an effort to inform the public about these products. H1N1 could remain a priority for FDA in 2010, depending on the prevalence of the virus and the likely related prevalence of products claiming to treat or prevent it. ---What is somewhat surprising is the dramatic drop in letters targeting cancer-related products. In 2008, 36 of the 44 letters (82 percent) involved, at least in part, cancer-related claims, compared to only eight out of 73 in 2009 (11 percent). Even as a percentage of non-H1N1 letters, cancer-related letters only accounted for 22 percent (8/36)--One possible enforcement trend evidenced by FDA’s 2009 warning letters is the number of letters targeting two categories of products that are not dietary supplements but, like supplements, are generally marketed without FDA approval: homeopathic drug products and medical foods.What is a warning letter?
The agency sends warning letters to manufacturers or marketers to inform them of violations of FDA laws and regulations
. FDA may observe violations during an inspection of manufacturing or other facilities. The agency can also review product labeling and, importantly, claims made on websites. --One area of focus for dietary supplements is the distinction between permissible ‘structure/function’ claims and unlawful ‘disease’ or ‘drug’ claims - i.e. claims that state or imply the product will treat, cure, or prevent a disease. --Ivan Wasserman is a partner at Manatt Phelps & Phillips in Washington, DC. He specializes in advertising and labeling issues for the food and dietary supplement sectors.Don’t destroy hard-won health claim freedom, says ANH
The Alliance for Natural Health says a recent missive sent to the FDA by the
Center for Science in the Public Interest (CSPI) calling for the abolishment of structure-function and qualified health claims, would favor large companies and decimate the natural products industry. In a statement published today ANH executive and scientific director, Dr Robert Verkerk, responded to the 158-page CSPI document which highlighted examples of claims abuse, by highlighting the devastating effect revoking the claims would have on smaller players in the industry. --"It is the hundreds of much smaller companies that will feel the pinch if CSPI gets its way," Verkerk wrote. --"The US health food industry has for many years enjoyed one of the least restrictive claims environments in the world. This regulatory environment hasn’t come by accident. It’s been hard won," he said, noting the passage of the 1994 Dietary Supplement Health and Education Act (DSHEA). ---Without it, small and medium-sized companies would have been decimated by drug laws, "leaving only a sprinkling of very large corporations as players in the market." ---"Contrary to what CSPI alleges," Verkerk continued, "health claims in the US are far from out of control. As with all industries, there will be some irresponsible players, but there are already ample mechanisms in place to deal with false and misleading claims." ---While enforcement measures could be tweaked, wholesale changes were regressive, he said. ---"This would create the kind of exclusive health claims club that is benefiting the likes of transnational corporations like Unilever in Europe under the Article 14 procedure of the nutrition and health claims regulation." --"In the case of product advertising, the Federal Trade Commission has enormous power to penalise companies unable to substantiate claims, and highly publicised prosecutions have had the expected effect in making the vast majority of companies responsible in their use of claims." ---"Regardless of what CSPI or others wanting to eliminate the structure/function claims environment might say, these claims are not unregulated." ---He observed the FDA must be notified within 30 days of a structure/function claim being employed on-product.Qualified health claims ---Verkerk commented
that the qualified health claims system was already being compromised by excessive disclaimers that rendered them almost commercially unusable. Selenium and antioxidant claims, which the ANH and others are challenging in the courts, were cited as examples. ---"It is becoming increasingly clear that this process is controlled by pharmaceutical interests or their sympathisers conducting studies that are intended to yield negative results. These data are then used by the pharma industry’s accomplices at the FDA to give the supplement industry yet another knocking." ---Verkerk said the main drivers for claims restriction were coming from the European Union and Codex Alimentarius – the World Health Organization/Food and Agriculture Organization arm that concerns itself with global food regulations. --He said a lack of clarity in what constitutes ‘generally accepted scientific data’ was allowing a bias toward drug-style criteria. --Claims were drawing negative opinions under the EU nutrition and health claims regulation because they were supported, "largely by animal studies, biochemical evidence or emerging science." --Verkerk said regulatory harmonization initiatives such as Codex were inevitably influenced by "horsetrading" between governments and large corporations. --"We see it in virtually all areas in which big business is dominant, or has a lot to lose—or gain. The push to harmonise laws on carbon dioxide emissions is a recent and key example." ---He said the ANH was raising funds if legal action was required on either side of the Atlantic.Japan to ban 125 nutrients including glucosamine form
Japan’s Ministry of Health, Labour and Welfare (MHLW) has signaled its intention
to blacklist 125 nutrients including forms of glucosamine, aloe vera and krill because it says they are not being used in products, according to the US Department of Agriculture Foreign Agriculture Service (FAS). ---Others that appear on the list include isomaltodextranase, chitin, quercetin, mulberry bark extract, ginger extract and calcinated calcium and Eucalyptus leaf extract. --But it is believed the bans are not on the ingredients par se, just specific forms that have slipped out of usage. The USDA said the MHLW was requesting additional information from the companies concerned that may wish to continue using the ingredients. ---If cuts are made Japan's approved list will shrink from 418 to 293 approved substances. ---"The stated reason for the deletions is that the ministry believes these additives are not currently being used in foods sold in Japan," USDA said. --The MHLW issued a January 8, 2010 deadline for companies to submit documentation demonstrating why the substances should not be banned. ---"Once these additives have been deleted from the list, they will no longer be allowed for use in foods in Japan. Likewise, any imported foods found to contain a residue of these substances would not be allowed to be sold in Japan." --The Japanese government has sought foreign embassy feedback on the use of these substances and another public consultation period will be held. --"At that time US food and/or food additive manufacturers with interest in these additives should send comments to MHLW with a statement asserting that the chemical in question is currently in use and contained in food products exported to Japan."| Below is the list of table MHLW is planning to delete. Number | Additive names in Japanese | Additive names in English |
| 1 | アウレオバシジウム培養液 | Aureobasidium cultured solution |
| 10 | アスペルギルステレウス糖たん白質 | Aspergillus terreus glycoprotein |
| 11 | N-アセチルグルコサミン | N-Acetylglucosamine |
| 21 | アラビノガラクタン | Arabino galactan |
| 23 | アルカネット色素 | Alkanet colour |
| 28 | アロエベラ抽出物 | Aloe vera extract |
| 32 | イソマ\ト}キストラナーゼ | Isomaltodextranase |
| 37 | イモカロテン | Sweet potato carotene |
| 44 | エゴノキ抽出物 | Japanese styrax benzoin extract |
| 46 | エラグ酸 | Ellagic acid |
| 49 | オキアミ色素 | Krill colour |
| 52 | オリゴ-N-アセチルグルコサミン | Oligo-N-acetylglucosamnie |
| 53 | オリゴガラクチュロン酸 | Oligogalacturonic acid |
| 54 | オリゴグルコサミン | Oligoglucosamine |
| 55 | γ-オリザノール | γ-Oryzanol |
| 56 | オレガノ抽出物 | Oregano extract |
| 58 | 海藻灰抽出物 | Seaweed ash extract |
| 61 | カカオ炭末色素 | Cacao carbon black |
| 65 | ガストリックムチン | Gastric mucin |
| 87 | カワラヨモギ抽出物 | Rumput roman extract |
| 89 | カンゾ"油性抽出物 | Licorice oil extract |
| 94 | キダチアロエ抽出物 | Aloe extract |
| 96 | キチン | Chitin |
| 99 | キナ抽出物 | Redbark cinchona extract |
| 100 | キハダ抽出物 | Phellodendron bark extract |
| 106 | グァーガム酵素分解物 | Enzymatically hydrolyzed guar gum |
| 109 | クエルセチン | Quercetin |
| 113 | グッタハンカン | Gutta hang kang |
| 115 | クリストバル石 | Cristobalite |
| 116 | グリーンタフ | Green tuff |
| 119 | グルコサミン | Glucosamine |
| 133 | クワ抽出物 | Mulberry bark extract |
| 136 | ゲンチ"ナ抽出物 | Gentian root extract |
| 140 | 酵素処理カンゾ" | Enzymatically modified licorice extract |
| 141 | 酵素処理チャ抽出物 | Enzymatically modified tea extract |
| 147 | 酵素分解ハトムギ抽出物 | Enzymatically hydrolyzed coix extract |
| 148 | 酵素分解リンゴ抽出物 | Enzymatically decomposed apple extract |
| 156 | コバルト | Cobalt |
| 157 | ゴマ油不けん化物 | Sesame seed oil unsaponified matter |
| 160 | ゴム分解樹脂 | Resin of depolymerized natural rubber |
| 162 | コメヌカ酵素分解物 | Enzymatically decomposed rice bran |
| 165 | ササ色素 | Bamboo grass colour |
| 166 | サトウキビロウ | Cane wax |
| 171 | サンダ"ック樹脂 | Sandarac resin |
| 180 | シコン色素 | Shikon colour Lithospermum root colour |
| 182 | シソ抽出物 | Perilla extract |
| 185 | ジャマイカ}ッシア抽出物 | Jamaica quassia extract |
| 186 | ショウガ抽出物 | Ginger extract |
| 187 | 焼成カルシウム | Calcinated calcium |
| 193 | スクレロガム | Sclero gum |
| 197 | スフィンゴ脂質 | Sphingolipid |
| 202 | ゼオライト | Zeolite |
| 203 | セサモリン | Sesamolin |
| 205 | セスバニアガム | Sesbania gum |
| 206 | セピオライト | Sepiolite |
| 212 | ソ\バ | Sorva |
| 213 | ソ\ビンハ | Sorvinha |
| 214 | L-ソルボース | L-Sorbose |
| 215 | ダイズサポニン | Soybean saponin |
| 223 | 胆汁末 | Powdered bile |
| 226 | タンニン（抽出物） | Tannin (extract) |
| 231 | チャ種子サポニン | Tea seed saponin |
| 232 | チャ抽出物 | Tea extract |
| 233 | チルテ | Chilte |
| 235 | ツヌー | Tunu |
| 238 | 低分子ゴム | Depolymerized natural rubber |
| 239 | テオブロミン | Theobromine |
| 244 | 電気石 | Tourmaline |
| 248 | 動物性ステロール | Cholesterol |
| 249 | ドクダミ抽出物 | Dokudami extract |
| 258 | トリアシルグリセロールリパーゼ | Triacylglycerol lipase |
| 264 | ナフサ | Petroleum naphtha |
| 268 | ニガキ抽出物 | Quassia extract |
| 269 | ニガーグッタ | Niger gutta |
| 270 | ニガヨモギ抽出物 | Absinth extract |
| 271 | ニストース | Nystose |
| 273 | ニュウコウ | Olibanum |
| 275 | ニンニク抽出物 | Garlic extract |
| 278 | パーオキシダーゼ | Peroxidase |
| 281 | パフィア抽出物 | Paffia extract |
| 284 | パラジウム | Palladium |
| 287 | ヒアルロン酸 | Hyaluronic acid |
| 288 | ヒキオコシ抽出物 | Isodonis extract |
| 293 | L-ヒドロキシプロリン | L-Hydroxyproline |
| 294 | ヒマワリ種子抽出物 | Sunflower seed extract |
| 295 | ヒメマツタケ抽出物 | Himematsutake extract |
| 296 | ピメンタ抽出物 | Pimento extract |
| 299 | ファフィア色素 | Phaffia colour |
| 305 | フェルラ酸 | Ferulic acid |
| 309 | ブドウ果皮抽出物 | Grape skin-derived substance |
| 310 | ブドウ種子抽出物 | Grape seed extract |
| 317 | プロポリス抽出物 | Propolis extract |
| 322 | 粉末モミガラ | Powdered rice hulls |
| 331 | ヘスペレチン | Hesperetin |
| 335 | ベニノキ末色素 | Powdered annatto |
| 338 | ベネズエラチクル | Venezuelan chicle |
| 339 | ペパー抽出物 | Pepper extract |
| 343 | ヘマトコッカス藻色素 | Haematococus algae colour |
| 348 | ホウセンカ抽出物 | Garden balsam extract |
| 349 | ホコッシ抽出物 | Hokossi extract |
| 359 | マッサランドバチョコレート | Massaranduba chocolate |
| 360 | マッサランドババラタ | Massaranduba balata |
| 364 | 未焼成カルシウム | Non-calcinated calcium |
| 370 | ムラサキヤマイモ色素 | Purple yam colour |
| 372 | メチルチオアデノシン | Methylthioadenosine |
| 374 | メバロン酸 | Mevalonic acid |
| 375 | メラロイカ精油 | Melaleuca oil |
| 377 | モウソウチク炭抽出物 | Mousouchiku charcoal extract |
| 378 | モウソウチク抽出物 | Mousouchiku extract |
| 385 | モリン | Morin |
| 386 | モンタンロウ | Montan wax |
| 388 | 油煙色素 | Vegetable oil soot colour |
| 389 | ユーカリ葉抽出物 | Eucalyptus leaf extract |
| 403 | D-リボース | D-Ribose |
| 405 | リンターセルロース | Linter cellulose |
| 406 | ルチン酵素分解物 | Enzymatically decomposed rutin |
| 407 | ルチン（抽出物） | Rutin (extract) |
| 408 | ルテニウム | Ruthenium |
| 409 | レイシ抽出物 | Mannentake extract |
| 410 | レッチュデバカ | Leche de vaca |
| 411 | レバン | Levan |
| 412 | レモン果皮抽出物 | Lemon peel extract |
| 415 | ログウッド色素 | Logwood colour |
| 416 | ロシディンハ | Rosidinha |
| 419 | ワサビ抽出物 | Wasabi extract |
what is a poultice? The term poultice comes from the Latin word for porridge.
It was not uncommon to treat inflammations with porridge spread on a cloth and then applied to the inflamed area. They might also cover the chest during a chest cold. Usually, however, plain porridge mixed with mustard was applied directly on the chest and was called a plaster. Poultices may also be called cataplasms ( a medical dressing consisting of a soft heated mass of meal or clay that is spread on a cloth and applied to the skin to treat inflamed areas or improve circulation )---Ø Ø
The simplest poultice you can make is by using oatmeal or clay---Simply add water to a bowl and add either or both of the clay or oatmeal---this can either draw out or put into the are what is needed to balance out or rectify a health condition----Ø Ø
Another way of making a poultice is by adding herbs or using herbs---what you would do is powder down some herbs either by pestle and mortar or coffee grinder or blender ---you can add a combination of the herbs or just add one---you can heat the powder in little water to increase the release of the components of the herb by either adding it directly into a pot of wat and to simmer the herb til desired heat –and if needed add more powdered herb to a bowl if the herbal mix is to soppy ( sometimes after heating the herbs in a pot of water it can be a little runny so when you p0wder the herbs down always leave a little on the side just for this reason)Ø Ø
Another way is to just use clay—I use a diamatious clay---just add water and make a paste out of this ---again not to soppy or to dry ---it will lay on the skin like a paste and when it dries it will draw out the poisons that maybe underlying in the skin--When applying these poultices---consider raising the levels of antioxidants ( vitamin C—alpha lipoic acid—Vitamin A—Vitamin E—Thyme—Rosemary---Cinammon—Bayleaf---Green Tea—Astragulus—Reishi Mushrooms---etc---YOU DON’T have to Use all of these ---they are examples to consider ---straight or in combinationLet the almonds ( or other seed or grains you might want to explore ) sit in a glass container or Jar over night ( you can do it in a shorter period of time but you might find it takes longer to blend and mix) the next day blend mix with your favourite sweetener ( Unpasteurized honey, xylitol, maple syrup, corn syrup ?whatever you would like or even use unsweetened) Add xanthium gum as a binder it keeps every thing together ---Blend til smooth and add water as you blend til you fill to top of blender? blend til smooth--Stop pour out into another container ( preferably glass) refrigerate and drink or drink straight from the blender either way you will love it
TOP D
á á á == My Comments
Vitamin E may boost brain health after stroke--Recipe
Food Supplements Directive Stay positive --or bans may follow
Vitamin B12 May Protect The Brain In Old Age
Thyme Oil Can Inhibit COX2 and Suppress Inflammation---Recipe 2
Tocotrienols may prevent nerve cell death in the brain following a stroke, suggests new research on this emerging form of vitamin E
. ---Alpha-tocotrienol, one of eight forms of vitamin E, was found to inhibit an enzyme from releasing fatty acids that eventually kill neurons, according to findings from a study with mouse brain cells published in the Journal of Neurochemistry. ---The beneficial effects are observed at low levels of the nutrient, researchers from Ohio State University report following their National Institutes of Health-funded study. ---"Our research suggests that the different forms of natural vitamin E have distinct functions. The relatively poorly studied tocotrienol form of natural vitamin E targets specific pathways to protect against neural cell death and rescues the brain after stroke injury," said Professor Chandan Sen, lead researcher of the study. "Here, we identify a novel target for tocotrienol that explains how neural cells are protected." --"We have studied an enzyme that is present all the time, but one that is activated after a stroke in a way that causes neurodegeneration. We found that it can be put in check by very low levels of tocotrienol," he said. "So what we have here is a naturally derived nutrient, rather than a drug, that provides this beneficial impact." --Industrial welcome --The study’s results were welcomed by Carotech, the producer of the tocotrienol ingredient used in the study. Dr Sharon Ling, vice president, scientific affairs, sales & marketing (Europe) for Carotech Ltd (London) told NutraIngredients that the company is "very excited that tocotrienol - a natural dietary nutrient from palm oil - can be just as effective [as drugs or other therapeutic agents], if not more so, in neural protection. --"This should open up new possibilities into prevention and even treatment of stroke and other neurodegenerative diseases," she added. Dr Ling added that the potential neuroprotective effects of nanomolar levels of tocotrienol were first reported a decade ago. "This latest study from The Ohio State University elucidates how very low levels of tocotrienol, which are readily achievable by daily supplementation, protects the brain in artificially induced stroke," she added. ---"It shows tocotrienol inhibits the enzyme cPLA2 from releasing arachidonic acid into the brain. The release of arachidonic acid is an important step in causing neuronal death from glutamate induced state which mimics stroke," explained Dr Ling. --The vitamin E family ---There are eight forms of vitamin E: four tocopherols (alpha, beta, gamma, delta) and four tocotrienols (alpha, beta, gamma, delta). Alpha-tocopherol is the main source found in supplements and in the European diet, while gamma-tocopherol is the most common form in the American diet. Tocotrienols (TCT) are only minor components in plants, although several sources with relatively high levels include palm oil, cereal grains and rice bran. --While the majority of research on vitamin E has focused on alpha-Toc, studies into tocotrienols account for less than one per cent of all research into vitamin E. --Study details ---Sen and his co-workers looked at the effects of alpha-tocotrienol to inhibit the action of the enzyme called cystolic calcium-dependent phospholipase A2, or cPLA2. Following the trauma of blocked blood flow associated with a stroke, an excessive amount of the neurotransmitter glutamate is released in the brain. Despite playing an important role in learning and memory, too much glutamate can trigger the death of brain cells, or neurons, said to be the most damaging effects of a stroke.---( á á á if you eat things like cottage cheese or breads with GMO production then one way to offset a potential issue is by including either Taurine or glycine or gaba to offset the problem of glutamate á á á )---By introducting excess glutamate into the brain cells of mice, the Ohio-based researchers mimicked the brain’s environment after a stroke. In the presence of excess glutamate, cPLA2 released arachidonic acid into the brain, which subsequently underwent an enzymatic chemical reaction to become toxic. ---When tocotrienol was introduced to cells exposed to the high levels of glutamate arachidonic acid levels decreased by 60 per cent, said the researchers. This resulted in a cell survival rate four times higher than cells exposed to glutamate alone. ---Prof Sen noted that the effects were observable with a 250 nanomolar dose of tocotrienol. This is equivalent to a concentration about 10 times lower than the average amount of tocotrienol circulating in humans who consume the vitamin regularly. --"On a concentration basis, this finding represents the most potent of all biological functions exhibited by any natural vitamin E molecule," wrote the researchers in the Journal of Neurochemistry. --"This work provides first evidence in recognizing inducible cPLA2 activity as a key target of tocotrienol in protecting against glutamate-induced neurotoxicity," they added. --Amazing potential ---The new findings come after seven years of collaboration between Prof Sen and Carotech, said Mr W.H. Leong, vice president of Carotech Inc. ---"The science generated with Tocomin and Tocomin SupraBio for the last seven years has been amazing especially on the potent neuroprotective effect of tocotrienols," Mr Leong told NutraIngredients. "Being the largest and only GMP-certified tocotrienol producer, it underscores Carotech’s commitment to on science and clinical trials to bring this unique form of vitamin E to our customers." --Source: Journal of Neurochemistry--Published online ahead of print, doi: 10.1111/j.1471-4159.2009.06550.x--"Nanomolar vitamin E alpha-tocotrienol Inhibits glutamate-induced activation of phospholipase A2 and causes neuroprotection"--Authors: S. Khanna, N.L. Parinandi, S.R. Kotha, S. Roy, C. Rink, D. Bibus, C.K. Sená á á
Recipe---you can take a supplement based vitamin E with Magnesium and Taurine to assist with the process of eliminating the unwanted effects of glutamate overload---remember a lot of this comes from soy ( msg ) and wheat that has been GMO or GE ---the studies done on this was that the actual problem in the gluten was not the gluten itself but the abnormal levels of glutamate cause a lot to have a gluten intolerance when in fact it is a glutamate intolerance----a lot of the things consumed in packages and cans or bags have in fact things like autolysed yeast---canola---msg---or soy additives that will cause in some cases an allergic reaction from a roseae like blemish called RIBO RASH—to kidney issues and digestive issue and intestinal issues---Eliminating this in the diet will assist and adding these supplements can offset the glutamates---here are other things that can reduce the impact of glutamates----Folic Acid counteracts the toxicity of Glutamic Acid. ---Lipoic Acid inhibits the excitotoxic effects of Glutamic Acid.---Vitamin B12 (especially the Methylcobalamin form of Vitamin B12) helps to prevent the damage to Neurons caused by exposure to excessive levels of Glutamic Acid. ---Acetyl-L-Carnitine (ALC) helps to protect Neurons from the excitotoxic effects of excessive Glutamic Acid. N-Acetyl-Cysteine (NAC) inhibits the excitotoxic effects of Glutamic Acid. –Foods that will assist will be garlic ( it has Cysteine in several forms combine it with vinegar and you will have you NAC) consuming potatoes and wheat germ will also assist in the reduction of glutamatic acid---
Food Supplements Directive Stay positive --or bans may follow--
Products containing nutrients that don’t appear on the EU Food
Supplements Directive (FSD) positive lists are now officially illegal and can be stripped from store shelves after the derogation period expired on December 31, 2009. --While this is not a problem for most companies that have engaged in reformulation where necessary to ensure their products are in line with the FSD, there remains a question mark over products that may remain on-market, and the manner in which the regulation will be enforced across the 27 member states of the European Union bloc. ---Several member state trade associations have highlighted the issue, with concerned companies wondering what actions need to be taken in regard to unsold stock. ---According to the European Federation of Associations of Health Product Manufacturers (EHPM) regulatory affairs director, Lorène Courrège, it is difficult to tell exactly how the regulation will be enforced. --"It is up to the enforcement agencies in each member state now," she said. "It is difficult to say what actions will be taken , if any, but I suspect there is going to be a pragmatic approach." --Asking for trouble ---But she said companies were asking for trouble if they allowed products to remain on-shelf containing prohibited ingredients.---"This deadline has not come as a surprise – there has a lot of warning about it and prudent manufacturers will remove products otherwise there is a danger products could be removed from shelves."---A European Commission spokesperson said the Commission left it to member state enforcement bodies to get on with policing the regulation, unless it received a corporate or consumer complaint directly that may prompt it into action. "There are instances where we can deal with on a case-by-case basis but usually it is up to the member states to enforce the rule," she said. --Trade groups in Poland, Lithuania, the UK, the Czech Republic, Belgium and Hungary have registered concern about how the regulation is going to be enforced and what kind of advice they should be giving their members. ---The Polish Council for Supplements and Nutritional Foods (KRSiO) had lobbied for an extended transition period to 2014, but this failed. It called the imposition of the Directive into Polish law a "flawed transposition". ---Edvinas Butkus, executive director of the Lithuanian Self-medication Industry Association (LSIA), said its members had highlighted as potentially problematic products containing ingredients such as chromium nicotinate and nickel sulfate. --Butkus said he was aware of about 10 ingredients that were raising potential red flags for its members. --"We hope extra time will be given to allow some of these products, for which there are no safety concerns, to be sold through." Safety concerns ---Aušra Aleknavičiūtė, products and registration specialist at supplier Walmark in Lithuania, said a sell-through period should be allowed because nutrients not on the positive list did not necessarily possess safety concerns. ---In many cases the European Food Safety Authority (EFSA) did not, "have enough data for their evaluation." ---"Those substances have been on the EU market for a long time and there is no serious reason for immediate withdrawal of these substances from the market. For such substances, there is no reason not to allow a reasonable sell-out period on the national level." ---Information about the FSD, including the full text and the annexes, can be found here . ---EFSA processed 533 applications relating to 344 nutrients and identified safety concerns with 39 of them.Vitamin B12 May Protect The Brain In Old Age
Vitamin B12, a nutrient found in meat, fish and milk, may protect against brain volume loss in older people
. ---ScienceDaily (Sep. 11, 2008) — Vitamin B12, a nutrient found in meat, fish and milk, may protect against brain volume loss in older people, according to a study published in the September 9, 2008, issue of Neurology.---For the study, 107 people between the ages of 61 and 87 underwent brain scans, memory testing and physical exams. Researchers also collected blood samples to check vitamin B12 levels. Brain scans and memory tests were also performed again five years later.---The study found that people who had higher vitamin B12 levels were six times less likely to experience brain shrinkage compared with those who had lower levels of the vitamin in their blood. None of the people in the study had vitamin B12 deficiency. á á á SOY has been studied to cause brain shrinkage and it depletes vitamin B12 as one of the elements it depletes as well as zinc –vitamin E—cacium---magnesium and manganese to mention a few!!!----"Many factors that affect brain health are thought to be out of our control, but this study suggests that simply adjusting our diets to consume more vitamin B12 through eating meat, fish, fortified cereals or milk may be something we can easily adjust to prevent brain shrinkage and so perhaps save our memory," said study author Anna Vogiatzoglou, MSc, with the University of Oxford in the United Kingdom. "Research shows that vitamin B12 deficiency is a public health problem, especially among the elderly, so more vitamin B12 intake could help reverse this problem. Without carrying out a clinical trial, we acknowledge that it is still not known whether B12 supplementation would actually make a difference in elderly persons at risk for brain shrinkage."---"Previous research on the vitamin has had mixed results and few studies have been done specifically with brain scans in elderly populations. We tested for vitamin B12 levels in a unique, more accurate way by looking at two certain markers for it in the blood," said Vogiatzoglou.-Vogiatzoglou says the study did not look at whether taking vitamin B12 supplements would have the same effect on memory.---The study was supported by the UK Alzheimer's Research Trust, the Medical Research Council, the Charles Wolfson Charitable Trust, the Norwegian Foundation for Health and Rehabilitation through the Norwegian Health Association, Axis-Shield plc and the Johan Throne Holst Foundation for Nutrition Research. The research was part of the program of the Oxford Project to Investigate Memory and Aging at the University of Oxford.---Story Source:--Adapted from materials provided by American Academy of NeurolNew study confirms bisphenol A link to heart disease
More evidence linking bisphenol A (BPA) to heart disease has been found by a group of researchers in the UK
. ---A team from the Peninsula Medical School and the University of Exeter said analysis of new data from the United States demonstrates that "higher BPA exposure, reflected in higher urinary concentrations of BPA, is consistently associated with reported heart disease in the general adult population of the USA". The research was published in the journal PlosOne. ---The results of the latest study carried out last year, re-confirm findings from a similar review undertaken the year before, said the group as it stated more research to "clarify the mechanisms of these associations" was urgently needed. Professor David Melzer, the academic leading the study, said the results confirmed the original findings were not a statistical anomaly. BPA link to heart disease --Using data from National Health and Nutrition Examination Survey (NHANES) 2006- 2006 population study, researchers evaluated 1,493 people aged 18 to 74. They discovered that urinary concentrations of BPA had dropped by 30 per cent compared to previous results from 2003-04. However, they also found that higher BPA concentrations in urine were still associated with an increased prevalence of coronary heart disease in 2005-06. ---"This is only the second analysis of BPA in a large human population sample," said Melzer, professor of Epidemiology and Public Health at Exeter’s Peninsula Medical School. "It has allowed us to largely confirm our original analysis and exclude the possibility that our original findings were a statistical blip." ---Professor Tamara Galloway, professor of Ecotoxicology at the University of Exeter and senior author of the paper said more investigation was needed into the cause of the health risk associations to clarify whether they were caused by BPA itself or some other factors linked to BPA exposure. ---"The risks associated with exposure to BPA may be small, but they are relevant to very large numbers of people. This information is important since it provides a great opportunity for intervention to reduce the risks," she added. ----BPA is a chemical used in polycarbonate baby bottles and sippy cups, as well as in the expoxy lining s of food cans. Its continued inclusion in food packaging has provoked considerable consumer anxiety in the United States. The US Food and Drug Administration (FDA) is currently reviewing its stance that the chemical poses no threat at existing acceptable levels. The agency was due to deliver its verdict by 30 November, 2009, but has yet to release its decision. ---Lack of evidence ---The American Chemistry Council (ACC) said the study lacked sufficient evidence. "Studies of this type are very limited in what they tell us about potential impacts on human health," said Steven G. Hentges, of the body’s Polycarbonate/BPA Global Group. ---"While they can provide helpful information on where to focus future research, by themselves they cannot and should not be used to demonstrate that a particular chemical can cause a particular effect." --He added: "The study itself does not establish a cause-and-effect relationship between BPA exposure and heart disease. In addition, the robustness of these limited findings is questionable, as fewer than 50 participants self-reported health conditions without medical confirmation." ---David Melzer, Neil E. Rice, Ceri Lewis, William E. Henley, Tamara S. Galloway. Association of Urinary Bisphenol A Concentration with Heart Disease: Evidence from NHANES 2003/06. PLoS ONE, 2010; 5 (1): e8673 DOI: 10.1371/journal.pone.0008673 á á á ---Interesting Note here---the studies are not conclusive based on the retort from industry but the fact is A) in huge populace utilizing these materials and then discarding them will cause an overload environmentally which in turn comes back into us B) Xenoestrogens have in fact connected to cancer and when several of them are exposed together they have a synergy to increase the detrimental impact to people and there health causing immune system break down---cancer---hormonal disruption and balance for both men and womenThyme Oil Can Inhibit COX2 and Suppress Inflammation
Thyme growing. Researchers have found that six essential oils -from thyme, clove, rose, eucalyptus, fennel and bergamot -- can suppress the inflammatory COX-2 enzyme, in a manner similar to resveratrol, the chemical linked with the health benefits of red wine
. --ScienceDaily (Jan. 14, 2010) — For those who do not drink, researchers have found that six essential oils -from thyme, clove, rose, eucalyptus, fennel and bergamot -- can suppress the inflammatory COX-2 enzyme, in a manner similar to resveratrol, the chemical linked with the health benefits of red wine. They also identified that the chemical carvacrol was primarily responsible for this suppressive activity.--These findings, appearing in the January issue of Journal of Lipid Research, provide more understanding of the health benefits of many botanical oils and provide a new avenue for anti-inflammatory drugs.---Essential oils from plants have long been a component of home remedies, and even today are used for their aromatherapy, analgesic (e.g. cough drops), or antibacterial properties. Of course, the exact way they work is not completely understood. However, Hiroyasu Inoue and colleagues in Japan believed that many essential oils might target COX-2 much like compounds in wine and tea.---So, they screened a wide range of commercially available oils and identified six (thyme, clove, rose, eucalyptus, fennel and bergamot) that reduced COX-2 expression in cells by at least 25%. Of these, thyme oil proved the most active, reducing COX-2 levels by almost 75%.---When Inoue and colleagues analyzed thyme oil, they found that the major component -carvacrol- was the primary active agent; in fact when they use pure carvacrol extracts in their tests COX-2 levels decreased by over 80%.Story Source:--Adapted from materials provided by American Society for Biochemistry and Molecular Biology, via EurekAlert!, a service of AAAS.--Journal Reference:--Mariko Hotta, Rieko Nakata, Michiko Katsukawa, Kazuyuki Hori, Saori Takahashi, and Hiroyasu Inoue. Carvacrol, a component of thyme oil, activates PPAR-gamma and suppresses COX-2 expression. Journal of Lipid Research, January, 2010á á á
Recipe 2---take the essential oil of thyme 1-2 drops---add 1 tablespoon of honey---add 1/8 tsp off cayenne pepper –and mix well ---and use 1/8 tsp of this---you have made an analgesic ( pain killer) Brain enhancer ( thyme increases DHA levels in the brain heart and kidneys )Immune enhancer---you will have the second strongest antioxidant in the world with thyme—circulation—anti bacterial—antifungal—antiviral impact from thisá á á You can make a tea with thyme as well by adding 2-3 sprigs of thyme with bay leaf 2-3 leafs and rosemary 1-2 sprigs---in a 2 pint pot---this will again be very potent for anti fungal –anti bacterial—anti microbial—antiviral—good for the reduction of yeast and mold---impacting brain efficiency and the reduction of brain fog a well as a Antioxidant and Immune support
U.S. and Canadian Alliances for Raw Milk (ARMs) have announced their formation
Does cholesterol act as a protector of cholinergic projections in Alzheimer's disease?
Ontario Health Protection and Promotion Act in running a ---cowshare-- program
Healing Poultice for sealing and pulling---Remedy
U.S. and Canadian Alliances for Raw Milk (ARMs) have announced their formation
TORONTO, ONTARIO, CANADA (January 10, 2010)? U.S. and Canadian Alliances for Raw Milk (ARMs) have announced their formation. These Alliances for Raw Milk (US ARM and Canadian ARM) and Family Farm and Food Freedom are to promote connections between natural farmers and dairies and families who want fresh, wholesome and healthy natural food choices based on their nutritional education.--The ARMs and their members have declared they have the right and freedom to choose the foods they deem to maintain and restore their health and the right to farm their own land and trade/share the produce with others. The Alliances also come at a time of unwarranted and rapidly increasing legal, regulatory and enforcement actions by state, provincial and federal agencies against small natural, sustainable and organic farms and food operations, especially in the dairy arena.---The Canadian ARM is already organized in Ontario and British Columbia. In the U.S. the states of Wisconsin and Ohio are well underway with thousands of members and more states are pending. Sources in major U.S. raw milk groups say there is strong interest for the EU and Australia and India to join forces in the Alliance.--Internationally known Michael Schmidt, co-director of Canadian ARM told the Journal that he wishes to communicate to the new Alliances and to all farmers and consumers of local, fresh food that:
Forming local state, federal and international alliances of concerned individuals is of utmost importance. What has to be burning in our soul, is the urge to be free and the determination not to be returned to a modern form of slavery. Blinded by wealth, comfort and convenience we are in grave danger of unconsciously consenting to the takeover of our well being by Government.This battle about raw milk is a battle about food freedom and our individual rights.This is not an isolated battle, this is a global issue beyond our imagination.
Michael Schmidt, a Canadian degreed biodynamic dairy farmer and teacher has become a well-known North American icon in the food freedom battle. Schmidt owns Glencolton Farms and got arrested this summer again at raw milk Dumpsite 41. His farm was raided by the Ministry of Health and police by 20 armed guards ? holding him as a prisoner in his own house for an entire day three years ago ? taking all the milk products to the city dump. This is the latest in a series of harassments that date back since 1994. He faces a $50,000 fine and imprisonment on January 21. Schmidt is charged for his disobedience for three years of court orders to make him stop providing raw milk to friends and family who actually own the cows he cares for.--At a court and rally right before Christmas in Viroqua, WI, Michael Badnarik, a Libertarian Presidential candidate in 2004 and considered a constitutional scholar and statesman, declared that nowhere is there in laws or constitutions that governments must tell us what we can or cannot eat. Who owns our bodies? We do.!!! That event led to the formation of the Wisconsin ARM.---Kaythlene Pirtle, a well-known Chicago musician, author and motivational speaker on nutrition told the Journal,
The new unified Alliances and many new raw milk alliances that are beginning to form around the world are voicing a universal outcry of citizens that are saying, We, as human beings on this planet earth, demand the freedom and basic right to choose what kind of food we purchase and eat for ourselves and our families. We will not compromise our lives and health by eating the substandard food produced by a broken profit-driven, government-corporate controlled food system whose only concern is making sure their pockets are lined with money.
Kurtis Staven, an Alliance coordinator and dairy farmer in British Columbia told the Journal of the dairy farmers concerns there:
At this point in history, when more people are becoming aware of the foods they eat and the consequences of those actions, there appears to be a political backlash as the guise of food safety is revealed as being geared toward supporting the major agri-business players. We can no longer sit idle and watch our inherent rights be cast aside in favor of corporate profits.!!!
According to one Alliance member interviewed, who did not want his name disclosed, said: People are getting fed up with the government/corporate partnerships in their kitchens and dictating what healthy is and feeding so much nutritional, health and food safety misinformation and disinformation to the general public.-The inside environmental health regulatory specialist says It is no longer a debate of the health benefits of clean natural milk; that has been settled for a long time. All these people seem to be saying is they want the freedom to eat and farm like grandma and grandpa did without guilt or fear of government intrusion. Now it is a battle over civil rights and basic freedoms .---The first co-sponsored event of the Alliances, along with other groups, will be in Ontario at the court judgments and rally for Michael Schmidt on January 21. Anyone can attend and for more information and to RSVP go to the event posting.---Michael Schmidt, also had this to say concerning the groups and alliances that are forming:
This is the chance to return to our fundamental values. This is a battle of individuals uniting to preserve what our children and grand children expect us to do. We battle not for us, we carry the burden of responsibility for the future, we carry the future of our children.
Farmers and consumers can freely
join the
U.S. Alliance for Raw Milk and
Canadian Alliances for Raw Milk and several state/provincial ARMs at their
internet locations. There, connections can be made with natural farms and food,
educational events and upcoming rallies and court proceedings. More information
will be disseminated at meetings and events on the local levels.
TO: FARM, FOOD, HEALTH, FREEDOM CIRCUITS/ CN, US, INTNL
Suzuki I, Matsumoto Y, Adjei AA, Asato L, Shinjo S, Yamamoto S. --Department of Food and Nutrition, Kumamoto Women's University, Japan.---
The following study was undertaken to determine whether dietary supplementation with glutamine can be used to modulate the immune response following challenge with methicillin-resistant Staphylococcus aureus (MRSA) organisms in mice. Thirty BALB/c female mice were randomized into 3 groups: group A (n = 10) were fed 20% casein diet (control), whereas the mice in Groups B (n = 10) and C (n = 10) were given 20% casein diet supplemented with 2 and 4% glutamine, respectively. The diets were made isonitrogenous by glycine and alanine supplementation. On the 10th day on these treatments, each mouse was challenged intravenously with 2 x 10(8) colony-forming units (CFU)/ml of MRSA organisms and mortality was noted for 20 days. The survival rate in Group A (20%) tended to be lower than the rates in Group B (40%), and Group C (70%). CFU values of spleen and kidney of the surviving mice 20 days post challenge were not different among the three groups (p < 0.05). The present results suggest that dietary glutamine supplementation may be effective as a nutritional immunomodulator for the recovery from MRSA infection.
Oak bark against MRSA
Determining the effect of an oak bark formulation on methicillin-resistant staphylococcus aureus and wound healing in porcine wound models.--Ostomy Wound Manage. 2008 Oct;54(10):16-8, 20, 22-5--Authors: Davis SC, Mertz PM--------Control of wound infections, especially those associated with methicillin-resistant Staphylococcus aureus, is necessary for the wound healing process. Selection of topical agents should be based not only on their ability to eliminate pathogenic bacteria, but also on whether they may be detrimental to tissue repair. Two randomized, controlled in vivo studies using different porcine models were conducted to evaluate the effect of a topical oak bark ointment (treatment) on 1) methicillin-resistant Staphylococcus aureus in partial-thickness wounds, and 2) healing of second-degree burn wounds. Silver sulfadiazine, oak bark ointment vehicle control (polyethylene glycol), and no treatment (untreated wounds) were used as controls in both studies. In the first study, 108 partial-thickness wounds in three animals were inoculated with a methicillin-resistant S. aureus suspension (average 6.96+/-0.4 log CFU/mL) and covered for 24 hours with a polyurethane film. After polyurethane film removal, treatments were applied twice daily and nine wounds per day (three per animal) from each treatment group were cultured after 24, 48, and 72 hours. Methicillin-resistant S. aureus colonization was lowest in the active treatment group at all three assessment times and after 72 hours ranged from (5.01+/-1.1 CFU/mL) in the treatment to (6.20+/-0.8 CFU/mL) in the vehicle control treated wounds. In the second study, treatments were applied twice daily to second-degree burn wounds (n = 720) on eight animals. Daily epithelialization assessment (n = five wounds) was performed on day 7 through 10 after wounding. At every assessment time, the proportion of wounds healed was higher in the treatment than in the control treatment groups - days 8, 9, and 10 (active versus vehicle and untreated), P <0.01; days 9 and 10 (vehicle versus untreated), P <0.001. The oak bark formulation studied reduces methicillin-resistant S aureus contamination and facilitates healing in vivo. Research to ascertain the importance of these findings for clinical practice is needed.
PMID: 18927480 [PubMed - indexed for MEDLINE]
Bay Leaf knocks out MRSA
Anti-methicillin resistant Staphylococcus aureus (MRSA) compounds isolated from Laurus nobilis.
Biol Pharm Bull. 2008 Sep;31(9):1794-7
Authors: Otsuka N, Liu MH, Shiota S, Ogawa W, Kuroda T, Hatano T, Tsuchiya TWe found that an extract from Laurus nobilis L. (Lauraceae) leaves showed antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). We purified two flavonoids as the effective compounds and identified them as kaempferol 3-O-alpha-L-(2'',4''-di-E-p-coumaroyl)-rhamnoside (C2) and kaempferol 3-O-alpha-L-(2''-Z-p-coumaroyl-4''-E-p-coumaroyl)-rhamnoside (C3). Both compounds showed strong antibacterial activity not only against MRSA but also against vancomycin-resistant enterococci (VRE). There was low or no antibacterial activity of C2 and C3 for Streptococcus pneumoniae, Pseudomonas aeruginosa and Serratia marcescens.
Does cholesterol act as a protector of cholinergic projections in Alzheimer's disease?
Iwo J
Bohr
1
1University
of Newcastle, Department of Neurology, Neurobiology and Psychiatry, Institute
for Ageing and Health, Newcastle General Hospital, Westgate Road,
Newcastle-upon-Tyne, NE4 6BE, UK--Corresponding
author.--Iwo J Bohr:
iwo.bohr@ncl.ac.uk
Received May 12, 2005; Accepted June 10, 2005.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
The relationship between Alzheimer's disease (AD) and progressive degeneration of the forebrain cholinergic system is very well established, whereas mechanisms linking this disease with cholesterol, apolipoprotein E (apoE) phenotype, and amyloid precursor protein (APP) metabolism have not been fully elucidated even though there is a plethora of publications separately on each of these issues. The intention of this hypothesis is to unify knowledge coming from all of these areas. It is based on an assumption that the process of APP hypermetabolism is a neuroprotective response for age-related cholinergic deterioration. In some individuals this initially positive process becomes highly overregulated by genetic or/and epigenetic risk factors and after many years of accumulations lead eventually to AD. I hypothesise that neuroprotective role of APP-hypermetabolism might be related to enrichment of neuronal membranes (lipid rafts in particular) in cholesterol in order to compensate for decrease in presynaptic cholinergic transmission and/or AD-related decrease in cholesterol levels. The above is consistent with findings indicating that activity of both muscarinic and nicotinic cholinergic receptors is correlated in a positive manner with cholesterol plasmalemmal content. Briefly – APP metabolism together with transport of cholesterol in apoE containing lipoproteins seem to play a key role in mobilising cholesterol into neuronal membranes.
Background
The role of cholesterol in Alzheimer's disease (AD) is attracting increasing attention of researchers [1] and there are conflicting messages coming form a great deal of reports. Despite the fact that a wide-spread opinion about high levels of this lipid in the organism still remains negative, there is a growing body of evidence suggesting its beneficial role in the brain. It is for example corroborated by the study showing that high cholesterol blood levels correlate with a lower mortality index and a better outcome following a first stroke [2]. There was also a positive relationship between a hypercholesterolemic diet and improved preservation of cognitive functions in rats which previously underwent anoxic period [3]. The significance of the results obtained with the use of a dietetic paradigm has recently been confirmed by findings reporting a net flux of peripheral cholesterol through Blood-Brain Barrier in the form of 27-hydroxycholesterol [4]. It has also been found that patients suffering from AD have lower levels of cholesterol in cerebrospinal fluid[5] in the lipid fraction of brain membranes resulting in altered membrane physical properties [6] and recently in cholesterol-enriched lipid microdomains in plasmalemma – lipid rafts [7]. Moreover a relationship between AD and down-regulation of seladin-1; a protein involved in cholesterol synthesis was found, reviewed in [7] which may be due to a genetic disorder.--It appears that cholesterol has universal neuroprotective properties. However for the purpose of this article this activity will be described only in connection to AD.--The hypothesis combines within one unifying concept well established facts from the three following main streams of AD research:--- the prevalence of forebrain cholinergic system deficits in the disease development, – metabolism of amyloid precursor protein (APP) and--- the role of apolipoprotein E4 (apoE4) isoform as a risk factor in association with cholesterol metabolism in the brain.--These key issues will be briefly introduced before presenting the hypothesis.--The main type of neurons primarily affected by AD are these belonging to and innervated by the cholinergic forebrain projection. It is a neuromodulatory system related to high cognitive functions. Deficits in these commands are the first clinical manifestations of AD [8].--Forebrain cholinergic neurons and areas extensively innervated by them (hippocampus and neocortex) contain the largest amounts of senile plaques. According to amyloid cascade hypothesis, widely accepted by scientists, senile plaques are primary factors causing neuronal death in AD, whereas neurofibrillary tangles are secondary [9]. The major constituent of senile plaques are peptides called β-amyloids, products of enzymatic cleavage of APP. Formation of senile plaques is a result of many years of accumulation of β-amyloids and other peptides forming extracellular insoluble aggregates. However it appears that in shorter periods APP and its metabolites demonstrate neuroprotective activity. The increased deposition of APP is a relatively quick reaction to factors deteriorating brain functioning, see for example:[10]. Direct neuroprotective effects were shown in the rat hippocampus [11]. They also were reported to protect cognitive functions following application of anticholinergic agent [12]. Recently Koudinov and Berezov have reviewed evidence showing a positive role of β-amyloids in the brain [13].Cholinergic neurons display particular vulnerability to any negative factors affecting brain function, see for example: [14-16]. Ageing is a major process causing chronic deterioration of brain functioning, the cholinergic system being particularly susceptible and inducing long lasting overproduction of β-amyloids. If this process is aggravated by genetic and/or epigenetic factors it may eventually lead to development of AD.--The importance of cholesterol in the brain functioning is suggestively reflected by the fact that the human brain making up only 2% of total body weight contains as much as 25% of the total pool of this lipid [17]. To a big extent it is concentrated in myelin sheath. However there are also considerable amounts also in neuronal plasmalemma and in lipid rafts in particular. Lipid rafts seem to play a key role in transmembrane signalling processes, including synaptic transmission [18]. Importantly, APP is suggested to occur in lipid rafts [19,20].--The hypothesis aims at explaining this positive role of cholesterol in the brain in association with geriatric cholinergic deficits and APP metabolism.
Presentation of the hypothesis--As suggested above age-related dysfunction in the forebrain cholinergic system results in APP hypermetabolism. However the mechanisms by which APP metabolites fulfil their neuroprotective functions despite some attempts, have not been fully elucidated. I hypothesise that these properties are due to the involvement of APP metabolites in the process of internalization of lipoproteins labelled with apoE, enriched with cholesterol. What could be the aim of this process ? There are data indicating a positive dependence of cholinergic receptors (both muscarinic and nicotinic) on cholesterol content in plasma membranes [21] and the mechanism of molecular interactions between cholesterol and nicotinic receptors have been proposed [22]. In contrast, receptors for monoaminergic agonists, seem to be negatively modulated by high membrane cholesterol [21,23]. In this respect increased uptake of cholesterol might be at least in part a process aiming at compensating cholinergic deficits and/or cholesterol deficits in AD caused for instance by genetic factors. Within the framework of this concept it is possible to explain the causal relationship between AD and a phenotype of apoE. The importance of apoE containing lipoproteins in neuroregenerative processes in connection to the role of cholesterol seems to be well established [20,24], although the role of APP and relationship of apoE-dependent transport with cholinergic transmission has not been fully clarified, despite some interesting proposals [24], which may be regarded as complementary to this hypothesis. There are three allele: ε2, ε3 and ε4 coding different isoforms of the protein. Expression of apoE4 isoform increases the risk of both sporadic and familial late onset of AD. Consequently one can assume that a higher demand of neurons for cholesterol results in higher production of β-amyloids which are engaged in internalization of apoE containing lipoproteins. Possibly interaction between the apoE4 isoform and β-amyloids in contrast to other isoforms is more prone to accumulation of insoluble aggregates and in addition might be less effective in cholesterol uptake as suggested in[20]. The relationship between levels of expression of APP metabolites, amount of apoE and cholesterol levels has been shown in several instances. An interesting example of such a relationship is provided by Howland et al [25] who carried out experiments exploring a mouse model of AD. In these mice exposure to a high cholesterol diet resulted in reduction of APP metabolites and concomitant increase of apoE. Similarly, it was reported that cells in culture exposed to high cholesterol reduced APP metabolism [26]. Reduction in APP metabolite production in conditions of high cholesterol in these publications may be explained by the negative feedback principle.
Testing the hypothesis
The best way to test the hypothesis might be by experiments combining all of its main constituents. For instance by inducing APP hypermetabolism, and then verify whether supplementation of high cholesterol would result in:
- lowering of APP hypermetabolism
- better survival of neurons in crucial areas like the forebrain cholinergic system, hippocampus and some neocortical areas
- better preservation of cognitive functions
Implications of the hypothesis--If the hypothesis is proved to be true it should first of all change negative attitude towards blood high cholesterol levels in clinical practice. In particular the use of statins in older subjects with neurological disorders should be revised. Recently there is an increasing number of reports indicating uncertainties related to this issue [20,27]. However this should be handled with care, since some authors even acknowledging the positive role of cholesterol in the brain do not exclude some beneficial actions of this group of drugs see e.g. [7]. Nevertheless, if the hypothesis is validated it may result in changes in some diet recommendations, especially while considering that definitely not in all cases high blood cholesterol must result in arteriosclerosis, this is supported by findings indicating homocysteine and not cholesterol as the primary vessel damaging factor in this disease [28], see also a strong criticism of the concept "blaming" cholesterol as a primary factor in the disease [29].--Moreover it would open up new alleys in brain function studies in general and AD in particular. It would imply the need of widening our understanding of the activity of cholesterol in the plasmalemma of neurons and mechanisms by which cholinergic receptors interact with plasmalemmal cholesterol.
References
Ontario Health Protection and Promotion Act in running a ---cowshare-- program
Raw
milk enthusiasts say it's a health panacea, loaded with nutrients, live, whole
and delicious. Health Canada says it's potentially ridden with harmful bacteria
just waiting to infect anyone who gets near it. So who's right about raw
milk?---Pasteurization of milk and other beverages is the process of heating the
liquid to kill possible pathogenic bacteria that could cause human illness and
it extends shelf life by preventing spoilage. Originally invented by Louis
Pasteur in 1862 as a means for preventing souring of wine and beer,
pasteurization was applied to milk in the early part of the last century. Before
wide scale pasteurization came into effect in the 1930s, all milk consumed by
anyone was raw. Now all milk bought in Canada has been pasteurized. ----Raw
milk advocates say the pasteurization process is essentially killing a
whole, live food. They say that pasteurizing renders the milk life-depleting,
actually putting a burden on the system when it is drunk, unlike raw milk, which
is full of nutrients, enzymes and
beneficial bacteria vital to the human digestive tract. Advocates state
pasteurized milk consumption is associated with allergies, colic in young
children, tooth decay, growth problems, arthritis, osteoporosis, and even heart
disease and cancer. Dr. Edward Group of
Global Healing Center says, "The milk everybody drinks today [pasteurized]
is far from a whole food, and in my research is not fit for human
consumption".---Some in the pro-raw milk camp claim that lactose intolerance
would not exist if people were drinking milk in its natural raw state instead of
the pasteurized milk we drink today. The heating of milk converts the milk sugar
lactose to beta-lactose, a form that is more rapidly absorbed in the system.
Pasteurization also destroys enzymes that help break down lactose leading to a
product that is more difficult to digest. Mildly lactose intolerant people are
reportedly able to drink raw milk without incident.---On the other side of the
fence, Health Canada maintains that drinking unpasteurized milk is dangerous.
"Any possible benefits are far outweighed by the serious risk of illness from
drinking raw milk," says
their webite. They say that raw milk can easily and silently harbour harmful
bacteria, including salmonella, E. coli and listeria, which can cause human
illness and even death. It is currently illegal to sell unpasteurized milk in
Canada.-- Although it is undoubtedly beneficial to destroy dangerous pathogens
in our milk, pasteurization amounts to throwing the baby out with the bathwater,
destroying all
probiotic bacteria and enzymes in the process. As it stands, pasteurized
milk needs to be fortified with vitamins to put back in nutrients that were
destroyed in its processing.
Pasteurization also destroys the
chemical make-up of calcium found naturally in raw milk,
according to Dr. Group and it destroys all the vitamin C.---Critics accuse
Health Canada of being in bed with the milk industry (one of the reasons that
milk features so prominently on the government-created food pyramid or the "four
basic food groups" of the past; programs that have been informing Canadians of
the "right" way to eat for decades). Since the large scale distribution of raw
milk would be impossible due to its delicate nature, getting real, raw milk from
safe, small-scale producers around the country would be a threat to the dairy
industry. The raw milk campaigners say money rather than safety is the real
concern here.---Is drinking raw milk dangerous? Personally I don't think so as
long as the precautions given by the raw milk crowd are followed. They say that
only organic, pasture-raised, grass-fed cow, goat and sheep milk should be
consumed raw. This is because grain and soy fed animals have different milk
composition and that milk is missing important antibacterial components which
stave off any harmful pathogens. Organic green grass is a cow's natural food
source, so it makes sense that this would produce the healthiest, safest milk
(note that this is not how cows within the dairy industry are generally raised
or fed).---Because it is illegal to sell, raw milk is not easy to find in
Canada. However,
yesterday an Ontario court found that
farmer Michael Schmidt was not guilty of
violating the Milk Act and the Ontario Health Protection and Promotion Act in
running a "cowshare" program. Because the rules for pasteurization do not apply
to farmers, if you own a share of a cow, you're technically drinking your own
farmed milk. This ruling
will likely open the doors for other such programs around the province and may
set a precedence for similar cases in other provinces.
The Healthy Foodie is Doug DiPasquale, Holistic Nutritionist and trained chef,
living in Toronto. You can email him with questions at
dugdeep@gmail.com.
Healing Poultice for sealing and pulling --- Remedy
This recipe works fast and can seal a wound within minutes – it will draw out and seal wounds---what you will need is Comfrey extract ---Wormwood ( powdered ) Diatomacious Earth ( clay ) and mullein and gelatin---take equal parts of the gelatin and powdered wormwood and mullein add to bowl –then add 1 tsp of the comfrey extract---add then your clay and mix til pasty the use a spreader or back of a spoon and smooth this on over the open wound---this will cause the wound to seal up and smoothly---the wormwood and comfrey will assist in disinfecting the wound on a microbial level as well as an antibacterial--the clay and gelatin and comfrey will utilize the proteins and nutrients the skin needs as well to regenerate---this will be an asset even those with other skin conditions--such as exczema and psoriasis---may even impact those with skin contaminats that maybe lodged in the skin( to expedite this utilize again enzymes such as serrepeptase and edta and iodine internally to break down metal contaminats---
TOP G
HOME
RAW MILK –Facts and Nutrition
Fallacies of the Medical System
PROPYLENE GLYCOL
Recipe for Raw Milk
Diet Of Whipping Cream, Butter, Oil Can Help Control Epileptic Seizures In Many Children
Recipe ---Immune enhancer with Garlic –Iodine –and Vinegar---
"If people let the government decide what foods they eat and
what medicines they take, their bodies will soon be in as
sorry a state as the souls who live under tyranny."
-- Thomas Jefferson
"Most men die of their remedies, not of their illnesses."
-- Moliere
"Doctors Are The Third Leading Cause of Death in the US."
-- Dr. Joseph Mercola
"The very first requirement of a hospital is that it
should do the sick no harm."
-- Florence Nightengale
"Doctors give drugs of which they know little, into bodies,
of which they know less, for diseases of which they know
nothing at all."
-- Voltaire
"...the estimated total number of iatrogenic deaths—that is,
deaths induced inadvertently by a physician or surgeon or
by medical treatment or diagnostic procedures— in the US
annually is 783,936....while 553,251 died of cancer."
-- Gary Null, et al., Death by Medicine
"In nothing do men more nearly approach the gods than
in giving health to men."
-- Cicero
"The Lord hath created medicines out of the earth;
and he that is wise will not abhor them."
-- Ecclesiasticus 38:4
"But, it's not my job."
If you're not actively supporting health freedoms, you're
doing exactly what they are counting on you to do.
"In all the controversies over what the causes of diversities
might be, no one seem to have paid much attention to the
factor in the environment that has the most obvious effect
on any organism: food."
-- Michael Crawford & David Marsh
"Most over-the-counter and almost all prescribed drug
treatments merely mask symptoms or control health problems or
in some way alter the way organs or systems such as the
circulatory system work. Drugs almost never deal with the
reasons why these problems exist, while they frequently create
new health problems as side effects of their activities."
-- John R. Lee, M.D.
"What we find now is the fleecing of the American public’s
pocketbooks by the environmental movement for their political
use. What we find now is exhausting litigation, instigation of
false claims, misleading science, and scare tactics to fool
Americans into believing disastrous environmental scenarios
that are untrue."
-- US Senator James Inhofe, Chairman, Environment and Public
Works Committee October 10, 2004
RAW MILK –Facts and Nutrition
Back in the 20's Americans could buy fresh raw whole milk, real clabber and buttermilk, luscious naturally yellow butter, fresh farm cheeses and cream in various colors and thicknesses. Today's milk is accused of causing everything from allergies to heart disease to cancer, but when Americans could buy Real Milk, these diseases were rare. In fact, a supply of high quality dairy products was considered vital to American security and the economic well being of the nation.--What's needed today is a return to humane, non-toxic, pasture-based dairying and small-scale traditional processing, in short...........A CAMPAIGN FOR REAL MILK!
Real Milk comes from Real Cows--The source of most commercial milk is the modern holstein, bred to produce huge quantities of milk--three times as much as the old-fashioned cow. She needs special feed and antibiotices to keep her well. Her milk contains high levels of growth hormone from her pituitary gland, even when she is spared the indignities of genetically engineered Bovine Growth Hormone to push her to the udder limits of milk production.
Real Milk Comes from Cows that Eat Real Food--Real feed for cows is green grass in Spring, Summer and Fall; green feed, silage, hay an root vegetables in Winter. it is not soy meal, cottonseed meal or other commercial feeds, nor is it bakery waste, chicken manure or citrus peel cake, laced with pesticides. Vital nutrients like vitamins A and D, and the fat-soluble catalyst that promotes optimum mineral assimilation are greatest in milk from cows eating green grass, especially rapidly growing green grass. Vitamins A and D are greatly diminished, and the fat-soluble catalyst disappears, when milk cows are fed commercial feed. Soy meal has the wrong protein profile for the dairycow, resulting in a short burst of high milk production followed by premature death. Most milk (even most milk labeled "organic") comes from dairy cows that are kept in confinement their entire lives and never see green grass!
Pasteurization Destroys Nutrients--Pasteurization destorys enzymes, diminishes vitamin content, denatures fragile milk proteins, destroys vitamin B12, and vitamin B6, kills beneficial bacteria, promotes pathogens and is associated with allergies, increased tooth decay, colic in infants, growth problems in children, osteoporosis, arthritis, heart disease and cancer. Calves fed pasteurized milk die before maturity. Raw milk sours naturally but pasteurized milk turns putrid and processors must remove slime and pus from pasteurized milk by a process of centrifugal clarification. Inspection of dairy herds for disease is not required for pasteurized milk. The practice of heating milk to kill germs was instituted in the 20s to combat TB, infant diarrhea, indulant fever and other diseases caused by poor animal nutrition and dirty production methods. But times have changed and modern stainless steel tanks, milking machines, refrigerated trucks and inspection methods make pasteurization absolutely unnecessary for public protection. (and pasteurization does not always kill the bacteria for Johne's disease, with which most modern cows are infected. The Johne's bacteria is suspected of causing Crohn's disease in humans.) Clean raw milk from healthy cows is available here at Prairie Rose Ranch.
Real Milk is Not Homogenized--Homogenization is a process that breaks down butterfat globules so they do not rise to the top. Homogenized milk has been linked to heart disease.
Real Milk Contains Butterfat...and lots of it!---Average butterfat content from old-fashioned cows at the turn of the century was over 4% (or more than 50% of calories). Today butterfat comprises less than 3% (or less than 35% or calories). Worse, consumers have been duped into believing that low-fat and skim milk products are good for them. Only by marketing low-fat and skim milk as a health food can the modern dairy industry get rid of its excess poor-quality, low-fat milk from modern high-production hers. butterfat contains vitamins A and D needed for assimilation of calcium and protein in the water fraction of the milk. Without them protein and calcium are more difficult to utilize and possibly toxic. butterfat is rich in short- and medium chain fatty acids which protect against disease and stimulate the mmune system. It contains glyco-spingolipids which prevent intestinal distress and conjugated linoleic acid which has strong anticancer properties.
Real Milk Contains No Additives
Powdered skim milk, a source of dangerous oxidized cholesterol and neuortoxic amino acids, is added to 1% and 2% milk. Low-fat yogurts and sour creams contain mucopolysaccharide slime to give them body. Pale butter from hay-fed cows contains colorings to make it look like vitamin-rich butter from grass-fed cows. Bioengineered enzymes are used in large scale cheese production. Many mass produced cheeses contain additives and colorings and imitation cheese products contain vegetable oils.--Pasteurization laws favor large, industrialized dairy operations and squeeze out small farmers. When farmers have the right to sell unprocessed milk to consumers, they can make a decent living, even with small herds.--Our herd here at Prairie Rose Ranch numbers only six Jerseys. We hope to add more cows in the future, especially cows that are bred to produce milk on grass alone. We will never have more than ten Jerseys in our herd. Now that's small!
****
Recipe for Raw Milk--- Add 12 ounces of raw milk ( more if you like) into a 20 ounce blender---then add 1 raw egg ( free range from a farm not store bought) add 1-2 drops of lugols iodine—2 tablespoons of unpasteurized honey—1 -2 drops of the essential oil of cinnamon or clove or nutmeg-or even oil of oregano or the use of either propolis or balm of gilead 1-2 drops—Blend til all components are totally saturated—stop blender and pour and drink ( as much as you like) this will give approximately 18-22 grams of protein ( complete ) with the fats from both egg and milk –all the nutrients needed—with the iodine and the essential oil of choice this will increase protection and antioxidant and nutrient balancing as well.—With the Unpasteurized Honey you increase propolis and peroxide as well to insure better health and protection—and with the propolis or balm of gilead you further boost your immune system Now if you combine this with a potato you can literally live on this---you have a complete diet
PROPYLENE GLYCOL
http://www.cosmeticsdatabase.com/
About PROPYLENE GLYCOL: Propylene glycol is practically non-toxic when taken orally, i.e. added to food. However, it has been found to provoke skin irritation and sensitization in humans as low as 2% concentration, while the industry review panel recommends cosmetics can contain up to 50% of the substance. ------PROPYLENE GLYCOL has reported used in the following product types: facial moisturizer/treatment (849); hair color and bleaching (673); moisturizer (671); anti-aging (533); facial cleanser (444); sunscreen spf 15 and above (431); conditioner (422); styling gel/lotion (366); shampoo (365); body wash/cleanser (344)
Allergies/immunotoxicity
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type of concern |
product conditions |
reference |
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Limited evidence of skin and immune system toxicity |
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CIR (Cosmetic Ingredient Review), 2006 |
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type of concern |
product conditions |
reference |
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Limited evidence of respiratory toxicity |
products that may be aerosolized (airborne) |
Agency for Toxic Substances and Disease Registry, 2004 |
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type of concern |
product conditions |
reference |
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Classified as skin irritant |
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National Library of Medicine HazMap |
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Developmental/reproductive toxicity
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type of concern |
product conditions |
reference |
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One or more animal studies show reproductive effects at moderate doses |
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RTECS®- Kaibogaku Zasshi 1962 |
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type of concern |
product conditions |
reference |
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One or more in vitro tests on mammalian cells show positive mutation results |
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RTECS®- Acta Pathologica et Microbiologica Scandinavica, Section A, Supplement 1981 |
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type of concern |
product conditions |
reference |
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Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications |
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Cosmetic Ingredient Review Assessments |
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type of concern |
product conditions |
reference |
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One or more animal studies show endocrine system disruption at high doses |
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RTECS®- Toxic Substance Mechanisms 1995 |
Neurotoxicity
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type of concern |
product conditions |
reference |
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One or more animal studies show brain and nervous system effects at high doses |
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RTECS®- Journal of Pediatrics 1978 |
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type of concern |
product conditions |
reference |
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Penetration enhancer |
|
Cosmetic Ingredient Review Assessments |
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type of concern |
product conditions |
reference |
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Designated as safe for general or specific, limited use in food |
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FDA Food Additive Status |
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Designated as safe for general or specific, limited use in food |
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FDA Everything Added to Food |
|
type of concern |
product conditions |
reference |
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Safety assessment was based on related chemical |
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Cosmetic Ingredient Review Assessments |
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1,195 studies on toxicity in PubMed see search results -> |
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Systemic contact dermatitis from propylene glycol.
Lowther A, McCormick T, Nedorost S.
University Hospitals Department of Dermatology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.--
A 39-year-old woman presented with pruritic eczematous plaques on her face, neck, and right hand that she had had for approximately 2 months, following an abrasive injury caused by the deployment of an airbag in a car accident. Results of patch testing were positive for several medicaments and propylene glycol (PG). The patient's condition cleared after discontinuation of all topical products containing PG and her other identified allergens, but she noted flares of her contact dermatitis following the ingestion of foods containing PG. A subset of patients will have a recurrence of dermatitis after the ingestion of a contact sensitizer. Recurrent dermatitis despite complete avoidance of identified topical allergens and a history of recurrent eczema at the patch-test site are clues to the diagnosis of systemic contact dermatitis. Even weak patch reactions to PG, if they persist to a day-7 reading, should be considered potentially relevant. Avoidance of dietary PG includes attention to labels on food and medication and the avoidance of certain foods in restaurants when ingredients cannot be verified.|
type of concern |
product conditions |
reference |
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Limited evidence of skin and immune system toxicity |
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CIR (Cosmetic Ingredient Review), 2006 |
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type of concern |
product conditions |
reference |
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Limited evidence of respiratory toxicity |
products that may be aerosolized (airborne) |
Agency for Toxic Substances and Disease Registry, 2004 |
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type of concern |
product conditions |
reference |
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Classified as skin irritant |
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National Library of Medicine HazMap |
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type of concern |
product conditions |
reference |
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One or more animal studies show reproductive effects at moderate doses |
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RTECS®- Kaibogaku Zasshi 1962 |
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Cancer
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type of concern |
product conditions |
reference |
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One or more in vitro tests on mammalian cells show positive mutation results |
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RTECS®- Acta Pathologica et Microbiologica Scandinavica, Section A, Supplement 1981 |
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type of concern |
product conditions |
reference |
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Determined safe for use in cosmetics, subject to concentration or use limitations - Safe for use in cosmetics with some qualifications |
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Cosmetic Ingredient Review Assessments |
Endocrine disruption
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type of concern |
product conditions |
reference |
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One or more animal studies show endocrine system disruption at high doses |
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RTECS®- Toxic Substance Mechanisms 1995 |
Neurotoxicity
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type of concern |
product conditions |
reference |
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Penetration enhancer |
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Cosmetic Ingredient Review Assessments |
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type of concern |
product conditions |
reference |
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Designated as safe for general or specific, limited use in food |
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FDA Food Additive Status |
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Designated as safe for general or specific, limited use in food |
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FDA Everything Added to Food |
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type of concern |
product conditions |
reference |
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Safety assessment was based on related chemical |
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Cosmetic Ingredient Review Assessments |
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1,195 studies on toxicity in PubMed see search results -> |
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PubMed |
Government, industry, academic studies and classifications
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government/industry list/academic study |
appears on list as |
classification(s) |
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FDA Food Additive Status |
PROPYLENE GLYCOL |
• miscellaneous |
|
Cosmetic Ingredient Review Assessments |
PROPYLENE GLYCOL |
•Safe for use in
cosmetics with some qualifications |
|
FDA Everything Added to Food |
PROPYLENE GLYCOL |
• Fully up-to-date toxicology information has been sought. |
|
National Library of Medicine HazMap |
PROPYLENE GLYCOL |
•Skin Sensitizer - An
agent that can induce an allergic reaction in the skin or lungs: Yes; |
|
NTP - Risks to Human Reproduction |
PROPYLENE GLYCOL |
REPRO: Negligible concern || DEVELOPMENT: Negligible concern |
|
CIR (Cosmetic Ingredient Review), 2006 |
PROPYLENE GLYCOL |
Propylene glycol was found to provoke allergic reactions in patients with eczema and other skin allergies. |
|
Agency for Toxic Substances and Disease Registry, 2004 |
PROPYLENE GLYCOL |
• Respiratory Toxicity Hazards: suspected |
|
RTECS®- "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill, V 1977 |
PROPYLENE GLYCOL |
• skin - Primary skin irritant ( human ) |
|
RTECS®- "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J 1986 |
PROPYLENE GLYCOL |
• sense organ - Primary eye irritant (rabbit ) |
|
RTECS®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia" 1984 |
PROPYLENE GLYCOL |
• brain and nervous
system - Ataxia (rat LD50) |
|
RTECS®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia" 1984 |
PROPYLENE GLYCOL |
• brain and nervous
system - Ataxia (rabbit LDLo) |
|
RTECS®- Acta Pathologica et Microbiologica Scandinavica, Section A, Supplement 1981 |
PROPYLENE GLYCOL |
• mutagenic -
Positive mutation assay: Cytogenetic Analysis (mouse scu) |
|
RTECS®- Arzneimittel-Forschung 1976 |
PROPYLENE GLYCOL |
• broad systemic - Broad systemic toxicity (rat LD50) |
|
RTECS®- FAO Nutrition Meetings Report Series 1974 |
PROPYLENE GLYCOL |
• broad systemic - Broad systemic toxicity (rabbit LD50) |
|
RTECS®- Federation Proceedings, Federation of American Societies for Experimental Biology 1947 |
PROPYLENE GLYCOL |
• kidney or renal
system - Changes in both tubules and glomeruli (mouse LD50) |
|
RTECS®- Food and Chemical Toxicology 1982 |
PROPYLENE GLYCOL |
• sense organ - Primary eye irritant (rabbit ) |
|
RTECS®- Food and Chemical Toxicology 1984 |
PROPYLENE GLYCOL |
• mutagenic - Positive mutation assay: Cytogenetic Analysis (hamster fbr) |
|
RTECS®- Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute, Memorandum, June 17, 1974 17JUN1974 |
PROPYLENE GLYCOL |
• broad systemic - Broad systemic toxicity (rat LD50) |
|
RTECS®- Journal of Industrial Hygiene and Toxicology 1941 |
PROPYLENE GLYCOL |
• broad systemic - Broad systemic toxicity (guinea pig LD50) |
|
RTECS®- Journal of Investigative Dermatology 1970 |
PROPYLENE GLYCOL |
• skin - Primary skin irritant ( human ) |
|
RTECS®- Journal of Pediatrics 1978 |
PROPYLENE GLYCOL |
• brain and nervous
system - General anesthetic (child TDLo) |
|
RTECS®- Journal of Pharmacology and Experimental Therapeutics 1932 |
PROPYLENE GLYCOL |
• brain and nervous
system - Coma (rabbit LDLo) |
|
RTECS®- Journal of Pharmacology and Experimental Therapeutics 1937 |
PROPYLENE GLYCOL |
• cardiovascular - Other changes (chicken LDLo) |
|
RTECS®- Journal of Pharmacology and Experimental Therapeutics 1939 |
PROPYLENE GLYCOL |
• broad systemic - Broad systemic toxicity (mouse LD50) |
|
RTECS®- Journal of the American Academy of Dermatology 2000 |
PROPYLENE GLYCOL |
• skin - Primary skin irritant (child ) |
|
RTECS®- Kaibogaku Zasshi 1962 |
PROPYLENE GLYCOL |
• reproductive -
Fetotoxicity (mouse TDLo) |
|
RTECS®- Kriobiologiya i Kriomeditsina 1981 |
PROPYLENE GLYCOL |
• brain and nervous
system - Changes in motor activity (specific assay) (mouse LD50) |
|
RTECS®- Kriobiologiya i Kriomeditsina 1981 |
PROPYLENE GLYCOL |
• broad systemic - Broad systemic toxicity (rat LD50) |
|
RTECS®- National Technical Information Service |
PROPYLENE GLYCOL |
• broad systemic - Broad systemic toxicity (rabbit LD50) |
|
RTECS®- Pediatrics 1983 |
PROPYLENE GLYCOL |
• metabolic - Other changes (infant TDLo) |
|
RTECS®- Raw Material Data Handbook, Vol 1974 |
PROPYLENE GLYCOL |
• broad systemic - Broad systemic toxicity (rabbit LD50) |
|
RTECS®- Toxic Substance Mechanisms 1995 |
PROPYLENE GLYCOL |
• endocrine system -
Hyperglycemia (rat TDLo) |
|
RTECS®- Toxicology and Applied Pharmacology 1978 |
PROPYLENE GLYCOL |
• broad systemic - Broad systemic toxicity (rat LD50) |
|
government/industry list/academic study |
reference |
|
FDA Food Additive Status |
FDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006. |
|
Cosmetic Ingredient Review Assessments |
CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC. |
|
FDA Everything Added to Food |
FDA (U.S. Food and Drug Administration). 2006. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition. |
|
National Library of Medicine HazMap |
NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents. |
|
NTP - Risks to Human Reproduction |
NTP (National Toxicology Program). 2006. NTP Center for the Evaluation fo Risks to Human Reproduction (CERHR). NTP-CERHR Reports and Monographs. |
|
Open scientific literature |
CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC. |
|
Scorecard.org Toxicity Information |
Agency for Toxic Substances and Disease Registry. Minimal risk Levels for Hazardous Substances. January 2004. http://www.atsdr.cdc.gov/mrls.html, 2004 |
|
RTECS®- "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill, V 1977 |
RTECS®- "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill, V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977 -,127,1977 |
|
RTECS®- "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J 1986 |
RTECS®- "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 -,206,1986 |
|
RTECS®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia" 1984 |
RTECS®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994 -,149,1984 |
|
RTECS®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia" 1984 |
RTECS®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994 -,150,1984 |
|
RTECS®- Acta Pathologica et Microbiologica Scandinavica, Section A, Supplement 1981 |
RTECS®- Acta Pathologica et Microbiologica Scandinavica, Section A, Supplement. (Copenhagen, Denmark) No.210-274, 1970-81. For publisher information, see ACPADQ. 274,304,1981 |
|
RTECS®- Arzneimittel-Forschung 1976 |
RTECS®- Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- 26,1581,1976 |
|
RTECS®- FAO Nutrition Meetings Report Series 1974 |
RTECS®- FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued. 53A,491,1974 |
|
RTECS®- Federation Proceedings, Federation of American Societies for Experimental Biology 1947 |
RTECS®- Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. 6,342,1947 |
|
RTECS®- Food and Chemical Toxicology 1982 |
RTECS®- Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- 20,573,1982 |
|
RTECS®- Food and Chemical Toxicology 1984 |
RTECS®- Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- 22,623,1984 |
|
RTECS®- Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute, Memorandum, June 17, 1974 17JUN1974 |
RTECS®- Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute, Memorandum, June 17, 1974 17JUN1974 |
|
RTECS®- Journal of Industrial Hygiene and Toxicology 1941 |
RTECS®- Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. 23,259,1941 |
|
RTECS®- Journal of Investigative Dermatology 1970 |
RTECS®- Journal of Investigative Dermatology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1938- 55,190,1970 |
|
RTECS®- Journal of Pediatrics 1978 |
RTECS®- Journal of Pediatrics. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1932- 93,515,1978 |
|
RTECS®- Journal of Pharmacology and Experimental Therapeutics 1932 |
RTECS®- Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- 44,109,1932 |
|
RTECS®- Journal of Pharmacology and Experimental Therapeutics 1937 |
RTECS®- Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- 60,312,1937 |
|
RTECS®- Journal of Pharmacology and Experimental Therapeutics 1939 |
RTECS®- Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- 65,89,1939 |
|
RTECS®- Journal of the American Academy of Dermatology 2000 |
RTECS®- Journal of the American Academy of Dermatology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) 1979- 42,355,2000 |
|
RTECS®- Kaibogaku Zasshi 1962 |
RTECS®- Kaibogaku Zasshi. Journal of Anatomy. (Nippon Kaibo Gakkai, c/o Tokyo Daigaku Igakubu, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113, Japan) V.1- 1928- 37,239,1962 |
|
RTECS®- Kriobiologiya i Kriomeditsina 1981 |
RTECS®- Kriobiologiya i Kriomeditsina. Cryobiology and Cryomedicine. (Izdatel'stvo Naukova Dumka, Kiev, USSR) No.1- 1975- 8,46,1981 |
|
RTECS®- Kriobiologiya i Kriomeditsina 1981 |
RTECS®- Kriobiologiya i Kriomeditsina. Cryobiology and Cryomedicine. (Izdatel'stvo Naukova Dumka, Kiev, USSR) No.1- 1975- 9,36,1981 |
|
RTECS®- National Technical Information Service |
RTECS®- National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. PB280-477 |
|
RTECS®- Pediatrics 1983 |
RTECS®- Pediatrics. (American Academy of Pediatrics, P.O. Box 1034, Evanston, IL 60204) V.1- 1948- 72,353,1983 |
|
RTECS®- Raw Material Data Handbook, Vol 1974 |
RTECS®- Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015) 1,101,1974 |
|
RTECS®- Toxic Substance Mechanisms 1995 |
RTECS®- Toxic Substance Mechanisms. (Taylor & Francis, 1900 Frost Rd., Suite 101, Bristol, PA 19007) V.14- 1995- 14,13,1995 |
|
RTECS®- Toxicology and Applied Pharmacology 1978 |
RTECS®- Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- 45,362,1978 |
Diet Of Whipping Cream, Butter, Oil Can Help Control Epileptic Seizures In Many Children
ScienceDaily (Apr. 8, 2009) — A new study by researchers at The Medical College of Wisconsin and Children’s Hospital of Wisconsin has shown that the highly regimented ketogenic diet, a high-fat nutritional therapy used to limit seizures, requires long-term medical management and strong parental commitment to achieve both sufficient nutrition and improved seizure control in children.---The study, by Mary L. Zupanc, M.D., professor of pediatrics and medical director of the pediatric epilepsy program, and Beth Zupec-Kania, R.D., C.D., appeared in the Nov. 4, 2008, issue of Epilepsia. Their approach to the diet includes a thorough diet history and metabolic assessment of the child, long-term seizure, nutrition, and medical monitoring, and vitamin/mineral supplementation.---“This diet cannot be tried by parents without close medical management and follow-up,” cautions Dr. Zupanc. “It requires careful metabolic monitoring and precise supplementation of missing nutrients.”--Their approach has been effective, as seen in an as yet unpublished study of 43 patients at Children’s Hospital, between the ages of twelve months and 15 years. Of these children who started on the ketogenic diet between 2002 and 2006, half had a greater than 90 percent reduction in seizure frequency. The majority of the children who responded to the diet had either a severe form of childhood epilepsy called Lennox-Gastaut syndrome or symptomatic generalized epilepsy. Their brain activity, as measured by electro encephalograms also improved significantly, paralleling the dramatic changes in seizure control. “Lack of compliance or of consistent medical monitoring can lead to poor growth, impaired nutrition and seizure recurrence,” says Dr. Zupanc. “There has to be careful monitoring and consistent communication between the dietitian and the physician managing the diet. Metabolic screening should be performed after the first month and every three months afterward. The family should keep a detailed seizure diary. Growth and weight parameters require ongoing monitoring, as do side effects such as lethargy or nausea, which may indicate a hidden metabolic defect.”--The carbohydrate-restricted ketogenic diet also requires strong parental support, according to Zupec-Kania. “Fat comprises between 80 and 90 percent of the diet’s calories and is provided by foods such as whipping cream, butter and seed oils. The remaining calories are allocated to essential protein requirements from meat and fish, and secondarily to low-carbohydrate vegetables and fruit,” she says. “The elimination of carbohydrate-rich foods such as simple sugars, bread, pasta, cereals grains and milk makes this diet difficult for many patients to follow.”ATKINS DIET--While the mechanism of seizure control by the ketogenic diet is not fully understood, the diet forces the body to accumulate large amounts of compounds such as acetone and acetoacidic acid, ( Vinegar or Yogurt ) produced by the oxidation of fatty acids. The diet also restricts the intake of micronutrients such as vitamin D, calcium and phosphorous, which may already be low in those on long-term anti-epileptic drug therapy.----Adapted from materials provided by Medical College of Wisconsin, via Newswise
Recipe ---Immune enhancer with Garlic –Iodine –and Vinegar---
Take 1 whole bulb of garlic---peel and load into a blender—then add 2 cups of vinegar 6 drops of lugols iodine and then blend til the mix is totally liquified---5-8 minutes—strain and use 1 tsp increments daily to alleviate circulatory issues---digestion---thyroid—lung---brain---arteries---liver—antiparacitical—antiviral—increases uptake of calcium and magnesium in the colon—increases fat conversion into energy—anti estrogen---arsenic remover---protects against cancer---protects chromosomes—anti mucous---antiaging
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