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Show of the Month  June 2014

Show of the Month  June 7 2014

Show of the Month  June  14 2014

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Show of the Month June 28 2014

Studies Showing Adverse Effects of Isoflavones, 1950-2010

Oral Supplements of Aqueous Extract of Tomato Seeds Alleviate Motor Abnormality, Oxidative Impairments and Neurotoxicity

Radiation for prostate cancer linked to secondary cancers

Dangers of chemotherapy regimen for bladder cancer patients uncovered by clinical trial

Effect of Aqueous Allium cepa -Onion Extract- and Ixora brachiata Root Extract on Leishmania major Promastigotes

Effects of nitrate on the power-duration relationship for severe-intensity exercise

Icariin- does it have an osteoinductive potential for bone tissue engineering

Carnitine versus androgen administration in the treatment of sexual dysfunction, depressed mood, and fatigue associated with male aging

L-Carnitine Better Than Testosterone in Treating Erectile Dysfunction

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Oral Supplements of Aqueous Extract of Tomato Seeds Alleviate Motor Abnormality, Oxidative Impairments and Neurotoxicity Induced by Rotenone in Mice: Relevance to Parkinson's Disease.

Gokul K¹, Muralidhara.

Author information

Abstract

Although tomato seeds (an industrial by-product) are known to contain several bioactive compounds, studies describing their health effects are limited. Previously, we evidenced that aqueous extract of tomato seeds (TSE) markedly attenuated rotenone (ROT)-induced oxidative stress and neurotoxicity in Drosophila system. This study investigated the neuroprotective effect of TSE in a chronic ROT model of neurotoxicity in mice. Initially, we assessed the potential of oral supplements of TSE to modulate the levels of endogenous markers of oxidative stress in brain regions of mice. Subsequently, employing a co-exposure paradigm, the propensity of TSE (100 mg/kg bw, 3 weeks) to attenuate ROT-induced behavioral phenotype (gait abnormalities, anxiety-like state), oxidative dysfunctions and neurotoxicity was examined. We found that mice provided with TSE supplements exhibited progressive improvement in gait pattern and exploratory behavior. TSE markedly offset ROT-induced oxidative impairments, restored reduced glutathione levels, antioxidant defenses (superoxide dismutase, glutathione peroxidase) and protein carbonyls content in brain regions. Specifically, TSE effectively diminished ROT induced elevation in the activity levels of acetylcholinesterase and restored the dopamine levels in striatum. Interestingly, in mitochondria, TSE was able to restore the activity of mitochondrial complexes and redox state. Collectively, our findings in the chronic ROT model demonstrate the ability of TSE to alleviate behavioral phenotype, oxidative stress, mitochondrial dysfunction and neurotoxicity. Further studies in dopaminergic cell models are necessary to understand the precise molecular mechanism/s by which tomato seed bioactives offer significant neuroprotection.--PMID—24831121--[PubMed - as supplied by publisher]

Recipe---one way to do this is to extract  the seeds like a tea

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Radiation for prostate cancer linked to secondary cancers

Date:

May 30, 2014

Source:

University of Michigan Health System

Among men treated for prostate cancer, those who received radiation therapy were more likely to develop bladder or rectal cancer, according to a new study from the University of Michigan Comprehensive Cancer Center.---"Overall the incidence of these cancers is low. But when men have received radiation treatments, it's important to evaluate carefully any symptoms that could be a sign of bladder or rectal cancer," says senior study author Kathleen A. Cooney, M.D., professor of hematology/oncology and urology at the U-M Medical School.--The study, which will be presented at the American Society of Clinical Oncology annual meeting, looked at 441,504 men diagnosed with prostate cancer between 1992 and 2010. Men were identified from the Surveillance, Epidemiology and End Results (SEER) program, a network of National Cancer Institute-sponsored, population-based cancer registries that collect information on cancer diagnoses and treatment. SEER performs regular follow-up for survival and to capture new invasive cancer diagnoses.--The researchers looked at the number of secondary cancers that developed 10 or more years after men were diagnosed with prostate cancer.[F1]  As a whole, men diagnosed with prostate cancer were at a lower risk of developing a second cancer. But when researchers looked at patients who received external beam radiation therapy, they found these patients were estimated to be 70 percent more likely to be diagnosed with a rectal cancer and 40 percent more likely for bladder cancer than the general public.--Radiation therapy is a standard treatment for prostate cancer and the researchers stress that their findings should not prohibit anyone from choosing this treatment[F2] , in particular men who are not good candidates for surgery.--"Prostate cancer has an excellent prognosis. But because patients typically survive a long time, it raises concerns about the risk of second cancers," says study author Elizabeth J. Davis, M.D., a fellow at the U-M Medical School. "Long-term survivors who have undergone treatment with radiation and their physicians should be careful to monitor for symptoms of bladder and rectal cancer."--Story Source-The above story is based on materials provided by University of Michigan Health System. Note: Materials may be edited for content and length.--Journal Reference--Elizabeth J. Davis, Jennifer L. Beebe-Dimmer, Cecilia L. Yee, Kathleen A. Cooney. Risk of second primary tumors in men diagnosed with prostate cancer: A population-based cohort study. Cancer, 2014; DOI: 10.1002/cncr.28769

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Dangers of chemotherapy regimen for bladder cancer patients uncovered by clinical trial

Date:

May 30, 2014

Source:

Fox Chase Cancer Center

Patients with muscle-invasive bladder cancer often benefit from chemotherapy before surgery to remove the tumor, but a test of one regimen by researchers at Fox Chase Cancer Center was halted when too many people experienced serious side effects such as heart attacks and blood clots in the legs and lungs.--All of the 31 patients included in the study received a combination of gemcitabine and cisplatin, two drugs normally administered for 12 weeks before surgery to remove the tumors. This became the standard of care after one study looked back, retrospectively, at a their experience with a group of patients who had already received the drugs over 12 weeks and found that more than one-quarter saw their tumors disappear before surgery. Although this is the standard of care, no one had yet followed a group of patients taking these drugs from the start -- known as a "prospective" study -- which is the best way to test how well the treatment works and to uncover any issues, said Dr. Plimack.--"It's important to prospectively investigate both the activity and the potential side effects of these two chemotherapy drugs in patients with bladder cancer," said Elizabeth R. Plimack, MD, MS, Attending Physician the Department of Medical Oncology at Fox Chase Cancer, who reported these findings during the 50th Annual Meeting of the American Society of Clinical Oncology. "In patients who may be cured of their cancers, chemotherapy regimens that cause blood clots and other complications may delay or prevent life-saving surgery."--In Dr. Plimack's study, she and her colleagues gave patients gemcitabine and cisplatin over 6 weeks, rather than the usual 12. "Hitting tumors with chemotherapy more frequently might be more effective, and for patients who don't respond, a shorter regimen causes less of a delay in surgery," said Dr. Plimack, "and patients spend less of their life in cancer treatment."--But Dr. Plimack and her colleagues had to stop the phase II clinical trial before it was complete after 7 patients (23%) experienced serious cardiovascular events such as stroke, heart attack, and potentially deadly blood clots in the lungs or legs.--Even though gemcitabine is known to increase the risk of cardiovascular problems, she and her colleagues were "surprised" to see so many patients were affected. It's possible that condensing the doses into 6 weeks caused problems, but that's not the only explanation, said Dr. Plimack. "Two of the most severe cardiovascular events occurred after one treatment, so the dosing schedule was not the only factor here."--Gemcitabine is a frequently administered drug, so it is critical that researchers continue to follow patients receiving it, said Dr. Plimack. "In the meantime, patients who have concerns about taking gemcitabine should consult their doctors about their individual plan."--Story Source-The above story is based on materials provided by Fox Chase Cancer Center. Note: Materials may be edited for content and length.

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Effect of Aqueous Allium cepa -Onion Extract- and Ixora brachiata Root Extract on Leishmania major Promastigotes.

Jundishapur J Nat Pharm Prod. 2014 May;9(2):e15442

Authors: Sadeghi-Nejad B, Saki J

Abstract
BACKGROUND: Leishmaniasis is a major worldwide public health problem with about two to three million humans threatened by this disease annually. Allium cepa (onion) is an important dietary vegetable and was used as a herbal medicine for centuries. The root of Ixora brachiata is medicinally important.
OBJECTIVES: The aim of this study was to investigate the anti-Leishmania effect of the ethanolic and methanolic extracts of Ixora brachiata root and aqueous onion extracts on Leishmania major promastigotes.
PATIENTS AND METHODS: The parasites isolated from cutaneous leishmaniasis[F3]  were exposed with different concentrations of selected plant extracts and their inhibitory effects on the promastigotes[F4]  were evaluated after 24 and 48 hours.
RESULTS: Among tested plant extracts, Ixora brachiata root extracts revealed the best activity against Leishmania major promastigotes with IC100 value of 2.5 mg/mL and IC50 value of 0.078 mg/mL.
CONCLUSIONS: This study showed that aqueous Allium cepa and Ixora brachiata root extracts as natural products could be used as alternative drugs in treatment of leishmaniasis.---PMID: 24872942 [PubMed]

Special Comment--So by boiling up some onions and apply this topically may have an effect against a parsitical induced bug bite

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Effects of nitrate on the power-duration relationship for severe-intensity exercise.

Med Sci Sports Exerc. 2013 Sep;45(9):1798-806

Authors: Kelly J, Vanhatalo A, Wilkerson DP, Wylie LJ, Jones AM

Abstract
PURPOSE: The power asymptote (critical power [CP]) and curvature constant (W') of the power-duration relationship dictate the tolerance to severe-intensity exercise. We tested the hypothesis that dietary nitrate supplementation would increase the CP and/or the W' during cycling exercise.
METHODS: In a double-blind, randomized, crossover study, nine recreationally active male subjects supplemented their diet with either nitrate-rich concentrated beetroot juice (BR; 2 × 250 mL·d, ∼8.2 mmol·d nitrate) or a nitrate-depleted BR placebo (PL; 2 × 250 mL·d, ∼0.006 mmol·d nitrate). In each condition, the subjects completed four separate severe-intensity exercise bouts to exhaustion at 60% of the difference between the gas exchange threshold and the peak power attained during incremental exercise (60% Δ), 70% Δ, 80% Δ, and 100% peak power, and the results were used to establish CP and W'.
RESULTS: Nitrate supplementation improved exercise tolerance during exercise at 60% Δ (BR, 696 ± 120 vs PL, 593 ± 68 s; P < 0.05), 70% Δ (BR, 452 ± 106 vs PL, 390 ± 86 s; P < 0.05), and 80% Δ (BR, 294 ± 50 vs PL, 263 ± 50 s; P < 0.05) but not 100% peak power (BR, 182 ± 37 vs PL, 166 ± 26 s; P = 0.10). Neither CP (BR, 221 ± 27 vs PL, 218 ± 26 W) nor W' (BR, 19.3 ± 4.6 vs PL, 17.8 ± 3 kJ) were significantly altered by BR.
CONCLUSION: Dietary nitrate supplementation improved endurance during severe-intensity exercise in recreationally active subjects without significantly increasing either the CP or the W'.--PMID: 23475164 [PubMed - indexed for MEDLINE]

Beet Juice + Arginine –would be one way

Beet Juice + Creatine—Would be another

Celery + Arugula

Pycnogenol +Celery Juice

Ginger + Garlic

These would be another means of increasing some form of nitrate/nitrite which would increase Nitric oxide and increase stamina

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Icariin- does it have an osteoinductive potential for bone tissue engineering?

Phytother Res. 2014 Apr;28(4):498-509

Authors: Zhang X, Liu T, Huang Y, Wismeijer D, Liu Y

Abstract
Traditional Chinese medicines have been recommended for bone regeneration and repair for thousands of years. Currently, the Herba Epimedii and its multi-component formulation are the attractive native herbs for the treatment of osteoporosis. Icariin, a typical flavonol glycoside, is considered to be the main active ingredient of the Herba Epimedii from which icariin has been successfully extracted. Most interestingly, it has been reported that icariin can be delivered locally by biomaterials and that it has an osteoinductive potential for bone tissue engineering. This review focuses on the performance of icariin in bone tissue engineering and on blending the information from icariin with the current knowledge relevant to molecular mechanisms and signal pathways. The osteoinductive potential of icariin could be attributed to its multiple functions in the musculoskeletal system which is involved in the regulation of multiple signaling pathways in anti-osteoporosis, osteogenesis, anti-osteoclastogenesis, chondrogenesis, angiogenesis, and anti-inflammation. The osteoinductive potential and the low price of icariin make it a very attractive candidate as a substitute of osteoinductive protein-bone morphogenetic proteins (BMPs), or as a promoter for enhancing the therapeutic effects of BMPs. However, the effectiveness of the local delivery of icariin needs to be investigated further.--PMID: 23824956 [PubMed - indexed for MEDLINE]

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Carnitine versus androgen administration in the treatment of sexual dysfunction, depressed mood, and fatigue associated with male aging.

Cavallini G¹, Caracciolo S, Vitali G, Modenini F, Biagiotti G.

Author information

Abstract

OBJECTIVES:

To To compare testosterone undecanoate versus propionyl-L-carnitine plus acetyl-L-carnitine and placebo in the treatment of male aging symptoms.

METHODS:

A total of 120 patients were randomized into three groups. The mean patient age was 66 years (range 60 to 74). Group 1 was given testosterone undecanoate 160 mg/day, the second group was given propionyl-L-carnitine 2 g/day plus acetyl-L-carnitine 2 g/day. The third group was given a placebo (starch). Drugs and placebo were given for 6 months. The assessed variables were total prostate-specific antigen, prostate volume, peak systolic velocity, end-diastolic velocity, resistive index of cavernosal penile arteries, nocturnal penile tumescence, total and free testosterone, prolactin, luteinizing hormone, International Index of Erectile Function score, Depression Melancholia Scale score, fatigue scale score, and incidence of side effects. The assessment was performed at intervals before, during, and after therapy.

RESULTS:

Testosterone and carnitines significantly improved the peak systolic velocity, end-diastolic velocity, resistive index, nocturnal penile tumescence, International Index of Erectile Function score, Depression Melancholia Scale score, and fatigue scale score. Carnitines proved significantly more active than testosterone in improving nocturnal penile tumescence and International Index of Erectile Function score. Testosterone significantly increased the prostate volume and free and total testosterone levels and significantly lowered serum luteinizing hormone; carnitines did not. No drug significantly modified prostate-specific antigen or prolactin. Carnitines and testosterone proved effective for as long as they were administered, with suspension provoking a reversal to baseline values. Only the group 1 prostate volume proved significantly greater than baseline 6 months after testosterone suspension. Placebo administration proved ineffective. Negligible side effects emerged.

CONCLUSIONS:

Testosterone and, especially, carnitines proved to be active drugs for the therapy of symptoms associated with male aging.

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L-Carnitine Better Than Testosterone in Treating Erectile Dysfunction

The April 2004 issue of the journal Urology published the findings of Italian researchers that the amino acid carnitine was more active than testosterone in improving symptoms of aging in men, such as sexual dysfunction and depression, associated with the decline of androgenic hormones. ---One hundred twenty men between the ages of 60 and 74 with symptoms of low testosterone were randomized to receive 160 milligrams orally administered testosterone undecanoate, 2 grams propionyl-L-carnitine plus 2 grams acetyl-L-carnitine per day, or a placebo for a six month period. Prostate-specific antigen, prostate volume, nocturnal penile tumescence, total and free testosterone, prolactin, luteinizing hormone, erectile function scores, depression, fatigue and other parameters were assessed before treatment, at three months, and after the treatment period. --Erectile function, sexual desire, sexual satisfaction and nocturnal penile tumescence increased over the course of the study in the group receiving testosterone as well as the group receiving carnitine. In addition, the group receiving carnitine experienced an increase in orgasm and general sexual well-being. Erectile function and nocturnal penile tumescence were significantly more improved in this group than in those receiving testosterone. While both treatments lowered depression scores, carnitine’s effect was greater. --Predictably, treatment with testosterone increased serum total and free testosterone and decreased luteinizing hormone levels, but carnitine’s effect on these hormones was not significant. Treatment with carnitine was not associated with an increase in prostate volume as was testosterone treatment after six months. PSA levels did not increase in any of the groups. --Fatigue was likewise improved in both groups. As one negative effect, the men taking testosterone developed enlargement of their prostates, which did not occur in the carnitine-treated group. Although both testosterone and carnitine improved symptoms of male aging, there was overall superior benefit to carnitine with no real side effects.

Abstract

OBJECTIVES: To To compare testosterone undecanoate versus propionyl-L-carnitine plus acetyl-L-carnitine and placebo in the treatment of male aging symptoms.

METHODS: A total of 120 patients were randomized into three groups. The mean patient age was 66 years (range 60 to 74). Group 1 was given testosterone undecanoate 160 mg/day, the second group was given propionyl-L-carnitine 2 g/day plus acetyl-L-carnitine 2 g/day.[F5]  The third group was given a placebo (starch). Drugs and placebo were given for 6 months. The assessed variables were total prostate-specific antigen, prostate volume, peak systolic velocity, end-diastolic velocity, resistive index of cavernosal penile arteries, nocturnal penile tumescence, total and free testosterone, prolactin, luteinizing hormone, International Index of Erectile Function score, Depression Melancholia Scale score, fatigue scale score, and incidence of side effects. The assessment was performed at intervals before, during, and after therapy.

RESULTS: Testosterone and carnitines significantly improved the peak systolic velocity, end-diastolic velocity, resistive index, nocturnal penile tumescence, International Index of Erectile Function score, Depression Melancholia Scale score, and fatigue scale score. Carnitines proved significantly more active than testosterone in improving nocturnal penile tumescence and International Index of Erectile Function score. Testosterone significantly increased the prostate volume and free and total testosterone levels and significantly lowered serum luteinizing hormone; carnitines did not. No drug significantly modified prostate-specific antigen or prolactin. Carnitines and testosterone proved effective for as long as they were administered, with suspension provoking a reversal to baseline values. Only the group 1 prostate volume proved significantly greater than baseline 6 months after testosterone suspension. Placebo administration proved ineffective. Negligible side effects emerged. --CONCLUSIONS: Testosterone and, especially, carnitines proved to be active drugs for the therapy of symptoms associated with male aging.---Source--Cavallini G, Caracciolo S, Vitali G, Modenini F, Biagiotti G.  Carnitine versus androgen administration in the treatment of sexual dysfunction, depressed mood, and fatigue associated with male aging. Urology. 2004 Apr;63(4):641-6.

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Show of the Month  June  14 2014

Statin use associated with less physical activity

Limiting carbs could reduce breast cancer recurrence in women with positive IGF1 receptor

Starch intake may influence risk for breast cancer recurrence, study suggests

Restrictions on use of human subjects for testing of chemical or biological agents

Elderly Banking

Toxins in the environment might make you older than your years

NANOPARTICLES---

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Statin use associated with less physical activity

Date:

June 9, 2014

Source:

Oregon State University

 

Staying active is important for older men, especially those taking a statin, to maintain independence and to stay healthy.--One of the longest studies of its type has found that use of statins in older men is associated with less physical activity, a significant issue for a population that's already sedentary.--The findings, published in JAMA Internal Medicine, raise concerns about a decline in much-needed physical activity among men who take some of the most widely prescribed medications in the world. Almost one-third of older Americans take statins, usually to reduce their cholesterol levels.--The research did not identify why men who took statins exercised less -- it just confirmed that they did. Possible causes include the muscle pain that can be a side effect of statin use, and also disruption of the mitochondrial function in cells, which could contribute to fatigue and muscle weakness.--"Physical activity in older adults helps to maintain a proper weight, prevent cardiovascular disease and helps to maintain physical strength and function," said David Lee, an assistant professor in the Oregon State University/Oregon Health & Science University College of Pharmacy, and lead author of the study.--"We're trying to find ways to get older adults to exercise more, not less," Lee said. "It's a fairly serious concern if use of statins is doing something that makes people less likely to exercise."--Muscle pain is found in 5-30 percent of people who take statins, Lee said, and some people also report feeling less energetic, weak or tired.-[F1] -In an analysis of 3,071 community-living men, age 65 or older, from six geographic regions in the United States, researchers found that men who took statins averaged about 40 minutes less of moderate physical activity over a one-week period, compared to those who weren't taking the medication.--That would equate to the loss of 150 minutes a week of slow-paced walking, Lee said.--"For an older population that's already pretty sedentary, that's a significant amount less exercise," he said. "Even moderate amounts of exercise can make a big difference."--Of some significance, the study also found that new statin users had the largest drop in physical activity. An increase in sedentary behavior, which is associated with all-cause mortality and also death from cardiovascular disease, was also observed in statin users.--Some previous studies with older adults and statins had found similar results, but those analyses were short-term. This research followed men for almost seven years after initial baseline studies were done, and compared changes in physical activity among users and non-users of statins. In parts of the experiments, men wore accelerometers for a week to track by the minute their level of activity.--"Given these results, we should be aware of a possible decrease in physical activity among people taking a statin," Lee said.---"This could decrease the benefit of the medication," he said. "If someone is already weak, frail, or sedentary, they may want to consider this issue, and consult with their doctor to determine if statin use is still appropriate."--This study was done with older men, and generalization of the findings to older women may not be appropriate, the researchers noted in their study.--Story Source-The above story is based on materials provided by Oregon State University. Note: Materials may be edited for content and length.--Journal Reference--David S. H. Lee, Sheila Markwardt, Leah Goeres, Christine G. Lee, Elizabeth Eckstrom, Craig Williams, Rongwei Fu, Eric Orwoll, Peggy M. Cawthon, Marcia L. Stefanick, Dawn Mackey, Douglas C. Bauer, Carrie M. Nielson. Statins and Physical Activity in Older Men. JAMA Internal Medicine, 2014; DOI: 10.1001/jamainternmed.2014.2266

 

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Limiting carbs could reduce breast cancer recurrence in women with positive IGF1 receptor

Date:

June 10, 2014

Source:

The Geisel School of Medicine at Dartmouth

Dartmouth researchers have found that reducing carbohydrate intake could reduce the risk of breast cancer recurrence among women whose tumor tissue is positive for the IGF-1 receptor. The study, "Risk of Breast Cancer Recurrence Associated with Carbohydrate Intake and Tissue Expression of IGFI Receptor," will appear in the July issue of Cancer Epidemiology Biomarkers & Prevention.--"There is a growing body of research demonstrating associations between obesity, diabetes, and cancer risk," said lead author Jennifer A. Emond, an instructor in the Department of Community and Family Medicine at the Geisel School of Medicine at Dartmouth College. "There are similarities between the biological pathways that underlie all of these conditions, and there is some evidence to suggest that over-activation of the insulin/insulin-like growth factor axis, which increases the availability of IGF1 in the blood, may relate to a poor prognosis among breast cancer survivors."---Receptors for IGF1 have been found in breast tumor tissue, and expression of those receptors may contribute to treatment resistance among breast cancer survivors. Since diet can influence insulin activation, the researchers wondered whether diet could impact breast cancer prognosis based on expression of the IGF1 receptor in the primary breast tumor tissue.---Using an unusual approach, this study assessed the combined association of two factors implicated in tumor growth -- carbohydrate intake and IGF1 receptor status -- to test whether activating the insulin/insulin-like growth-factor axis can impact breast cancer. Since carbohydrates stimulate the biological pathway that can increase concentrations of IGF1, the researchers focused on carbohydrate intake. The women they studied were part of a larger intervention trial called the Women's Healthy Eating and Living (WHEL) study conducted between 2001 and 2007.---"We found an association between increased breast cancer recurrence in women with a primary breast cancer tumor that was positive for the IGF1 receptor, which is consistent with other studies," said Emond. "We further found that a decreased carbohydrate intake was associated with decreased breast cancer recurrence for these women."--This is the first study to suggest that it might be possible to personalize recommended diets for breast cancer survivors based on the molecular characteristics of their primary tumor. Further research is needed to confirm these findings, and Emond notes that breast cancer survivors should not be concerned about dramatically lowering their carbohydrate intake based on this study.[F2] ---"There are still many unanswered questions regarding this study, including what type of carbohydrate-containing foods may be the most important foods that breast cancer survivors should limit," she said. "Breast cancer survivors should continue to follow a plant-based dietary pattern as suggested by the American Association for Cancer Research and the American Cancer Association, which means eating lots of fiber rich vegetables,  and fruits; consuming CNO grains, starchy vegetables, and added sugar."[F3] --Story Source-The above story is based on materials provided by The Geisel School of Medicine at Dartmouth. Note: Materials may be edited for content and length.---Journal Reference-J. A. Emond, J. P. Pierce, L. Natarajan, L. R. Gapuz, J. Nguyen, B. A. Parker, N. M. Varki, R. E. Patterson. Risk of Breast Cancer Recurrence Associated with Carbohydrate Intake and Tissue Expression of IGFI Receptor. Cancer Epidemiology Biomarkers & Prevention, 2014; DOI: 10.1158/1055-9965.EPI-13-1218

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Starch intake may influence risk for breast cancer recurrence, study suggests

Date:

December 23, 2011

Source:

American Association for Cancer Research

Researchers have linked increased starch intake to a greater risk for breast cancer recurrence, according to results presented at the 2011 CTRC-AACR San Antonio Breast Cancer Symposium, held Dec. 6-10, 2011.---"The results show that it's not just overall carbohydrates, but particularly starch," said Jennifer A. Emond, M.S., a public health doctoral student at the University of California, San Diego. "Women who increased their starch intake over one year were at a much likelier risk for recurring."--Researchers conducted a subset analysis of 2,651 women who participated in the Women's Healthy Eating and Living (WHEL) Dietary Intervention Trial, a plant-based intervention trial that enrolled about 3,088 survivors of breast cancer. WHEL researchers studied breast cancer recurrence and followed the participants for an average of seven years.---The subset analysis involved an examination of how changes in carbohydrate intake influenced breast cancer recurrence. "The WHEL dietary trial, even though it focused on fruits and vegetables, fiber and fat, didn't really have a specific carbohydrate goal," Emond said.--She and her colleagues obtained carbohydrate intake information from multiple 24-hour dietary recalls at baseline and at one year. In an annual phone interview, participants reported everything they had eaten during the last 24 hours. At baseline, carbohydrate intake was 233 grams per day. Results showed that women whose cancer recurred had a mean increase in carbohydrate intake of 2.3 grams per day during the first year, while women whose cancer did not recur reported a mean decrease of 2.7 grams per day during the first year.--Starches were particularly important, Emond said. Changes in starch intake accounted for 48 percent of the change in carbohydrate intake. Mean change in starch intake during the first year was -4.1 grams per day among women whose cancer recurred vs. -8.7 grams per day among women whose cancer did not recur.---When change in starch intake during one year was grouped into quartiles of change, the rate of an additional breast cancer event was 9.7 percent among women who decreased their starch intake the most during one year, compared with an event rate of 14.2 percent among women who increased their starch intake the most during one year.--The change in starch intake was "independent of dietary changes that happened in the intervention arm," Emond said. "It is independent of more global changes in diet quality."---After stratifying patients by tumor grade, Emond and colleagues found that the increased risk was limited to women with lower-grade tumors.--These results indicate a need for more research on dietary recommendations that consider limited starch intake among women with breast cancer.--Story Source-The above story is based on materials provided by American Association for Cancer Research. Note: Materials may be edited for content and length.

 

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(mg of Starch per 100 grams)

 

Almost all Plant Foods contain Starch.  The following is a list of Foods that have a  particularly high Starch content.

 

Cereal Grains-Rice (white, raw)-85,800--Rice (white, boiled)-23,100

Rice (brown, raw)-80,000  Rice (brown, boiled)-31,600- Wheat Bran-23,000-Corn Flour-92,000--Wheat Germ  28,700--Flour (white)-76,200

Maize (Corn) -Oatmeal-64,900

 

Processed Foods:            Bread (white)-46,700--Custard Powder-92,000

Bread (brown)-41,300--Peanut Butter-6,400--Pasta (raw)-71,000--Pasta(boiled)-19,500--Bread (wholemeal)-39,800           

 

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50 USC 1520a: Restrictions on use of human subjects for testing of chemical or biological agents Text contains those laws in effect on June 11, 2014

From Title 50-WAR AND NATIONAL DEFENSECHAPTER 32-CHEMICAL AND BIOLOGICAL WARFARE PROGRAM

Jump To: Source CreditCodificationAmendments

§1520a. Restrictions on use of human subjects for testing of chemical or biological agents

(a) Prohibited activities

The Secretary of Defense may not conduct (directly or by contract)-

(1) any test or experiment involving the use of a chemical agent or biological agent on a civilian population; or

(2) any other testing of a chemical agent or biological agent on human subjects.

(b) Exceptions

Subject to subsections (c), (d), and (e) of this section, the prohibition in subsection (a) of this section does not apply to a test or experiment carried out for any of the following purposes:

(1) Any peaceful purpose that is related to a medical, therapeutic, pharmaceutical, agricultural, industrial, or research activity.

(2) Any purpose that is directly related to protection against toxic chemicals or biological weapons and agents.[F4] 

(3) Any law enforcement purpose, including any purpose related to riot control.

(c) Informed consent required

The Secretary of Defense may conduct a test or experiment described in subsection (b) of this section only if informed consent to the testing was obtained from each human subject in advance of the testing on that subject.

(d) Prior notice to Congress

Not later than 30 days after the date of final approval within the Department of Defense of plans for any experiment or study to be conducted by the Department of Defense (whether directly or under contract) involving the use of human subjects for the testing of a chemical agent or a biological agent, the Secretary of Defense shall submit to the Committee on Armed Services of the Senate and the Committee on Armed Services of the House of Representatives a report setting forth a full accounting of those plans, and the experiment or study may then be conducted only after the end of the 30-day period beginning on the date such report is received by those committees.

(e) “Biological agent” defined

In this section, the term “biological agent” means any micro-organism (including bacteria, viruses, fungi, rickettsiac, or protozoa), pathogen, or infectious substance, and any naturally occurring, bioengineered, or synthesized component of any such micro-organism, pathogen, or infectious substance, whatever its origin or method of production, that is capable of causing-[F5] 

(1) death, disease, or other biological malfunction in a human, an animal, a plant, or another living organism;

(2) deterioration of food, water, equipment, supplies, or materials of any kind; or

(3) deleterious alteration of the environment.

(Pub. L. 105–85, div. A, title X, §1078, Nov. 18, 1997, 111 Stat. 1915; Pub. L. 106–65, div. A, title X, §1067(4), Oct. 5, 1999, 113 Stat. 774.)

Codification

Section is comprised of section 1078 of Pub. L. 105–85. Subsec. (f) of section 1078 of Pub. L. 105–85 amended section 1523(b) of this title. Subsec. (g) of section 1078 of Pub. L. 105–85 repealed section 1520 of this title.

Section was enacted as part of the National Defense Authorization Act for Fiscal Year 1998, and not as part of Pub. L. 91–121, title IV, §409, Nov. 19, 1969, 83 Stat. 209, which comprises this chapter.

Amendments

1999-Subsec. (d). Pub. L. 106–65 substituted “and the Committee on Armed Services” for “and the Committee on National Security”.

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Elderly Banking... PRICELESS!!

Shown below, is an actual letter that was sent to a bank by an 86 year old woman.

 The bank manager thought it amusing enough to have it
published in the New York Times.
 

 

Dear Sir:

 

I am writing to thank you for bouncing my check with which I endeavored to pay my plumber last month.

 

By my calculations, three nanoseconds must have elapsed between his presenting the check and the arrival in my account of the funds needed to honor it..

 

I refer, of course, to the automatic monthly deposit of my entire pension, an arrangement which, I admit, has been in place for only eight years.

 

You are to be commended for seizing that brief window of opportunity, and also for debiting my account $30 by way of penalty for the inconvenience caused to your bank.

 

My thankfulness springs from the manner in which this incident has caused me to rethink my errant financial ways. I noticed that whereas I personally answer your telephone calls and letters, --- when I try to contact you, I am confronted by the impersonal, overcharging, pre-recorded, faceless entity which your bank has become.

 

From now on, I, like you, choose only to deal with a flesh-and-blood person.

 

My mortgage and loan repayments will therefore and hereafter no longer be automatic, but will arrive at your bank, by check, addressed personally and confidentially to an employee at your bank whom you must nominate.

 

Be aware that it is an OFFENSE under the Postal Act for any other person to open such an envelope.

 

Please find attached an Application Contact which I require your chosen employee to complete.

 

I am sorry it runs to eight pages, but in order that I know as much about him or her as your bank knows about me, there is no alternative.

 

Please note that all copies of his or her medical history must be countersigned by a Notary Public, and the mandatory details of his/her financial situation (income, debts, assets and liabilities) must be accompanied by documented proof.

 

In due course, at MY convenience, I will issue your employee with a PIN number which he/she must quote in dealings with me.

 

I regret that it cannot be shorter than 28 digits but, again, I have modeled it on the number of button presses required of me to access my account balance on your phone bank service.

 

As they say, imitation is the sincerest form of flattery.

 

Let me level the playing field even further.

 

When you call me, press buttons as follows:

 

IMMEDIATELY AFTER DIALING, PRESS THE STAR (*) BUTTON FOR ENGLISH

 

#1. To make an appointment to see me

 

#2. To query a missing payment.

 

#3. To transfer the call to my living room in case I am there.

 

#4 To transfer the call to my bedroom in case I am sleeping.

 

#5. To transfer the call to my toilet in case I am attending to nature.

 

#6. To transfer the call to my mobile phone if I am not at home.

 

#7. To leave a message on my computer, a password to access my computer is required.

 

Password will be communicated to you at a later date to that Authorized Contact mentioned earlier.

 

#8. To return to the main menu and to listen to options 1 through 7 again

 

#9. To make a general complaint or inquiry.

 

The contact will then be put on hold, pending the attention of my automated answering service.

 

#10. This is a second reminder to press* for English.

 

While this may, on occasion, involve a lengthy wait, uplifting music will play for the duration of the call.

 

Regrettably, but again following your example, I must also levy an establishment fee to cover the setting up of this new arrangement.

 

May I wish you a happy, if ever so slightly less prosperous New Year?

 

Your Humble Client

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Toxins in the environment might make you older than your years

Date:

May 28, 2014

Source:

Cell Press

Why are some 75-year-olds downright spry while others can barely get around? Part of the explanation, say researchers writing in the Cell Press journal Trends in Molecular Medicine on May 28, is differences from one person to the next in exposure to harmful substances in the environment, chemicals such as benzene, cigarette smoke, and even stress.[F6] --While the birth date on your driver's license can tell you your chronological age, that might mean little in terms of the biological age of your body and cells. The researchers say that what we need now is a better understanding of the chemicals involved in aging and biomarkers to measure their effects.--"The rate of physiologic, or molecular, aging differs between individuals in part because of exposure to 'gerontogens', i.e., environmental factors that affect aging," said Norman Sharpless from the University of North Carolina, Chapel Hill. "We believe just as an understanding of carcinogens has informed cancer biology, so will an understanding of gerontogens benefit the study of aging. By identifying and avoiding gerontogens, we will be able to influence aging and life expectancy at a public health level."[F7] --In the future, blood tests evaluating biomarkers of molecular age might be used to understand differences amongst individuals in aging rates. Those tests might measure key pathways involved in the process of cellular senescence or chemical modifications to DNA. In fact, Sharpless said in the interest of full disclosure that he has founded a company to commercialize molecular tests of aging.--From a public health perspective, cigarette smoke is likely the most important gerontogen, Sharpless said. Cigarettes are linked with cancers but also with atherosclerosis, pulmonary fibrosis, and other diseases associated with age. UV radiation from the sun makes us older too, and Sharpless and his colleagues recently showed that chemotherapy treatment is also a strong gerontogen. With the aid of a mouse model that they developed, his team is prepared to study these gerontogens and others in much greater detail.--The researchers call for a concerted research effort to understand the clinical uses for molecular tests of aging as well as the epidemiology of accelerated aging.--"We believe the comparison of molecular markers of aging to clinical outcomes should begin in earnest," Sharpless said. For example, he asked, can biomarkers to aging predict toxicity from surgery or chemotherapy in patients in whom chronological age is already a known risk factor?

Story Source-The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.-Journal Reference-Jessica A. Sorrentino, Hanna K. Sanoff, Norman E. Sharpless. Defining the toxicology of aging. Trends in Molecular Medicine, 2014; DOI: 10.1016/j.molmed.2014.04.004

  

 

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 [F1]It causes a drain on the cq 10 levels which affects the ATP production of the mitochondria---so as a result pain and no energy

 [F2]Would not Hurt to reduce this---most starches and carbs are sugars anyway and as a result this in of itself could feed cancer so maintain a non starch diet and increase saturated fat to regulate insulin as well

 [F3]This was modified by myself after years of seeing people with cancers the best solution is total abstinence of grains and soy which seem to cause the cancers to grow or return

 [F4]This is a loophole in allowing areas to be tested so they can come up with better ways to offer”Protection”

 [F5]May want to read this carefully ---bioengineered or synthesized component ( nano particlaes—polymers)whatever it’s origin or method ofproduction( chemtrails—vaccines—food supply-) this is weaponizing

 

 [F6]Now add Chemtrails-NanoParticles-Vaccines—GMO’s and Smart Meters and Towers---not to mention the current levels of pollution  ongoing

 [F7]This is hysterical---you would have to live underground in a environment that is complete free of any exposure to what is currently being done planet wide

 

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Show of the Month  June 21 2014

On the uselessness of process

Biotech Companies Set To Be Given Legal Right In Decisions To Ban GM Crops In EU

Useful properties of nicotine

Probiotics prevent deadly complications of liver disease

The study analysed the efficacy of probiotics in preventing the development of HE

Which treatment is effective in maintaining remission in ulcerative colitis- Probiotic or placebo

Vitamin A derivative potentially treats type 2 diabetes, prevents its cardiovascular complications

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On the uselessness of process

REUTERS/Lucy Nicholson

"I don't believe in process. In fact, when I interview a potential employee and he or she says that 'it's all about the process,' I see that as a bad sign.[F1] 

"The problem is that at a lot of big companies, process becomes a substitute for thinking. You're encouraged to behave like a little gear in a complex machine. Frankly, it allows you to keep people who aren't that smart, who aren't that creative

Read more: http://www.businessinsider.com/brilliant-elon-musk-quotes-2014-6?op=1#ixzz35CANElxf

 

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Biotech Companies Set To Be Given Legal Right In Decisions To Ban GM Crops In EU

- Biotech Companies Set to Be Given Legal Right in Decisions to Ban GM Crops in EU (Sustainable Pulse, May 27, 2014):

A new GM law being discussed in Brussels this week could grant biotech companies, like Monsanto and Syngenta, unprecedented power over decisions on whether to ban genetically modified (GM) crops in Europe, according to Friends of the Earth Europe.---The new law is being promoted as a way to give governments more sovereignty over decisions on whether to ban GM crops. However, the current proposals give biotech companies the legal right to decide whether a ban should be allowed. If companies refuse, governments are forced to fall back on vague, non-scientific legal grounds upon which to ban GM crops, opening the door to legal challenges [1].---Adrian Bebb, food campaign coordinator for Friends of the Earth Europe said: “It is an affront to democracy that companies like Monsanto will be given legal status in any decision to ban their products. Governments must be able to ban unwanted and risky GM crops without needing the permission of the companies who profit from them.”--“For more than 15 years national governments have fought against new GM crops and strongly defended their rights to ban them. This proposal is a poisoned chalice that fails to give member states the solid legal grounds to ban genetically modified crops.”--Friends of the Earth Europe are calling for national governments to be given genuine powers to keep their fields GM-free and to protect consumer choice. As a minimum, the proposal that national governments must first request permission for a ban from the biotech company should be rejected, and the legal basis for banning GM crops strengthened.

NOTES:

[1] Briefing, A poisoned chalice (April 2014):
www.foeeurope.org/sites/default/files/news/foee_optout_empty_offer_analysis_0414.pdf

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Useful properties of nicotine

- Nicotine and its derivatives, cotinine and nornicotine and even aqueous extract of cigarette tar prevent the development of cancer caused by carcinogens in tobacco smoke (see sec. 51 Source 2002);

- Nicotine addiction (as a drug) does not exist (the source of 8.23.10, the)

- Nicotine suppresses the condition of acute painful craving for drugs and could potentially be used to treat addiction (23/05/2006, the source), and niacin (vitamin B3) splits and displays the body of LSD, marijuana and other drugs (source 1)

- Nicotine is an antidote against chemical weapons - chemical agents ricin. This effect of nicotine have been linked with its anti-inflammatory properties. (02.07.2010, the source) (source 05.07.2010, the)

- Nicotine increases mental efficiency and speeds up the processing of information in non-smokers (Baron JA. Benefical effects of nicotine and cigarette smoking: the real, the possible and spurious. British Medical Bulletin, 1996:52:58-73 see, ref 2)

- Nicotine in the doses in which it is contained in cigarettes, has a powerful antiestrogenic effect, it is women who smoke, are in a group near 100% risk for fibromatosis and endometrial cancer (age over 50 and overweight), the disease still not developed (source 1)

- Nicotine has beneficial effects on the course of Parkinson's disease, found that very clearly because it is planned to create a cure for Parkinson's disease on the basis of nicotine (...)

- The main transformation product of nicotine in the body - cotinine - improves memory and treat Alzheimer's disease.(29.04.2011, the source, the source of 14.07.2008)

- Nicotine stimulates circulation, restoration of blood vessels, and therefore can be used to heal wounds and treat diseases associated with blood circulation and Diabetes (04/12/2001, the source)

- Nicotine reduces appetite (10/06/2011, the source, the source 2)

- Nicotine is an effective means of normalization of body weight. People who regularly engaged in smoking, body weight close to ideal, and the fat content is 1.5 times less than in non-(...)

- Nicotine weakens the effect of alcohol (istochnik1)

- Nicotine helps in the treatment is very difficult to be treated ulcerative colitis (chronic inflammatory bowel disease), due to its anti-inflammatory properties, improves peristalsis (wavelike motion of the walls) of the intestine, stimulates the formation of a protective layer of mucus (15.09.1998, the source, the source of Mr. 26.02.2002 .)

- Nicotine is a provitamin and the body turns into vitamin B3, also known as vitamin PP, nicotinamide, nicotinic acid or "nikotinka" This is the only vitamin that modern medicine to recognize the independence of official medicine

 

- Nicotine is effective even against tubercle bacilli that have acquired resistance to antibiotics (istochnik1, source 2, source3), which is not surprising, since widely used anti-TB drugisoniazid (isonicotinic acid hydrazide) is a derivative of nicotine

 

 

- Nicotine rescues from depression, suppresses the symptoms of schizophrenia (source 1, source 2, source 3)

- Nicotine improves coordination, reaction time and endurance, it can be used in the sport as no illegal drug (source 1)

- Nicotine is unique compared to most drugs, as the nature of its action varies from stimulus to the sedative (calming, analgesic) with increasing the dose (source 1) You can read the most comprehensive found in the current pharmacological descriptions of nicotine, more again emphasizing the effect of nicotine dose-dependent: in small doses, it stimulates the nervous system, increases blood pressure (not all good), but in large doses, it appears calming (sedative, the inhibitory effect). The same source revealed the most severe the side effects of nicotine:
"CNS: dizziness, headache, anxiety.

 

- Found that pregnant women who smoke risk of developing pre-eclampsia and eclampsia (by definition this is convulsion Brockhaus at birth, similar to an epileptic, a pregnant woman starts vomiting, loss of consciousness, is frothing at the mouth) is reduced by 30-50%. In addition, it was found that among smokers rarer hypertension in pregnancy. Moreover, smokers are much less common so-called vomiting in pregnancy.According to data published in quite decent Russian medical journal article about the benefits of smoking in black and white that "tobacco acts as an antiestrogen, in smokers there is a state of estrogen deficiency, which has a positive impact on diseases that occur on the background of their excess. Therefore, intensive smoking reduces, for example, the risk of fibrosis of the uterus (up to 50%, particularly in lean women and postmenopausal) and, presumably, endometriosis (if smoking is initiated at an early age). "And as for pre-eclampsia and eclampsia observed that" the inhibited the synthesis of thromboxane, reduced the rate of increase in plasma volume or affect the hypotensive effect of thiocyanate contained in tobacco smoke. " Ibid: "Some researchers point to decrease the incidence of Down syndrome among infants of smoking mothers, compared with nonsmokers."

- Anecdotal evidence showed "positive effects of smoking" on aphthous ulcerative stomatitis (remember the warning quoted company Pfizer!), Ulcerative colitis, allergic alveolitis ("light farmer" and "pigeon lung"), hay fever. There is evidence that smoking inhibits cutaneous inflammatory processes.

- Smokers less likely to become victims of Parkinson's disease.Nicotine also significantly reduces the rate of development of Alzheimer's disease. In addition, it improves the condition of patients with ulcerative colitis and relieves pain in many diseases of the gastrointestinal tract. It is believed that smokers rarely develop allergic reactions. (Source 15.05.2010 year) brings to mind the famous Che Guevara, who became addicted to smoking cigars just because it allowed him to deal with asthma attacks.

 

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With Today’s chemical matrix in foods and herbs ---an alternative choice has to be considered—there is Nicotine product on the market that is in a inhalant format that has only in it menthol-ethanol( alcohol used in hard liquor) and nicotine –Nicorette—

The other method would to be either grow it yourself

Or buy it as a ceremonial tobacco as the natives used to utilize

 

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Probiotics prevent deadly complications of liver disease, study finds

Date:

June 6, 2014

Source:

American Gastroenterological Association

Probiotics are effective in preventing hepatic encephalopathy in patients with cirrhosis of the liver, according to a new study in Clinical Gastroenterology and Hepatology, the official clinical practice journal of the American Gastroenterological Association. Hepatic encephalopathy is a deterioration of brain function that is a serious complication of liver disease.--"This rigorous new research finds that probiotics modify the gut microbiota to prevent hepatic encephalopathy in patients with cirrhosis of the liver," said David W. Victor III, MD, who contributed an editorial in Clinical Gastroenterology and Hepatology on this research. "These results offer a safe, well-tolerated and perhaps cheaper alternative to current treatments."--The investigators from Govind Ballabh Pant Hospital, New Delhi, India, conducted a single-center, prospective, open-label, randomized trial with cirrhosis patients who showed risk factors for hepatic encephalopathy, but had yet to experience an obvious episode. When comparing treatment with probiotics versus placebo, the researchers found that the incidence of hepatic encephalopathy was lower in patients treated with probiotics.--Probiotic supplementation was not associated with any side effects and none of the patients required discontinuation of therapy. These results suggest that probiotics are similar in effectiveness to the current standard of care, lactulose, in the prevention of hepatic encephalopathy, yet they appear to be much better tolerated. The effectiveness of lactulose, a nonabsorbable disaccharide, is limited by side effects (diarrhea, bloating and gas) and a narrow therapeutic window.--"By virtue of its size, study duration and design, as well as the thorough nature of the baseline and follow-up assessments, this study represents an important contribution to the hepatic encephalopathy literature," added Dr. Victor, a practicing hepatologist in the Methodist J.C. Walter Jr. Transplant Center at Houston Methodist Hospital, TX.--Up to 45 percent of patients with cirrhosis develop hepatic encephalopathy, a loss of brain function that occurs when the liver is unable to remove toxins from the blood. Prognosis is poor, with a 58 percent mortality rate at one year, and a 77 percent mortality rate at three years. Research into safer and more effective treatments is essential for these patients.--The microbial communities that reside in the human gut and their impact on human health and disease are one of the most exciting and promising areas of research today. The AGA Center for Gut Microbiome Research and Education is committed to advancing this research.--Story Source-The above story is based on materials provided by American Gastroenterological Association. Note: Materials may be edited for content and length.

Journal References-Manish Kumar Lunia, Barjesh Chander Sharma, Praveen Sharma, Sanjeev Sachdeva, Siddharth Srivastava. Probiotics Prevent Hepatic Encephalopathy in Patients With Cirrhosis: A Randomized Controlled Trial. Clinical Gastroenterology and Hepatology, 2014; 12 (6): 1003 DOI: 10.1016/j.cgh.2013.11.006 -----David W. Victor, Eamonn M.M. Quigley. Hepatic Encephalopathy Involves Interactions Among the Microbiota, Gut, Brain. Clinical Gastroenterology and Hepatology, 2014; 12 (6): 1009 DOI: 10.1016/j.cgh.2014.01.022

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The study analysed the efficacy of probiotics in preventing the development of HE

The study analysed the efficacy of probiotics in preventing the development of HE in 160 cirrhotic patients over a period of approximately nine months and found significant improvements in reducing patients' arterial ammonia levels after three months of treatment with probiotics.---Ammonia, produced by gut bacteria, is thought to be one of the main mediators of cerebral dysfunction in HE. Probiotics work by enriching the gut flora with a non-urease producing microorganisms, which decrease ammonia production. Probiotics are live microorganisms (mostly bacteria) that produce a health benefit on the host when administered in adequate amounts.---Twice as many patients taking a placebo developed overt HE (the study's primary endpoint) compared to patients taking probiotics in the form of a capsule.---EASL's Treasurer, Prof. Mauro Bernardi welcomed the findings and said they would provide a positive impact for cirrhotic patients at risk of developing HE for whom the prognosis is typically very poor.--Prof. Bernardi said: "Hepatic encephalopathy is an insidious disease that's caused by an accumulation of toxins in the blood that are normally removed by the liver. Treatment normally involves the use of antibiotics or laxatives to suppress the production of toxic substances in the intestine but there is still a great deal of room for improvement so it will be exciting to see the results of further studies to determine if clinicians have a new form of treatment on the cards."--Hepatic encephalopathy is a spectrum of neuropsychiatric abnormalities including personality changes, intellectual impairment and reduced levels of consciousness in patients with liver failure, after exclusion of other known brain disease.----Story Source-The above story is based on materials provided by European Association for the Study of the Liver. Note: Materials may be edited for content and length.

 

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Which treatment is effective in maintaining remission in ulcerative colitis- Probiotic or placebo?

Date:

April 19, 2010

Source:

World Journal of Gastroenterology

Inflammatory bowel disease is a chronic recurrent disease, which mainly consists of ulcerative colitis and Crohn's disease, and whose causes are as yet unclear. Many clinical and research studies have indicated that intestinal flora dysbacteriosis contributes to the pathogenesis of ulcerative colitis.---Probiotics are non-pathogenic beneficial flora, which have important effects on maintaining the balance of intestinal flora. Many studies have discussed the positive effects of probiotics for treating stomach and intestine diseases, including ulcerative colitis. However, the sample size has been relatively small, such that there is no definitive evidence as to whether probiotics are helpful.--A research team from China systematically evaluated probiotics' curative effects for treating ulcerative colitis based on existing random control trials. Their study will be published on April 21, 2010 in the World Journal of Gastroenterology.--Through meta-analysis, they concluded that probiotics should be considered as an auxiliary medicine in the remission induction stage and maintenance stage of ulcerative colitis.---Story Source--The above story is based on materials provided by World Journal of Gastroenterology. Note: Materials may be edited for content and length.--Journal Reference--Sang LX, Chang B, Zhang WL, Wu XM, Li XH, Jiang M. Remission induction and maintenance effect of probiotics on

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Vitamin A derivative potentially treats type 2 diabetes, prevents its cardiovascular complications

Date:

June 16, 2014

Source:

Universite de Montreal

At a time when obesity, type 2 diabetes, and their complications are a veritable epidemic worldwide, researchers at the University of Montreal and CHUM Research Centre (CRCHUM) recently demonstrated the potential of retinoic acid (RA), a derivative of Vitamin A, in treating obesity and type 2 diabetes and preventing their cardiovascular complications. The findings were presented June 6, 2014 at the Annual Conference of the Canadian Nutrition Society in Saint John's, Newfoundland.---"In obese and insulin resistant mice, retinoic acid reduces the risk of cardiac apoptosis, stimulates the expression of cardio-protective genes reduced by the disease, and protects against the accumulation of collagen in the cardiac muscle, thus avoiding the occurrence of fibrosis and possible associated future complications," says the first author of the study, Daniel-Constantin Manolescu. Apoptosis is the process of programmed cell death. The discovery follows other research conducted by his team on the effects of RA on insulin resistance, diabetes, and obesity. "Blood glucose, insulin resistance, body weight, and adipocyte size were significantly decreased in treated animals, including abdominal fat, while dietary intake and physical activity were similar for treated or non-treated animals. This suggests an increase in basal energy expenditure," says Manolescu. White fat is an energy reserve formed by the accumulation of fat in the form of triglycerides to meet unexpected increases in energy costs, but it is also a hormonal tissue with a delicate balance. Overall, if energy intake is greater than expenditures over an extended period, obesity increases, while hormonal balance and energy metabolism are disturbed. In this context, resistance to type 2 diabetes develops over time.---Brown fat also stores triglycerides, but it has the ability to produce heat. Abundant in babies, brown fat does not disappear completely in adulthood. It is irrigated by blood vessels and has many mitochondria, the energy factories of cells. Vitamin A derivatives stimulate a mitochondrial uncoupling protein (UCP1) that allows uncoupling of the mitochondria pathway (oxidative phosphorylation ), which uses energy from the oxidation of nutrients for the production of adenosine triphosphate (ATP). For a period of time, they generate heat (thermogenesis) instead of ATP, which is traditionally the energy required for active metabolism. Exposure to cold leads to the stimulation of brown fat and white fat, promoting the conversion of triglycerides to free fatty acids and glycerol. However, in brown adipocytes, these fatty acids are rapidly oxidized in the mitochondria and produce heat (under the influence of the UCP1 protein). Brown fat thus helps to increase basal energy metabolism. As a result, hibernating mammals fatten in the fall without developing diabetes and lose weight without moving too much in the winter (while warming their den). They are also the animals that accumulate the most Vitamin A in their livers. Retinoic acid (a Vitamin A derivative) is recognized for its involvement in cell maturation and differentiation and may guide pre-adipocytes to become brown (or beige) instead of white. It is as if "boilers" were installed directly in reserves of white fat to melt it on the spot and prevent it from over-accumulating.--"Vitamine A is a bioactive nutrient. The originality of our project is in addressing obesity and type 2 diabetes through the involvement of retinoids. We have attracted international attention and were named among 12 teams in the world to bring conclusive data in this regard," says Dr. Pangala V. Bhat.--"Our studies on animals show that retinoic acid induces normalization of blood glucose and reduction of obesity. It is an important contribution to understanding RA action on the liver, fat, muscles, and the heart, and on retinoid metabolism, energy metabolism, fatty acid oxidation, and insulin resistance. Our research identifies new metabolic effects of retinoids and may lead to anti-obesity and anti-diabetic medicines," says Dr. Jean-Louis Chiasson.--Story Source-The above story is based on materials provided by Universite de Montreal. -Journal Reference-Daniel-Constantin Manolescu, Marek Jankowski, Bogdan Alexandru Danalache, Donghao Wang, Tom L Broderick, Jean-Louis Chiasson, Jolanta Gutkowska. All-trans retinoic acid stimulates gene expression of the cardio-protective natriuretic peptide system, and prevents fibrosis and apoptosis in cardiomyocytes of obese ob/ob mice. Applied Physiology, Nutrition, and Metabolism, 2014; 140430143753005 DOI: 10.1139/apnm-2014-0005

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 [F1]Robotic Programming that does not allow for any real solution solving and just keeps you in a pattern of circular---to solve issues or gain solutions you have to be somewhat inventive and take what is known and go to another level to discover the unknown this is where you get real results

 

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Show of the Month  June 28 2014

War Pigs—Prophecy or Game Plan

WHY ORGANIC CONSUMER ASSOCIATION  BELIEVES THAT MOST “NATURAL” FOODS ARE A FRAUD

Evening Primrose Oil

Microplastics- scientific evidence

Bioactive components from flowers of Sambucus nigra L. increase glucose uptake and reduce fat

Confirmed- DNA From Genetically Modified Crops Can Be Transferred Into Humans Who Eat Them

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War Pigs—Prophecy or Game Plan

Generals gathered in their masses,just like witches at black masses.
Evil minds that plot destruction,sorcerers of death's construction[F1] .
In the fields the bodies burning, as the war machine keeps turning.
Death and hatred to mankind,
poisoning their brainwashed minds...Politicians hide themselves away
They only started the war Why should they go out to fight? They leave that role to the poor-Time will tell on their power minds Making war just for fun
Treating people just like pawns in chess Wait `till their judgment day comes, yeah! Now in darkness, world stops turning, as you hear the bodies burning. No more war pigs of the power, hand of God has struck the hour.
Day of judgment, God is calling, on their knees the war pigs crawling.
Begging mercy for their sins, Satan, laughing, spreads his wings...

 

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WHY ORGANIC CONSUMER ASSOCIATION  BELIEVES THAT MOST “NATURAL” FOODS ARE A FRAUD

• There is widespread use of GMO (genetically modified organisms) ingredients in so-called “natural” foods, including the “natural” brands that make up most of WFM and UNFI’s sales.
• So-called “natural” (non-organic) soy milk, including leading brands such as “Silk,” are made with conventional soy lecithin, utilizing the hazardous chemical, hexane, as an extraction agent.
• 90% or more of the vitamins and supplements now on the market labeled as “Whole Foods,” “natural” or “food based” are spiked with synthetic chemicals.

Why Target Whole Foods and United Natural Foods?

Corporate Takeovers & Monopolistic Practices

The $25 Billion organic marketplace has enjoyed substantial growth for over a decade, thanks to growing consumer consciousness and farmer innovation.--No longer a passing trend or simply a niche market, organic food and farming are proving to be a viable alternative to the unhealthy, unsustainable and unjust conventional food system.--[F2] Unprecedented wholesale and retail control of the organic marketplace by UNFI and Whole Foods, employing a business model of selling twice as much so-called “natural” food as certified organic food, coupled with the takeover of many organic companies by multinational food corporations such as Dean Foods, threatens the growth of the organic movement.

Perpetrating “Natural” Fraud

Consumers are confused about the difference between conventional products marketed as “natural,” and those nutritionally and environmentally superior products that are “certified organic.[F3] ”--Retail stores like WFM and wholesale distributors like UNFI have failed to educate their customers about the qualitative difference between natural and organic.[F4] --A troubling trend in organics today is the calculated shift on the part of certain large companies from certified organic ingredients and products to so-called “natural” products. With the exception of the “natural” meat sector, where there are limited voluntary guidelines, there is no definition of “natural.” In the majority of cases, “natural” products are green washed conventional products, with “natural” label claims neither policed nor monitored.--Whole Foods and UNFI are maximizing their profits by selling quasi-natural products at premium organic prices. Organic consumers are increasingly left without certified organic choices while organic farmers continue to lose market share to “natural” impostors. It’s no wonder that less than 1% of American farmland is certified organic.---[F5] 

Excluding Small and Family Farms

Whole Foods and UNFI’s business model of centralized sourcing and prioritizing natural products over organic rewards large corporate farms and processors, to the detriment of local and regional small-scale organic farmers and brands.--Organic farmers must “get big or get out” to be able to compete and have free access to markets. Many industrial organic farms and dairy operations reflect the same abuses and problems of the conventional food system: extremely energy intensive, systematic abuse of workers, reduced food quality, and damage to biodiversity.[F6] --So-called “natural” products, since they are actually in most cases conventional products in disguise, are being sold at lower prices than genuine organic products–thereby retarding the growth of the organic sector.

Organic and Local Food?

In light of the food system’s significant contribution to the climate crisis and the deepening economic troubles facing local food economies, it is more important than ever to prioritize locally produced organic food.--Though Whole Foods talks a lot about supporting local food and producers, the fact is that the vast majority of their products are not local, and much of what they sell is sourced from a small number of industrial organic operations in California, often owned by the same conventional food conglomerates responsible for destroying the world’s food system.

Organic Monopoly and the “Whole Paycheck” Phenomena

UNFI has undermined the growth of the organic movement by implementing an unfair tiered pricing system that gives Whole Foods deep discounts while other grocers, coops and independent retailers pay significantly higher prices, in effect subsidizing UNFI for its reduced profits at Whole Foods.---With UNFI as the largest organic (but of course their sales are mostly so-called “natural” products) food wholesaler and Whole Foods as the largest organic (like UNFI most of its sales are “natural”) food retailer, organic consumers are assured higher prices, lower quality and fewer choices.

Cancer in a Bottle?

In 2008, the Organic Consumers Association exposed a problem which particularly threatens women – a large number of leading conventional as well as “natural” and “organic” brands of shampoos, lotions, cosmetics and household cleaning products which contained the carcinogen 1,4-Dioxane.

Included in the list of products were several Whole Food’s 365 brand products and many products in the UNFI catalog.--While several dozen companies have committed to eliminating the 1,4-Dioxane, neither Whole Foods, nor UNFI, have endorsed OCA’s Coming Clean Campaign, nor have they called on the USDA to crack down on blatant labeling fraud in the organic personal care and cosmetics sector.

Corporate Consolidation of Organics

In the last decade, the organic marketplace has experienced hyper consolidation, with numerous small to medium-sized farmers, manufacturers and retailers being taken over by larger, profit-hungry corporations.--Whole Foods has employed an expansion strategy that resembles Wal-Mart with its targeting of local and independent retailers with new store locations while steadily buying out competitors like Wild Oats.--UNFI has also grown rapidly over the last decade, in part by aggressively taking over other distributors, regional wholesalers and manufacturers.

Organics for Elites?

The organic food and farming movements were born out of the desire to provide healthy and safe food to all. Whole Foods’ business model: selling overpriced conventional foods as “natural,” with organics in a subordinate role, is a recipe for maximizing profits rather than maximizing the growth of organic food and farming.--Worse yet, Whole Food’s high prices have not translated into larger profits for family farms or small-scale manufacturers. Likewise, UNFI’s growing market share and near-monopoly of the organic and “natural” market has reduced the options for consumers and independent retailers alike, undermining the growth of consumer buying clubs and the lower-cost alternatives.

Anti-worker

UNFI and Whole Foods have a history of cutting workers’ benefits. Both have gone to extreme lengths to block their employees from choosing to unionize. Whole Foods has long fought unionization of its retail locations, largely ignored the demands of farm workers organizations, like the United Farm Workers, and kept workers’ wages consistently low by industry standards.---UNFI has repeatedly fought efforts by its employees to fight for better pay, benefits and working conditions. Where workers have sucessfully formed unions, UNFI has begun moving jobs to new, non-union locations.

Source:

www.organicconsumers.org

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Evening Primrose Oil

Procyanidins from evening primrose (Oenothera paradoxa) defatted seeds inhibit invasiveness of breast cancer cells and modulate the expression of selected genes involved in angiogenesis, metastasis, and apoptosis.

Nutr Cancer. 2013;65(8):1219-31

Authors: Lewandowska U, Szewczyk K, Owczarek K, Hrabec Z, Podsędek A, Sosnowska D, Hrabec E

Abstract
There is a growing interest in plant polyphenols (including flavanols) that exhibit pleiotropic biological activities [F7] such as antiinflammatory, antioxidant, and anticancer effects. Here, we report for the first time the inhibition of MDA-MB-231 breast cancer cell viability and invasiveness by an evening primrose flavanol preparation (EPFP). We observed a decrease in MDA-MB-231 viability of 50% vs. a control after 72 h of incubation with EPFP at a concentration of 58 μM gallic acid equivalents (GAE) and an inhibition of their invasiveness of 65% vs. a control at 75 μM GAE after 48 h of incubation. EPFP caused a 10-fold reduction in matrix metalloproteinase-9 (MMP-9) activity at 100 μM GAE. Furthermore, through modulation of mRNA expression, EPFP reduced the expression levels of the following proteins: antiapoptotic Bcl-2, angiogenic vascular endothelial growth factor (VEGF), and 2 transcription factors (c-Jun, c-Fos). Moreover, analysis by flow cytometry revealed that EPFP induced apoptosis in MDA-MB-231 cells. In conclusion, our data shows that EPFP inhibits cell viability by increasing apoptosis and decreases cell invasiveness by decreasing angiogenesis.--PMID: 24099118 [PubMed - indexed for MEDLINE]

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The effect of oral evening primrose oil on menopausal hot flashes- a randomized clinical trial.

Arch Gynecol Obstet. 2013 Nov;288(5):1075-9

Authors: Farzaneh F, Fatehi S, Sohrabi MR, Alizadeh K

Abstract
PURPOSE: Hot flashes are common experience for menopausal women, and for many, are severe enough to significantly compromise their overall sense of well being and quality of life. The aim of this study was to compare the efficacy of evening primrose with placebo in improvement of menopausal hot flashes.
METHODS: In a 6-week randomized clinical trial, a total of 56 menopausal women aged 45-59 years were participated in this study. The patients were asked for their hot flashes characteristics and responded to HFRDIS (hot flash related daily interference scale) questionnaire before and after the intervention. The participants were randomly assigned to take two capsules per day (totally 90 capsules for 6 weeks) of placebo or evening primrose (500 mg) for continuous 6 weeks. Then, the improvement in hot flashes was compared between two groups.
RESULTS: The percent of improvement in hot flash frequency, severity and duration were 39, 42 and 19 %, in evening primrose group compared with 32, 32 and 18 % in placebo group, respectively. Although all three characters of hot flash was ameliorated in evening primrose arm, only its severity was significantly better in this arm compared with placebo group (P < 0.05). All HFRDIS score were significantly improved in two groups, but the percentage of improvement in social activities, relations with others, and sexuality was significantly superior to placebo group (P < 0.05).
CONCLUSIONS: The application of oral evening primrose oil compared with placebo for controlling hot flashes may decrease more the intensity of attacks as well as ameliorating the HFRDIS score.-PMID: 23625331 [PubMed - indexed for MEDLINE]

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Microplastics- scientific evidence

Today, a significant number of personal care products such as scrubs and toothpastes are known to contain thousands of minuscule balls of plastic called microplastics, or more specifically, microbeads. Over the years, microbeads have replaced traditional, biodegradable alternatives such as ground nut shells, and salt crystals[F8] .---The microbeads used in personal care products are mainly made of polyethylene (PE), but can be also be made of polypropylene (PP), polyethylene terephthalate (PET), polymethyl methacrylate (PMMA) and nylon[F9] . Where products are washed down the drain after use, microbeads flow through sewer systems around the world before making their way into rivers and canals and ultimately, straight into the seas and oceans, where they contribute to the plastic soup.[F10]  Typically, microplastics are defined as: plastic pieces or fibres measuring less than 5 mm. The microbeads found in personal care products are almost always smaller than 1 mm.[F11] --In 2004, the findings of a research programme led by Professor Richard Thompson (University of Plymouth) were published in Science and detailed the distribution of microplastic pollution. The article was the first to conclude the spread of microplastics and plastic fibres throughout the entire marine environment. And since larger pieces of plastic break down into smaller pieces and do not biodegrade, the amount of microplastics is accumulating.^I Plastic degrades into ever smaller pieces upon exposure to UV radiation and as a result of abrasive wave action.^II The concentration of marine microplastics is accumulating rapidly.^III--In addition to these indirect, secondary sources of microplastics, there are several direct sources of microplastics – including the flushing of microbeads used in personal care products. Hundreds, if not thousands, of different personal care products use microbeads as abrasive scrubbers and for cleansing purposes. In 2009, Fendall and Sewell (University of Auckland) published their observations that microbeads pass into household waste water streams directly and are too small to be retained by the standard filters used at sewage treatment plants and therefore enter the marine environment. Not only do they enter the sea, they can also enter the food chain.^IV--Although the full extent and consequences is hard to quantify, the accumulation of plastic, including microplastics, in the marine environment is today recognised as a serious, global environmental issue.^V As scientists and policymakers alike start to question the full extent of the problem in terms of impacts to marine biodiversity and associated implications for human health, the number of research programs studying microplastics is increasing consequentially.

Some scientific findings:

Marine species are unable to distinguish between food and microplastics and therefore indiscriminately feed on microplastics. In an overview published for the Convention on Biological Diversity, it was shown that over 663 different species were negatively impacted by marine debris with approximately 11% of reported cases specifically related to the ingestion of microplastics.^VI Some species of fish excrete plastic easily, but others do not and so accumulate plastic internally. To cite one study: around 35% of 670 fish examined (total of 6 species) had microplastics in their stomachs. The highest number of fragments found in one fish was 83.^VII--The surface of microplastics has been proven to attract and absorb persistent organic pollutants (POPs) such as PCBs and DDT from the marine environment. Relatively high concentrations of POPs have been found on the surface of microplastics.^VIII The International Pellet Watch, led by Professor Takada at the University of Tokyo, is conducting research to this effect. Takada’s research indicates that certain POPs found in bird tissue were ingested together with their plastic hosts.^IX In theory, ingested POPs could remain on the surface of ingested microplastics and could be egested.^X However, fish and seafood regularly consumed by humans have been recorded with plastic fragments inside their guts and body tissues. Scientists hypothesise that over time, POPs will start accumulating in the food chain, transferring from species to species, with consequences ultimately for humans.^XI--Toxic chemicals added to plastic during the manufacturing process (such as plasticisers and flame retardants) leach out of plastic in the marine environment and pose serious threats to marine fauna.^XII The most common plasticisers have been recorded in fish, marine mammals and molluscs.^XIII The smallest particles of plastic are ingested and retained by filter feeders such as mussels. Belgian toxicologist Colin Janssen (University of Ghent) found that on average, each gram of mussel flesh contains one particle of plastic.^XIV Species of plankton are also found to ingest and retain plastic particles.^XV--Once microbeads reach the marine environment, it is impossible to pinpoint the source of origin. German researchers Liebezeit and Dubaish (University of Oldenburg) hypothesise that cosmetics, and especially peelings, make up most of the microplastics they found in the Wadden Sea.^XVI--In terms of relative contributions to microplastic pollution, a range of studies have looked at the number or concentration of microbeads in individual products. The American non-governmental organisation (NGO) 5Gyres, found a large number of microplastics in the Great Lakes and estimates that one single care product (Neutrogena's Deep Clean) contains 360,000 microbeads.^XVII Dr. Leslie (Free University, Amsterdam) found that microplastics made up 10.6% of one scrub (Exofonic scrub of L'Oreal).^XVIII--Water treatment plants are not designed to filter out microbeads. A number of studies have found that water treatment plants do not filter all microbeads from the waste water.^XIX Moreover, not all waste water gets purified. Following heavy rain, waste water with microbeads can overflow directly into surface waters. Some countries lack the infrastructure to treat waste water completely.--As scientific understanding of the effects of microplastics on the environment continues to grow, the fate of microplastics has become an extremely important question. Increasingly, sources and impacts of microplastic pollution are being questioned and considered closely by scientists and policymakers alike. For instance, within the framework of the CleanSea European research project, seventeen European research institutes are conducting interdisciplinary investigations into the effects of microplastics.--Research into the quantity and consequences of microplastics in the environment is important. In light of growing evidence confirming the seriousness of this issue, there is a pressing need to address direct sources of microplastic pollution – something that is both avoidable and highly unnecessary.--Producers have been asked to act responsibly and stop adding microplastics to cosmetics.

---

^I R.C. Thompson, et al. ‘Lost at Sea: Where Is All the Plastic?’, in: Science, 304 (May 2004).

^II P.K. Roy, et al., ‘Degradable Polyethylene: Fantasy or Reality’, in: Environmental Science and Technology, 2011, pp. 4217–4227.

^III M.C. Goldstein et al., ‘Increased oceanic microplastic debris enhances oviposition in an endemic pelagic insect’, in: Biology Letters published on line 9 May 2012; C.J. Moore, ‘Synthetic polymers in the marine environment: A rapidly increasing, long-term threat’, in: Environmental Research108 (2008), pp. 131-139.

^IV L.S. Fendall, M.A. Sewell, ‘Contributing to marine pollution by washing your face: microplastics in facial cleansers’, in: Marine Pollution Bulletin, 58 (8) (2009), pp. 1225-1228.

^V W.J. Sutherland et al., ‘A horizontal scan of global conservation issues for 2010’, in: Trends in Ecology and Evolution, 25, pp. 1-7.

^VI Secretariat of the Convention on Biological Diversity and the Scientific and Technical Advisory Panel—GEF (2012). Impacts of Marine Debris on Biodiversity: Current Status and Potential Solutions, Montreal, Technical Series No. 67.

^VII Chr.M. Boerger et al., ‘Plastic ingestion by planktivorous fishes in the North Pacific Central Gyre’, in: Marine Pollution Bulletin 60 (2010), pp. 2275-2278.

^VIII Y. Mato et al., ‘Plastic Resin Pellets as a Transport Medium of Toxic Chemicals in the Marine Environment’, in: Environmental Science & Technology, 2001, 35(2), pp.318-324.

^IX H. Takada, et al., ‘Accumulation of plastic-derived chemicals in tissues of seabirds ingesting marine plastics’ in: Marine Pollution Bulletin69 (2013), pp 219-222.

^X E.M. Foekema et al., ‘Plastic in North Sea fish’, in: Environmental Science & Technology, 47 (2013), pp. 8818-8824.

^XI P. Farrel en K. Nelson, ‘Trophic level transfer of microplastic: Mytilus edulis (L.) to Carcinus maenas (L.)’, in: Environmental Pollution 177 (2013), pp. 1-3.

^XII D. Lithner et al., ‘Environmental and health hazard ranking and assessment of plastic polymers based on chemical composition’, in: Science of the total environment 409 (2011), pp. 3309–3324.

^XIII STAP. Marine Debris as a Global Environmental Problem: Introducing a solutions based framework focused on plastic. In A STAP Information Document, p. 40. Washington, DC: Global Environment Facility, 2011.

^XIV L. Van Cauwenberghe, ‘Occurrence of microplastics in mussels (Mytilus edulis) and lugworms (Arenicola marina) collected along the French-Belgian-Dutch coast, in: J. Mees, et al. (ed.), Book of abstracts - VLIZ Young Marine Scientists' Day. Brugge, Belgium, 24 February 2012. VLIZ Special Publication, 55.

^XV Cole M., et al., ‘Micro-plastic ingestion by zooplankton’, in: Environmental Science & Technology, 2013 47 (12), pp. 6646-6655.

^XVI G. Liebezeit, F. Dubaish, ‘Microplastics in Beaches of the East Frisian Islands Spiegeroog and Kacheloplate’, in: Bulletin environmental contamination and toxicology, 89 (2012), p. 213-127.

^XVII http://5gyres.org/how_to_get_involved/campaigns/

^XVIII Leslie, H.A., Microplastic in Noordzee zwevend stof en cosmetica. Eindrapportage W-12/01, IVM Institute for Environmental Studies, Amsterdam, 2012.

^XIXM.A. Browne et al., ‘Accumulations of microplastic on shorelines worldwide: sources and sinks’, in: Environmental Science &Technology 45 (2011), pp. 9175/9179; H.A. Leslie et al., ‘Verkennende studie naar lozing van microplastics door rwzi’s’ in: H2O 14/15 (juli 2012), pp. 45-47.

 

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Bioactive components from flowers of Sambucus nigra L. increase glucose uptake and reduce fat in primary porcine myotube cultures accumulation in Caenorhabditis elegans.

Bhattacharya S¹, Christensen KB, Olsen LC, Christensen LP, Grevsen K, Færgeman NJ, Kristiansen K, Young JF, Oksbjerg N.

Author information

Abstract

Obesity and insulin resistance in skeletal muscles are major features of type 2 diabetes. In the present study, we examined the potential of Sambucus nigra flower (elderflowers) extracts to stimulate glucose uptake (GU) in primary porcine myotubes and reduce fat accumulation (FAc) in Caenorhabditis elegans. Bioassay guided chromatographic fractionations of extracts and fractions resulted in the identification of naringenin and 5-O- caffeoylquinic acid exhibiting a significant increase in GU. In addition, phenolic compounds related to those found in elderflowers were also tested, and among these, kaempferol, ferulic acid, p-coumaric acid, and caffeic acid increased GU significantly. FAc was significantly reduced in C. elegans, when treated with elderflower extracts, their fractions and the metabolites naringenin, quercetin-3-O-rutinoside, quercetin-3-O-glucoside, quercetin-3-O-5″-acetylglycoside, kaempferol-3-O-rutinoside, isorhamnetin-3-O-rutinoside, and isorhamnetin-3-O-glucoside and the related phenolic compounds kaempferol and ferulic acid. The study indicates that elderflower extracts contain bioactive compounds capable of modulating glucose and lipid metabolism, suitable for nutraceutical and pharmaceutical applications.

USE- make a tea with this or use as a extract to be utilized for mass management as well as regulating glucose and lipid use---this may also be used for intestinal health-respiratory support- blood vessel permeability for brain eyes—and body and possibly assisting in lipofuscin removal or regulating for  the brain

 

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Confirmed- DNA From Genetically Modified Crops Can Be Transferred Into Humans Who Eat Them

by ARJUN WALIA

In a new study published in the peer reviewed Public Library of Science (PLOS), researchers emphasize that there is sufficient evidence that meal-derived DNA fragments carry complete genes that can enter into the human circulation system through an unknownmechanism. (0) I wonder if the scientists at these biotech corporations have already identified this method? In one of the blood samples the relative concentration of plant DNA is higher than the human DNA.[F12]   The study was based on the analysis of over 1000 human samples from four independent studies. PLOS is an open access, well respected peer-reviewed scientific journal that covers primary research from disciplines within science and medicine.  It’s great to see this study published in it, confirming what many have been suspecting for years.---When it comes to genetically modified crops and foods, we really have no idea of what the long term effects will be on the public. The very first commercial sale of genetically modified foods was only twenty years ago in the year 1994. There is no possible way that our health authorities can test all possible combinations on a large enough population, over a long enough period of time to be able to say with certainty that they are harmless. Geneticist David Suzuki recently expressed his concern, saying that human beings are part of a “massive genetic experiment” over many years, as thousands of people continue to consume GMO’s, and it makes sense.---Advances in genome science over the past few years have revealed that organisms can share their genes. Prior to this, it had been thought that genes were shared only between individual members of a species through reproduction. Geneticists usually followed the inheritance of genes in what they would call a ‘vertical’ fashion, such as breeding a male and female -you follow their offspring and continue down the road from there. Today, scientists recognize that genes are shared not only among the individual members of a species, but also among members of different species[F13] .---“Our bloodstream is considered to be an environment well separated from the outside world and the digestive tract. According to the standard paradigm large macromolecules consumed with food cannot pass directly to the circulatory system. During digestion proteins and DNA are thought to be degraded into small constituents, amino acids and nucleic acids, respectively, and then absorbed by a complex active process and distributed to various parts of the body through the circulation system. Here, based on the analysis of over 1000 human samples from four independent studies, we report evidence that meal-derived DNA fragments which are large enough to carry complete genes can avoid degradation and through an unknown mechanism enter the human circulation system. while non-plasma (cord blood) control sample was found to be free of plant DNA.” (0)-- In one of the blood samples the relative concentration of plant DNA is higher than the human DNA. The plant DNA concentration shows a surprisingly precise log-normal distribution in the plasma samples---It’s not like a human being mates with an apple, banana or a carrot plant and exchanges genes. What biotechnology and biotech corporations like Monsanto have done, is they have allowed for the transfer of genes from one to the other without any regard for the biological limitations, or constraints. The problem with this is that it is based on very bad science. The conditions and biological ‘rules’ that apply to vertical gene transfer, at least those that we are aware of, do not necessarily apply to horizontal gene transfer. Biotech science today is based on the assumption that the principles governing the inheritance of genes are the same when we move genes horizontally as they are when they are moved vertically. It just goes to show that GMO’s should be subjected to much more experimentation and rigorous research before we continue to consume them.---How can our governing health authorities approve these as safe? It’s almost as if they told us they were safe, and we just believed them without questioning it. We seem to be a very gullible race, but things are changing and more are starting to question the world around them.---“One small mutation in a human being can determine so much, the point is when you move a gene, one gene, one tiny gene out of an organism into a different one you  completely change its context. There is no way to predict how it’s going to behave and what the outcome will be. We think that we design these life forms, but it’s like taking the Toronto orchestra prepared to play a Beethoven symphony and then you take some random drummers from “here” and flip them in with the Toronto symphony  and you say play music. What comes out is going to be something very very different. Publicists say that there is good intention behind GMOs, but the fact of the matter is it’s driven by money.” – David Suzuki-- It’s also pretty clear that DNA from food can and does end up in animal tissues and the milk products that people eat. (4)(5)---There are studies that show when humans or animals digest genetically modified foods, the artificially created genes transfer into and alter the character of the beneficial bacteria in the intestine. Researchers report that microbes found in the small bowel of people with ilestomy are capable of acquiring and harboring DNA sequences from GM plants.(1) Genetically modified crops have infiltrated animal feed since 1996, and it’s normal for them to have a complete GM diet. Studies have linked GMO animal feed to  severe stomach inflammation and enlarged uteri in pigs.--It’s also important to note that gene transfer among genetically engineered agricultural crops and surrounding native species has given rise to a highly resistant species called super weeds. According to the world health organization, gene transfer and the movement of genes from GM plants into conventional crops or related species may have an effect on food safety and food security. “This risk is real, as was shown when traces of maize type which was only approved for feed use appeared in maize products from human consumption in the United States.” (3)--The truth is, genetic engineers have never taken the reality of gene transfer into consideration when they produce these things and introduce them into the environment. As a result, we are now starting to see the consequences of genes that are engineered, particularly how they spread and alter other organisms in various environments. Watrud et al (2004) found that the herbicide-resistance transgene spread via pollen to an area up to 21 km beyond the control area perimeter and had pollinated wild creeping bentgrass.(2)--Prior to this year, governments concluded that transfer of DNA from GM crops/foods is unlikely to occur. Now we can see that they are wrong, or perhaps they had knowledge of this already? Regardless of the fact that DNA from GM foods can be transferred to humans and animals, very little is still known today and what is known does not look good. There are studies linking GMO’s and pesticides to various ailments. We’ve presented and written about them on our website numerous times, this is another article to add to the growing amount of evidence to suggest we need to halt the production of GMO’s until we conclusively know that they are safe for human consumption.--- 

SOURCES:

(0) http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0069805

(1) http://www.ncbi.nlm.nih.gov/pubmed/14730317

(2) http://natureinstitute.org/nontarget/reports/bentgrass_001.php

(3) http://www.who.int/foodsafety/publications/biotech/20questions/en/

 

 

TOP C

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 [F1]A Sorcerer was one who dabble in chemicals to be utilized ---as the Pharmacopia uses this day to subvert human heallth

 [F2]If you can find a real organic food—that is not croos contaminated with GMO or having Nanoparticle exposure to cause a severe Chemical reaction---it’s called weaponizing the food supply

 [F3]The error here is even certified organic means so little today ---THE USDA has been undermining food and safety values dating way back to 1904---so this is again something to be aware not everything certified is safe either

 [F4]More Like Purposely mislead the public so there profit margins can be excessive for the same thing of equal value elsewhere wnd with 2/3’s less

 [F5]Again the alarm here is if 99% of the farms are not organic then what  authentic value does that 1% reall have since they would be inundated with genetics and other pollutants and genetics---not to mention the irradiating before it goes on the shelf

 [F6]Not to mention ifthey need money to run there operations thenBanks willonly lend them money on a contingency they grow a GMO Seed

 [F7]Pleiotropy is a condition in which a single gene influences more than one phenotypic trait in an organism. A phenotypic trait is any observable trait, in contrast to a genotypic trait, which is involved with the genetic composition of an organism. The word pleiotropy has a Greek origin; it comes from the words pleion, meaning "more," and trepein, meaning "to turn" or "to convert." If an animal had a gene that affected both the length and color of its fur, that gene would be considered pleiotropic. People commonly say pleiotrophic instead of pleiotropic, but this is incorrect; pleiotropic is the correct term to describe a gene that affects multiple traits

 [F8]Funny how this sounds---they replaced something totally biodegradeable with something that is polymerized

 [F9]Poly= Polymer

 [F10]YUM---now the interesting thing is they cannot be filtered out with the current filtration system we have for clean water !!! hmm

 [F11]I millionth of  meter

 [F12]Plant cross over of DNA ---would and should makeyou concerned in that these DNA sequencies were designed in a lab---designer DNA

 [F13]Again designer genetics ---