Show Of The Month Of March 2012
Show of the Week March 2 2012
Show of the Week March 12 2012
Show of the Week March 16 2012
Show of the Week March 19 2012
Show of the Week March 23 2012
Show of the Week March 26 2012
Show of the Week March 30 2012
B.C. paves way for all-in-one identity card-ID to start out as more secure CareCard
Nanoparticles in Food Vitamins Could Harm Human Health
Building Bone from Cartilage- Orthopaedic Researchers Take the Road Less Travelled
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Attention: This is in no way an e-mail forgery, this is sent by the Customer Support of Verified by Visa ! [U1]
Dear Customer Verified by Visa , [U2]
Your credit card is temporarily suspended , Because we have noticed a problem on your carte. --We determine that someone might try to use your card without your permission. For your protection, we temporarily suspended your credit card. Pour lever cette suspension, Click here suivez la procйdure indiquer pour Update your Credit card.--Note: If this is not completed February 20, 2012, we will be forced to suspend your card !--Please note that in 50% of cases you will receive this email in the SPAM box, this is because of the increased security of emailing services you use. --We appreciate your cooperation in the context of your file.
Thank you,
Customer Service Support of Verified by Visa.
Call your bank immediately before filling out this form---I did to validate my cards activation---and you have to understand that this is a set up to go to a site and give up or out privy info--And what this will do is compromise your security---never allow this---validate before you respond
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Zapping Food---when buying meat or poultry- or any fruits or veges – to increase the safety measures of eliminating any potential contaminant—microbes—parasites- mold fungus- bacteria---So to set a “charge “ this will neutralize whatever or burn out what may be there---so take a zapper –stunner or cattle prod and place the prods on the meat or produce and let the charge go for a moment—if the animal protein is large then do it on 2 sides-apply this to fruit and veges as well—
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Fruit Flies Use Alcohol as a Drug to Kill Parasites
If fruit flies infected with wasps tap the alcohol in rotting fruit, it raises their blood-alcohol levels and their survival rates. The alcohol doesn't just kill some of the wasps, it essentially liquifies them. ScienceDaily (Feb. 16, 2012) — Fruit flies infected with a blood-borne parasite consume alcohol to self-medicate, a behavior that greatly increases their survival rate, an Emory University study finds.--"We believe our results are the first to show that alcohol consumption can have a protective effect against infectious disease, and in particular against blood-borne parasites," says Todd Schlenke, the evolutionary geneticist who led the research.--"It may be that fruit flies are uniquely adapted to using alcohol as medicine," he adds, "but our data raise an important question: Could other organisms, perhaps even humans, control blood-borne parasites through high doses of alcohol?"----Current Biology is publishing the study, co-authored by Emory graduate student Neil Milan and undergraduate student Balint Kacsoh.-The results add to the growing body of evidence that some animals know how to use toxic substances found in nature as medicine. Drosophila melanogaster, the common fruit fly that swirls around browning bananas in your kitchen, is an important biological model system. The Schlenke lab uses D. melanogaster to study how immune systems adapt to pathogens. The fly larvae eat the rot, or fungi and bacteria, that grows on overripe, fermenting fruit. "They're essentially living in booze," Schlenke says. "The amount of alcohol in their natural habitat can range from 5 to 15 percent. Imagine if everything that you ate and drank all day long was 5-percent alcohol. We wouldn't be able to live like that, but fruit flies are really good at detoxifying alcohol."--Tiny, endoparasitoid wasps are major killers of fruit flies. The wasps inject their eggs inside the fruit fly larvae, along with venom that aims to suppress their hosts' immune response. If the venom is effective enough, the wasp egg hatches, and the wasp larva begins to eat the fruit fly larva from the inside out. Eventually, an adult wasp emerges from the remains of the fruit fly pupa. Some fruit flies, however, can overcome the effects of wasp venom and mount an immune response against wasp eggs. The blood cells in these fly larvae swarm over the wasp eggs and release nasty chemicals to kill them, allowing the fruit fly larvae to grow into adults.--"A constant co-evolutionary battle is going on between the immune systems of the flies and the venoms of the wasps," Schlenke says. "Any new mechanism of defense that protects flies from wasps will tend to spread through fly populations by natural selection." Schlenke wondered if the fruit flies could be tapping the toxic effects of alcohol in their natural habitat to fight off wasps.
To test the theory, the researchers used a bisected petri dish filled with the yeast that fruit flies are normally fed in a lab environment. The yeast on one side of the dish was mixed with 6 percent alcohol, while the yeast on the other side remained alcohol-free. The researchers then released fruit fly larvae into the dish, allowing them to freely move to either side.
After 24 hours, 80 percent of the fruit fly larvae that were infected with wasps were on the alcohol side of the dish, while only 30 percent of the non-infected fruit fly larvae were on the alcohol side.---"The strength of the result was surprising," Schlenke says. "The infected fruit flies really do seem to purposely consume alcohol, and the alcohol consumption correlates to much higher survival rates." Infected fruit flies that consumed alcohol beat out the wasps in about 60 percent of the cases, compared to a 0 percent survival rate for fruit fly controls that fed on plain yeast.--"The wasps aren't as good as the flies at handling alcohol," Schlenke says. A developing wasp knocked out within an alcohol-consuming fly larva dies in a particularly horrible way, he adds. "The wasp's internal organs disperse and appear to be ejected out of its anus. It's an unusual phenotype that we haven't seen in our wasps before," Schlenke says.---The lab repeated the experiment using another species of wasp that specializes in laying its eggs in D. melanogaster, rather than the generalist wasp used previously. Again, 80 percent of the infected flies wound up on the alcohol side of the dish, while only 30 percent of the uninfected flies did. But the alcohol diet was far less effective against the specialist wasps, killing them in only 10 percent of the cases.---"You would expect this kind of result," Schlenke says, "since the generalist wasp species can attack plenty of other flies, but the specialist wasps are under strong pressure to adapt to the alcohol-infused habitat of D. melanogaster."--The researchers hope that their data will lead to more studies of how alcohol may control pathogens in other organisms, including humans.---"Although many studies in humans have shown decreased immune function in chronic consumers of alcohol, little attempt has been made to assay any beneficial effect of acute or moderate alcohol use on parasite mortality or overall host fitness following infection," Schlenke says. Story Source- The above story is reprinted from materials provided by Emory University. Note: Materials may be edited for content and length. For further information, please contact the source cited above. Journal Reference-Neil F. Milan, Balint Z. Kacsoh, Todd A. Schlenke. Alcohol Consumption as Self-Medication against Blood-Borne Parasites in the Fruit Fly. Current Biology, 2012; DOI: 10.1016/j.cub.2012.01.045
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Recipe with alcohol—utilize any brandy or vodka or clean alcohol beverage—then add to it wormwood or clove or black walnut extract with the beverage or balm of gilead or bee Propolis and add 3 drops
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B.C. paves way for all-in-one identity card-ID to start out as more secure CareCard
The B.C. government is moving forward with plans for high-tech identity cards that will one day let people access a host of provincial services on the Internet. The province intends to sign a $20-million, six-year deal with Toronto-based SecureKey to provide card reader technology, the government says. It's the latest in a series of new laws and contracts that pave the way for expanded government Internet services.--The cards may one day be used to access government websites for electronic health records, prescription histories, age verification, driver's licence details, electronic voting and school registration for children. Currently, you have to visit a government office in person and show appropriate ID to access such services.--Health Minister Mike de Jong announced last May the government was developing new CareCards, with improved security features, to combat the millions of dollars lost to health insurance fraud.[U3]--Those cards should be available in November, and will roll out over the next five years. They'll be free and mandatory for all British Columbians, requiring millions of people to re-enrol into the healthcare system. The project is expected to cost the government about $150 million.--People will also have the option of combining their new CareCard and driver's licence into one B.C. Services Card.--The new government cards will have embedded security chips, similar to certain credit cards that allow customers to wirelessly make purchases by touching or waving their credit card in front of a terminal.--The government's contract with SecureKey will develop B.C. card readers - key-sized devices that plug into a computer's USB port. People tap their new CareCard or Services Card onto the SecureKey reader and enter a PIN number on a government website, to authenticate their identity.---There won't be any online government services available when the cards launch in November. The province has proposed a rollout of features from different ministries over the next five years.--B.C. said it will directly award SecureKey a contract because the company already holds a contract with the federal government and the province wants its system to be compatible with Canada's service.---NDP critic Doug Routley said the Liberal government has a dismal track record on protecting privacy and should have asked for other bids. "I know some pretty good roofers, but I'd still get three quotes on a roof," he said. "It'd still be prudent to put this out there for competition."--There remains many privacy questions about the direction the government is headed, said Vince Gogolek, executive director of the B.C. Freedom of Information and Privacy Association. He said the government rushed through legislation last fall that allows for crossministry sharing of personal information needed by the new cards.---The government said it is consulting with the independent privacy commission on the technology.--Identity cards won't store any information inside their chips, and the SecureKey readers simply create a secure path and network to approve a person's ID and re-direct them back to government information, officials said Friday.-The cards can be remotely cancelled if lost, and will only access the minimum amount of personal information required for a service - for example, a birth date to prove an age or a health number for prescriptions.
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Nanoparticles in Food, Vitamins Could Harm Human Health
ScienceDaily (Feb. 16, 2012) — Billions of engineered nanoparticles in foods and pharmaceuticals are ingested by humans daily, and new Cornell research warns they may be more harmful to health than previously thought.---A research collaboration led by Michael Shuler, the Samuel B. Eckert Professor of Chemical Engineering and the James and Marsha McCormick Chair of Biomedical Engineering, studied how large doses of polystyrene nanoparticles -- a common, FDA-approved material found in substances from food additives to vitamins -- affected how well chickens absorbed iron, an essential nutrient, into their cells.--The results were reported online Feb. 12 in the journal Nature Nanotechnology. According to the study, high-intensity, short-term exposure to the particles initially blocked iron absorption, whereas longer-term exposure caused intestinal cell structures to change, allowing for a compensating uptick in iron absorption.-- The researchers tested both acute and chronic nanoparticle exposure using human gut cells in petri dishes as well as live chickens and reported matching results. They chose chickens because these animals absorb iron into their bodies similarly to humans, and they are also similarly sensitive to micronutrient deficiencies, explained Gretchen Mahler, Ph.D. '08, the paper's first author and former Cornell graduate student and postdoctoral associate.--The researchers used commercially available, 50-nanometer polystyrene carboxylated particles that are generally considered safe for human consumption. They found that following acute exposure, a few minutes to a few hours after consumption, both the absorption of iron in the in vitro cells and the chickens decreased.---But following exposure of 2 milligrams per kilogram for two weeks -- a slower, more chronic intake -- the structure of the intestinal villi began to change and increase in surface area. This was an effective physiological remodeling that led to increased iron absorption.--"This was a physiological response that was unexpected," Mahler said.--Shuler noted that in some sense this intestinal villi remodeling was positive because it shows the body adapts to challenges. But it serves to underscore how such particles, which have been widely studied and considered safe, cause barely detectable changes that could lead to, for example, over-absorption of other, harmful compounds.[U4]--Human exposure to nanoparticles is only increasing, Shuler continued.--"Nanoparticles are entering our environment in many different ways," Shuler said. "We have some assurance that at a gross level they are not harmful, but there may be more subtle effects that we need to worry about."--The paper included Cornell co-authors Mandy Esch, a research associate in biomedical engineering; Elad Tako, a research associate at the Robert W. Holley Center for Agriculture and Health; Teresa Southard, assistant professor of biomedical sciences; Shivaun Archer, senior lecturer in biomedical engineering; and Raymond Glahn, senior scientist with the USDA Agricultural Research Service and courtesy associate professor in the Department of Food Science. The work was supported by the National Science Foundation; New York State Office of Science, Technology and Academic Research; Army Corp of Engineers; and U.S. Department of Agriculture.---Story Source-The above story is reprinted from materials provided by Cornell University, via Newswise. The original article was written by Anne Ju. --Journal Reference-Gretchen J. Mahler, Mandy B. Esch, Elad Tako, Teresa L. Southard, Shivaun D. Archer, Raymond P. Glahn, Michael L. Shuler. Oral exposure to polystyrene nanoparticles affects iron absorption. Nature Nanotechnology, 2012; DOI: 10.1038/nnano.2012.3
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Building Bone from Cartilage- Orthopaedic Researchers Take the Road Less Travelled
ScienceDaily (Feb. 14, 2012) — A person has a tumor removed from her femur. A soldier is struck by an improved explosive device and loses a portion of his tibia. A child undergoes chemotherapy for osteosarcoma but part of the bone dies as a result. Every year, millions of Americans sustain fractures that don't heal or lose bone that isn't successfully grafted. But a study presented at the Orthopaedic Research Society (ORS) 2012 Annual Meeting in San Francisco offers new hope for those who sustain these traumas. Orthopaedic researchers with the University of California, San Francisco (UCSF), Orthopaedic Trauma Institute, have found a very promising, novel way to regenerate bone. "Cartilage graft induces bone that actually integrates with the host bone and vascularizes it," said Ralph S. Marcucio, PhD, Associate Professor, UCSF School of Medicine.--Cartilage graft is very different than the current methods used for bone grafting -- autograft bone (a person's own bone) or allograft materials (donor bone). For various reasons, these two grafting techniques can result in poor graft integration and osteonecrosis.---"With millions of bone grafting procedures performed every year in just the United States, developing improved technologies could directly enhance patient care and clinical outcomes," Dr. Marcucio said.--Chelsea S. Bahney, PhD, Postdoctoral Scholar, UCSF School of Medicine, concedes their approach is less orthodox. "It is not the pathway that most people think about, but it made a lot more sense to follow the normal developmental mechanism.""This cartilage is naturally bioactive. It makes factors that help induce vascularization and bone formation," added Dr. Bahney. "When people use a bone graft, it is often dead bone which requires something exogenous to be added to it or some property of the matrix in the graft." Through a process called endochondral ossification, cartilage grafts produce new tissue that is very similar to the person's own bone. Without additional properties to it, the researchers found the cartilage graft integrated well and was fully vascularized.--"We're just taking a very similar cartilage that can induce bone formation, putting it into a bone defect and letting it just do its thing," Dr. Marcucio said.---In the study, the researchers chose a non-stabilized tibial fracture callus as a source of a cartilage graft. "Healing of the transplanted cartilage grafts supported our hypothesis by producing a well-vascularized bone that integrated well with the host," Dr. Bahney said.--"A cartilage graft could offer a promising alternative approach for stimulating bone regeneration," Dr. Marcucio said. "Future work will focus on developing a translatable technology suitable for repairing bone through a cartilage intermediate at a clinical level."--Story Source--The above story is reprinted from materials provided by Orthopaedic Research Society (ORS).
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Scientists Prepare Test-tube Burger
300,000 Organic Farmers Sue Monsanto in Federal Court
Decision on March 31st to Go to Trial
Secret GPS tracker terrifies Ontario man
New Ability to Regrow Blood Vessels Holds Promise for Treatment of Heart Disease
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Scientists Prepare Test-tube Burger
CLIVE COOKSON - Financial Times (U.K.)
I think there is going to be a tremendous emphasis on this. It will become a growing trend, because industrial cattle operations are going to become unprofitable due to the rising cost of water as it becomes scarcer. It takes 1,300 gallons of water to produce an eight ounce hamburger. As affluence increases across the world -- not to be confused with wealth, only more than subsistence -- eating meat will increase. The demands for ! water and grain (and the water it requires) will become unsustainable. The world’s first test-tube hamburger, created in a Dutch laboratory by growing muscle fibres from bovine stem cells, will be ready to grill in October, scientists believe.--'I am planning to ask Heston Blumenthal [the celebrity chef] to cook it,” Mark Post, leader of the artificial meat project at Maastricht University in the Netherlands, told the American Association for the Advancement of Science annual meeting in Vancouver.--Researchers believe that meat grown in factories, rather than on farms, will be a more sustainable and less environmentally harmful source of food. Live cattle and pigs are only 15 per cent efficient at converting vegetable proteins to meat from the grass and cereals they eat[U5].--
'If we can raise the efficiency from 15 to 50 per cent by growing meat in the lab, that would be a tremendous leap forward,” Professor Post said.---Starting with bovine stem cells[U6], the Dutch researchers have grown muscle fibres up to 3cm long and 0.5mm thick. The fibres are tethered and exercised as they grow, like real muscles, by bending and stretching in the culture dishes. They feed on a broth of vegetable proteins and other nutrients, equivalent to the grass or grain diet of cattle.[U7]---At present the fibres are a pallid yellowish-pink colour, rather than the red of raw ground beef, because they do not contain blood,[U8] but Prof Post plans to improve their appearance.--Patrick Brown, biochemistry professor at Stanford University in California, told the AAAS that global meat consumption was expected to double by 2050, yet livestock farming already accounted for 18 per cent of man-made greenhouse gas emissions and threatened biodiversity worldwide[U9].--
To provide fat, an essential element in real burgers, They will be minced in with bovine fat cells are also being grown in the lab.the muscle fibres.---
This project was started about six years ago, and I expect it will be another 10 to 20 years before we can mass-produce our meat,” Prof Post said.
An anonymous individual has financed the Maastricht project with a €250,000 grant[U10]. He is expected to contribute further funds after the planned production of a 'proof of concept” burger from the lab-grown muscle in October.
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300,000 Organic Farmers Sue Monsanto in Federal Court: Decision on March 31st to Go to Trial
The GMO movement is perhaps the leading example in our culture of how the greed of a single corporation can destabilize and entire ecosystem, thus effecting the lives of millions; all so a small group of people already rich can get richer. Nelson states, 'Corporate control of our food system has led to the loss of millions of family farmers, destruction of our soil…”-Hundreds of citizens, (even including NYC chefs in their white chef hats) joined Occupy the Food System groups, ie Food Democracy Now, gathered outside the Federal Courts in Manhattan on January 31st, to support organic family farmers in their landmark lawsuit against Big Agribusiness giant Monsanto. (Organic Seed Growers & Trade Association v. Monsanto) Oral arguments were heard that day concerning the lawsuit by 83 plaintiffs representing over 300,000 organic farmers, organic seed growers, and organic seed businesses.---The lawsuit addresses the bizarre and shocking issue of Monsanto harassing and threatening organic farmers with lawsuits of 'patent infringement” if any organic farmer ends up with any trace amount of GM seeds on their organic farmland.[U11] Judge Naomi Buckwald heard the oral arguments on Monsanto’s Motion to Dismiss, and the legal team from Public Patent Foundation represented the rights of American organic farmers against Monsanto, maker of GM seeds, [and additionally, Agent Orange, dioxin, etc.]---After hearing the arguments, Judge Buckwald stated that on March 31st she will hand down her decision on whether the lawsuit will move forward to trial.--Not only does this lawsuit debate the issue of Monsanto potentially ruining the organic farmers’ pure seeds and crops with the introduction of Monsanto’s genetically modified (GM) seeds anywhere near the organic farms, but additionally any nearby GM fields can withstand Monsanto’s Roundup herbicides, thus possibly further contaminating the organic farms nearby if Roundup is used.[U12]---Of course, the organic farmers don’t want anything to do with that ole contaminated GM seed in the first place. In fact, that is why they are certified organic farmers. But now they have to worry about getting sued by the very monster they abhor, and even have to spend extra money and land (for buffers which only sometimes deter the contaminated seed from being swept by the wind into their crop land). [U13]At this point, they are even having to resort to not growing at all the following organic plants: soybeans, corn, cotton, sugar beets, and canola, …just to protect themselves from having any (unwanted) plant that Monsanto could possibly sue them over.[U14]
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Secret GPS tracker terrifies Ontario man
An Ontario man says he's angry and frightened after discovering someone hid a GPS tracking device under his vehicle, apparently to secretly monitor his movements.---“I was doing just a regular inspection on my truck and I found this black box under my truck … with flashing lights inside,” Ben Ferrill of Warsaw, Ont., told Go Public. “I didn’t know what it was. I didn’t know if it was a bomb. We were scared to death … It felt like a movie — unreal.”---After making the discovery last fall he reported it the next morning to the Ontario Provincial Police. Ferrill said the OPP tried to find out whom the device belonged to to lay a mischief charge, but were stymied in their investigation.---“I feel powerless. I can’t do anything about it and I really wish the police did more. I really wish they would do more — and I’m upset,” Ferrill said. Ferrill said he and his wife haven’t been able to sleep properly since, because they are worried someone is watching them.[U15] “We spent lots of nights up until three in the morning crying and talking about it — not sleeping and looking out the windows and being suspicious of vehicles that drive by,” Ferrill said. “Are they following me? Are they watching me? Are they going to try to do something to me? Are they going to try to do something to our family? The fear in finding something like that is unreal.”Ferrill’s lawyer, Ian Wilson, said is illegal to put a tracking device on someone else’s vehicle without their knowledge or consent unless there is a search warrant.---“The trouble is, we don’t know who is behind this,” Wilson said.[U16] The device Ferrill found, Wilson said, was sold by an American company, U.S. Fleet Tracking, which sells GPS systems to companies that want to track their fleet vehicles. The OPP obtained a production order, compelling the Canadian company that provides the wireless connection, Kore Wireless, to disclose whose device it is. However, Kore said it didn’t have that information[U17]. “I’ve [also] tried to get answers from Kore Wireless and their lawyer but they will tell me nothing,” Wilson said. Kore Wireless president Alex Brisbourne told CBC News his company only provides "connectivity. We don’t know who the end user is.”He said U.S. Fleet bills the customer and gives access to its website, where the customer can track its fleet vehicles in real time. “Our customer [U.S. Fleet] is in the United States. They have no responsibility or accountability to provide that information [to Canadian police],” Brisbourne said. When asked whether he requested the customer information from U.S. Fleet in this case, Brisbourne replied it "is not appropriate for us to ask for that. Security of information is particularly critical.” U.S. Fleet’s website makes it clear the company does not give up information easily, even to American authorities. “U.S. Fleet Tracking will not under any circumstance make your information or any data specific to your vehicle tracking account available to any third party — including local, state or federal law enforcement authorities [U18]… Even if presented with a court order, we promise to fight the courts to keep this information private and respect the privacy of our paying customers,” the website reads.
Wilson and Ferrill said the OPP told them it would be too expensive and time-consuming to pursue the case through U.S. courts. The OPP told CBC News the file is now closed.--Ferrill insisted the device could not have been put there by his wife or any family member. In addition, U.S. Fleet sells to to businesses, not individuals.--He said the only dispute he is involved in is with his former employer, a car dealership in Peterborough, Ont.--Ferrill worked for a decade as a mechanic for Holiday Ford Lincoln. Two years ago, he injured his shoulder on the job. The Workplace Safety and Insurance Board (WSIB) in Ontario said he needed to be on light, restricted duty for several months.--After a few months, Holiday Ford fired him for allegedly stealing a bottle of windshield washer fluid.--A WSIB investigation found it was a pretext – that Ferrill had been fired because he was injured, which is a violation of the law. The WSIB report concluded: “A breach of their re-employment obligation has occurred.”Holiday Ford is appealing that decision, but it faces significant fines if the ruling stands. It is also facing a wrongful-dismissal lawsuit filed by Ferrill.--The company has denied Ferrill's allegations in court filings.--Ferrill said he discovered the GPS device a few months after filing his lawsuit. He and his lawyer said they suspect the dealership could be involved, but they have no way of proving or disproving that.--CBC News left several messages with Ferrill’s former manager at Holiday Ford, but received no reply.--He has no idea how long it was there, and said the combined stress has pushed his family to the edge.--“Losing my job was really stressful, and then this is just a part of more stress,” Ferrill said. “It’s really testing our family. It’s the most stress and discomfort we have ever had.” Ferrill and his lawyer want Canadians to realize how technology can now be used against them and — at least in this case —there is no recourse.“It’s extremely frustrating to know that [customer] information exists in the U.S. somewhere … and we simply can’t get at it,” Wilson said. “[Ferrill] hasn’t had any peace of mind for the last 2½ years since he lost his job.”--Wilson said he finds it ironic this is happening to his client at the same time the federal government is talking about allowing police to monitor people’s internet use without a warrant.--“The same federal government that is responsible for this crime bill is also responsible for these wireless companies,” Wilson said.---He said he believes wireless companies in Canada should be required by law to know who the end users of the technology are: “This is a changing environment and steps have to be taken to protect people.” “We want to know who put this on our truck and why,” Ferrill said. “I’m sure whoever did this wants to do some type of harm to me, because whoever did this wants to know what I am doing all the time and wants to follow me for some reason.”
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New Ability to Regrow Blood Vessels Holds Promise for Treatment of Heart Disease
Hindlimb ischemia was created in rats and treatments were delivered over seven days with an osmotic pump. The laser doppler imaging above shows the rat's hind limb prior to treatment (on the left) and with increased blood flow (image on the right) just seven days after treatment.
ScienceDaily (Feb. 16, 2012) — University of Texas at Austin researchers have demonstrated a new and more effective method for regrowing blood vessels in the heart and limbs -- a research advancement that could have major implications for how we treat heart disease, the leading cause of death in the Western world.---The treatment method developed by Cockrell School of Engineering Assistant Professor Aaron Baker could allow doctors to bypass surgery and instead repair damaged blood vessels simply by injecting a lipid-incased substance into a patient. Once inside the body, the substance stimulates cell growth and spurs the growth of new blood vessels from pre-existing ones.---Aaron Baker is an assistant professor in the Department of Biomedical Engineering.---The method has been tested successfully on rats, and findings of the study were published recently in the Proceedings of the National Academy of Sciences --"Others have tried using growth factors to stimulate vessel growth in clinical trials and have not been successful," said Baker, a faculty member in the school's Department of Biomedical Engineering. "We think that a major reason for this is that previous methods assumed that the diseased tissues retained the ability to respond to a growth stimulus. Our method basically delivers extra components that can restore growth factor responsiveness to the tissue of patients with long-standing clinical disease."—[U19] The ability to regrow blood vessels could prove crucial to treating chronic myocardial ischemia disease, which affects up to 27 million patients in the U.S. and leads to a reduction of blood flow in the heart and lower limbs -- ultimately causing organ dysfunction and failure.--Central ischemia, which affects the heart, occurs when the coronary vessels that feed blood to the heart become blocked or narrow because of a buildup of fatty deposits called plaques. Such plaques are typically the result of a prolonged unhealthy diet or smoking, and factors such as age, high blood pressure and diabetes increase the risks of the disease, Baker said.
Doctors have typically treated ischemia by physically opening the closed artery with a stent or surgically rerouting blood flow to the poorly perfused tissue. Both methods have limitations, however, and are not effective long-term.--The new method introduced by Baker and his research team builds on a promising revascularization approach that, up until now, has shown limited efficacy in clinical trials for treating human disease.---The method combines a growth factor -- a substance capable of stimulating cellular growth, proliferation and cellular differentiation, as well as healing wounds -- known as fibroblast growth factor 2 (FGF-2) with a lipid-embedded receptor to enhance its activity.---A challenge for scientists and engineers, however, has been getting FGF-2 to bind with cell receptors -- the very molecules often found on the surface of the cell that receive chemical signals and direct activity in the cell from outside sources.---To overcome this, Baker's method embeds the growth factors in synthetic lipid-based nanoparticles containing a coreceptor known as syndecan-4. The nanoparticles containing co-receptors that, when delivered with the growth factor, enable improved cell binding so that the growth factor can direct the targeted cell to divide, proliferate and form new cells for tissue regrowth.---The incased substance was injected into rats with hindlimb ischemia and stimulated a complete recovery from the ischemia in just seven days.---"We hope this research will increase our understanding of how tissues become resistant to revascularization therapies and may lead to more effective treatments for this widespread and debilitating disease," said Baker, who was recognized last year with the National Institutes of Health Director's New Innovator Award.-Story Source---The above story is reprinted from materials provided by University of Texas at Austin. -Journal Reference-E. Jang, H. Albadawi, M. T. Watkins, E. R. Edelman, A. B. Baker. Syndecan-4 proteoliposomes enhance fibroblast growth factor-2 (FGF-2)-induced proliferation, migration, and neovascularization of ischemic muscle. Proceedings of the National Academy of Sciences, 2012; 109 (5): 1679 DOI: 10.1073/pnas.1117885109
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add the whites of the Citrus -about 8 slices- then add 1 whole apple- add a pectin capsule ( if you wish not mandatory ) add bht 1 capsule-or any other antioxidant you see fit to add--example vitamin C-add sodium alginate 1 tsp -tumeric 1 tsp- bromelain powder or capsule 1 tablespoon -add 1/8 cup of water and allow to blend at slow to medium speed til it gelatinizes--once this is done pour into a glass container and consume several tsp through out the day and use a good load of water---this will bind to metals-toxins-will support the liver-digestive system-and potentially reduce fatty deposits in the gall bladder and liver
[U2]Should have Your Name—not dear customer
[U3]Again the Excuse to Violate Privacy
[U4]In other words if you are exposed to to other metals or poisons or foods that may produce a poison this will allow for a higher uptake of these contents further damaging the internals—and If there are air borne particles as well then what you may have is an exacbrated level of these being absorbed
[U5]Well I wonder why!! Since the soy shuts down there thyroids and there pancreas how can the animal process anything accurately???---these GE or GMO foods are not meant for them to consume either
[U6]Now am I the only one seeing this GMO MEAT or GE meat—playing with genetics to alter the dna of this meat and then feed it to the Human race----we must be less then dust in the eyes of the powers that be!! Time to send them home!
[U7]Vegetable Proteins—SOY or other GMO and this is going to be used in the Genetic sequencing----now what does this do to People!!!
[U8]Life is in the blood so what then is this---the is a design of food for something other then life as we know it—this is to feed something else and if people eat this then there will be health hazards
[U9]Another lie---the green house gasses being emitted are not from the animals but rather the Bio diversity of the GMOs and there interference with the balance of this planet
[U10]BG –Bill Gates---orrr my likely guess since he has financial power or perhaps the Vatican since they own the gmos and GE through monsanto
[U11]The Law has to change if a seed is found on a piece of land then Monsanto is responsible for it so farmer do not lose there lands because of second hand negligence and this would contain or limit the amount of cross breeding of the seed with the real crop---the law is stacked in Monsanto’s favour and this needs to be addressed
[U12]This is already happening ---you cannot co exist in the real world—the moment you plant this abomination it corrupts what is naturally occurring---the biggest lie being perpetrated in the health food industry next to GMP ---all Crap
[U13]This would be enough for a lawsuit since it is on the land and there according to Monsanto illegally even the buffer doe not deter any kind of genetic anomaly with this barrier
[U14]Not growing Soy or Canola or corn at this stage of the game may not be a bad idea
[U15]Time to wake up –a truck driver is always being monitored
[U16]The Question everyone should be asking is –what was he hauling that required him to be under surveillance---what could have been so important as to have this kind of Black opp to take place---the fact he was monitored is not an issue –truckers are always monitored but to have this kind of sophistication –there must have been something of the utmost importance—maybe a Bio contaminant for military use –maybe a military equipment needing to be transported unnoticed---who knows
[U17]Now does this sound funny---I mean with everything today asking you for id and wanting to know if you had cornflakes or pancakes in the morning does this not see a touch odd “ they don’t know”
[U18]I think this is good actually and more companies need to apply this kind of security---
[U19]It is in the delivery ---the fat could be a lipsome to carry to the area what is required for regenerating the issues
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Food Fried in Olive or Sunflower Oil Is Not Linked to Heart Disease
Stronger Intestinal Barrier May Prevent Cancer in the Rest of the Body
Boosting Longevity With Good Bacteria
The effect of hydro alcoholic Nettle (Urtica dioica) extracts on insulin sensitivity and some inflammatory indicators in patients with type 2 diabetes-
What are you to do if you have a heart attack While you are alone
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Food Fried in Olive or Sunflower Oil Is Not Linked to Heart Disease
ScienceDaily (Jan. 24, 2012) — Eating food fried in olive or sunflower oil is not linked to heart disease or premature death, finds a paper published in the British Medical Journal online (bmj.com).-The authors stress, however, that their study took place in Spain, a Mediterranean country where olive or sunflower oil is used for frying and their results would probably not be the same in another country where solid and re-used oils were used for frying.--In Western countries, frying is one of the most common methods of cooking. When food is fried it becomes more calorific because the food absorbs the fat of the oils.[U1]--While eating lots of fried food can increase some heart disease risk factors such as high blood pressure, high cholesterol and obesity, a link between fried food and heart disease has not been fully investigated.---So the authors, led by Professor Pilar Guallar-Castillón from Autonomous University of Madrid, surveyed the cooking methods of 40,757 adults aged 29 to 69 over an 11-year period. None of the participants had heart disease when the study began. Trained interviewers asked participants about their diet and cooking methods. Fried food was defined as food for which frying was the only cooking method used. Questions were also asked about whether food was fried, battered, crumbed or sautéed.--The participants' diet was divided into ranges of fried food consumption, the first quartile related to the lowest amount of fried food consumed and the fourth indicated the highest amount.--During the follow-up there were 606 events linked to heart disease and 1,134 deaths.---The authors conclude: "In a Mediterranean country where olive and sunflower oils are the most commonly used fats for frying, and where large amounts of fried foods are consumed both at and away from home, no association was observed between fried food consumption and the risk of coronary heart disease or death."--In an accompanying editorial, Professor Michael Leitzmann from the University of Regensburg in Germany, says the study explodes the myth that "frying food is generally bad for the heart" but stresses that this "does not mean that frequent meals of fish and chips will have no health consequences." He adds that specific aspects of frying food are relevant, such as the type of oil used.---Story Source- The above story is reprinted from materials provided by BMJ-British Medical Journal. Journal References-P. Guallar-Castillon, F. Rodriguez-Artalejo, E. Lopez-Garcia, L. M. Leon-Munoz, P. Amiano, E. Ardanaz, L. Arriola, A. Barricarte, G. Buckland, M.-D. Chirlaque, M. Dorronsoro, J.-M. Huerta, N. Larranaga, P. Marin, C. Martinez, E. Molina, C. Navarro, J. R. Quiros, L. Rodriguez, M. J. Sanchez, C. A. Gonzalez, C. Moreno-Iribas. Consumption of fried foods and risk of coronary heart disease: Spanish cohort of the European Prospective Investigation into Cancer and Nutrition study. BMJ, 2012; 344 (jan23 3): e363 DOI: 10.1136/bmj.e363---M. F. Leitzmann, T. Kurth. Fried foods and the risk of coronary heart disease. BMJ, 2012; 344 (jan23 3): d8274 DOI: 10.1136/bmj.d8274
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Stronger Intestinal Barrier May Prevent Cancer in the Rest of the Body
ScienceDaily (Feb. 21, 2012) — A leaky gut may be the root of some cancers forming in the rest of the body, a new study published online Feb. 21 in PLoS ONE by Thomas Jefferson University researchers suggests.---It appears that the hormone receptor guanylyl cyclase C (GC-C) -- a previously identified tumor suppressor that exists in the intestinal tract -- plays a key role in strengthening the body's intestinal barrier, which helps separate the gut world from the rest of the body, and possibly keeps cancer at bay. Without the receptor, that barrier weakens.---A team led by Scott Waldman, M.D., Ph.D., chair of the Department of Pharmacology and Experimental Therapeutics at Jefferson and director of the Gastrointestinal Cancer Program at Jefferson's Kimmel Cancer Center, discovered in a pre-clinical study that silencing GC-C in mice compromised the integrity of the intestinal barrier. It allowed inflammation to occur and cancer-causing agents to seep out into the body, damaging DNA and forming cancer outside the intestine, including in the liver, lung and lymph nodes.---Conversely, stimulating GC-C in intestines in mice strengthened the intestinal barrier opposing these pathological changes.---A weakened intestinal barrier has been linked to many diseases, like inflammatory bowel disease, asthma and food allergies, but this study provides fresh evidence that GC-C plays a role in the integrity of the intestine. Strengthening it, the team says, could potentially protect people against inflammation and cancer in the rest of the body.--"If the intestinal barrier breaks down, it becomes a portal for stuff in the outside world to leak into the inside world," said Dr. Waldman. "When these worlds collide, it can cause many diseases, like inflammation and cancer."--The role of GC-C outside the gut has remained largely elusive. Dr. Waldman and his team have previously shown its role as a tumor suppressor and biomarker that reveals occult metastases in lymph nodes. They've used to it better predict cancer risk, and have even shown a possible correlation with obesity.---Reporting in the Journal of Clinical Investigation, Dr. Waldman colleagues found that silencing GC-C affected appetite in mice, disrupting satiation and inducing obesity. Conversely, mice who expressed the hormone receptor knew when to call it quits at mealtime.--However, its role in intestinal barrier integrity, inflammation, and cancer outside the intestine is new territory in the field. A new drug containing GC-C is now on the verge of hitting the market, but its intended prescribed purpose is to treat constipation.--This study helps lays the groundwork, Dr. Waldman said, for future pre-clinical and clinical studies investigating GC-C's abilities beyond those treatments in humans, including prevention and treatment of inflammatory bowel disease and cancer."We've shown that when you pull away GC-C in animals, you disrupt the intestinal barrier, putting them at risk for getting inflammatory bowel disease and cancer. And when you treat them with hormones that activate GC-C it helps strengthen the integrity of the intestinal barrier," Dr. Waldman said. "Now, if you want to prevent inflammation or cancer in humans, then we need to start thinking about feeding people hormones that activate GC-C to tighten up the barrier."--Story Source--The above story is reprinted from materials provided by Thomas Jefferson University, via Newswise. ---Journal References---Jieru Egeria Lin, Adam Eugene Snook, Peng Li, Brian Arthur Stoecker, Gilbert Won Kim, Michael Sullivan Magee, Alex Vladimir Mejia Garcia, Michael Anthony Valentino, Terry Hyslop, Stephanie Schulz, Scott Arthur Waldman. GUCY2C Opposes Systemic Genotoxic Tumorigenesis by Regulating AKT-Dependent Intestinal Barrier Integrity. PLoS ONE, 2012; 7 (2): e31686 DOI: 10.1371/journal.pone.0031686--Michael A. Valentino, Jieru E. Lin, Adam E. Snook, Peng Li, Gilbert W. Kim, Glen Marszalowicz, Michael S. Magee, Terry Hyslop, Stephanie Schulz, Scott A. Waldman. A uroguanylin-GUCY2C endocrine axis regulates feeding in mice. Journal of Clinical Investigation, 2011; 121 (9): 3578 DOI: 10.1172/JCI57925
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Boosting Longevity With Good Bacteria
ScienceDaily (Jan. 22, 2012) — A diet supplemented with a specific probiotic bacterial strain increases the lifespan of mice.---The mammalian gut is home to hundreds of bacterial species that contribute to food digestion and, in some cases, inflammatory gut diseases. Probiotics, beneficial bacterial species, can enhance gut health by keeping the resident bacteria in check. Now, a team of researchers at the RIKEN Innovation Center in Wako, including Mitsuharu Matsumoto, report that administration of the probiotic bacterial strain Bifidobacterium animalis subspecies lactis LKM512 to mice can lengthen their lifespan. Matsumoto and colleagues previously showed that LKM512 could reduce inflammatory markers in elderly humans and modify the makeup of intestinal bacteria2, but the effects of it on lifespan still required investigation. After starting 10-month-old mice on a diet including LKM512 for 11 months, the researchers found that LKM512-treated mice lived longer, had fewer skin lesions, and had better hair quality than untreated mice. Analyses of the gut of these mice revealed elevated gene expression in some bacterial species compared with control mice, indicating that LKM512 may improve gut health indirectly by regulating the levels of other bacterial species. The LKM512 treatment also prevented some age-related changes in bacterial composition of the gut, suggesting that the probiotic treatment protects the gut from developing characteristics associated with aging.---Acting as a barrier between the bacteria and food within the gut and the rest of the human body is an important role of the gut lining. Breakdown of this lining can cause infectious or inflammatory diseases. The researchers found that the gut of LKM512-treated mice served as a stronger barrier than the gut of control mice. LKM512 seemed to perform this function by increasing the expression of various proteins that maintain the tight connection between gut epithelial cells.-Polyamines are chemicals that reduce inflammation, and their levels decrease as an individual ages. Matsumoto and colleagues observed increases in intestinal polyamine levels in LKM512-treated mice, which may be caused by the greater numbers of bacteria promoted by LKM512. The increase in polyamines caused by LKM512 appeared to reduce inflammation in the body of the mice, as inflammatory markers in the blood and urine were lower in LKM512-treated mice compared with controls. In aged mice treated with LKM512, inflammatory marker levels were similar to those observed in younger mice, indicating that adults can benefit from probiotics.---"In future work, we hope to clarify the effectiveness of LKM512 in humans," explains Matsumoto. If the findings extend to humans, inclusion of LKM512 into the human diet could enhance overall health and increase the human lifespan.---Story Source-The above story is reprinted from materials provided by RIKEN, via ResearchSEA.
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The effect of hydro alcoholic Nettle (Urtica dioica) extracts on insulin sensitivity and some inflammatory indicators in patients with type 2 diabetes-
Pak J Biol Sci. 2011 Aug 1;14(15):775-9-Authors: Namazi N, Esfanjani AT, Heshmati J, Bahrami A
Abstract
Type 2 diabetes is a metabolic disorder that is strongly associated with cardiovascular risk. Inflammation is a potential risk factor for cardiovascular disease. In this study, hydro alcoholic extract of Nettle (Urtica dioica) on insulin sensitivity and some inflammatory indicators in type 2 diabetic patients were studied. A randomized double-blind clinical trial on 50 men and women with type 2 diabetes was done for 8 weeks. Patients were adjusted by age, sex and duration of diabetes, then randomly divided into two groups, an intervention and control group. They received, 100 mg kg-1nettle extract or placebo in three portions a day for 8 weeks[U2]. Interleukin 6 (IL-6), Tumor Necrosis Factor-alpha (TNF-alpha), High Sensitive C-Reactive protein (hs-CRP) and Fasting Insulin concentration were measured. Insulin Sensitivity was calculated, at the beginning and the end of the study. The data were analyzed by SPSS version 18, p<0.05 was considered significant for all variables. After 8 weeks, IL-6 and hs-CRP showed a significant decrease in the intervention group compared to the control group (p<0.05). The findings showed that the hydro alcoholic extract of nettle has decreasing effects on IL-6 and hs-CRP in patients with type 2 diabetes after eight weeks intervention.--PMID: 22303583 [PubMed - indexed for MEDLINE]How to prepare this—take equal parts of either wine or vodka-or tequila or grappa Add to the slow cooker-then add equal portion of distilled water or RO water-NEVER TAP WATER—allow it to simmer for 3 days—strain it and bottle it and use it accordingly—measure off your body weight and go from there as it is stated in the comments—take your weight divide by 2.2 and then mutiply by 100mg this will give dosing for your body weight so in the case of a 180 lb person—they would go 180/2.2-=== 81 kgs then multiply by 100 and you get 8100 mgs or 8.1 grams which a teaspoon holds 5 grams so you would either do a tsp and a half+ or do more dosing qith just the one teaspoon—say you take one dose several times in his case 1. ½ + 3 times a day orr 1 tsp 5 times a day—so approximate on how you want to utilize this—
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What are you to do if you have a heart attack While you are alone.
The Johnson City Medical Center staff actually Discovered this and did an in-depth study On it in our ICU. The two individuals that discovered this then did An article on it, had it published and have had it incorporated into ACLS and CPR classes. It is very true and has and does work. It is called cough CPR. A cardiologist says it's the truth If everyone who gets this sends it to 10 people,
You can bet that we'll save at least one life. It could save your life Let's say it's 6:15 p.m. And you're driving home (alone of course), after an usually hard day on the job. You're really tired, upset and frustrated. Suddenly you start experiencing severe pain In your chest that starts to radiate out Into your arm and up into your jaw. You are only about five miles from the hospital Nearest your home. Unfortunately you don't know if you'll be Able to make it that far. What can you do? You've been trained in CPR But the guy that taught the course didn't tell You what to do if it happened to yourself Since many people are alone when they suffer a heart attack, this article seemed to be in order. Without help, the person whose heart is beating improperly and who begins to feel faint, Has only about 10 seconds left before losing consciousness. However, these victims can help themselves by coughing repeatedly and very vigorously. A deep breath should be taken before each Cough, and the cough must be deep And prolonged, as when producing sputum From deep inside the chest. A breath and a cough must be repeated About every two seconds without let up Until help arrives, or until the heart is felt to be beating normally again. Deep breaths get oxygen into the lungs and coughing movements squeeze the heart and Keep the blood circulating. The squeezing pressure on the heart also helps it regain normal rhythm. In this way, heart attack victims can get to a hospital. Tell as many other people as possible about this, it could save their lives! From Health Cares, Rochester General Hospital via Chapter 240s newsletter 'AND THE BEAT GOES ON ' (reprint from The Mended Hearts, Inc. Publication, Heart Response
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[U1]The question here is if this is not affecting the meditereanens then it is the type of foods perhaps they are frying and perhaps these foods are not genetically tampered with—this to would make the difference in the impact of the foods and oils used
[U2]Take your body weight and divide by 2.2 and then multiply this by 100mgs to get the total of grams used—180lb person/2.2=81 kgs the Multiply by 100 and you would need approximately 8100mgs or 8.1 grams—approximately 1 tsp and and just slightly more then half
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Show of the Week March 12 2012
Pfizer snaps up Emergen-C vitamin C makerResearchers Test Sugary Solution to Alzheimer's Disease
Stopping Hormone Therapy Might Help Breast Cancer to Regress
Potential 'Safe Period' For Hormone Replacement Use Identified
Long-Term Estrogen Therapy Linked To Breast Cancer Risk
Estrogen Therapy May Be Associated With Kidney Stones in Postmenopausal Women
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Pfizer snaps up Emergen-C vitamin C maker28-Feb-2012Drug giant Pfizer Inc. has added Alacer Corp., maker and distributorof Emergen-C products, to its Consumer Healthcare division.[U1]Financial terms of thetransaction were not disclosed, but Alacer says it produces almost 500 million packets ofEmergen-C annually, with products sold in health food stores, supermarkets,drug stores, mass merchandisers and club stores nationwide. [U2]We are verypleased that the Emergen-C family of products will become part of Pfizer’s portfolio said PaulSturman, President of Pfizer Consumer Healthcare. We expect that our global network anddeep expertise in dietary supplements combined with our desire to provide consumers withhigh-quality products will make Emergen-C more accessible than it has ever been beforeEmergen-C products add to and greatly complement our market-leading dietary supplementportfolio--Market Sales of vitamin C supplements – the biggest single category in the vitaminsand minerals market - were up 2.8% to $221.27m in the year to October 1 across conventionaland natural channels combined---While vitamin C sales were down 2.4% in the natural channel(natural supermarkets excluding Whole Foods) to $31.43m, they were up 3.7% in theconventional channel (FDMx) to $189.85m. In January, Pfizer CEO Ian Read told attendeesat the JP Morgan Healthcare Conference in San Francisco that the company was still planning tooffload its $1.87bn nutrition division, with Nestlé, Danone, Abbott Laboratories and Heinz still inthe running. Last year, Pfizer agreed to sell hard-capsule manufacturer Capsugel for $2.375 billionin cash to an affiliate of Kohlberg Kravis Roberts & Co L.P. (KKR). A spokesperson for Pfizertold NutraIngredients-USA.com: "The acquisition of Alacer Corp., will fall within Pfizer’s ConsumerHealthcare business. As such, this doesn’t impact the evaluation of strategic options for our Nutritionbusiness. "We have said that we would continue to pursue bolt-on business development activitiesthat support our strategies. For example, in December 2011, we acquired Ferrosan’s consumer healthcarebusiness, which strengthens our presence in dietary supplements as well as expand our footprint --Unique opportunity Ron Fugate, President and CEO of Alacer said that being acquired by Pfizer marked“the beginning of an exciting new chapter for Alacer and the Emergen-C health and wellness brand.By becoming part of Pfizer, we can access the resources and reach that will help us support healthy,active lifestyles across the globe.”[U3]
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Researchers Test Sugary Solution to Alzheimer's Disease
ScienceDaily (Feb. 28, 2012) — Slowing or preventing the development of Alzheimer's disease, a fatal brain condition expected to hit one in 85 people globally by 2050, may be as simple as ensuring a brain protein's sugar levels are maintained.--That's the conclusion seven researchers, including David Vocadlo, a Simon Fraser University chemistry professor and Canada Research Chair in Chemical Glycobiology, make in the latest issue of Nature Chemical Biology.-The journal has published the researchers' latest paper "Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation."Vocadlo and his colleagues describe how they've used an inhibitor they've chemically created -- Thiamet-G -- to stop O-GlcNAcase, a naturally occurring enzyme, from depleting the protein Tau of sugar molecules.-"The general thinking in science," says Vocadlo, "is that Tau stabilizes structures in the brain called microtubules. They are kind of like highways inside cells that allow cells to move things around."---Previous research has shown that the linkage of these sugar molecules to proteins, like Tau, in cells is essential. In fact, says Vocadlo, researchers have tried but failed to rear mice that don't have these sugar molecules attached to proteins.---Vocadlo, an accomplished chess player in his spare time, is having great success checkmating troublesome enzymes with inhibitors he and his students are creating in the SFU chemistry department's Laboratory of Chemical Glycobiology.--Research prior to Vocadlo's has shown that clumps of Tau from an Alzheimer brain have almost none of this sugar attached to them, and O-GlcNAcase is the enzyme that is robbing them.---Such clumping is an early event in the development of Alzheimer's and the number of clumps correlate with the disease's severity.--Scott Yuzwa and Xiaoyang Shan, grad students in Vocadlo's lab, found that Thiamet-G blocks O-GlcNAcase from removing sugars off Tau in mice that drank water with a daily dose of the inhibitor. Yuzwa and Shan are co-first authors on this paper.---The research team found that mice given the inhibitor had fewer clumps of Tau and maintained healthier brains.--"This work shows targeting the enzyme O-GlcNAcase with inhibitors is a new potential approach to treating Alzheimer's," says Vocadlo. "This is vital since to date there are no treatments to slow its progression.--"A lot of effort is needed to tackle this disease and different approaches should be pursued to maximize the chance of successfully fighting it. In the short term, we need to develop better inhibitors of the enzyme and test them in mice. Once we have better inhibitors, they can be clinically tested. Story Source-The above story is reprinted from materials provided by Simon Fraser University. ---Journal Reference-Scott A Yuzwa, Xiaoyang Shan, Matthew S Macauley, Thomas Clark, Yuliya Skorobogatko, Keith Vosseller, David J Vocadlo. Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation. Nature Chemical Biology, 2012; DOI: 10.1038/nchembio.797
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Stopping Hormone Therapy Might Help Breast Cancer to Regress
ScienceDaily (Feb. 28, 2012) — As soon as women quit hormone therapy, their rates of new breast cancer decline, supporting the hypothesis that stopping hormones can lead to tumor regression, according to a report e-published in Cancer Epidemiology, Biomarkers, & Prevention.---As part of the national Breast Cancer Surveillance Consortium, researchers studied 741,681 woman-years of data (with a median of 3.3 years per woman) on 163,490 women aged 50-79 who were Group Health Cooperative members and had no prior history of breast cancer.--"This is the first study to look over time at screening mammography use among individual women by their hormone therapy status linked with their breast cancer diagnoses," said lead author Diana S.M. Buist, PhD, a senior investigator at Group Health Research Institute.--Previous research has shown a rapid decline in new breast cancers -- and also in use of hormone therapy and of screening mammography -- since 2002, when the Women's Health Initiative published that breast cancer rates were higher in women taking estrogen and progestin than in those taking either a placebo or only estrogen.---Some have suggested that the decline in use of hormone therapy may have caused the fall in the breast cancer rate, perhaps by making tumors regress, Dr. Buist explained. But others have countered that the explanation for the declines in both breast cancer and hormone use might instead be that because former hormone users are less concerned about breast cancer or see their doctors less often, they may get less screening mammography than do women who have never taken hormones.--"We set out to test this idea," Dr. Buist said, "and our results seem to refute it." Before 2002, former users of hormone therapy had lower rates of screening mammography than did current users. "But we found that this is no longer true," she said. Indeed, former users had the same or even slightly higher screening rates than current users.---"We concluded that differences in rates of screening mammography don't explain the declines in rates of the incidence of invasive breast cancer among women who've stopped using hormone therapy, Dr. Buist said. The National Cancer Institute, which supports the Breast Cancer Surveillance Consortium, funded this study. The collection of cancer data was also supported in part by several state public health departments and cancer registries throughout the United States.---In addition to Dr. Buist, the other co-authors were Diana L. Miglioretti, PhD, Rod Walker, MS, and Erin J. Aiello Bowles, MPH, of Group Health Research Institute; Walter Clinton, PhD, of Veterans Affairs (VA) Puget Sound Healthcare System; Patricia A. Carney, PhD, of Oregon Health & Science University, in Portland; Stephen H. Taplin, MD, MPH, of the National Cancer Institute; Tracy Onega, PhD, of Dartmouth Medical School, in Lebanon, NH; and Karla Kerlikowske, MD, of the University of California, San Francisco.-Story Source--The above story is reprinted from materials provided by Group Health Research Institute. \Journal Reference-Diana S.M. Buist, Rod Walker, Erin J. Aiello Bowles, Patricia A. Carney, Stephen H. Taplin, Tracy Onega, Karla Kerlikowske, Walter Clinton, and Diana L. Miglioretti. Screening Mammography Use among Current, Former, and Never Hormone Therapy Users May Not Explain Recent Declines in Breast Cancer Incidence. Cancer Epidemiol Biomarkers Prev, February 1, 2012 DOI: 10.1158/1055-9965.EPI-11-1115
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Potential 'Safe Period' For Hormone Replacement Use Identified
ScienceDaily (Feb. 8, 2009) — A new study makes important new findings on the role of hormone use on the risk of breast cancer, confirming that the use of estrogen plus progesterone increases the risk of both ductal and lobular breast cancer far more than estrogen-only; suggesting a two-year "safe" period for the use of estrogen and progesterone; and finding that the increased risk for ductal cancers observed in long-term past users of hormone replacement therapy drops off substantially two years after hormone use is stopped.--Previous studies have shown that hormone replacement therapy after menopause increases the risk of breast cancer and that use of a regimen that includes both estrogen and progesterone is more detrimental for the breast than the use of estrogen alone. But more data from large prospective studies are needed to fully characterize the impact of exogenous hormones (Exogenousor exogeneous) refers to an action or object coming from outside a system. It is the opposite of endogenous, something generated from within the system ) on breast cancer incidence by type of hormone preparation and histology of the cancer.---To investigate the association in more detail, American Cancer Society epidemiologists led by Eugenia E. Calle, PhD, did a prospective study of 68,369 postmenopausal women who were cancer-free at baseline in 1992. They examined the use of estrogen-only and estrogen and progesterone in current and former users of varying duration, and the subsequent risk of developing invasive ductal and lobular carcinoma of the breast. They also looked at whether the risk for each type of breast cancer and each type of hormone regimen varied by body mass index (BMI), stage of disease at diagnosis, and estrogen receptor (ER) and progesterone receptor (PR) status. For the present study, the follow-up period ended on June 30, 2005.---They confirmed the findings from previous work that estrogen and progesterone increases the risk of both ductal and lobular breast cancer far more estrogen alone. They also found the risk associated with use of estrogen and progesterone increases significantly and substantially within three years of beginning hormone use. The data showed no increased risk for women who used estrogen and progesterone for less than two years, potentially identifying a "safe" period for estrogen and progesterone use.---The study also found no increased risk of breast cancer in women who had stopped using estrogen and progesterone two or more years ago, suggesting a window of two to three years for the risks of estrogen and progesterone both to become apparent after initial use and to diminish after cessation. Few estimates of risk within two to three years of initiation and cessation are available, so these findings need replication in other large studies. The study found the use of estrogen and progesterone was associated with a doubling of risk of lobular cancer after three years of use, and a doubling of risk of ductal cancer with 10 years of use. Estrogen-only use was not associated with increased risk of ductal cancer, even after 20 years of use, but was associated with a 50 percent increase in risk of lobular cancer after 10 years of use.---Story Source: The above story is reprinted (with editorial adaptations by ScienceDaily staff) from materials provided by American Cancer Society, via EurekAlert!, a service of AAAS. -- Journal Reference: --Eugenia E. Calle et al. ---Postmenopausal hormone use and breast cancer associations differ by hormone regimen and histologic subtype. Cancer, Published Online: January 20, 2008 DOI: 10.1002/cncr.24101
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Long-Term Estrogen Therapy Linked To Breast Cancer Risk
ScienceDaily (May 9, 2006) — Long-term estrogen therapy may be related to a higher risk of breast cancer among postmenopausal women who have had a hysterectomy, according to an article in the May 8 issue of Archives of Internal Medicine, one of the JAMA/Archives journals. ---Previous studies have linked the use of hormone therapy to breast cancer among postmenopausal women, but have primarily focused on the hormone combination of estrogen plus progestin, according to background information in the article. Recently released results from the Women's Health Initiative (WHI), a large clinical trial of hormone therapy, found no significant link between estrogen therapy and breast cancer in women who took the hormone for seven years. ---Wendy Y. Chen, M.D., M.P.H., Brigham and Women's Hospital and Dana Farber Cancer Institute, Boston, and colleagues evaluated women who were part of the Nurses' Health Study, a group of female nurses that have been followed since 1976. In 1980, 11,508 women from the study were postmenopausal and had had a hysterectomy. Every two years the researchers enrolled all the additional women who become postmenopausal and had a hysterectomy, so 28,835 women were included by the end of the study in 2002. Women were asked by questionnaire every two years if they used hormones and whether they had developed breast cancer. For women who developed breast cancer, the researchers obtained permission to review the women's medical records, which they used to record the hormone receptor information. Tumors were classified as positive or negative for estrogen receptor or progesterone receptor based on how they responded to specific hormonal therapies. ---Throughout the study period, 934 invasive breast cancers developed, 226 among women who had never used hormones and 708 among women who were using estrogen at the time. The longer a woman used estrogen, the higher her risk of breast cancer. Those who had been taking estrogen for fewer than 10 years did not appear to have a higher risk than those who had never taken hormones, but those who had been taking estrogen for more than 20 years had a significantly increased risk. The association was strongest for cancers that were estrogen receptor positive and progesterone receptor positive. The results were similar when the researchers evaluated only women who were older than age 60; only women who had begun estrogen therapy after reaching age 50; and only women who were at least age 50 and had undergone a hysterectomy, even if they had not gone through menopause. ---"In conclusion, we found that estrogen therapy was associated with an increased risk of breast cancer with longer-term use," the authors write. "Although current use of estrogen therapy for less than 10 years was not associated with a statistically significant increase in breast cancer risk, the WHI has shown an increased risk of stroke and deep-vein thrombosis in the same time period. Women who take estrogen therapy for prevention or treatment of osteoporosis typically require longer-term treatment and should thus explore other options, given the increased risk of breast cancer with longer-term use."---(Arch Intern Med. 2006; 166: 1027-1032. Available pre-embargo to media at www.jamamedia.org.) --Editor's Note: This study was supported by a grant from the National Institutes of Health, Bethesda, Md. ---Story Source: The above story is reprinted (with editorial adaptations by ScienceDaily staff) from materials provided by JAMA and Archives Journals, via EurekAlert!, a service of AAAS ---
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Estrogen Therapy May Be Associated With Kidney Stones in Postmenopausal Women
ScienceDaily (Oct. 12, 2010) — Use of estrogen therapy is associated with an increased risk of developing kidney stones in postmenopausal women, according to a report in the October 11 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.-- "Nephrolithiasis [kidney stones] is a common condition that affects 5 percent to 7 percent of postmenopausal women in the United States," according to background information in the article. "Because the process of kidney stone formation is influenced by a variety of lifestyle and other health-related factors, the true impact of estrogen therapy on the risk of kidney stone formation is difficult to infer from observational studies." -- Using data from the national Women's Health Initiative study, Naim M. Maalouf, M.D., of the University of Texas Southwestern Medical Center, Dallas, examined data from two trials: 10,739 postmenopausal women with hysterectomy who received either an estrogen-only treatment or matching placebo and 16,608 postmenopausal women without hysterectomy who received either an estrogen plus progestin treatment or matching placebo. Data were collected for an average of 7.1 years in the estrogen-only trial and 5.6 years for the estrogen plus progestin trial. -- A total of 335 cases of kidney stones were reported in the active treatment groups, while 284 cases occurred in the placebo groups. The beginning demographic characteristics and risk factors for kidney stones were similar in the two groups, and the authors found that estrogen therapy was associated with a significant increase in risk of kidney stones. The corresponding annualized incidence rate per 10,000 women per year was 39 in the treatment group and 34 in the placebo group. Development of kidney stones was five times more common in women with a history of kidney stones at the beginning of the study, but was not significantly altered by estrogen therapy. In this trial, estrogen therapy increased the risk of development of kidney stones irrespective of age, ethnicity, body mass index, prior hormone therapy use or use of coffee or thiazide diuretics.The authors conclude that their results "indicate that estrogen therapy increases the risk of nephrolithiasis in healthy postmenopausal women. The mechanisms underlying this higher propensity remain to be determined. In view of the sizable prevalence of nephrolithiasis in this segment of the population, these findings need to be considered in the decision-making process regarding postmenopausal estrogen use."---Story Source:--The above story is reprinted (with editorial adaptations by ScienceDaily staff) from materials provided by JAMA and Archives Journals.--Journal Reference: N. M. Maalouf, A. H. Sato, B. J. Welch, B. V. Howard, B. B. Cochrane, K. Sakhaee, J. A. Robbins. Postmenopausal Hormone Use and the Risk of Nephrolithiasis: Results From the Women's Health Initiative Hormone Therapy Trials. Archives of Internal Medicine, 2010; 170 (18): 1678 DOI: 10.1001/archinternmed.2010.342
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[U1]I can almost bet there will be dilutions and contaminants in the product as of take over
[U2]Imagine the amount of people getting the NEW and Improved Pfizer C
[U3]What is happening is that the pharmaceuticals are going to take over the Nutraceutical brands—and with all the deregulating and re regulating going on the entrepreneur who does have a viable supplement will eventually be either litigated out or squeezed out---the fact they actually paid this much out to acquire this companies portfolio is the way it starts and eventually the FDA –DEA- Codex-EFSA will exterminate the ones that have something viable that works well with health conditions
T
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Show of the Week March 16 2012
Activation of the nuclear receptor PPARγ by metabolites isolated from sage (Salvia officinalis L.).—for Diabetes
Flavonol kaempferol improves chronic hyperglycemia-impaired pancreatic beta-cell viability and insulin secretory function.----Health Benefits of Kaempferol
Remedies for Respiratory-Heart-Sugar Issues
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Ingredients---Psorlea-Dodder-Juniper berry-Nettle-Muira Purma-Celery Seed
Tribulus-Shilajit- Deer Antler-- put all in at equal parts---Designed to increase T levels—Stimulate the ebb and flow—regulate the insulin-regulate the kidneys-increase blood vessel flexibility—Use By either one of 2 steps---Step 1 blend all contents to a powder and then apply 1 tablespoon to a 2 cup pot of water ( preferably distilled or reverse osmosis ) and bring to a boil ---when done pour into a cup and drink at least 3 servings a day and about 30 minutes before intercource---can be added with the T Up—Step 2 shake bag contents til there is a total mix---a and add to a 2 cup pot 1-2 tablespoons and bring to boil when that is done then allow the stove to be off and allow it to simmer for 5 minutes then drink
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Activation of the nuclear receptor PPARγ by metabolites isolated from sage (Salvia officinalis L.).—for Diabetes
Christensen KB, Jørgensen M, Kotowska D, Petersen RK, Kristiansen K, Christensen LP.
Source --Institute of Chemical Engineering, Biotechnology and Environmental Technology, University of Southern Denmark, Niels Bohrs Allé 1, DK-5230 Odense M, Denmark. kbch@kbm.sdu.dk
Abstract-ETHNOPHARMACOLOGICAL RELEVANCE:
Salvia officinalis has been used as a traditional remedy against diabetes in many countries and its glucose-lowering effects have been demonstrated in animal studies. The active compounds and their possible mode of action are still unknown although it has been suggested that diterpenes may be responsible for the anti-diabetic effect of Salvia officinalis.
AIM OF THE STUDY--To investigate whether the reported anti-diabetic effects of Salvia officinalis are related to activation of the nuclear receptor peroxisome proliferator-activated receptor (PPAR)γ and to identify the bioactive constituents.
MATERIALS AND METHODS:
From a dichloromethane extract of Salvia officinalis able to activate PPARγ several major metabolites were isolated by chromatographic techniques. To assess bioactivity of the isolated metabolites a PPARγ transactivation assay was used.
RESULTS:
Eight diterpenes were isolated and identified including a new abietane diterpene being the epirosmanol ester of 12-O-methyl carnosic acid and 20-hydroxyferruginol, which was isolated from Salvia officinalis for the first time, as well as viridiflorol, oleanolic acid, and α-linolenic acid. 12-O-methyl carnosic acid and α-linolenic acid were able to significantly activate PPARγ whereas the remaining metabolites were either unable to activate PPARγ or yielded insignificant activation.
CONCLUSIONS:
Selected metabolites from Salvia officinalis were able to activate PPARγ and hence, the anti-diabetic activity of this plant could in part be mediated through this nuclear receptor
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Flavonol kaempferol improves chronic hyperglycemia-impaired pancreatic beta-cell viability and insulin secretory function.
Source--Faculty of Life Science, Northwestern Polytechnical University, Xi'an, 710072, China.
Considerable evidence shows that chronic hyperglycemia can cause pancreatic beta-cell dysfunction, which contributes to progressive deterioration of glucose homeostasis and overt diabetes. In the present study, we found that kaempferol, a flavonol compound present in various Chinese medicinal herbs, has cytoprotective effects on cultured clonal beta-cells and pancreatic human islets. Kaempferol treatment dose-dependently promoted viability, inhibited cellular apoptosis, and reduced caspase-3 activity in beta-cells and human islets exposed to chronic high glucose, with 10 μM kaempferol exerting the maximum effect. In addition, kaempferol treatment improved the expression of anti-apoptotic proteins Akt and Bcl-2 that was significantly reduced in beta-cells and human islets chronically exposed to hyperglycemia. Furthermore, exposure of beta-cells and human islets to kaempferol restored high glucose-attenuated intracellular cAMP and ATP production. Inhibition of protein kinase A or Akt activation ablated the anti-apoptotic effect of kaempferol. These cytoprotective effects of kaempferol were associated with improved insulin secretory function and synthesis in beta-cells and human islets. These findings provide evidence that kaempferol may be a naturally occurring anti-diabetic compound by protecting pancreatic beta-cell survival and function in a hostile environment that would otherwise lead to type 2 diabetes.----- Tea (black) (dry leaf)-126.96--- Tea (green) (dry leaf)
Health Benefits of Kaempferol---Keampferol is a strong antioxidant and helps to prevent oxidative damage of our cells, lipids and DNA. Kaempferol seems to prevent arteriosclerosis by inhibiting the oxidation of low density lipoprotein and the formation of platelets in the blood. Studies have also confirmed that kaempferol acts as a chemopreventive agent, which means that it inhibits the formation of cancer cells.
An in vitro study by Jan Kowalski et al (Pharmacological Reports, 2005) showed that kaempferol inhibits monocyte chemoattractant protein (MCP-1). MCP-1 plays a role in the initial steps of atherosclerotic plaque formation.
The flavonoids kaempferol and quercetin seems to act synergistically in reducing cell proliferation of cancer cells, meaning that the combined treatments with quercetin and kaempferol are more effective than the additive effects of each flavonoid. This was a conclusion from a study by ML Ackland et al (In Vivo, Feb 2005) titled "Synergistic antiproliferative action of the flavonols quercitin and kaempferol in cultured human cancer cell lines"".
A study "Inhibition of P-glycoprotein function and expression by kaempferol and quercetin" by the Chiang Mai University, Thailand, found that kaempferol can help to fight cancer because it reduces the resistance of cancer cells to anti-cancer drugs such as vinbalstine and paclitaxel.Synonyms--Campherol, indigo yellow, nimbecetin, 3,4',5,7-Tetrahydroxyflavone
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Remedies for Respiratory-Heart-Sugar Issues
Garlic-Sage- Bioflavonoid-Honey—Take 3-4 bulbs of garlic and 1 tablespoon of powdered Sage-8-9 pieces of the Bioflavonoids from citrus-add to 1-1/12 cup of unpasteurized honey---blend all the ingredients til there is a total fusion or the honey liquifies all the components---use 1 tsp as needed---this will clearly remove toxic waste and particulates that may occur in the system from respiratory to liver—this will dramatically reduce Sugar and sustain heart balance and flow---will increase permeability of the blood vessels—this will regulate the insulin as well from the sage and garlic will have strong antibacterial-antifungal properties-and potent antioxidant properties—
Would be used for Respiratory-issues –Congestions and Cloggy lungs—Heart and Circulation-Permeability and Flow-Anti Plaque and Fat build up in arteries and liver-Immune Support to resist Bacteria and Fungal infections-Chelating elements and Pollutants out of the system
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Hawthorn Berry – Rose-Honey- Take ½ cup of Roses and Hawthorn berry and ½ cup of Unpasteurized Honey—add the Honey and get it going whipping it for about 5 minutes then add the other 2 ingredients slowly and pause in the loading-allowing the blender to fuse the honey and the components—then add more –repeat this til you completely empty your content---allow this to blend for about 15-20 minutes optimum speed or high speed---this will heat and completely saturate—when done stop blender—add to glass container---
Use 1 tablespoon several times a day as a means to balance out heart irregularities
Consuming rose and Hawthorn berry this will stabilize heart and allow for a steady heart rate---in conjunction to this you may want to utilize Taurine 500 mgs 2-3 times a day Magnesium Citrate 100-200 mgs 2-3 times a day
And utilizing a good Vitamin E supplement 200-400 IU’s 2 times a day
Consume adequate Salt and potassium as well to stabilize heart functions—
At the same time ALL PROCESS SUGARS ARE TO CEASE—NO EXCEPTIONS—NO SYNTHETIC SWEETNERS—NO EXCEPTIONS-NO SOY BASED FOODS UNDER ANY CIRCUMSTANCE SINCE THIS LEACES OUT MAGNESIUM AS WELL AS VITAMIN E-NO EXCEPTIONS-ALL GRAINS AND CEREALS ARE TO CEASE-NO EXCEPTIONS
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Show of the Week March 19 2012
Identification of antiplatelet and acetylcholinesterase inhibitory constituents in betel nut
Antioxidants from black tea may aid diabetics--- Recipe For Sugar Regulating
Garlic (Allium sativum) supplementation with standard antidiabetic agent provides better diabetic control in type 2 diabetes patients
Exercise and Caffeine Change Your DNA in the Same Way
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Identification of antiplatelet and acetylcholinesterase inhibitory constituents in betel nut.
Zhong Xi Yi Jie He Xue Bao. 2011 Jun;9(6):619-25---Authors: Ghayur MN, Kazim SF, Rasheed H, Khalid A, Jumani MI, Choudhary MI, Gilani AH
OBJECTIVE: To investigate the possible mechanism and the compound(s) responsible for the antiplatelet and acetylcholinesterase (AChE) inhibitory effects of Areca catechu crude extract (Ac.Cr).
METHODS: Aqueous-methanol (70%) was used for extraction of plant material (betel nut). Antiplatelet activity was measured in human platelet-rich plasma by using a Lumi-aggregometer while anti-AChE activity was measured spectrophotometrically in vitro. In an attempt to find the responsible compound(s) in betel nut for antiplatelet and anti-AChE activities, different commercially available betel nut compounds were tested.
RESULTS: Ac.Cr inhibited platelet aggregation induced by arachidonic acid (AA), adenosine diphosphate (ADP), platelet-activating factor (PAF), epinephrine and Ca(2+)-ionophore. Ac.Cr was the most potent in inhibiting ADP- and Ca(2+)-ionophore-induced aggregation. In the AChE assay, Ac.Cr showed significant AChE inhibitory activity with almost complete inhibition of the enzyme. Out of the tested compounds, none of the compounds in betel nut showed any antiplatelet effect except for catechin that was the most potent against epinephrine-induced aggregation. Catechin was significantly less potent than Ac.Cr, indicating a presence of additional compound(s) with antiplatelet activity. For the AChE inhibitory effect, only tannic acid, gallic acid, diosgenin and isoguvacine were found to be active, whereby tannic acid was more potent than Ac.Cr.
CONCLUSION: This study shows the possible antiplatelet and AChE inhibitory potential of betel nut while further studies are needed to confirm and identify more compounds in betel nut for these actions.--PMID: 21669165 [PubMed - indexed for MEDLINE]************************************************************************
Phytomedicine. 2010 Sep 10;
Authors: Figueiró M, Ilha J, Pochmann D, Porciúncula LO, Xavier LL, Achaval M, Nunes DS, Elisabetsky E
The goal of acetylcholinesterase inhibitors (AChEIs) used to treat Alzheimer's patients is an improvement in cholinergic transmission. While currently available AChEIs have limited success, a huge impediment to the development of newer ones is access to the relevant brain areas. Promnesic, anti-amnesic and AChEI properties were identified in a standardized ethanol extract from Ptychopetalum olacoides (POEE), a medicinal plant favored by the elderly in Amazon communities. The purpose of this study was to provide conclusive evidence that orally given POEE induces AChE inhibition in brain areas relevant to cognition. Histochemistry experiments confirmed that the anticholinesterase compound(s) present in POEE are orally bioavailable, inducing meaningful AChE inhibition in the hippocampus CA1 (â¼33%) and CA3 (â¼20%), and striatum (â¼17%). Ellman's colorimetric analysis revealed that G1 and G4 AChE isoforms activities were markedly inhibited (66 and 72%, respectively) in hippocampus and frontal cortex (50 and 63%, respectively), while G4 appeared to be selectively inhibited (72%) in the striatum. Western blotting showed that POEE did not induce significant changes in the AChE immunocontent suggesting that its synthesis is not extensively modified. This study provides definitive proof of meaningful anticholinesterase activity compatible with the observed promnesic and anti-amnesic effects of POEE in mice, reaffirming the potential of this extract for treating neurodegenerative conditions where a hypofunctioning cholinergic neurotransmission is prominent. Adequate assessment of the safety and efficacy of this extract and/or its isolated active compound(s) are warranted.---PMID: 20833520 [PubMed - as supplied by publisher]
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Garlic (Allium sativum) supplementation with standard antidiabetic agent provides better diabetic control in type 2 diabetes patients.
Pak J Pharm Sci. 2011 Oct;24(4):565-70--Authors: Ashraf R, Khan RA, Ashraf I
Abstract
Garlic has been used safely since ancient times as both food and medicine in human populations, but studies of its efficacy in the management of diabetes have yielded conflicting results. This study has evaluated the potential hypoglycemic effects of garlic in type 2 diabetic patients. The study was conducted in diagnosed type 2 diabetic patients (n=60) with fasting blood sugar level above 126 mg/dl to evaluate the effects of adding garlic tablets with standard antidiabetic therapy on blood sugar. Patients were divided randomly into 2 groups. Group 1 (n=30) was given tablet Garlic (KWAI) 300 mg thrice daily + Metformin 500 mg twice daily and Group 2 (n=30) was given Placebo+Metformin 500 mg twice daily respectively for 24 weeks. Serum lipids and fasting blood glucose were measured at week 0, 12 and week 24. Group1 showed significant reduction in fasting blood sugar at week 24 with a percentage decrease of (-3.12 percent) (P = <0.005) as compared to group 2 (0.59 percent). At the end of week 24, GR1 group also showed considerable decrease in mean total cholesterol (6.2 mg/dl, -2.82%, P=<0.005), LDL-C (-3 mg/dl, 2.18% P=<0.005), triglycerides (-5.2 mg/dl, 3.12%, P<0.005) while HDL cholesterol was significantly increased (2.36 mg/dl, 6.72%, P<0.005) as compared to GR2 group. Combination of garlic with typical antidiabetic remedy has shown to improve glycemic control in addition to antihyperlipidemic activity. Garlic may be a good addition in the management of patients with diabetes and hyperlipidemia.---PMID: 21959822 [PubMed - indexed for MEDLINE]Recipe---take a garlic extract or supplement and add with it juniper berry and bitter melon---this should in fact increase the efficiency of the organs in regulating insulin—repairing the pancreas—assisting the liver-----this should reduce not only the cholesterol but as well the sugar in the system
You can mix equal parts of an extract or tincture of the juniper 1/3 or 33 % -bitter melon 1/3 or 33%-and garlic 1/3 or 33% in a 1 oz or 2 oz glass container and utilize ¼ tsp 3 times a day either after a meal or before bed
You can as well take the garlic supplement and utilize the tincture of bitter melon and juniper either mixed or separate then use ¼ tsp of each and 1 capsule of garlic
You can take a capsule of each 1--- 3 times a day—even though they used the KWAI product the Kyolic will do well formulas like 108-or 110 will be adequate or even just the plain 100
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Exercise and Caffeine Change Your DNA in the Same Way
You might think that the DNA you inherited is one thing that you absolutely can't do anything about, but in one sense you'd be wrong. Researchers have found that when healthy but inactive men and women exercise for a matter of minutes, it produces a rather immediate change to their DNA. Perhaps even more tantalizing, the study suggests that the caffeine in your morning coffee might also influence muscle in essentially the same way. ---The underlying genetic code in human muscle isn't changed with exercise, but the DNA molecules within those muscles are chemically and structurally altered in very important ways. Those modifications to the DNA at precise locations appear to be early events in the genetic reprogramming of muscle for strength and, ultimately, in the structural and metabolic benefits of exercise.--"Our muscles are really plastic," says Juleen Zierath of Karolinska Institutet in Sweden. "We often say "You are what you eat." Well, muscle adapts to what you do. If you don't use it, you lose it, and this is one of the mechanisms that allows that to happen."---The DNA changes in question are known as epigenetic modifications and involve the gain or loss of chemical marks on DNA over and above the familiar sequence of As, Gs, Ts, and Cs. The new study shows that the DNA within skeletal muscle taken from people after a burst of exercise bears fewer chemical marks (specifically methyl groups) than it did before exercise. Those changes take place in stretches of DNA that are involved in turning "on" genes important for muscles' adaptation to exercise.---When the researchers made muscles contract in lab dishes, they saw a similar loss of DNA methyl groups. Exposure of isolated muscle to caffeine had the same effect.--Zierath explained that caffeine does mimic the muscle contraction that comes with exercise in other ways, too. She doesn't necessarily recommend anyone drink a cup of joe in place of exercise. It's nevertheless tempting to think that athletes who enjoy a coffee with their workout might just be on to something.---Broadly speaking, the findings offer more evidence that our genomes are much more dynamic than they are often given credit for. Epigenetic modifications that turn genes on and back off again can be incredibly flexible events. They allow the DNA in our cells to adjust as the environment shifts.---"Exercise is medicine," Zierath says, and it seems the means to alter our genomes for better health may be only a jog away. And for those who can't exercise, the new findings might point the way to medicines (caffeinated ones, perhaps?) with -Story Source--The above story is reprinted from materials provided by Cell Press, via EurekAlert!, a service of AAAS. --Journal Reference-Romain Barrès, Jie Yan, Brendan Egan, Jonas Thue Treebak, Morten Rasmussen, Tomas Fritz, Kenneth Caidahl, Anna Krook, Donal J. O'Gorman, Juleen R. Zierath. Acute Exercise Remodels Promoter Methylation in Human Skeletal Muscle. Cell Metabolism, 2012; 15 (3): 405 DOI: 10.1016/j.cmet.2012.01.001
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Antioxidants from black tea may aid diabetics
Polysaccharides from black tea may blunt the spike in sugar levels after a meal more than similar compounds from green and oolong tea, and offer potential to manage diabetes, says a new study.
The black tea polysaccharides also exhibited the greatest activity for scavenging free radicals, which are linked to development of diseases such as cancer and rheumatoid arthritis, according to new findings published in the Journal of Food Science. Interest in tea and its constituents has bloomed in recent years, with the greatest focus on the leaf’s polyphenol content. Green tea contains between 30 and 40 per cent of water-extractable polyphenols, while black tea (green tea that has been oxidized by fermentation) contains between 3 and 10 per cent. Oolong tea is semi-fermented tea and is somewhere between green and black tea. The new research looked at the polysaccharide content of green, black and oolong tea, and measured their ability to inhibit the effects of alpha-glucosidase activity. By inhibiting this carbohydrate hydrolyzing enzyme, it is possible to reduce the spike in glucose levels in the blood following a meal (postprandial hyperglycemia). If additional studies support the potential effects of the polysaccharides, it could see the black tea extracts positioned in the diabetic supplements market.
Study details
“Many efforts have been made to search for effective glucose inhibitors from natural materials,” said lead researcher Haixia Chen. “There is a potential for exploitation of black tea polysaccharide in managing diabetes.” Researchers from Tianjin University isolated three polysaccharide-rich fractions from green, black, and oolong tea. The black tea was found to contain lower molecular weight polysaccharides. Green tea had a range from 9.2 to 251.5 KDa, while black tea polysaccharides ranged from 3.8 to 32.7 KDa. When tested for their ability to inhibit alpha-glucosidase, as well as antioxidant activities relating to hydroxyl radicals and DPPH radicals, the black tea polysaccharides were found to produce the best results, said Chen and co-workers. “The differences in antioxidant activities and glycosidase inhibitory properties among the three polysaccharide-rich fractions appeared to be related to differences in monosaccharide composition and molecular weight distribution of the polysaccharide,” wrote the researchers. ----“Physicochemical Properties and Antioxidant Capacity of 3 Polysaccharides from Green Tea, Oolong Tea, and Black Tea”--Authors: H. Chen, Z. Qu, L. Fu, P. Dong, X. Zhang
Recipe For Sugar Regulating---take Black Tea and Sage and make a brew out of them—and drink through out the day to minimize the ravages of sugar---this can assist in the reduction of the medications and increase the restoration of the Pancreas
Orrrr
Use Black Coffee and Sage as well---utilize equal parts of both the sage and the Tea or Coffee
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Show of the Week March 23 2012
Induction of insulin secretion by a component of Urtica dioica leave extract in perifused Islets of Langerhans and its in vivo effects in normal
Inhibition of severe acute respiratory syndrome coronavirus replication in a lethal SARS-CoV BALB
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4.13. Allium Sativum L. and Allium Cepa (Garlic and Onion)
Prophet Mohammad (PBUH) said “although onion and garlic have a bad smell, they are cures for 70 different illnesses that cannot be cured by any other means”. Onion (A. cepa) and garlic (A. sativa) are closely related vegetables that belong to the Allium class of bulb-shaped plants, which also includes chives, leeks, and scallions. Garlic is used for flavoring in cooking and is unique due to its high sulfur content, along with arginine, oligosaccharides, flavonoids, and selenium, all of which might promote health [116]. The association between the consumption of Allium vegetables and the risk for cancer was assessed in several epidemiologic studies, showing the protective effect of garlic and onion on cancer. In China, high consumption of Allium vegetables was associated with lower incidence of gastric cancer [117, 118]. Additional studies in the Netherlands suggested an inverse correlation between the risk of colorectal, breast, and lung cancers and the consumption of onion and garlic [119]. Steinmetz et al. [120] studied the association between garlic consumption and the risk of colon cancer and found that women who consumed high amounts of garlic had a 50 percent lower incidence of distal colon cancer compared with women who consumed less garlic [120]. The risk of breast cancer was also found to be reduced in women consuming greater amounts of fiber garlic and onions [31], as well as that of esophageal and stomach cancers [121]. Similar findings were noted with reference to the risk of prostate cancer [122, 123], pancreatic cancer [33], and other known cancer types [124]. The amount of garlic consumed in the above studies varied from 2 to 20
g daily (The World Health Organization (WHO) guidelines for general health promotion for adults recommend a daily dose of 2 to 5
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The origin of its Latin name, Urtica, means “I burn”, indicative of the stings caused by glandular hairs on the leaves that contain formic acid and histamine, two agents known to cause the stinging and skin irritation after contact. U. dioica leaf has a long history as an herbal remedy and nutritious addition to the diet. Nettle leaves are a rich source of essential amino acids, ascorbic acid, several mineral element, and vitamins, such as iron, provitamin A, and vitamin C [113]. Nettle extracts can be used to treat arthritis, hay fever, kidney problems, pain, and anemia. Nettle extracts possess hypoglycaemic properties and improve glucose tolerance [35]. U. dioica is believed to be antioxidant, immunesuppressive, antirheumatoid, antiulcer, anti-inflammatory, and anticarcinogenic [14]. Indeed, its leaf [114] and roots [115] extracts were effective against prostate cancer proliferation.
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Induction of insulin secretion by a component of Urtica dioica leave extract in perifused Islets of Langerhans and its in vivo effects in normal and streptozotocin diabetic rats.
Farzami B, Ahmadvand D, Vardasbi S, Majin FJ, Khaghani Sh.
Source
Department of Medical Biochemistry, Tehran University of Medical Sciences, P.O. Box 14155-5399, Tehran, Iran. Bfarzamj@neda.net
Abstract
The blood glucose lowering effect of Urtica dioica (Stinging Nettle) as a medicinal plant has been noted in old writings such as those of Avicenna. Recently, there has also been other investigators that indicated the hypoglycemic effect of Urtica dioica. But so far, the mechanism of this effect has not been deduced. In this report, a perifusion system is arranged in which an exact number of Langerhans Islets were exposed to several fractions of extracts of Urtica dioica by TLC. The active ingredient fraction named F(1), caused a marked increase in insulin secretion. A simultaneous assay of glucose showed that the increase in insulin level was associated with a decrease in glucose level. Furthermore, the active component of Urtica dioica was found to increase the insulin content of blood sera in normal and streptozotocin diabetic rats that were injected intraperitoneally (i.p.) with the active ingredient of the extract. The in vivo studies presented in this report show that not only an increase in insulin level of blood sera was observed in rats after 30 min from the initial point of injection but a simultaneous decrease of blood sugar was detected when similar sera was tested for glucose. The increase in insulin level was six times during the 120 min of our determination. The decrease in blood sugar was found to be similar both in the level and time of initiation. On the basis of our findings, we assume that F(1) is the active ingredient of plant leaves extract. The results show that the blood lowering effect of the extract was due to the enhancement of insulin secretion by Langerhance Isletes.
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Inhibition of severe acute respiratory syndrome coronavirus replication in a lethal SARS-CoV BALB/c mouse model by stinging nettle lectin, Urtica dioica agglutinin.
Kumaki Y, Wandersee MK, Smith AJ, Zhou Y, Simmons G, Nelson NM, Bailey KW, Vest ZG, Li JK, Chan PK, Smee DF, Barnard DL.
Source---Institute for Antiviral Research, Department of Animal, Dairy and Veterinary Science, 5600 Old Main Hill, Utah State University, Logan, UT 84322, USA.
Abstract------- Urtica dioica agglutinin (UDA) is a small plant monomeric lectin, 8.7 kDa in size, with an N-acetylglucosamine specificity that inhibits viruses from Nidovirales in vitro. In the current study, we first examined the efficacy of UDA on the replication of different SARS-CoV strains in Vero 76 cells. UDA inhibited virus replication in a dose-dependent manner and reduced virus yields of the Urbani strain by 90% at 1.1 ± 0.4 μg/ml in Vero 76 cells. Then, UDA was tested for efficacy in a lethal SARS-CoV-infected BALB/c mouse model. BALB/c mice were infected with two LD50 (575 PFU) of virus for 4 h before the mice were treated intraperitoneally with UDA at 20, 10, 5 or 0 mg/kg/day for 4 days. Treatment with UDA at 5 mg/kg significantly protected the mice against a lethal infection with mouse-adapted SARS-CoV (p < 0.001), but did not significantly reduce virus lung titers. All virus-infected mice receiving UDA treatments were also significantly protected against weight loss (p < 0.001). UDA also effectively reduced lung pathology scores. At day 6 after virus exposure, all groups of mice receiving UDA had much lower lung weights than did the placebo-treated mice. Thus, our data suggest that UDA treatment of SARS infection in mice leads to a substantial therapeutic effect that protects mice against death and weight loss. Furthermore, the mode of action of UDA in vitro was further investigated using live SARS-CoV Urbani strain virus and retroviral particles pseudotyped with SARS-CoV spike (S). UDA specifically inhibited the replication of live SARS-CoV or SARS-CoV pseudotyped virus when added just before, but not after, adsorption. These data suggested that UDA likely inhibits SARS-CoV infection by targeting early stages of the replication cycle, namely, adsorption or penetration. In addition, we demonstrated that UDA neutralizes the virus infectivity, presumably by binding to the SARS-CoV spike (S) glycoprotein. Finally, the target molecule for the inhibition of virus replication was partially characterized. When UDA was exposed to N-acetylglucosamine and then UDA was added to cells just prior to adsorption, UDA did not inhibit the virus infection. These data support the conclusion that UDA might bind to N-acetylglucosamine-like residues present on the glycosylated envelope glycoproteins, thereby preventing virus attachment to cells.
Recipe for Nettle--Make a tea with this by adding ¼ cup of nettle to a pot of water ( distilled ) bring to a boil and when boiled turn off and pour---you can as well fuse this with other herbs such as black tea –sage or do all 2 to increase the immune and sugar regulating functions as well and will synergize t o increase the potency of the properties of each herb
Ancient Remedial Use of Nettle----Horse Nettle, Bull Nettle. S. E. United States.---The fresh juice of the fruit is concentrated by exposure to currents of air at a low temperature and preserved by the addition of some alcohol. This is the process. adopted by McHoy, Howe Co., of Indianapolis. They prepare it double strength. It is recommended largely in the treatment of epilepsy. Powder of the root has during recent years gained some repute as a remedy in infantile and hysterieal convulsions, but chiefly in epilepsy and paroxysms connected with menstrual derangements. Dose of Pdr. Root 10 grs. to 1 dr.-----The roots, leaves and tops are a positive, stimulating, tonic astringent; a powerful arrester of hemorrhages whether of the nose, lungs, stomach, bowels, uterus or urinary organs. It will also stop hemorrhages when applied locally and relieve painful hemorrhoids. The Fluid Extract when diluted forms a good wash for some eczemas
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Health benefits of Savory
§ Savory leaves and tender shoots contain incredibly high quality chemical compounds that are known to have anti-oxidant, disease preventing and health promoting properties. In addition, dietary fiber in this herb helps reduce LDL or bad cholesterol while increasing HDL or good cholesterol levels.
§ Savory leaves contain many essential volatile oils phenols such as thymol and carvacrol, as well as linalool, camphene, caryophyllene, terpineol, myrcene, and other terpenoids.
§ Thymol, one of the important essential oils, has scientificaly been found to have antiseptic, anti-fungal characteristics.
§ In addition, another phenolic compound, carvacrol in savory inhibits the growth of several bacteria strains like E. coli and Bacillus cereus. Carvacol, therefore, has been used as food additive for its anti-bacterial properties and in addition, it gives pleasant tangy taste and marjoram like smell to the food.
§ Savory herb is an excellent source of minerals and vitamins that are essential for optimum health. Its leaves and tender shoots are one of the richest source of potasium, iron, calcium, magnesium, manganese, zinc and selenium. Potassium in an important component of cell and body fluids that helps controlling heart rate and blood pressure. Manganese is used by the body as a co-factor for the antioxidant enzyme superoxide dismutase. Iron is required for red blood cell formation.
§ The herb is also a rich source of many important vitamins such as B-complex group vitamins, vitamin-A, vitamin-C, niacin, thiamin and pyridoxine.
§ Dry savory provides 1.810 mg of vitamin B-6 or pyridoxine; furnishing about 130% of RDA. Pyridoxine keeps up GABA (soothening neurotransmitter) levels in the brain which has stress buster function.
§ Vitamin C helps body develop resistance against infectious agents and scavenge harmful, pro-inflammatory free radicals.
§ Vitamin A is a fat soluble vitamin and antioxidant that is required maintaining healthy mucus membranes and skin and is also essential for vision. Consumption of natural fruits rich in flavonoids like vitamin A, carotenes helps protect from lung and oral cavity cancers.
Dry savory herb has amazingly high levels of vitamins and minerals. Just 100 g of ground dry herb provides (% of Recommended daily allowance)
120% of dietary fiber,
25% of Niacin,
130% of vitamin B-6 (pyridoxine),
83% of vitamin C,
177% of vitamin A,
474% of iron,
210% of calcium,
94% magnesium,of and
265% of manganese
but no cholesterol.
table below for in depth analysis of nutrients:
Savory (Satureja hortensis), Dry, ground,
Nutrient value per 100 g
(Source: USDA National Nutrient data base)Principle
Nutrient Value
Percentage of RDA
Energy
272 Kcal
13.5%
Carbohydrates
68.73 g
53%
Protein
6.73 g
12%
Total Fat
5.91 g
30%
Cholesterol
0 mg
0%
Dietary Fiber
45.7 g
120%
Vitamins
Niacin
4.080 mg
25.5%
Pyridoxine
1.810 mg
139%
Riboflavin
0.471 mg
36%
Thiamin
0.366 mg
30.5%
Vitamin A
5310 IU
177%
Vitamin C
50 mg
83%
Electrolytes
Sodium
24 mg
1.5%
Potassium
1051 mg
22%
Minerals
Calcium
2132 mg
210 %
Copper
0.847 mg
94%
Iron
37.88 mg
474%
Magnesium
377 mg
94 %
Manganese
6.100 mg
265%
Phosphorus
140 mg
20%
Selenium
4.6 mcg
8%
Zinc
4.30 mg
39%
Medicinal uses
§ Savory herb contains many important essential oils which are found to have anti-bacterial and anti-fungal applications.
§ As in thyme, distilled tepid savory water is used for throat gargling to help relieve sore throat and bronchitis symptoms.
§ The constituents in this herb parts, especially the flowering shoots, has anti-septic, carminative (anti-flatulence), digestive (helps digestion), expectorant (help clear throat), stomachic and anti-rheumatic (relieves joint pain) functions.
§ Attributed Medicinal Properties
While both varieties are used in cooking, Summer Savory has a much longer tradition of medicinal use.It has long been reputed to be a general tonic to the digestive tract and as a powerful antiseptic. Branches of savory were tossed onto fire to create an aromatic disinfectant. Even today, because of its pungent oils, it is commonly used in toothpaste and soaps. Active compounds of the savory leaf include volatile oils (carvacrol, p-cymene, alpha-thujene, alpha-pinene, beta-myrcene, beta-caryophyllene, terpinene, and thymol), and tannic acid. The carvacol and p-cymene content of this herb give it a mild antiseptic effect. The tannin content is responsible for savory’s astringent qualities, making it a popular choice in the relief of diarrhea. The herb has also been used as a gargle for sore throat. As a digestive aid, savory is used in cases of indigestion and flatulence. It is often added as a spice to dishes containing beans for this reason. The most common medicinal use of savory today is in the treatment of gastrointestinal enteritis, the inflammation of the intestinal tract. In some folk cultures, savory has been used to increase libido.****************************************************************************************************************
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Show of the Week March 26 2012
Milk Thistle---
Immunostimulatory effect of Silybum Marianum (milk thistle) extract
Review of clinical trials evaluating safety and efficacy of milk thistle
Milk thistle in liver diseases- past, present, future
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Immunostimulatory effect of Silybum Marianum (milk thistle) extract.
Wilasrusmee C, Kittur S, Shah G, Siddiqui J, Bruch D, Wilasrusmee S, Kittur DS.
Source--Department of Surgery SUNY Upstate Medical University, Syracuse, New York 13210, USA. kitturd@upstate.edu
BACKGROUND--Herbal products are increasingly used for their effects on the immune system. Milk Thistle, a commonly used herbal product is known to inhibit growth of certain tumors, although the mechanism of this effect remains unknown. Previously we have shown that Milk Thistle extracts stimulate neurons in culture. Since other drugs that affect the neuronal; system also affect the immune system, we investigated the effects of Milk Thistle on the immune system.--MATERIAL/METHODS-Standardized Milk Thistle extract was studied in murine lymphocyte proliferation tests using Concanavalin A (ConA) as mitogen for non-specific stimulation and mixed lymphocyte culture (MLC) as allospecific stimulation. Th1 and Th2 cytokine levels in MLC were assayed by two antibody capture ELISA technique. All tests were performed in triplicate and repeated twice.—RESULTS-We found that Milk Thistle is immunostimulatory in vitro. It increased lymphocyte proliferation in both mitogen and MLC assays. These effects of Milk Thistle were associated with an increase in interferon gamma, interleukin (IL)-4 and IL-10 cytokines in the MLC (table). This immunostimulatory effect increased in response to increasing doses of Milk Thistle.---CONCLUSIONS-Our study has uncovered a novel effect of milk thistle on the immune system. This immunostimulatory effect may be of benefit in increasing the immunity to infectious diseases.--PMID-12444368-[PubMed - indexed for MEDLINE]
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Review of clinical trials evaluating safety and efficacy of milk thistle (Silybum marianum [L.] Gaertn.).
Source--Research and Development at Flora Inc, Bethesda, MD 20817, USA. ctamayo2@comcast.net
Abstract--Milk thistle extracts have been used as traditional herbal remedies for almost 2000 years. The extracts are still widely used to protect the liver against toxins and to control chronic liver diseases. Recent experimental and clinical studies suggest that milk thistle extracts also have anticancer, antidiabetic, and cardioprotective effects. This article reviews clinical trials of milk thistle conducted in the past 5 years including pharmacokinetic and toxicity studies, herb-drug interactions, and other safety issues. Several trials have studied the effects of milk thistle for patients with liver diseases, cancer, hepatitis C, HIV, diabetes, and hypercholesterolemia. Promising results have been reported in the protective effect of milk thistle in certain types of cancer, and ongoing trials will provide more evidence about this effect. In addition, new established doses and improvement on the quality and standardization of this herb will provide the much-awaited evidence about the efficacy of milk thistle in the treatment of liver diseases. Milk thistle extracts are known to be safe and well tolerated, and toxic or adverse effects observed in the reviewed clinical trials seem to be minimal. The future of milk thistle research is promising, and high-quality randomized clinical trials on milk thistle versus placebo may be needed to further demonstrate the safety and efficacy of this herb.-PMID-17548793-[PubMed - indexed for MEDLINE]
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The potential of milk thistle (Silybum marianum L.), an Israeli native, as a source of edible sprouts rich in antioxidants.
Vaknin Y, Hadas R, Schafferman D, Murkhovsky L, Bashan N.
Source--Department of Agronomy and Natural Resources, Institute of Plant Sciences, Agricultural Research Organization, Volcani Center, Bet Dagan, Israel. yiftachv@volcani.agri.gov.il
Abstract--The potential of wild plants in Israel as sources of edible sprouts has not been investigated until now. Milk thistle (Silybum marianum L.) is native to the Mediterranean basin and is now widespread throughout the world; its young fleshy stems are traditionally eaten by the local Arab sector in Israel, and its sprouts are rich in antioxidants and have been used as a traditional medicine for diseases of the liver and biliary tract. The active extract of milk thistle, silymarin, is a mixture of flavonolignans and is a strong antioxidant that has been proved to promote liver cell regeneration, to reduce blood cholesterol and to help prevent cancer. The present objective was to investigate the potential of milk thistle as a source of edible sprouts rich in antioxidants. We found that seed germination within 3-4 days was high (96%, except for striated seeds). Exposure to light significantly reduced sprout growth and significantly increased the polyphenol content and antioxidative capacity. The polyphenol content was 30% higher in seeds originating from purple inflorescences than in those from white ones. We thus found milk thistle to be a good candidate source of healthy edible sprouts.
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Milk thistle in liver diseases- past, present, future.
Abenavoli L, Capasso R, Milic N, Capasso F.
Source
Department of Experimental and Clinical Medicine, University Magna Graecia, Catanzaro, Italy. l.abenavoli@unicz.it
Abstract
Silybum marianum or milk thistle (MT) is the most well-researched plant in the treatment of liver disease. The active complex of MT is a lipophilic extract from the seeds of the plant and is composed of three isomer flavonolignans (silybin, silydianin, and silychristin) collectively known as silymarin. Silybin is a component with the greatest degree of biological activity and makes up 50% to 70% of silymarin. Silymarin is found in the entire plant but it is concentrated in the fruit and seeds. Silymarin acts as an antioxidant by reducing free radical production and lipid peroxidation, has antifibrotic activity and may act as a toxin blockade agent by inhibiting binding of toxins to the hepatocyte cell membrane receptors. In animals, silymarin reduces liver injury caused by acetaminophen, carbon tetrachloride, radiation, iron overload, phenylhydrazine, alcohol, cold ischaemia and Amanita phalloides. Silymarin has been used to treat alcoholic liver disease, acute and chronic viral hepatitis and toxin-induced liver diseases.--PMID-20564545-[PubMed - indexed for MEDLINE]
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Recipe for Milk Thistle Usage---Take Milk thistle in seed form make a tea with it and take in conjunction with it 1000 mgs if Vitamin C and 1000mgs of MSM---this will increase the impact of the liver by increasing interferon production as welldetox the liver of harmful chemicals------If you are around solvents then you may want to add Arginine 500 mgs -1000mgs to the mix or even just add it to the milk thistle------If you have liver poisoning then add Alpha Lipoic Acid 100-200 mgs with vitamin C 1000mgs and milk thistle------For Excess Fat in the Liver you may want to increase B5 500-1000mgs and L Carnitine 500-2grams with it and the use of Taurine 500-1000mgs and Bile Salts (as suggested on the bottle)-----For issues in the restoring and regenerating of the liver ---utilizing milk thistle with sage in equal parts in water and drinking---adding things like nettle and dandelion will assist as well in the blood purifying effect as well----Sprouting the seeds –as well and consuming them will assist as well with the antioxidant effect of the herb and may even slow down the effects of aging
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Show of the Week March 30 2012
Metalloestrogens- A New Class Of Cancer-Causing Estrogens
What is Calorie Restriction (CR)?
Protocols for Reducing and Regenerating Colon health—Reduction in Body Mass
H. Pylori Bacteria Linked to Blood Sugar Control in Adult Type II Diabetes
The Truth About Cholesterol and Saturated Fat
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Metalloestrogens- A New Class Of Cancer-Causing Estrogens
Post date:
Sunday, March 18th 2012 at 10:00 am by Sayer Ji
this can be a male testis as well as a female breast having these metals in our endocrine system so the genders should be aware
Metals like aluminum have been linked to breast cancer for some time, but new research is confirming the existence of an entirely new class of cancer-causing estrogens known as "metalloestrogens,"[U1] and which are in thousands of consumer products -- some which are even used in supplements and foods as "nutrients"...----A new study published in journal Cancer Research reveals that dietary cadmium exposure increases the risk of postmenopausal breast cancer, confirming earlier research that a broad range of metals we are now being increasingly exposed to represent an emerging class of “metalloestrogens” with the potential to add to the estrogenic burden of the human breast. [U2]---In a 2006 report published in the Journal of Applied Toxicology, researchers found that the following metals were capable of binding to cellular estrogen receptors and then mimicking the actions of physiological estrogens: “aluminium, antimony, arsenite, barium, cadmium, chromium (Cr(II)), cobalt, copper, lead, mercury, nickel, selenite, tin and vanadate.” [U3]----As we revealed in an earlier exposé on the use of toxic forms of selenium in USDA certified organic infant formula, exposure to sodium selenite (and sodium selenate) is difficult to avoid, as it is the primary source of supplemental selenium in mass market vitamins, foods, beverages, etc. The same is true for inorganic forms of chromium, copper, nickel, tin and and vanadium, which you will find on the labels of many mass market multivitamins. --Another daily source of metalloestrogen exposure for millions of consumers is aluminum-based antiperspirants. Investigations into the link between these personal care products and breast cancer risk came to a head earlier this year in a story we broke, and excerpt from below: --Aluminium salts used as antiperspirants have been incriminated as contributing to breast cancer incidence in Western societies. To date, very little or no epidemiological or experimental data confirm or infirm this hypothesis. We report here that in MCF-10A human mammary epithelial cells, a well-established normal human mammary epithelial cell model, long-term exposure to aluminium chloride (AlCl(3) ) concentrations of 10-300 µm, i.e. up to 100 000-fold lower than those found in antiperspirants, and in the range of those recently measured in the human breast, results in loss of contact inhibition and anchorage-independent growth." [emphasis added]--If a metal can exhibit carcinogenic properties at a concentration 100,000-fold lower than presently used in personal care products, it is critical that there be a paradigm shift in the way toxicological risk assessments are performed. --Presently, the risk assessments depend on animal studies, where the goal is to find out how much of a chemical it takes to acutely kill 50% of an exposed population (LD50). Only then, is an “acceptable level of harm” extrapolated for humans (as if determining an “acceptable level of harm” were an ethically neutral objective). --------------------The problem is that humans are not mice, there are profound synergistic toxicities that are never accounted for when we are exposed to more than one chemical simultaneously,[U4] the LD50 does not indicate what constitutes a chronic/sublethal toxic dose or an acknowledgment that chronic toxic effects do occur at far lower doses, and mostly importantly for the purpose of this article, the concept of increasing toxicity as the concentration decreases is not even considered. ---This, in fact, is what happens in certain types of radiation and petrochemical exposure. Low-dose radiation may be far more carcinogenic than high-dose radiation, which is why "early detection" through x-ray mammography is such a brutally dishonest practice, as it likely causes much more cancer than it is said to prevent. --This is also what happens with certain petrochemicals, e.g. bisphenol A, benzene, pthlatates, which is to say, they may be more toxic at lower concentration than higher ones, due to their hormone-mimicking, blocking and/or intensifying effects, as well as their ability to interact on a molecular level with cell surfaces and structures, which would not be possible were they aggregated in greater volumes or quantities. The entire field of nanotechnology, in fact, suffers from this counterintuitive problem: the smaller the size, the higher the potential toxicity or the greater the unintended, adverse health effects.------The problem of aluminum and similar metallogestrogen exposure, however, is greater than simply reforming manufacturers and consumer products. The military releases at least 500 tons of aluminum chaff annually during training within selected military operating areas in the United States, and only clandestine organizations know how much metal has been released into the environment in the name of "saving the earth" through "geoengineering." Indeed, in what is known as Atmospheric Aerosol Spraying, our environment has increasingly become saturated through with metal pollution. The problem has become so bad that biotech corporations have begun engineering aluminum-resistant plants[U5], since many soils have become too acidified due to metal contamination to adequately sustain plants that produce food.
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What is Calorie Restriction (CR)?
The goal of Calorie Restriction is to achieve a longer and healthier life by
- eating fewer calories
- consuming adequate vitamins, minerals, and other essential nutrients
Extensive scientific research has shown that a CR diet improves the health and extends the lifespan of every species so far tested, including worms, spiders, rodents, dogs, cows and monkeys. We believe that people who adopt a CR diet will see the same results longer life and better health.
Getting Started
Simply eating less may not improve health or extend lifespan - it can lead to malnutrition.
Replace calorie-dense foods with calorie-sparse, nutrient-dense foods
Before worrying about how many calories you're eating, make sure that the foods in your diet provide sufficient nutrition to avoid malnutrition once you begin to restrict them.
- Avoid simple sugars and flours.
Sugars and flours generally contain very little nutrition for their calorie content. They also have high glycemic indices, which means that your body absorbs them quickly, leaving you wanting more a short time later.- Eat both green leafy (salad) and other vegetables.
Vegetables -- both green leafy vegetables and non-leaf vegetables -- contain the highest content of a wide variety of nutrients for their calorie content. By volume (and often by calories), vegetables are the major component of many calorie restricted but not nutrient deficient diets.- Carefully select your protein and fat sources.
Both protein and fat are required macronutrients, but their form can have a significant influence on a person's risk factors for a wide variety of diseases.- Make sure your protein intake is sufficient, but not overly abundant.
Common recommendations for total protein intake range from 0.6 to 0.8 grams per kilogram of body weight, and some recommendations are much higher. This is probably a minimum.---another easier way to figure this out is to take either 60% of body weight or 80 % and multiply it by your weight this will give a close approximation of the amount of protein you should have---an example would be say a 110 lb person minimal amount would be 66grams a day and up to 88gams a day---take the .6 X 110=66--- take .8 X110=88---or multiply the 60% X110 and remove the zero’s---again gives you 66 same with the 80% X 110 = 88—remove the zeros---will give a good approximation- Make sure your proteins are complete and balanced.
A complete protein contains all the essential amino acids, while a balanced protein contains all those amino acids in ratios that are most useful to human biophysiology.
- Most animal proteins are complete and well-balanced
There are very few perfectly balanced proteins in our food supply, but animal proteins tend to be among the most balanced. Unfortunately, animal proteins also tend to include undesirable components. For example, red meat is carcinogenic [PMID: 12376502], and meat (especially red meat) and dairy often contain large quantities of saturated fats. The nutrient density (as always, on a per-calorie basis) of meats is often lower than other choices.—Again this is outdated badly---red meats should be broiled or cooked thoroughly after cleaned---but not to subsist on red meat totally which can be unhealthy—there are other animal proteins that are easier to consume and digest---this would be easier and more efficient for most- Non-animal proteins can be balanced by combining different food families
One can get extremely detailed in finding "complementary" foods, but in general, combining legumes (beans) or seeds or nuts in balance-- will yield a balanced protein, and rice protein can complement the proteins in vegetables like broccoli, cauliflower, or spinach. Be aware, however, that both rice and grains (even whole grains) have relatively high glycemic indices and relatively low nutrient densities. If you're going to consume these, choose Cassava or Some other form or Starch where potassium or other nutrients can be uptaken properly
- Comment here this information is outdated badly due to the GMO and GE contamination You may want to reconsider these foods especially the rice an legumes which are high in starch ( sugars) and will turn to fat----if consuming to act as a cleanse fashion then it would be best to utilize the fibres from other foods such as fruits and veges---most rice today is GMO’d and should be avoided
- Select Healthy fats, and consume some Omega-3 fats
Foods containing monounsaturated fats include olive oil, almonds, hazelnuts, and avocados. Most of your fat intake should be from these foods. A very small amount of fat should be in the form of Omega-3 fatty acids, which are found in fatty fish (e.g. salmon) – ( minimize fish oils due to the mercury loads in these fish ) and flax oil, walnut oil, and perilla. Caution- fatty foods, even healthy choices, are high in calories so be sure that you carefully track your intake so as to stay within your Calorie goal.---Get baseline blood tests done
In order to chart your progress, and to make sure that you are avoiding nutrient deficiencies and other hazards, get at least the minimal recommended blood tests done. You'll want to know these results from before your calorie-restricted diet begins, so that you'll have a baseline for comparison as you move into a calorie-restricted diet.
Reduce calories after improving diet quality (i.e. nutrition)
Once your diet consists primarily of nutrient-dense, calorie-sparse foods, you can safely begin to reduce your total calorie intake. There are some things to consider at this point, if you have not already considered them.
Lose weight slowly----Many people lose weight simply by changing their diet to include more calorie-sparse foods. Even this weight loss should not be allowed to happen too quickly, but by the time you're able to restrict calories, your weight loss should proceed very slowly. There are two reasons for this:
- Pesticides and other toxins are fat soluble.
There are many pesticides and other toxins in our food supply that are fat soluble. Human bodies store these toxins relatively harmlessly in body fat. If you lose that fat too quickly, however, all these toxins are flushed into your bloodstream, and your detoxification mechanisms (i.e., your kidney and liver) are unable to remove them [B120YD, 78-80]. You may thus wind up with much higher blood toxin levels than what people are normally subjected to, which may have any number of life-shortening effects.
- Sudden adult onset Calorie Restriction shortens the lifespans of mice.---Though the lifespan enhancing effects of calorie restriction have been known since the 1930s, it was also known that if adult mice were suddenly put on a calorie restricted diet, their lifespans were actually shortened. Dr. Walford found in the 1980s, however, that if mice were slowly transitioned from an ad lib to a calorie restricted diet, then their lifespans increased. The time for this transition recommended by Dr. Walford is a minimum of 6 to 9 months, but preferably 1 to 2 years. [p. 78, BY120YD]
Be aware of the potential risks in CR dieting!
Any significant dietary change should be done in consultation with a knowledgeable physician. There are several other risks that you should be aware of.
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Protocols for Reducing and Regenerating Colon health—Reduction in Body Mass
There are things needed to be applied In the area of reduction—and with reduction of body mass, there will be a reduction to the amount of poisons, toxins, build up and inflammation—So when applying these protocols do them at least once a month at any time of the month and watch unwanted health conditions disappear—and a new vigor come back.
Here is the NO list: NO : Bread(s) or any Facsimile of bread( crackers donuts, tacos, pita, breads ) – Pasta –Rice –Corn – Cereal ( not even oatmeal during this time ) Grains in general—No Stores bought Juices,-No Pop ( Soda for the easterners ) No Milk or Dairy Products that are Sugar or Fat Free—No Sugar (Brown or White or Pasteurized Honey- Agave Syrup ) Molasses-NO MICROWAVE ( not to be used any time—totally Damages the Body from cellular level to tissues and DNA damaging ) Margarine-Canola Oil – Vegetable Oil – Soybean oil ( or any Soy whatsoever or any Derivatives – TVP –HVP – AVP –HPP – MSG –Disodium Guanylate – Disodium Inosinate-Bananas – Grapes – Raisons – Watermelon—Dates-Pork or Pork Byproducts ( sausauges, bacon, hot dogs, pork rinds etc)
Here is the YES List: Yes to -Meat – Poultry –Fish –Lamb – Eggs – Yogurt ( Plain and with Fat ) Kefir ( plain and with Fat ) Whey Protein – Gelatin Broths ( Plain or Vanilla Without Artificial Sweetners –Aspartame—Splenda – Aceslfame Potassium ) Cottage Cheese ( unless you have a yeast or fungal infection ) Cream – Olive oil – Butter - Ghee – Almond Oil – Pumpkin Seed Oil – Macadamian Nut Oil – Apricot oil – Sesame Seed Oil – Coconut Oil- Palm Oil – Animal Fat ( try to make sure the animals are GRASS FED not GRAIN FED---the fat then will be beneficial if the fat is from a grass Fed Animal ) Fruit with Fibre ( Apple, Peaches, Plums, Pears, Apricot, Nectarines etc PEEL BEFORE CONSUMING TO MINIMIZE PESTICIDE OR WAXES even if organic)Citrus Fruits – Oranges – Lemons – Pommelo’s – Grapefruit – Tangerines- Mannelos, etc Berries ( Wash and clean with either Peroxide. GSE, Vinegar, Lemon Juice- Use an Iodine Spray ) Veggies all kinds (Wash and clean with either Peroxide. GSE, Vinegar, Lemon Juice- Use an Iodine Spray ) Make Juice fresh and Home made Use Sprouts—Seeds - Nuts – Make Nut or Seed butters—
Do this for 5-10 days and afterwards if you wish to consume rice or pasta or polenta then introduce them back slow and minimize the consumption—breads if you consume then utilize Rye, Barley, or Oat and again Minimally—the idea is to get off breads and cereals which are actually Fermenting inside and potentially causing DNA damage and Restructuring--- Potato Can be used as long as it is not fried---Can be used if -broiled—boiled—mashed-or baked this will assist in the cleansing of the colon as well as provide energy
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H. Pylori Bacteria Linked to Blood Sugar Control in Adult Type II Diabetes
A new study by researchers at NYU Langone Medical Center reveals that the presence of Helicobacter pylori (H. pylori) bacteria is associated with elevated levels of glycosylated hemoglobin (HbA1c), an important biomarker for blood glucose levels and diabetes.)---ScienceDaily (Mar. 14, 2012) — A new study by researchers at NYU Langone Medical Center reveals that the presence of Helicobacter pylori (H. pylori) bacteria is associated with elevated levels of glycosylated hemoglobin (HbA1c), an important biomarker for blood glucose levels and diabetes. The association was even stronger in obese individuals with a higher Body Mass Index (BMI).---The results, which suggest the bacteria may play a role in the development of diabetes in adults, are available online in The Journal of Infectious Diseases.---There have been several studies evaluating the effect of the presence of H. pylori on diabetes outcomes, but this is the first to examine the effect on HbA1c, an important, objective biomarker for long-term blood sugar levels, explained Yu Chen, PhD, MPH, associate professor of epidemiology at NYU School of Medicine, part of NYU Langone Medical Center. "The prevalence of obesity and diabetes is growing at a rapid rate, so the more we know about what factors impact these conditions, the better chance we have for doing something about it," Dr. Chen said. Looking at the effects of H. pylori on HbA1c, and whether the association differs according to BMI status, provided what could be a key piece of information for future treatment of diabetes, she explained.---Type II diabetes causes an estimated 3.8 million adult deaths globally. There have been conflicting reports about the association between H. pylori infection and type II diabetes. To better understand the relationship between H. pylori and the disease, Dr. Chen and Martin J. Blaser, MD, the Frederick H. King Professor of Internal Medicine and professor of microbiology, analyzed data from participants in two National Health and Nutrition Surveys (NHANES III and NHANES 1999-2000) to assess the association between H. pylori and levels of HbA1c.----"Obesity is an established risk factor for diabetes and it is known that high BMI is associated with elevated HbA1c. Separately, the presence of H. pylori is also associated with elevated HbA1c," said Dr. Blaser, who has studied the bacteria for more than 20 years. "We hypothesized that having both high BMI and the presence of H. pylori would have a synergistic effect, increasing HbA1c even more than the sum of the individual effect of either risk factor alone. We now know that this is true."----H. pylori lives in the mucous layer lining the stomach where it persists for decades. It is acquired usually before the age of 10, and is transmitted mainly in families. Dr. Blaser's previous studies have confirmed the bacterium's link to stomach cancer and elucidated genes associated with its virulence, particularly a gene called cagA.
Regarding H. pylori's association with elevated HbA1c, Drs. Chen and Blaser believe the bacterium may affect the levels of two stomach hormones that help regulate blood glucose, and they suggest that eradicating H. pylori using antibiotics in some older obese individuals could be beneficial.---More research will be needed to evaluate the health effects of H. pylori and its eradication among different age groups and in relation to obesity status, the authors noted."If future studies confirm our finding, it may be beneficial for individuals at risk for diabetes to be tested for the presence of H. pylori and, depending on the individual's risk factor profile" Dr. Chen.-----In an accompanying editorial in The Journal of Infectious Diseases, Dani Cohen, PhD, of Tel Aviv University in Israel, pointed out that while previous studies have addressed the association between type II diabetes and H. pylori in small samples, this study analyzed two independent large national samples of the general population. Dr. Cohen agreed with the study authors, suggesting that adults infected with H. pylori with higher BMI levels, even if asymptomatic, may need anti-H. pylori therapy to control or prevent type II diabetes. If the study findings are confirmed, Dr. Cohen wrote, they "could have important clinical and public health implications."--Story Source-The above story is reprinted from materials provided by NYU Langone Medical Center, via Newswise.
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The Truth About Cholesterol and Saturated Fat
[U1]Chemtrail fallout has Over 28 components and one of them is aluminum not to mention managese and barium and uranium and thorium
[U2]Not Just the breast—the whole endocrine system
[U3]Some of these are in the chemtrails
[U4]Again—take the 28 components of chemtrails---add that to the water you drink if you are still drinking from the tap---then figire out the levels in your plants ( organic or otherwise since they will uptake the toxic metals as well from the ground released by the pesticides and chemtrails) and you now have a chemical mix killing or debilitating a human being
[U5]Which will further increase the levels in our system since these plants will be able to absorb more of the metal ---it makes them more resistant –not more healthy—big difference
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