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Show of The Month April 2014

Show of the Month  April 5 2014

Show of the Month  April 12 2014

Show of the Month  April 19 2014

Show of the Month April 26 2014

CoffeeGrounds&Beans – Coffee Hair Growth Benefits

Effect of caffeine and testosterone on the proliferation of human hair follicles in vitro

Blood poisoning increases the risk of blood clots, new research shows

Blood Poisoning Causes---- Sepsis can be triggered by an infection in any part of the body

Colorado House Passes Forced Vaccination Bill- One of 18 States Pushing Corporate Drugs

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Response to the Lab test

 

Answer: In January last year a study was carried out and published in the International Journal of Dermatology. The study involved hair follicles being removed from balding men and cultured (artificially grown) in a lab. All the follicles were exposed to testosterone and some were also exposed to caffeine. The hair growth from follicles exposed to testosterone was significantly reduced (as is the case with follicles affected by Male Pattern Hair Loss) whereas not only did caffeine seem to prevent testosterone from negatively affecting hair growth, but it also stimulated growth of the hair.

Journal of Dermatology Study – Coffee Hair Growth Benefits

A study published in the International Journal of Dermatology (Volume 46, Issue 1, pages 27-35) addressed coffee hair growth benefits as a possible stimulant for hair follicles.   The study found that caffeine works by blocking the effects of a chemical known as DHT which damages hair follicles and is thought to cause Male Pattern Baldness (MPB).

CoffeeGrounds&Beans – Coffee Hair Growth Benefits

Germany’s University of Jena researcher Dr. Tobias Fischer studied the effect of caffeine on human hair follicle growth.  He said “caffeine is a well-known substance, yet little is known about its effect on human hair follicle growth.  Caffeine shows it’s a promising candidate for hair growth stimulation.”

Dr. Fischer conducted his study by taking scalp biopsies from men in the early stages of hair loss.  He extracted hair follicles from the 14 men in the trial and placed them in test tubes with solutions containing different levels of caffeine.   The hair samples were left in the lab for up to 8 days to monitor the growth results.

Increase In Average Growth Of Hair Follicles

When Dr. Fischer compared the hair follicles treated with caffeine against those that weren’t, he discovered some interesting results.  The average growth of the follicles treated with caffeine increased by around 46 per cent compared to the control group In addition, the life cycle of the hair treated with caffeine was extended by 37 percent. Caffeine boosted the length of the hairs by between 33 and 40 per cent.---Dr Fischer noted that “hair follicles treated with caffeine showed a highly significant growth rate at 24 hours and still showed further significant growth at eight days.”

Caffeinated Tea Vs Coffee Hair Growth Benefits?

Although hair growth and hair loss experts have studied coffee hair growth benefits, some experts point out that it’s the caffeine in the popular drink which is thought to help stimulate hair follicle growth.  While coffee hair growth benefits are the focal point of many studies, others have studied the possible benefits of caffeinated teas to achieve similar results.

Dark Brazilian Santos Beans – Coffee Hair Growth

It’s important to note that all testing of coffee hair growth benefits were linked to topical applications and not to drinking lots of coffee or similar caffeinated drinks.

Follicular Penetration of Topically Applied Caffeine Via Shampoo

As a result of studies performed on hair follicles to determine coffee hair growth benefits, some hair loss and hair growth related shampoo products contain caffeine or coffee related ingredients.

Researchers in Germany wanted to determine if topically applied caffeine could be delivered to the follicle as a shampoo.  The studies showed that after 2 minutes of shampooing, the caffeine in the shampoo was able to penetrate into the scalp via the hair follicles and outermost layer of the skin (stratum corneum).

DIY Coffee Hair Oils & Butters – Coffee Hair Growth Benefits

Some hair consumers interested in conducting their own tests of coffee hair growth benefits have created special hair mask recipes utilizing a base coffee oil.

Coffee grounds can easily be dried and then infused into an oil which can be applied to the scalp in a variety of delivery methods ranging from direct application to the scalp, pre-shampoo treatments, shampoo applications and/or rinse-out or leave-in conditioners.  The coffee grounds or oil can also be combined with a shea butter or coconut oil  base to create a special scalp mask.

As a side benefit, used coffee grounds are known to be a great exfoliant for the scalp.  Coffee grounds are also a great skin treatment as well as helping to reduce cellulite in some cases.  Coffee is also often used as part of a henna rinse.

Coffee In The Shower

Organic Coconut Oil – Coffee Hair Growth Benefits

Some hair consumers have discovered that cold brewed coffee, when used on wet hair ,as an after shampoo rinse, will often help slow or stop shedding.

After shampooing, completely rinse hair.  Gently squeeze excess liquid from hair with fingers.  Pour pre-brewed cool coffee into hair using a clean plastic bowl or container to catch the drippings.  Continue to pour coffee through the hair until all the drippings have ceased.  Allow to sit on hair for 5 minutes.

Add desired rinse-out or leave-in conditioner .  Wrap hair in stain-proof towel or cloth and allow the coffee conditioner mixture to remain on hair for 30 to 60 minutes.  Rinse with lukewarm water and finish with a cool water final rinse.  Towel blot and air dry if possible. Style as normal.

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Effect of caffeine and testosterone on the proliferation of human hair follicles in vitro.

Fischer TW1, Hipler UC, Elsner P.

Abstract

BACKGROUND:

Androgenetic alopecia (AGA) is a common problem in men of all ages, affecting approximately 50% at 50 years of age. The underlying cause is an androgen-dependent miniaturization of genetically predetermined hair follicles. Here, the hair organ culture model was used to investigate the effects of testosterone and caffeine; the latter being a promising candidate for hair growth stimulation.

METHODS:

Hair follicles from 14 biopsies, taken from the vertex areas from male AGA patients, were cultivated for 120-192 h in vitro with normal William's E medium (control) or William's E medium containing different concentrations of testosterone and/or caffeine. Hair shaft elongation was measured daily and at the end of cultivation, cryosections of follicles were stained with Ki-67 to evaluate the degree and localization of keratinocyte proliferation.

RESULTS:

Significant growth suppression was found in hair follicles treated with 5 microg/ml testosterone. This was counteracted by caffeine in concentrations of 0.001% and 0.005%. Moreover, caffeine alone led to a significant stimulation of hair follicle growth. These results were confirmed immunohistochemically by Ki-67 staining.

CONCLUSIONS:

Androgen-dependent growth inhibition of ex vivo hair follicles from patients suffering from AGA was present in the human hair organ culture model, a constellation which may serve for future studies to screen new substances against androgen-dependent hair loss. Caffeine was identified as a stimulator of human hair growth in vitro; a fact which may have important clinical impact in the management of AGA.--PMID:17214716-[PubMed - indexed for MEDLINE]

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Blood poisoning increases the risk of blood clots, new research shows

Date:

March 14, 2014

Source:

Aarhus University

Every year, almost 10,000 Danes are admitted to hospital with blood poisoning, while more than 3,000 patients become infected while they are hospitalized. New research shows that Danes suffering from blood poisoning risk an extra challenge in the form of an increased risk of suffering a blood clot-"We have followed more than 4,000 people who have been admitted with blood poisoning. The study shows that the risk of suffering a blood clot in either the brain or the heart is twice as high for patients with blood poisoning in relation to other patients who are also admitted with acute illnesses,[F1] " says Michael Dalager-Pedersen , PhD student at Aarhus University and Registrar at Aalborg University Hospital. He has carried out the study in collaboration with colleagues from Aarhus University, Aarhus University Hospital, and Aalborg University Hospital.--The risk of a blood clot was highest within the first 30 days after the infection, where the risk was 3.6 percent against 1.7 percent for the other acutely admitted patients, and only 0.2 percent among the population in general.---The study has just been published in Circulation.---In recent years there has been a growing level of interest for the correlation between the risk of blood clots and infections such as blood poisoning. The researchers hope that the new knowledge can be utilized to ensure better prevention and earlier treatment. "It is important that we have now documented that there is a clear correlation between blood poisoning and blood clots. The new knowledge can be used by the medical doctors to increase focus on this patient group so they can begin relevant treatment quicker," says Reimar Wernich Thomsen from the Department of Clinical Epidemiology at Aarhus University and Aarhus University Hospital.--He explains that the correlation may, among other things, be due to the fact that the blood clots arise due to the increased strain on the heart and blood vessels that the infection causes.[F2] --Story Source-The above story is based on materials provided by Aarhus University. Note: Materials may be edited for content and length.-Journal Reference-M. Dalager-Pedersen, M. Sogaard, H. C. C. Schonheyder, H. Nielsen, R. Wernich Thomsen. Risk for Myocardial Infarction and Stroke after Community-Acquired Bacteremia: A 20-Year Population-Based Cohort Study. Circulation, 2014; DOI: 10.1161/%u200BCIRCULATIONAHA.113.006699

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Blood Poisoning Causes---- Sepsis can be triggered by an infection in any part of the body.  The most common sites of infection leading to sepsis are the lungs, urinary tract, abdomen and pelvis.

Sources of infection

Types of infection associated with sepsis include:

In approximately one in five cases, the infection and source of sepsis cannot be detected.

What causes the symptoms of sepsis?

Usually, your immune system will keep the infection limited to one place (known as a localised infection). Your body will produce white blood cells, which travel to the site of the infection to destroy the germs causing infection. A series of biological processes occur, such as tissue swelling, which helps fight the infection and prevents it spreading. This process is known as inflammation.--If your immune system is weakened or an infection is particularly severe, it can spread through the blood into other parts of the body. This causes the immune system to go into overdrive, and the process of inflammation affects the entire body.--This can cause more problems than the initial infection, as widespread inflammation damages tissue and interferes with the flow of blood, leading to a dangerous drop in blood pressure, which stops oxygen reaching your organs and tissue.

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Colorado House Passes Forced Vaccination Bill- One of 18 States Pushing Corporate Drugs

Christina Sarich

 

by
March 25th, 2014

Updated 03/25/2014 at 2:10 am

Parents will have little choice over whether or not to have their children vaccinated in Colorado now, due to a bipartisan measure passed by Colorado’s House Health, Insurance and Environment Committee this past Thursday. Parents who intended to claim the ‘opt out’ available in a current rendition of Colorado’s current law, due to religious or personal beliefs, will find it much more difficult to do so.--HB 14-1288, which gained traction after recent whooping cough outbreaks, will require parents to complete an online ‘education’ module and get the signature of their health care providers confirming that parents have been informed of health risks and a ‘possible detriment to the community’ if their children go unvaccinated.--House Bill 1288 completely ignores the fact that many vaccines have been proven dangerous to young children, and can even cause death and infertility. Parents and doctors also offered hours of testimony to House representatives, but to no avail. The bill was proposed by State Rep. Dan Pabon (D) as a means to make sure that parents weren’t just opting out of vaccines for ‘convenience,’ as he mentioned in a statement given to the Denver Post.

“Vaccine refusal results in higher rates of vaccine-preventable disease,” Pabon said. “This is a public health issue. These are very serious diseases.”

Colorado’s school children have the sixth-highest rate of non-vaccination among kindergarteners in public school. The new bill mandates that public record be made of all children who are not-vaccinated, via percentages reported by licensed schools and day care centers.[F5] ---Pabon argues that immuno-compromised children are being exposed to vaccine-preventable diseases, but these are the very children most at risk when they receive vaccines administered with a traditional vaccine schedule (or even an altered one). Vaccinations given to immuno-compromised children can cause death, even, as evidenced in records leak due to the freedom of information act in the UK.---Pabon also says that older populations are at risk when young children aren’t vaccinated, but how he determines this bit of propaganda is beyond reason.---?Although the bill would not eliminate the personal belief exemption,> parents opposing the legislation argued that increased education mandates could lead to the erosion of parental rights.

“Parents have a constitutional right to parent their children,” Susan Lawson, whose daughter developed encephalitis after a routine vaccine when she was a year old, told CBS Denver. “I am not an uneducated woman.”-----Anti-vaccination advocacy group National Vaccine Information Center has also attacked the proposal as one that “singles out and discriminates against a minority of parents with sincerely held personal beliefs … by assuming they are uneducated and should be forced into a state approved ‘education’ program.’--18 states have recently presented bills to make vaccination opt-outs more difficult. Our rights to choose what to do with our bodies and how to protect our children from vaccines containing dangerous adjuvants are being whittled away. Just look at this list presented by know-vaccines.org of just some of the additives currently in vaccines given to children and adults alike:

  • • aluminum hydroxide, acetone (solvent used in fingernail polish remover)
  • • aluminum phosphate (toxic)
  • • ammonium sulfate
  • • amphotericin B
  • • animal tissues: pig blood, horse blood, rabbit brain,
  • • dog kidney, monkey kidney
  • • chick embryo, chicken egg, duck egg
  • • calf (bovine) serum
  • • betapropiolactone
  • • fetal bovine serum
  • • formaldehyde – used to embalm dead bodies
  • • formalin
  • • gelatin
  • • glycerol
  • • human diploid cells (originating from human aborted fetal tissue)
  • • hydrolized gelatin
  • • monosodium glutamate (MSG)
  • • neomycin (antibiotic)
  • • neomycin sulfate
  • • phenol red indicator
  • • phenoxyethanol (antifreeze)
  • • potassium diphosphate
  • • potassium monophosphate
  • • polymyxin B
  • • polysorbate 20
  • • polysorbate 80
  • • porcine (pig) pancreatic hydrolysate of casein
  • • residual MRC5 proteins
  • • sorbitol
  • • sucrose
  • • streptomycin (antibiotic)
  • • thimerosal (mercury)
  • • tri(n)butylphosphate (neurotoxin)
  • • VERO cells, a continuous line of monkey kidney cells
  • • washed sheep red blood cells

These adjuvants cause everything from Alzheimer’s, neurotoxicity, brain injury, auto-immune disorders, gastrointestinal damage, liver and lung damage, cysts, arthritis, kidney damage, allergic reactions, seizures, and even death – but of course parents are opting out, simply due to convenience.

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Show of the Month  April 12 2014

Death Of Doctors

Diets High in Animal Protein May Help Prevent Functional Decline in Elderly Individuals

FAO reports rise in GM material in non-GM food trade

Flavonol isolated from ethanolic leaf extract of Thuja occidentalis arrests the cell cycle

Autism-Causative Effects of Soy and Gliadin-- Study Suggests Link Between Soy Formula and Seizures in Autistic Children---                                       Immune response to dietary proteins, gliadin and cerebellar peptides in children with autism.

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Death Of Doctors

 

Submitted by RateMDsJohn on Mon, 07/08/2013 - 22:30.

He just posted some of his sources in the comments to the post:

"Doctors are alcoholics: source: Prevalence of Alcohol Use Disorders Among American Surgeons
http://archsurg.jamanetwork.com/article.aspx?articleid=1107783

98,000 people die of medical mistakes: Source:
Medical Mistakes: More Common Than You Think
http://news.health.com/2008/06/18/medical-mistakes-more-common-than-you-think/?cnn=yes

Fake degrees. Source: Page on Ca
http://aaar.assembly.ca.gov/sites/aaar.assembly.ca.gov/files/reports/Intro%20to%20Degree%20Mills.pdf

Doctors have highest suicide rate: Source:
When Doctors Kill Themselves
http://www.thedailybeast.com/newsweek/2008/04/19/doctors-who-kill-themselves.html

53% of doctors are oveweight. Source:
What if your doctor is an overweight smoker?
http://blogs.livewellnebraska.com/2012/03/12/what-if-your-doctor-is-an-overweight-smoker/

 

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Diets High in Animal Protein May Help Prevent Functional Decline in Elderly Individuals

March 11th, 2014

NEW YORKA diet high in protein, particularly animal protein, may help elderly individuals maintain a higher level of physical, psychological, and social function according to a study published in the Journal of the American Geriatrics Society.------Due to increasing life expectancies in many countries, increasing numbers of elderly people are living with functional decline, such as declines in cognitive ability and activities of daily living. This can have profound effects on the health and well-being of older adults and their caregivers, as well as on health care resources.--Research suggests that as people age, their ability to absorb or process protein may decline. To compensate for this loss, protein requirements may increase with age. Megumi Tsubota-Utsugi, PhD, MPH, RD, of the National Institute of Health and Nutrition in Japan, and her colleagues in Tohoku University and Teikyo University, Japan, wondered whether protein intake might affect the functional capabilities of older adults. They designed a study to investigate the relationship between protein intake and future decline in higher-level functional capacity in older community-dwelling adults in Japan. Their analysis included 1,007 individuals with an average age of 67.4 years who completed food questionnaires at the start of the study and seven years later. Participants were divided into four groups (quartiles) according to their intake levels of total, animal, and plant protein. Tests of higher-level functional capacity included social and intellectual aspects as well as measures related to activities of daily living.---Men in the highest quartile of animal protein intake had a 39 percent decreased chance of experiencing higher-level functional decline than those in the lowest quartile. These associations were not seen in women. No consistent association was observed between plant protein intake and future higher-level functional decline in either sex.--"Identifying nutritional factors that contribute to maintaining higher-level functional capacity is important for prevention of future deterioration of activities of daily living,” said Dr. Tsubota-Utsugi. “Along with other modifiable health behaviors, a diet rich in protein may help older adults maintain their functional capacity.”

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FAO reports rise in GM material in non-GM food trade
 
The FAO said 75 out of 193 member countries responded to questions about low level GM crops found
 in non-GM food and feed imports in the first survey of its kind, carried out from February to June last year. 
They reported 198 cases of GM crops in non-GM deliveries from 2002 to 2012, with 70% of those (138) detected since 2009.
 Linseed, maize, rice and papaya were the most common crops found to contain unauthorised GM material. 
Food safety officer at the FAO, Sarah Cahill, said:“The biggest concern is the disruption to trade between countries and of course
 the associated economic impact. When low levels of GM crops are detected in a shipment of non-GM crops, the 
shipment is generally rejected by the importing country. The confinements are either returned to the country of 
origin, which in itself has cost implications, or in some cases they are destroyed. Now, the latter not only has economic
 implications but also contributes to food losses Under current EU regulations, the threshold limit for unintentional presence of 
GM materials in crops is 0.9%. Above this level, items containing approved GM products require labelling.[F6]  
However, most of the 75 countries involved in the study did not have policies in place for low levels of GM material. Cahill added 
that with increased production of GM crops – and improved sensitivity and frequency of testing – it was probably not unusual that
 detection was increasing in traded food. Consumer implications? Any of these GM products that are in the market have been subject 
to rigorous safety assessments, so from a safety perspective they are not marketed without undergoing that level of assurance, Cahill 
said.“We are aware that many consumers like to make a choice between GM foods and non-GM foods and, if it’s not clear whether a 
non-GM food has low levels of GM foods, this may have implications for the choice that they make. They may not have all the information 
they need to make that choice FAO senior food safety officer in charge of the survey Renata Clarke said the FAO also asked countries to 
help the organisation assess the safety of GM crops for human consumption We would like to see countries sharing any scientific 
findings they have on the subject, she said. With this in mind, the FAO has set up a GM foods platform for countries to share information 
on safety assessments, The survey is one way in which the FAO aims to tackle the issue of low level unauthorised GM crops in shipments, 
with the resulting information

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Flavonol isolated from ethanolic leaf extract of Thuja occidentalis arrests the cell cycle at G2-M and induces ROS-independent apoptosis in A549 cells, targeting nuclear DNA.

Cell Prolif. 2014 Feb;47(1):56-71

Authors: Mukherjee A, Sikdar S, Bishayee K, Boujedaini N, Khuda-Bukhsh AR

Abstract
OBJECTIVES: The K-ras gene mutation commonly found in lung adenocarcinomas contributes to their non-invasive expansion. Our main objective here was to develop a chemopreventive agent against K-ras-mutated lung adenocarcinoma cell line like-A549.
MATERIALS AND METHODS: We isolated flavonol from ethanolic leaf extract of Thuja occidentalis
[F7] , and evaluated its apoptotic potentials on A549 cells. They were treated with 1-10 μg/ml of flavonol and viability was tested retaining normal lung cells L-132 as control. We performed assays such as TUNEL, annexin V, cell-cycle and mitochondrial membrane potentials, by FACS analysis. ROS-mediated oxidative stress and drug-DNA interactions were analysed along with gene expression studies for p53, Bax-Bcl2, cytochrome c, the caspase cascade genes and PARP.
RESULTS: Flavonol reduced A549 cell viability in a dose- and time-dependent manner (IC50 value = 7.6 ± 0.05 μg/ml following 48 h incubation) sparing normal L-132 cells. It effected G2-M phase cell cycle arrest and apoptosis, as indicated by progressive increase in the sub-G1, annexin V and TUNEL-positive cell populations. Apoptotic effects appeared to be mitochondria-dependent, caspase-3-mediated, but ROS-independent. Analysis of circular dichroism data revealed that flavonol intercalated
[F8] with nuclear DNA. In vivo studies on non small cell lung carcinoma (NSCLC)-induced mice confirmed anti-cancer potential of flavonol.
CONCLUSION: Flavonol-induced apoptosis apparently resulted from intercalation of cells' nuclear DNA. Flavonol inhibited growth of induced lung tumours in the mice, indicating its potential as an effective agent against NSCLC.---PMID: 24267912 [PubMed - indexed for MEDLINE]

Recipe---make a tea---by using 2-3 pint pot and add 1-2 sprigs in the pot simmer---and pour a1-2 oz serving and drink or sip ---if there is a respiratory issue then do this 4-5 times daily without sweeteners or sugars---will taste strong –so it may take getting used to

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Autism-Causative Effects of Soy and Gliadin

Soy infant formula and seizures in children with autism- a retrospective study

Westmark CJ.

Author information

Abstract

Seizures are a common phenotype in many neurodevelopmental disorders including fragile X syndrome, Down syndrome and autism. We hypothesized that phytoestrogens in soy-based infant formula were contributing to lower seizure threshold in these disorders. Herein, we evaluated the dependence of seizure incidence on infant formula in a population of autistic children. Medical record data were obtained on 1,949 autistic children from the SFARI Simplex Collection. An autism diagnosis was determined by scores on the ADI-R and ADOS exams. The database included data on infant formula use, seizure incidence, the specific type of seizure exhibited and IQ. Soy-based formula was utilized in 17.5% of the study population. Females comprised 13.4% of the subjects. There was a 2.6-fold higher rate of febrile seizures [4.2% versus 1.6%, OR=2.6, 95% CI=1.3-5.3], a 2.1-fold higher rate of epilepsy comorbidity [3.6% versus 1.7%, OR=2.2, 95% CI=1.1-4.7] and a 4-fold higher rate of simple partial seizures [1.2% versus 0.3%, OR=4.8, 95% CI=1.0-23] in the autistic children fed soy-based formula. No statistically significant associations were found with other outcomes including: IQ, age of seizure onset, infantile spasms and atonic, generalized tonic clonic, absence and complex partial seizures. Limitations of the study included: infant formula and seizure data were based on parental recall, there were significantly less female subjects, and there was lack of data regarding critical confounders such as the reasons the subjects used soy formula, age at which soy formula was initiated and the length of time on soy formula. Despite these limitations, our results suggest that the use of soy-based infant formula may be associated with febrile seizures in both genders and with a diagnosis of epilepsy in males in autistic children. Given the lack of data on critical confounders and the retrospective nature of the study, a prospective study is required to confirm the association.

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Study Suggests Link Between Soy Formula and Seizures in Autistic Children

Cara Westmark
 

Madison, Wisconsin - A University of Wisconsin-Madison researcher has detected a higher rate of seizures among children with autism who were fed infant formula containing soy protein rather than milk protein.---“This needs to be studied more thoroughly. If soy formula is lowering the threshold for seizures or increasing the incidence of seizures, we need to know that.”- The study found excess seizures among girls and in the total sample of 1,949 children. The soy-seizure link reached borderline significance among boys, who comprised 87 percent of the children described in the database under study.---Seizures - caused by uncontrolled electrical currents in the brain - occur in many neurological disorders including epilepsy, Alzheimer's disease, Down syndrome and autism.---About 25 percent of infant formula sold in the United States is based on soy protein.[F9]   Study author Cara Westmark, a senior scientist in the Department of Neurology at the UW School of Medicine and Public Health, says her investigation was sparked by mouse studies of a drug that, it was hoped, would inhibit seizures by blocking signals that excite nerve cells.  "It was pure serendipity that we happened to look at soy," she says. To simplify the mouse study, she replaced the standard lab chow, which had a variable composition, with a diet containing purified ingredients. Unexpectedly, that diet reduced the rate of seizures by 50 percent compared to standard chow, Westmark says. "We were intrigued that a dietary alteration was as effective as many medicines in reducing seizure incidence and wanted to pursue that finding," she says. "We found that the main difference between the diets was the protein source. The standard diet was soy-based, while the purified diet was casein, or dairy, based."---The mechanism of action is unknown, but Westmark points to the high level of plant-derived estrogens in soy products as a possible cause of the excess seizures.

 Prevalance of Seizures Small But Significant 

People eat a lot of soy products, and when Westmark began to look for the effect in people, she decided to focus on infants, who may consume nothing but formula. Knowing that people with autism have a higher rate of seizures, Westmark turned to a database from the Simons Foundation Autism Research Initiative.---And that led to the new study, published today in the journal PLOS ONE, which showed that children with autism who were fed soy formula had 2.6 times as many febrile seizures as the children fed non-soy formula in the database. That means 4.2 percent of the soy group had a seizure associated with a fever, compared to 1.6 percent of the others.--To put it another way, the vast majority of both groups did not have seizures.---"This is not saying that all autistic children who eat soy-based formula are going to develop seizures," says Westmark.--And yet that increase is worrying, Westmark says. --"The prevalence of autism is increasing and currently affects one American child in 88," she says. "Soy is a widespread ingredient in many food products and 25 percent of infant formulas are soy based, so this is something that needs to be studied. If the child is lactose intolerant, there are alternatives that a pediatrician can recommend."---- 

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[F10]  Immune response to dietary proteins, gliadin and cerebellar peptides in children with autism.

Vojdani A1, O'Bryan T, Green JA, Mccandless J, Woeller KN, Vojdani E, Nourian AA, Cooper EL.

Author information

Abstract

The mechanisms behind autoimmune reaction to nervous system antigens in autism are not understood. We assessed the reactivity of sera from 50 autism patients and 50 healthy controls to specific peptides from gliadin and the cerebellum. A significant percentage of autism patients showed elevations in antibodies against gliadin and cerebellar peptides simultaneously. For examining cross-reaction between dietary proteins and cerebellar antigens, antibodies were prepared in rabbits, and binding of rabbit anti-gliadin, anti-cerebellar peptides, anti-MBP, anti-milk, anti-egg, anti-soy and anti-corn to either gliadin- or cerebellar-antigen-coated wells was measured. In comparison to anti-gliadin peptide binding to gliadin peptide at 100%, the reaction of anti-cerebellar peptide to gliadin peptide was 22%, whereas the binding of anti-myelin basic protein (MBP), anti-milk, anti-egg and anti-soy to gliadin was less than 10%. Further examination of rabbit anti-gliadin (EQVPLVQQ) and anti-cerebellar (EDVPLLED) 8 amino acid (AA) peptides with human serum albumin (HSA) and an unrelated peptide showed no binding, but the reaction of these antibodies with both the cerebellar and gliadin peptides was greater than 60%. This cross-reaction was further confirmed by DOT-immunoblot and inhibition studies. We conclude that a subgroup of patients with autism produce antibodies against Purkinje cells and gliadin peptides, which may be responsible for some of the neurological symptoms in autism.

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 [F3]Skin Infections today can be a cause of Chemtrail fall out=Smart meter Pulsing-Electro Smug—Wifi--RF’s- ELF’s-Towers pulsing-Chemical or Genetic Exposure to synthetic compounds-

 [F4]This Today can be caused by just consumption of foods which have solvents—canola oils which break down the myelin sheath---propylene glycol—and a host of other chemicals found in foods

 [F5]Who made these people spys and collaborators for unjust violation of  rights???don’t trust the teachers would not be a bad  policy

 [F6]This is a Clear Indication that the food supply is constantly being exposed to some form of GE or GMO Foods and as a result alot of this is being consumed without consumer awareness

 [F7]Cedar Leaf

 [F8]Intercalation may refer to: Intercalation (chemistry), the insertion of a molecule (or group) between two other molecules (or groups)

 [F9]Not Sure where they are getting these stats almost all the baby formulas have some form of soy in  it---ALL –the same can be said in Canada---it is a cheap filler which would have intestinal disrupting capabilities—stomach dysfunction-pancreas disabling and thyroid compromising---would have antinutrient  effects and would deny iodine for brain developments as well as folic acid and B12 up take and would have glutamates  that would cause neurol pathway overloads causing a over reactive brain--

 [F10]Gliadin is a class of proteins present in wheat and several other cereals within the grass genus Triticulae--- RYE—Spelt—Wheat- EINKORN-barley

 

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Show of the Month  April 19 2014

Fried Fat Cooking

Parasites in humans influence each other via shared food sources

Anti-anxiety drugs, sleeping pills linked to risk of death-Natural or Supplemental Methods For Sleep and AntiAnxiety

Potassium Ascorbate-- Scientifically shown homeostatic benefits ascorbate promotes or enhances

Researchers identify how zinc regulates key enzyme involved in cell death--

How zinc starves lethal bacteria to stop infection- Zinc discovery may shed light on Parkinson's, Alzheimer's--

Herbs and Foods with good levels of  Accessible Zinc

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Fried Fat Cooking

There are problems with deep fat fried food that affect our nutrition. These problems occur because of chemical alterations in the fat that happen as a consequence of deep fat frying food.

This frying process is as follows:

1. Food picks up oxygen from the air during frying that negatively alters the fat composition.
2. The foods fried in these fats pick up those altered fats.
3. These altered foods have a direct and negative influence on the nutritional value of the fat.

The changes in the fat are dependent on at least four factors:
1. The length of time it was exposed to heat—in commercial operations, the length of time a food is fried leads to how much fat is absorbed on the “cooked” food item;
[F1] 
2. The temperature of the fat;
[F2] 
3. The exact composition of the fat used, such as corn oil, cottonseed oil, soybean oil, beef tallow, or hydrogenated fat, and
[F3] 
4. What is being fried, e.g., chicken or fish.

The longer the frying fat is heated, the greater the changes in that fat. Feeding animals fats fried at varying lengths of time led to very different outcomes in the health of those animals.--Those animals fed the fats fried the shortest period of time were healthier than those fed the fats fried for the longest times. Those fed fats heated at higher temperatures were not as healthy as those fed on fat heated to lower temperatures.--Also it was interesting that animals fed on heated margarine did not grow as well as those on fresh margarine and that their plasma cholesterol level increased[F4] . Those fed on heated butter oil grew as well as those on fresh butter oil.--Oil from commercial fat fryers was used in a set of experiments that clearly showed that poor nutrition resulted. This is important because used fat from commercial operations is typically collected and fed to animals, such as pigs, to provide energy for rapid growth. --When we conducted experiments feeding the commercially used fat for frying to rats, they did not do well. When we added protein to their diets, the effect of the “bad” heated fat was countered because the added protein provided more adequate nutrition. [F5] --We tried to fortify the diets with adequate vitamins, but that could not counter the growth-depressing effect of the heated oil. A few vitamins, such as riboflavin, helped a bit.--Fish already contain high amounts of polyunsaturated fat that are not present in the fat of chicken or beef. Thus, when fish are fried, the polyunsaturated fat in them can leak into the frying fat causing the fat to be changed more radically into a less healthy version. Chicken and hamburger have less of this polyunsaturated fat and thus are healthier choices to fry. 

Eating excessive amounts of fried food also slows down digestion. People may get stomachaches as a result. As early as 1946, a link was shown between heated fats and cancer. What we don’t know yet is whether heated fats by themselves lead to cancer or whether the heated fat combined with specific foods cause cancer.--Animals fed heated fat combined with a known carcinogen developed cancer, whereas those fed fresh fat combined with a known carcinogen, did not. Thus the heated fat was a co-carcinogen.--Commercial frying of food has increased worldwide since our studies on heated fats. In Germany, fat fryers are required by law to test their frying fat for its freshness by a method approved by the German government. In the U.S. a test is also available but its use is not mandatory.[F6] 

Free Radicals
Free radicals are produced from oxidized linoleic (n-6) and linolenic acid (n-3); they are fragments of unsaturated fatty acids. This is especially likely to happen when the essential fatty acids are heated, especially the n-3 varietyAll oils change structures when they are heated, but those high in n-3 fatty acids have more problems than those high in n-6.-Free radicals provide another reason to avoid fried food. The first sign of fat becoming free radicals is that they are rancid, and they begin to smell “off” and their taste becomes bitter. --Roasted peanuts, for example, can become rancid and then shouldn’t be eaten. Free radicals are “bad” since they destroy vitamins A, D, C, and E, thus preventing these vitamins from doing positive things in the body. --Free radicals also destroy both the essential fatty acids and the essential amino acids. They oxidize the LDL into something called oxidized low density lipoproteins (oxLDL).  These oxLDL are very powerful components in the blood that have been considered since about 1990 as involved in the development of heart disease. -The best way to avoid free radicals is simply not eating fried food nor any foods with oil that smells “off.”

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Parasites in humans influence each other via shared food sources

Date:

March 12, 2014

Source:

University of Zurich

Over 1,400 species of parasites -- viruses, bacteria, fungi, intestinal worms and protozoa -- are able to infect humans. In most cases, the right medicine against a parasite cures the patient. If he or she suffers from an infection by two or more species of parasite at the same time, however, it soon becomes more difficult to diagnose and treat. Medication can even exacerbate the medical condition if one pathogen is killed off but the second flourishes. One reason is the little-understood interactions between the parasites that reside in the same host.[F7] --In a study published in Proceedings of Royal Society B, an international team of researchers including Professor Owen Petchey from the Institute of Evolutionary Biology and Environmental Studies at the University of Zurich presents a network that explains how different pathogens and parasite groups mutually influence each other in the human body. Surprisingly, the biologists discovered that the parasites are most likely to interact via the food source they share -- not the immune response or directly through contact with other parasites.

Complex overview with clear patterns---Co-infections are very common: Simultaneous infestations by different intestinal worms, for instance, affect around 800 million people worldwide. In order to develop effective treatment approaches for co-infections, says Owen Petchey, we need to understand the structures of the parasite communities in a host -- in this case individual humans -- and the interactions between the parasites better. The ecologists from Zurich, Liverpool, Sheffield and Edinburgh compiled a list of 305 parasite species, 124 resources in the host and 98 immune system components in a meta-study -- then analyzed over 2,900 combinations of all these factors in an unprecedented manner.

The network displays clear patterns: The infected part of the body and the same food resource are the most common contact points that can lead to an interaction between the different parasites. "We found twice as many parasites fighting for the same energy source as parasites that elicit the same immune response and are able to interact in that way," explains Petchey. The manner in which the immune system responds to the individual pathogens seems to be of secondary importance, despite the fact that other studies pointed towards precisely this. The direct influence from one parasite to the next is also rarer, with the exception of HIV, Staphilococcus aureus and the Hepatitis C virus, which are known to interact directly with other pathogens.

Personalized medicine in the spotlight

The network-like overview of the various interactions of parasites that can harm humans goes beyond the usual consideration of parasite pairs. "These results can serve as a basis for the development of new, personalized treatment schemes for infected patients," Petchey hopes. The biologist is currently testing his hypotheses of this synthesis study with different organisms.

Story Source-The above story is based on materials provided by University of Zurich. Note: Materials may be edited for content and length.---Journal Reference-E. C. Griffiths, A. B. Pedersen, A. Fenton, O. L. Petchey. Analysis of a summary network of co-infection in humans reveals that parasites interact most via shared resources. Proceedings of the Royal Society B: Biological Sciences, 2014; 281 (1782): 20132286 DOI: 10.1098/rspb.2013.2286


Remedy—One Simple way to treat this is to take a turpentine remedy either mixed with honey or oil to remove these past---depending on the severity you may want to start of with a tsp increment and if necessay to go up to a 1 oz intake---there have been reports of tapeworms of huge proportions have exited a persons insides

 

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Anti-anxiety drugs, sleeping pills linked to risk of death

Date:

March 31, 2014

Source:

University of Warwick

 

The large study, published in BMJ, shows that several anxiolytic (anti-anxiety) drugs or hypnotic drugs (sleeping pills) are associated with a doubling in the risk of mortality.--Anti-anxiety drugs and sleeping pills have been linked to an increased risk of death, according to new research from the University of Warwick.--The large study, published in BMJ, shows that several anxiolytic (anti-anxiety) drugs or hypnotic drugs (sleeping pills) are associated with a doubling in the risk of mortality. Although these findings are based on routine data and need to be interpreted cautiously, the researchers recommended that a greater understanding of their impact is essential.--Professor Scott Weich, Professor of Psychiatry at the University of Warwick, explained "The key message here is that we really do have to use these drugs more carefully. This builds on a growing body of evidence suggesting that their side effects are significant and dangerous. We have to do everything possible to minimise over reliance on anxiolytics and sleeping pills."--"That's not to say that they cannot be effective. But particularly due to their addictive potential we need to make sure that we help patients to spend as little time on them as possible and that we consider other options, such as cognitive behavioural therapy, to help them to overcome anxiety or sleep problems."--The study accounted, where possible, for other factors such as age, smoking and alcohol use, other prescriptions and socioeconomic status. Crucially, the team controlled for contributing risk factors such as sleep disorders, anxiety disorders and other psychiatric illness in all participants.--34,727 people were tracked for seven and a half years on average from the time that they first received prescriptions for either an anxiolytic or hypnotic drug.--Benzodiazepines were the most commonly prescribed drug class, including diazepam and temazepam. The study also examined the effects of two other groups of drugs; the so-called 'Z-drugs' and all other anxiolytic and hypnotic drugs. Many patients received more than one drug over the course of the study, and 5% received prescriptions for drugs from all three groups.-Story Source-The above story is based on materials provided by University of Warwick. Note: Materials may be edited for content and length.-Journal Reference-S. Weich, H. L. Pearce, P. Croft, S. Singh, I. Crome, J. Bashford, M. Frisher. Effect of anxiolytic and hypnotic drug prescriptions on mortality hazards: retrospective cohort study. BMJ, 2014; 348 (mar19 5): g1996 DOI: 10.1136/bmj.g1996

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Natural or Supplemental Methods For Sleep and AntiAnxiety

Taurine 500mgs + Inositol 500mgs taken 3-5 times a day

Niacinamide 500mgs + Gaba 500mgs  before bed for sleep

Niacinamide  500mgs + Glycine 500 3-5times a day

Trytophan 500 mgs+ Nicainamide 500 mgs before Bed

Melatonin 3 mgs + Nicainamide 500 mgs  before bed

Taurine 500mgs + Magnesium Citrate 100mgs+ Potassium Citrate 100mgs-daytime

Taurine 500mgs + Inositol  500mgs---during day

Pregnenolone 10-30 mgs  + B5 500—early morning

Iodine 1-2 drops + Tyrosine  500mgs early morning mid day

 

Chamomile tea + Motherwort equal portions in water as a tea-evening hours

St Johns Wort  + Passion flower equal portions in water as a tea-evening Hours

Ginger + Cinnamon Tea –first thing in the morning mid day

Coffee Black + Peppermint leaf –First thing in morning midday

 

Essential Oils of Rosemary-Lavender-Neroli-Orange-Lemon—just sniffing them or inhaling strongly  can relax a person

 

Cocoa + Vanilla mixed in Honey can have a relaxing effect

Vanilla + Black Pepper mixed in Honey

 

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Potassium Ascorbate

Potassium Ascorbate is a salt derived from Ascorbic Acid (Vitamin C), obtained by making a solution in cold water using two compounds (Ascorbic Acid and Potassium Bicarbonate) in an extremely pure crystalline form (not less than 97% purity). This compound has extremely powerful anti-oxidant properties. Since this salt possesses extraordinary efficacy against degenerative pathologies, its use in regular doses, including at a preventive level, stimulates the body’s immune defenses. It acts by restoring (or maintaining) correct intra-cellular Potassium levels, thus promoting healthy cell metabolism while reversing degenerative processes (if applicable) in that ascorbic acid acts as the Potassium carrier inside the body’s cells and the compound offers protective qualities thanks to its highly anti-oxidant properties.

Potassium ascorbate is a mineral salt of ascorbic acid. It is a non-acidic pH neutral form of Vitamin C that provides the great benefits of Vitamin C without upsetting the stomach and digestive system. Mineral ascorbates are especially helpful for those who do not tolerate regular Vitamin C formulas well. Potassium acorbate delivers a high-potency source of vitamin C in the form of high-bioavailability potassium. Potassium ascorbate offers the potent antioxident protection of Vitamin C along with the health benefits of potassium. It is a natural chelator that binds with minerals and carries the mineral throughout the body. Because of this, mineral ascorbates are easily absorbed and retained by the body.---Potassium Ascorbate would seem to exert an anti-angiogenetic [F8] influence. All cells have an affinity for potassium. Since cancer cells "steal" minerals from healthy cells, cancer cells effectively "steal" potassium ascorbate. In fact, a foundation in Italy has studied the effects that potassium ascorbate can contribute toward potential cancer aid and prevention, helping to defeat and prevent degenerative disease by working on the immune system, making degenerative disease cells essentially "die of hunger". (Dr Pantellini. www.pantellini.org)--It is worth bearing in mind that since the compound also has a balancing effect on the body’s hormone levels, Potassium Ascorbate may help to increase fertility. It also may have a tendency to regulate blood pressure.

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Scientifically shown homeostatic benefits ascorbate promotes or enhances:

* Scurvy resistance: improved blood vessel and cardiovascular integrity

* Enhances hormone healthy and reduces hormone unhealthy actions

* Enhances neurotransmitter functions healthy and reduces unhealthy actions

* Promotes immune system healthy and reduces unhealthy actions

* Enhances nitrous oxide (NO) functions

* Enhances and repairs detoxification functions

* Enhances ATP energy compound production

* Enhances healthy bone formation

* Enhances and rebuilds glutathione functions

* Promotes iron balance [uptake and release]

* Reduces bio-accumulation of toxins

* Improves transit time

* Protects DNA from oxidative damage

* Reduces toxic minerals in body

* Enhances natural anti-cancer surveillance

* Direct tumor cytolytic effects

Scientifically disproven ef fects that as corbate promotes or enhances:

* Immortality

* Fenton reactions in vivo

* B-12 remains active in vivo

* DNA replication error theory not confirmed in vivo

l-Ascorbate: Its scientific significance for human health

Vitamin C (ascorbic acid or l-ascorbate) is nature's most potent, safer antioxidant cofactor. Ascorbate has gotten a fair amount of attention from the media in the last few years, including whether it is helpful, neutral, or harmful in limiting the number of colds, their symptoms, and their duration.

1. Ascorbate aids in the maintenance of cellular membranes, cellular respiration, the peroxidase cleansing system, the restoration of vitamin E /selenomethionine complexes, and sulfhydryl enzymes such as glutathionesynthetase, thereby helping to detoxify various drugs and chemicals.

2. Ascorbate is also involved in hormone biosynthesis and maintaining the integrity of connective tissue, cartilage, capillaries, bones, and teeth. Vitamin C is , therefore, important in wound repair and tissue healing.

3. Ascorbate has been shown to increase cellular resistance to many common viral infections (most probably due to its interferon-like activity) and enhance specific parameters of immune function.

All of these actions of ascorbate are related to its antioxidant or reducing or electron donating abilities. The use of ascorbate in health and disease is complex and sometimes misunderstood, although much less so when one considers the following facts and supportive background information. While almost all animals and plants synthesize their own vitamin C, exceptions are guinea pigs, monkeys, and humans. The first two of those eat mostly fresh vitamin C-rich foods: fruits and vegetation. Non-human animals, when adjusted for size and weight, make the equivalent of 5 to 15 grams of vitamin C a day, mostly in their livers and when stress free. Production can more than double when the animal is distressed. Our genetic ancestors once had the ability to synthesize vitamin C but appear to have lost it years ago. One enzyme is missing in a 6-enzyme process converting glucose to vitamin C. Scientists estimate that without this mutation, when healthy we would be making 10-30 grams of vitamin C a day throughout our lives and more when we are unwell or distressed

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Researchers identify how zinc regulates key enzyme involved in cell death

Date:

April 2, 2014

Source:

Virginia Commonwealth University

The molecular details of how zinc, an essential trace element of human metabolism, interacts with the enzyme caspase[F9] -3, which is central to apoptosis or cell death, have been elucidated in a new study led by researchers at Virginia Commonwealth University. The study is featured on the cover of the April issue of the journal Angewandte Chemie's International Edition.--Dysregulation of apoptosis is implicated in cancer and neurodegenerative disease such as Alzheimer's disease. Zinc is known to affect the process by inhibiting the activity of caspases, which are important drug targets for the treatment of the above conditions. The findings may help researchers design therapeutic agents that target zinc-caspase interaction to specifically control the activity of caspases, and hence, apoptosis.--"The work is unique in helping to open up a broad new area of research which we call the bioinorganic chemistry of apoptosis -- understanding the role of essential metal ions in one of life's fundamental processes," said corresponding author Nicholas P. Farrell, Ph.D., member of the Developmental Therapeutics program at VCU Massey Cancer Center and professor of chemistry in the VCU College of Humanities and Sciences.--"Indeed, the zinc inhibition of apoptosis in fact contrasts with the role of its closely related neighbor copper, which is understood to enhance apoptosis," he said.--In the study, Farrell and his research team, A. Gerard Daniel, Ph.D., and Erica J. Peterson, used conventional enzymology and biophysical techniques combined with state-of-the-art computational methods, to show evidence for a hitherto unrecognized interaction site with caspase-3.--According to Farrell, caspases were discovered in the mid-1990s. There are 11 caspases known humans, and seven of these are involved in cell death. The study suggests a regulatory zinc site that may be common to all caspases. Previous findings have shown other zinc binding sites in caspase-6 and -9. Now, Farrell said, the generality of the team's observations must be extended and verified in other caspases.--"The [journal] cover epitomizes the contrasting but interdependent roles of the metal ions copper/zinc in the regulation of apoptosis and perfectly captures the duality of this most fundamental of biological processes," Farrell said.--Story Source-The above story is based on materials provided by Virginia Commonwealth University. The original article was written by Sathya Achia Abraham. Note: Materials may be edited for content and length.-Journal Reference-A. Gerard Daniel, Erica J. Peterson, Nicholas P. Farrell. The Bioinorganic Chemistry of Apoptosis: Potential Inhibitory Zinc Binding Sites in Caspase-3. Angewandte Chemie International Edition, 2014; DOI: 10.1002/anie.201401105

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How zinc starves lethal bacteria to stop infection

Date:

November 11, 2013

Source:

University of Adelaide

Australian researchers have found that zinc can 'starve' one of the world's most deadly bacteria by preventing its uptake of an essential metal.--The finding, by infectious disease researchers at the University of Adelaide and The University of Queensland, opens the way for further work to design antibacterial agents in the fight against Streptococcus pneumoniae.--Streptococcus pneumoniae is responsible for more than one million deaths a year, killing children, the elderly and other vulnerable people by causing pneumonia, meningitis, and other serious infectious diseases.--Published today in the journal Nature Chemical Biology, the researchers describe how zinc "jams shut" a protein transporter in the bacteria so that it cannot take up manganese, an essential metal that Streptococcus pneumoniae needs to be able to invade and cause disease in humans.--"It's long been known that zinc plays an important role in the body's ability to protect against bacterial infection, but this is the first time anyone has been able to show how zinc actually blocks an essential pathway causing the bacteria to starve," says project leader Dr Christopher McDevitt, Research Fellow in the University of Adelaide's Research Centre for Infectious Diseases.--"This work spans fields from chemistry and biochemistry to microbiology and immunology to see, at an atomic level of detail, how this transport protein is responsible for keeping the bacteria alive by scavenging one essential metal (manganese), but at the same time also makes the bacteria vulnerable to being killed by another metal (zinc)," says Professor Bostjan Kobe, Professor of Structural Biology at The University of Queensland.--The study reveals that the bacterial transporter (PsaBCA) uses a 'spring-hammer' mechanism to bind the metals. The difference in size between the two metals, manganese and zinc, causes the transporter to bind them in different ways. The smaller size of zinc means that when it binds to the transporter, the mechanism closes too tightly around the zinc, causing an essential spring in the protein to unwind too far, jamming it shut and blocking the transporter from being able to take up manganese.--"Without manganese, these bacteria can easily be cleared by the immune system," says Dr McDevitt. "For the first time, we understand how these types of transporters function. With this new information we can start to design the next generation of antibacterial agents to target and block these essential transporters."--Story Source-The above story is based on materials provided by University of Adelaide.-Journal Reference-Rafael M Couñago, Miranda P Ween, Stephanie L Begg, Megha Bajaj, Johannes Zuegg, Megan L O'Mara, Matthew A Cooper, Alastair G McEwan, James C Paton, Bostjan Kobe, Christopher A McDevitt. Imperfect coordination chemistry facilitates metal ion release in the Psa permease. Nature Chemical Biology, 2013; DOI: 10.1038/nchembio.1382

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Zinc discovery may shed light on Parkinson's, Alzheimer's

Date:

September 30, 2013

Source:

University of Wisconsin-Madison

Scientists at the University of Wisconsin-Madison have made a discovery that, if replicated in humans, suggests a shortage of zinc may contribute to diseases like Alzheimer's and Parkinson's, which have been linked to defective proteins clumping together in the brain.--With proteins, shape is everything. The correct shape allows some proteins to ferry atoms or molecules about a cell, others to provide essential cellular scaffolding or identify invading bacteria for attack. When proteins lose their shape due to high temperature or chemical damage, they stop working and can clump together -- a hallmark of Parkinson's and Alzheimer's.--The UW researchers have discovered another stress that decreases protein stability and causes clumping: a shortage of zinc, an essential metal nutrient.--Zinc ions play a key role in creating and holding proteins in the correct shape. In a study just published in the online Journal of Biological Chemistry, Colin MacDiarmid and David Eide show that the gene Tsa1 creates "protein chaperones" that prevent clumping of proteins in cells with a zinc shortage. By holding proteins in solution, Tsa1 prevents damage that can otherwise lead to cell death.--For simplicity, the researchers studied the system in yeast -- a single-celled fungus. Yeast can adapt to both shortages and excesses of zinc, says MacDiarmid, an associate scientist. "Zinc is an essential nutrient but if there's too much, it's toxic. The issue for the cell is to find enough zinc to grow and support all its functions, while at the same time not accumulating so much that it kills the cell."--Cells that are low in zinc also produce proteins that counter the resulting stress, including one called Tsa1.--The researchers already knew that Tsa1 could reduce the level of harmful oxidants in cells that are short of zinc. Tsa1, MacDiarmid says, "is really a two-part protein. It can get rid of dangerous reactive oxygen species that damage proteins, but it also has this totally distinct chaperone function that protects proteins from aggregating. We found that the chaperone function was the more important of the two."--"In yeast, if a cell is deficient in zinc, the proteins can mis-fold, and Tsa1 is needed to keep the proteins intact so they can function," says Eide, a professor of nutritional science. "If you don't have zinc, and you don't have Tsa1, the proteins will glom together into big aggregations that are either toxic by themselves, or toxic because the proteins are not doing what they are supposed to do. Either way, you end up killing the cell."--While the medical implications remain to be explored, there are clear similarities between yeast and human cells. "Zinc is needed by all cells, all organisms, it's not just for steel roofs, nails and trashcans," Eide says. "The global extent of zinc deficiency is debated, but diets that are high in whole grains and low in meat could lead to deficiency."--If low zinc supply has the same effect on human cells as on yeast, zinc deficiency might contribute to human diseases that are associated with a build-up of "junked" proteins, such as Parkinson's and Alzheimer's. Eide says a similar protective system to Tsa1 also exists in animals, and the research group plans to move ahead by studying that system in human cell culture.--Story Source-The above story is based on materials provided by University of Wisconsin-Madison. Note: Materials may be edited for content and length.-Journal Reference-C. W. MacDiarmid, J. Taggart, K. Kerdsomboon, M. Kubisiak, S. Panascharoen, K. Schelble, D. J. Eide. Peroxiredoxin chaperone activity is critical for protein homeostasis in zinc-deficient yeast. Journal of Biological Chemistry, 2013; DOI: 10.1074/jbc.M113.512384

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Herbs and Foods with good levels of  Accessible Zinc

HERBS

Burdock                     Chamomile   

Chickweed                 Dandelion      

Echinacea                   Equisetum    

Eyebright                   Feverfew      

Ginger 6.8                  Goldenseal    

Hawthorn                  Pau D’Arco   

Peppermint               Ribwort         

Sarsaparilla               Stevia

Suma                          Parsley          

Animal Proteins

Chicken          2.5

Beef (steak)   5.5       Lamb (chops) 5.5

Pork    0.5

 

Nuts and Seeds

Almonds         3.0      Cashew Nuts

Chestnuts      0.5      Hazel Nut       2.4

Macadamia    1.7       Peanuts          3.3

Pecan Nuts    5.0      Pine Nuts       4.3

Pistachio Nuts 1.3     Walnuts          3.0

Almond          3.1

Pumpkin Seeds         Sunflower Seeds 5.1

                       

Oils   

Olive Oil         0.5

Veges

Garlic  0.6

Turnip 1.1      Potato 0.9

Carrot 0.5     Cauliflower 0.5

Spinach 0.2    Cabbage 0.2

Cucumber 0.1

 

TOP B


 [F1]In  fast food places all they are doing these days is filtering the fat in the fryer and putting it right back in with some added carcinogenic fat and these burn 15-18 hours a day so all the French fries and  fish batter and chicken batter will all accumulate in this fat as well as the acylamide from the potato

 [F2]In fast food places 235+ fahr—110 + cel

 [F3]Soy and Canola are usually the ones used and canola has high levels of omega 3 which when heated above 104 fahr –becomes a lethal carcinogen

 [F4]In other words those fed on plastic had an increase in cholesterol levels---and margarine is made in heat—and they suggest to consume this knowing full well this will cause an increase in health issues

 [F5]Anyone want a Chicken fried in fat at a high temp??or fish—or possibly meat?

 [F6]And you know every fast food place is going to do these costly test ---and when people see what is actually done to the fat in the fryers ---you would not ever go back to these places

 [F7]This is the case with Morgellon Sufferers---more then one pathology is affecting the immune system in this case a Biopolymer/biofilm which may carry a host of combinations of parasitical and polymers in the system which interact and can be replicating and reproducing at the same time

 [F8]Anti-angiogenic therapy is the method of cutting off blood supply to the cancer

 [F9]Caspase - any of a group of proteases that mediate apoptosis peptidase, protease, proteinase, proteolytic enzyme - any enzyme that catalyzes the splitting of proteins into smaller peptide fractions and amino acids by a process known as proteolysis

 

 

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TOP C

HOME

 

 

Show of the Month April 26 2014

Peaches inhibit breast cancer metastasis in mice, study says

Misleading Information on the Properties of Vitamin C

Study reveals new role of vitamin C in skin protection

The prevention of vaccine reactions

Statins = Diabetes Increase

 

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Peaches inhibit breast cancer metastasis in mice, study says

March 25th, 2014 in Cancer /

 

These are peach trees in research plots at Texas A&M AgriLife Research. Credit: Texas A&M AgriLife Research

Lab tests at Texas A&M AgriLife Research have shown that treatments with peach extract inhibit breast cancer metastasis in mice.

AgriLife Research scientists say that the mixture of phenolic compounds present in the peach extract are responsible for the inhibition of metastasis, according to the study, which was this month published in the Journal of Nutritional Biochemistry.--"Cancer cells were implanted under the skin of mice with an aggressive type of breast cancer cells, the MDA-MB-435, and what we saw was an inhibition of a marker gene in the lungs after a few weeks indicating an inhibition of metastasis when the mice were consuming the peach extract," said Dr. Luis Cisneros-Zevallos, a food scientist for AgriLife Research in College Station. "Furthermore, after determining the dose necessary to see the effects in mice, it was calculated that for humans it would be equivalent to consuming two to three peaches per day."--This is very important because it can be translated into something that is also beneficial for people, he added.--This work builds upon previous work at AgriLife Research released a few years ago, which showed that peach and plum polyphenols selectively killed aggressive breast cancer cells and not the normal ones, Cisneros-Zavallos said.--The previous work as well as the present one was conducted by Cisneros-Zevallos, Dr. David Byrne, both with AgriLife Research; Dr. Weston Porter, Texas A&M University department of veterinary physiology and pharmacology; and then-graduate student Giuliana Noratto, who is now on the faculty at Washington State University.--In the western hemisphere, breast cancer is the most common malignant disease for women, he said. In the U.S. last year, the American Cancer Society estimated about 232,340 new cases of invasive breast cancer among women.--Most of the complications and high mortality associated with breast cancer are due to metastasis, Cisneros-Zevallos pointed out.--"The importance of our findings are very relevant, because it shows in vivo the effect that natural compounds, in this case the phenolic compounds in peach, have against breast cancer and metastasis. It gives opportunity to include in the diet an additional tool to prevent and fight this terrible disease that affects so many people," he said.--The study was conducted using the peach variety Rich Lady. However, according to Cisneros-Zevallos, most peach fruit share similar polyphenolic compounds but might differ in content. The study also determined that the underlying mechanism by which peach polyphenols are inhibiting metastasis would be by targeting and modulating the gene expression of metalloproteinases.[F1] --"In general, peach fruit has chemical compounds that are responsible for killing cancer cells while not affecting normal cells as we reported previously, and now we are seeing that this mixture of compounds can inhibit metastasis," said Cisneros-Zevallos. "We are enthusiastic about the idea that perhaps by consuming only two to three peaches a day we can obtain similar effects in humans. However, this will have to be the next step in the study for its confirmation."--Cisneros-Zevallos continues testing these extracts and compounds in different types of cancer as well as in diabetes studies in vitro and in vivo to understand the molecular mechanisms involved.Provided by Texas A&M University---"Peaches inhibit breast cancer metastasis in mice, study says." March 25th, 2014. http://medicalxpress.com/news/2014-03-peaches-inhibit-breast-cancer-metastasis.html

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Misleading Information on the Properties of Vitamin C

The Cochrane review by Douglas et al. [1], which is referenced in the Best Practice article by Douglas and Hemilä [2], covers 60 years of research into vitamin C and the common cold. However, the review omits pharmacokinetic data that invalidate the conclusion that vitamin C is ineffective. This conclusion is not derivable from the data presented.

The dual-phase pharmacokinetics of vitamin C are described by the dynamic flow model [3,4]. Low gram-level intakes of ascorbate, leading to blood plasma levels below 70 μM/l, have a half-life of 8–40 days. Higher gram-level intakes have a plasma half-life of 30 minutes [3]. A large oral dose raises blood plasma levels briefly: they reach a peak after two to three hours, before decaying back to baseline. Frequent repeated doses allow sustained high plasma levels of about 250 μM/l [4,5].

Douglas and Hemilä reviewed intakes that transiently raise plasma ascorbate levels above 70 μM/l. A single dose does not raise the median level [6,7]. Daily supplements would, thus, not increase disease resistance to any great degree [3,4]. Single or double doses daily will not increase background plasma levels, regardless of the magnitude of the dose [6,7]. Since plasma ascorbate is at background level for the majority of the day, effects will be minimal.--There is widespread confusion about nutritional and pharmacological levels of supplementation [3]. Linus Pauling, typically, described nutritional gram-level doses able to provide a degree of disease prevention [8]. By contrast, pharmacological doses used for treatment are, at minimum, an order of magnitude larger and involve frequent doses. The doses should be at intervals of three hours or less [3]. Treatment doses are described by Cathcart's paper on titration to bowel tolerance [9]. To treat the onset of a cold, the therapy is perhaps a minimum of 10 g of oral ascorbic acid, followed by at least 2 g each hour [3,4].--Douglas and Hemilä give a misleading impression by not making it clear that the doses they consider are not pharmacological. They claim that the results of one study, giving an 8-g dose at the start of symptoms, are tantalising and deserve further assessment. However, once this single dose has been excreted, the protective effects will be lost. During illness, ascorbate is depleted rapidly and higher oral intakes are tolerated—up to 200 g per day [9]. It would be surprising if this 8-g dose had a large effect.--Studies on ascorbate require appropriate doses. Douglas and Hemilä have only confirmed that 60 years of vitamin C research has largely been wasted because of confusion between nutritional and pharmacological intakes, and because of a misunderstanding of the pharmacokinetics. It is essential that high-dose studies take into account ascorbate's dual-phase pharmacokinetics. The dosing regime should allow sustained high plasma levels to be achieved. The claim that vitamin C cannot prevent or cure the common cold is both premature and unwarranted.

References

  1. 1. Douglas RM, Hemilä H, D'Souza R, Chalker EB, Treacy B (2004) Vitamin C for preventing and treating the common cold. Cochrane Database Syst Rev 4: CD000980. pub2.
  2. 2. Douglas RM, Hemilä H (2005) Vitamin C for preventing and treating the common cold. PLoS Med 2: e168. doi: 10.1371/journal.pmed.0020168.
  3. 3. Hickey S, Roberts HJ (2004) Ascorbate: The science of vitamin C. Napa (California): Lulu Press. 264 p.
  4. 4. Hickey S, Roberts HJ, Cathcart RF (2005) Dynamic flow: A new model for ascorbate. J Orthomol Med. In press.

 5. Padayatty SJ, Sun H, Wang Y, Riordan HD, Hewitt SM, et al. (2004) Vitamin C pharmacokinetics: Implications for oral and intravenous use. Ann Intern Med 140: 533–537.

  1. 6. Levine M, Conry-Cantilena C, Wang Y, Welch RW, Washko PW, et al. (1996) Vitamin C pharmacokinetics in healthy volunteers: Evidence for a recommended dietary allowance. Proc Natl Acad Sci U S A 93: 3704–3709.
  2. 7. Levine M, Wang Y, Padayatty SJ, Morrow J (2001) A new recommended dietary allowance of vitamin C for healthy young women. Proc Natl Acad Sci U S A 98: 9842–9846.
  3. 8. Pauling L (1970) Vitamin C and the common cold. New York: W. H. Freeman. 122 p.
  4. 9. Cathcart RF (1981) Vitamin C, titrating to bowel tolerance, anascoremia, and acute induced scurvy. Med Hypotheses 7: 1359–1376.

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Study reveals new role of vitamin C in skin protection

Published: Wednesday, September 9, 2009 - 08:38 in Health & Medicine

Scientists have uncovered a new role played by Vitamin C in protecting the skin. Researchers at the University of Leicester and Institute for Molecular and Cellular Biology in Portugal studied new protective properties of vitamin C in cells from the human skin, which could lead to better skin regeneration.--The work, by Tiago Duarte, Marcus S. Cooke and G. Don Jones, found that a form of Vitamin C helped to promote wound healing and also helped protect the DNA damage of skin cells. Their findings have been published in the journal Free Radical Biology and Medicine. This report is the latest in a long line of publications from these researchers, at the University of Leicester, concerning vitamin C. Previously, the group has published evidence that DNA repair is upregulated in people consuming vitamin C supplements. The researchers have now provided some mechanistic evidence for this, in cell culture, using techniques such as Affymetrix microarray, for looking at gene expression, and the 'Comet' assay to study DNA damage and repair.--Tiago Duarte, formerly of the University of Leicester, and now at the Institute for Molecular and Cellular Biology in Portugal, said: "The exposure to solar ultraviolet radiation increases in summer, often resulting in a higher incidence of skin lesions. Ultraviolet radiation is also a genotoxic agent responsible for skin cancer, through the formation of free radicals and DNA damage. --"Our study analysed the effect of sustained exposure to a vitamin C derivative, ascorbic acid 2-phosphate (AA2P), in human dermal fibroblasts[F2] . We investigated which genes are activated by vitamin C in these cells, which are responsible for skin regeneration. --"The results demonstrated that vitamin C may improve wound healing by stimulating quiescent fibroblasts to divide and by promoting their migration into the wounded area. Vitamin C could also protect the skin by increasing the capacity of fibroblasts to repair potentially mutagenic DNA lesions."-- Dr Marcus S. Cooke from the Department of Cancer Studies and Molecular Medicine and Department of Genetics, at the University of Leicester, added: "The study indicates a mechanism by which vitamin C could contribute to the maintenance of a healthy skin by promoting wound healing and by protecting cellular DNA against damage caused by oxidation". "These findings are particular importance to our photobiology interests, and we will certainly be looking into this further".--These results will be of great relevance to the cosmetics industry. Free radicals are associated with premature skin aging, and antioxidants, such as vitamin C, are known to counter these highly damaging compounds. This new evidence suggest that, in addition to 'mopping up' free radicals, vitamin C can help remove the DNA damage they form, if they get past the cell's defences. --The study has the potential to lead to advances in the prevention and treatment of skin lesions specifically, as well as contributing to the fight against cancer.--Source: University of Leicester

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The prevention of vaccine reactions

15 November 2004

We know that reports of severe reactions following infant vaccinations, though rare, are causing widespread anxiety among the population. Moreover, physicians are discussing the question as to how many days after vaccination an infant death should be considered as attributable to a vaccine (1). --A review of the World literature on vitamin C and vaccine reactions in animals has revealed that supplementary vitamin C (ascorbic acid) has a potent and highly significant protective effect (2). Ascorbic acid reduces both the morbidity and the mortality following the injection of all bacterial and viral toxins tested in guinea pigs, and even in rats and mice, which make their own ascorbic acid from simple sugars in the liver. Clearly, even the ascorbic acid-producing animals do not always make enough ascorbic acid for all their needs. The highly protective effect of vitamin C has also been reported in children by Kalokerinos (3) in his studies of aborigines in Australia. --One therefore cannot help wondering why the various national centers for disease control have not yet recommended vitamin C to be given before all vaccinations. It would surely be most beneficial, not only in reducing severe vaccine reactions and deaths, but also in reducing or preventing the residual disabilities which can occur following minor cerebral or subdural haemorrhages. --We now know that the bleeding of severe vitamin C deficiency (or scurvy) is due to capillary fragility arising from the accumulation of excessive levels of histamine in the blood (4), causing widening and separation of the tight-junctions between the endothelial cells of the capillaries and venules, from which the bleeding arises (5). The histamine accumulation in scurvy is due to the fact that ascorbic acid is essential for the body’s progressive removal of histamine by converting it to hydantoin-5-acetic-acid and on to aspartic acid in vivo (6). Nowadays, with so many vaccines being given simultaneously to infants, one has to consider that the histamine arising from the injection of these foreign proteins and the histamine arising from any childhood infection will be added to the already elevated blood histamine level due to ascorbic acid depletion, so leading to a toxic blood histamine level which can be fatal. Perhaps this severe condition should not be called Infantile Scurvy or Barlow’s Disease, but rather Toxic Histaminaemia or a Barlow’s Disease Variant. --No doubt Health Departments will soon conduct studies of plasma ascorbic acid and whole blood histamine levels on soldiers before and at various intervals after single and multiple vaccinations for overseas duty. Such studies will certainly confirm that outwardly normal people with somewhat low ascorbate levels have markedly elevated blood histamine levels, and that their blood histamine concentrations increase even more following vaccinations. A more useful estimation of the time range of vulnerability for each vaccine might then be made.

Until then, we can hope

1) That vaccinations will be postponed when an infant is premature or is ailing in any way, even with the common cold.

2) That consideration will be given to reducing the number of vaccines to be given at one time.

3) That 500 mg of vitamin C powder in fruit juice will be given to infants to drink before their vaccinations. (More vitamin C can be given by intramuscular injection, if the infant develops a high-pitched cry, a febrile illness, or has a convulsion.)

C.A.B. Clemetson, M.D., Professor Emeritus, Tulane University School of Medicine, New Orleans, Louisiana, Tele: 504-866-1525, Email: megcc2000@yahoo.com

References

1) Buttram H. Shaken baby syndrome, or vaccine-induced encephalitis? Med Sentinel 2001; 6:83-89.

2) Clemetson CAB. Vaccinations, inoculations, and ascorbic acid. J Orthomolecular Med 1999; 14:137-142.

3) Kalokerinos A. Medical Pioneer of the 20th Century. Melbourne, Victoria, Australia: Biological Therapies Publishing Pty Ltd; 2000.

4) Clemetson CAB. Histamine and ascorbic acid in human blood. J Nutr 1980; 110:662-668.

5) Clemetson CAB. Is it “shaken baby,” or Barlow’s disease variant? J Amer Phys Surg 2004; 9:78-80.

6) Chatterjee IB, Majumder AK, Nandi BK, Subramanian N. Synthesis and some major functions of vitamin C in animals. Ann NY Acad Sci 1975; 258:24 -47.

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Statins = Diabetes Increase

Because while more and more studies are showing us just how dangerous statins are, the vultures are circling more than ever. --Big Pharma’s latest plans for selling statins is very targeted — with just about every single person is in the crosshairs.-You know that old high cholesterol myth — the one that’s been drummed into us for years. Well, it didn’t seem to be selling enough statins to satisfy the profit-hungry drug makers. So their buddies at the American Heart Association and the American College of Cardiology put a “calculator” together to fix that problem.--That did away with the spin-the-wheel game of ‘cholesterol target numbers’ and replaced it with a simple seven-question quiz. --The numbers — just published in the New England Journal of Medicine show that practically all men over 60 and just about 50 percent of everyone else over 40 meet the new standards for a regular dose of Lipitor.--This is the first “independent” look at the impact of these new guidelines. --And it boils down to this — an immediate increase of over 13 million who will now “need” statins. --When the AHA and ACC “calculator” was first unveiled last year, experts from Harvard said it had “serious flaws” that could overestimate a person’s risk of heart disease by up to 150 percent. And they warned the heart groups about that over a year before this deadly ‘recalculation’ was released, saying it just didn’t work. --And the Harvard folks weren’t the only ones asking them to put the brakes on it. The top heart doc at the Cleveland Clinic also said it needed further evaluation before being “implemented on a widespread basis.”---And that’s probably because when statin sales go up, cases of diabetes go up with them. --In fact, a new study found that among statin users, one in every five new cases of diabetes was linked to the drug.— one in five! And women appear to be much more prone to this diabetes risk than men. If they did a study using only women, The numbers may reflect a different stat..But that’s not the only known side effect. Others include impotence, cataracts, muscle pains, mental impairment, fatigue, and liver dysfunction. -But over in the U.K. they’ve been sounding the alarm — The deputy chairman of the British Medical Association has said that plans to increase statin use would “only benefit drug companies.” Others said they will urge their government to “reconsider its move” before it puts millions more Brits at risk. --One even likened it to keeping “people from dying from heart disease by pushing them off a cliff.”

Sources:

“‘Eye-opening’ new report about statin eligibility” AP, March 19, 2014, cnbc.com

“Health chief slams statins: millions face terrible side effects as prescription escalates” Lucy Johnston, March 2, 2014, Express, express.co.uk

“Some doctors challenge new statin guidelines” Dennis Thompson, November 18, 2013, Health Day, webmd.com

- See more at: http://hsionline.com/2014/03/27/dangerous-rx/#sthash.WoWjeNB3.dpuf

 

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TOP C


 [F1]Metalloproteinases-are metals that prduce a estrogenic effect and can over load the receptor sites where estrogen bind and mutate to something they should not

 [F2]Ascorbic  Acid and Phosphorus